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Abstracts tagged "Ankylosing spondylitis (AS)"

  • Abstract Number: 1450 • ACR Convergence 2024

    Radiographic Structural Spine Assessment in Ankylosing Spondylitis According to the Presence or Absence of Psoriasis

    Inès Favre-Felix1, Andrea MENNINI2, Caroline Morizot3, Marie LAFFAIRE2, Isabelle Chary-Valckenaere4 and Damien Loeuille5, 1Nancy university, Vandœuvre-lès-Nancy, France, 2CHRU Nancy, Nancy, France, 3CHRU Nancy, Vandœuvre-lès-Nancy, France, 4Nancy University Hospital, Vandœuvre-lès-Nancy, Lorraine, France, 5Phd, Nancy Vandoeuvre, Lorraine, France

    Background/Purpose: Patients with ankylosing spondylitis and psoriasis (AS-Pso) were classically older, smokers, overweighted,  with lower prevalence of the HLA-B27 status and an equal sex ratio…
  • Abstract Number: 1985 • ACR Convergence 2024

    Underlying Autoimmune Disease Has Not Limited Immune Checkpoint Inhibitor Use or Increased Mortality Risk During Cancer Treatment of US Veterans

    Madeline O’Sullivan1, grant Cannon2, Sauer brian3, Jorge Rojas4, Gary Kunkel5, Jessica A Walsh6, Punyasha Roul7, shardool Patel1, Joshua Baker8, Bryant England9 and Tawnie Braaten1, 1University of Utah, Salt Lake City, UT, 2University of Utah and Salt Lake City VA, Salt Lake City, UT, 3Salt Lake City VA/University of Utah, Salt Lake City, UT, 4Seattle VA, Mexico, Mexico, 5University of Utah and George E Wahlen VAMC, Salt Lake City, UT, 6Division of Rheumatology, Salt Lake City Veterans Affairs Health and University of Utah Health, Salt Lake City, UT, 7UNMC, Omaha, NE, 8University of Pennsylvania, Philadelphia, PA, 9University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Immune checkpoint inhibitors (ICIs) can cause a variety of immune-related adverse events (irAEs) affecting multiple organ systems, and patients with pre-existing autoimmune disease (AID)…
  • Abstract Number: 0078 • ACR Convergence 2024

    Inhibition of the Deubiquitinase TRABID in a Pre-clinical Mouse Model of Axial Spondyloarthritis Decreases Disease Severity

    Archita Srinath1, Daniele Mauro2, Mariia Korshko3, Shaghayegh Foroozan4, Mansi Aparnathi5, Francesco Ciccia6 and Nigil Haroon7, 1University of Toronto, Toronto, ON, Canada, 2University of Campania, Italy, Naples, Naples, Italy, 3University Health Network, Toronto, ON, Canada, 4University Health Network/University of Toronto, Toronto, ON, Canada, 5University Health Network, Toronto, Canada, 6University of Campania, Naples, Italy, 7Department of Medicine/Rheumatology, University Health Network, Schroeder Arthritis Institute, University of Toronto, Toronto, ON, Canada

    Background/Purpose: Axial Spondyloarthritis is characterized by both inflammation and new bone formation. Current therapeutic targets aim to control inflammation, however, over 40% of patients do…
  • Abstract Number: 0562 • ACR Convergence 2024

    Serum Interleukin IL-40 as a Potential Biomarker Associated with Pro-inflammatory Activity in Inflammatory Bowel Diseases and Spondyloarthritis: A Preliminary Study

    Lucia Ondrejčáková1, Adéla Navrátilová2, Monika Gregová3, Kristýna Bubová4, Tomáš Grega5, Ladislav Šenolt6, Karel Pavelka7 and Lucie Andrés Cerezo8, 1Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, 21st Faculty of Medicine, Charles University and Institute of Rheumatology in Prague, Hlavní mesto Praha, Czech Republic, 3Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine Charles University, Prague, Czech Republic, 4Institute of Rheumatology and Charles University, Prague, Czech Republic, 53Department of Internal Medicine, First Faculty of Medicine, Charles University, Military University Hospital, Prague, Czech Republic, Prague, Czech Republic, 6Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, 7Institute of Rheumatology and Charles University, Praha, Czech Republic, 8Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic

    Background/Purpose: Interleukin 40 (IL-40) is a novel cytokine with a proposed role in the pathogenesis of inflammatory diseases. Inflammatory bowel diseases (IBD)-associated with spondyloarthritis (SpA)…
  • Abstract Number: 1020 • ACR Convergence 2024

    Health Inequalities Exist Between the United States and Europe for Patients with Axial Spondyloarthritis

    Elena Nikiphorou1, Alexis Ogdie2, Dan Twigg3, Emily Quiñones4, You-Li Ling5, Karim Masri6, Joseph C. Cappelleri7, Lidia Sanchez-Riera8, Megan Hughes9 and NICOLA MASSEY9, 1King's College London, London, United Kingdom, 2Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 3Adelphi Real World, Manchester, United Kingdom, 4Adelphi Real World, Macclesfield, United Kingdom, 5Pfizer Inc, New York, NY, 6Pfizer Inc, Collegeville, PA, 7Pfizer, Groton, 8Pfizer, Madrid, 9Adelphi Real World, Bollington, United Kingdom

    Background/Purpose: Structural differences exist between the healthcare systems in the United States (US) and Europe. In real-world clinical settings, we investigated whether these differences create…
  • Abstract Number: 1453 • ACR Convergence 2024

    Efficacy and Safety of the Recombinant Anti-human IL-17A/F Humanized Monoclonal Antibody Injection (XKH004) in Patients with Active Ankylosing Spondylitis: Findings from a 24-Week, Phase 2 Multicenter, Randomized, Placebo-Controlled Study

    Ling Zhou1, Juan Zhao1, Lingyun Sun2, Xuan Zhang3, Xiaomei Li4, Jiankang Hu5, Lijun Wu6, Zhenyu Jiang7, Min Yang8, Xiaoxia Wang9, Yongjun Mei10, Qingchun Huang11, Yongtao Chen12, Yang Li13, Lingli Dong14, Hui Luo15, Li Guo16, Jianguo You16, Yunpeng Zhang16, Ke Ren16 and Huji Xu1, 1Shanghai Changzheng Hospital, Shanghai, China (People's Republic), 2Nanjing Drum Tower Hospital, Nanjing, China (People's Republic), 3Beijing Hospital, Beijing, China, 4The First Affiliated Hospital of University of Science and Technology of China, Anhui, China (People's Republic), 5Department of Rheumatology, Pingxiang People's Hospital, Pingxiang, China, Pingxiang, China (People's Republic), 6People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China (People's Republic), 7The First Hospital of Jilin University, Changchun, China (People's Republic), 8Nanfang Hospital, Guangzhou, China (People's Republic), 9Second Hospital of Shanxi Medical University, Taiyuan, China (People's Republic), 10The First Affiliated Hospital of Bengbu Medical College, Bengbu, China, 11The Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China (People's Republic), 12West China Hospital, Sichuan University, Chengdu, China (People's Republic), 13Guangdong Provincial People's Hospital, Guangzhou, China (People's Republic), 14Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (People's Republic), 15Xiangya Hospital, Central South University, Changsha, China (People's Republic), 16Kanova Biopharma, Zhejiang, China (People's Republic)

    Background/Purpose: XKH004, the first recombinant anti-human IL-17A/F humanized monoclonal antibody in China (also known as XKH004), shares the same therapeutic target as Bimekizumab from UCB…
  • Abstract Number: 2049 • ACR Convergence 2024

    Genetically Proxied Glucose‑lowering Drug Target and Risk of Immune Mediated Inflammatory Disease: A Mendelian Randomization Study

    Dongze Wu1 and Yingzhao jin2, 1Department of Rheumatology and Immunology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China (People's Republic), 2Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, Hong Kong

    Background/Purpose: There are conflicting findings on the relationship between glucose-lowering drugs and risk of development of immune mediated inflammatory diseases (IMIDs). The study aimed to…
  • Abstract Number: 0080 • ACR Convergence 2024

    Enhanced Cytotoxicity of Aging Associated NKG2C+ CD8+ T Cells in Ankylosing Spondylitis via HLA-B27

    Kunhai Tang, Xiaobei Ma, Jian Gao, Feng Qian, Qi Zhu, Jiucun Wang and Jing Liu, Fudan University, Shanghai, China (People's Republic)

    Background/Purpose: Ankylosing spondylitis (AS) is an immune-related chronic inflammatory disease characterized by inflammatory pain in the lower back and spinal ankylosing, accompanied by immune system disorders, such…
  • Abstract Number: 0564 • ACR Convergence 2024

    The Risk of Venous Thromboembolism in Axial Spondyloarthritis: A Population-based Study

    Mayas Arraf1, Devy Zisman2, walid Saliba3, Nili Stein4 and Joy Feld5, 1Technion medical school, Haifa, Israel, 2Carmel Medical Center, Haifa, Israel, 3Carmel medical center, Haifa, Israel, 4Department of Community Medicine and Epidemiology, Haifa, Israel, 5Carmel and Zvulun Medical Centre, Haifa, Israel

    Background/Purpose: Scarce data exist regarding the incidence of venous thromboembolism events (VTE); pulmonary embolism (PE) and deep vein thrombosis (DVT), in patients with axial spondylarthritis…
  • Abstract Number: 1030 • ACR Convergence 2024

    Diversity in Axial Spondyloarthritis Drug Trials: Examining Enrollment by Sex, Race, Ethnicity and Geographic Region

    Mathieu Choufani1, Wissam Ghusn2 and Joerg Ermann3, 1Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Boston, MA, 2Department of Internal Medicine, Boston Medical Center, Boston, MA, 3Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA

    Background/Purpose: While axial spondyloarthritis (AxSpA) was historically perceived as a "white man's disease", it is now appreciated as a condition that can affect individuals of…
  • Abstract Number: 1459 • ACR Convergence 2024

    Dietary Modification and Intermittent Fasting Are Common in Patients with Axial Spondylarthritis and May Lead to Reduced Inflammatory Activity

    Michael Nissen1, Adrian Ciurea2, Raphael Micheroli3, Eric Trunk4 and Delphine Courvoisier5, 1Geneva University Hospital, Geneva, Switzerland, 2University Hospital Zurich, Zürich, Switzerland, 3University Hospital Zurich, Zurich, Switzerland, 4Geneva University Hospital, Geenva, Switzerland, 5University Hospitals of Geneva, Geneva, Switzerland

    Background/Purpose: Current EULAR recommendations highlight the importance of a healthy, balanced diet in patients with inflammatory rheumatic disease, including axial spondylarthritis (axSpA). A Mediterranean-style diet…
  • Abstract Number: 2119 • ACR Convergence 2024

    IL-17 Blockade Therapy Improves Symptoms in Patients with Active Axial Spondyloarthritis Without Occurrence of New Vertebral Fractures

    Chloe Heiting1, Donald McMahon1, Douglas Mintz1, Weijia Yuan1, Insa Mannstadt1, Linda A Russell1, Emily Stein1, Dalit Ashany2 and Susan Goodman3, 1Hospital for Special Surgery, New York, NY, 2Hospital for Special Surgery, Scarsdale, NY, 3Hospital for Special Surgery, New York 10025, NY

    Background/Purpose: Axial spondyloarthritis (AxSpA) is characterized by abnormal bone formation and, paradoxically, bone loss accompanied by increased bone fragility and vertebral fracture risk. Tumor necrosis…
  • Abstract Number: 0081 • ACR Convergence 2024

    The Axial Spondyloarthritis Risk Variant CARD9 S12N Enhances Neutrophil-mediated Th Responses

    Hillary Struthers1, Kofi Asare-Konadu2, Emily Vance1 and Ruth Napier3, 1Oregon Health & Science University, Portland, OR, 2Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR, 3Department of Molecular Microbiology and Immunology and Division of Arthritis and Rheumatic Disease, Oregon Health & Science University, VA Portland Health Care System, Portland, OR

    Background/Purpose: Axial spondyloarthritis (axSpA) is a type of inflammatory arthritis that primarily affects the entheses of the spine and/or sacroiliac joints. The cause of axSpA…
  • Abstract Number: 0565 • ACR Convergence 2024

    Low Vitamin D Serum Level Is a Risk Factor for Ankylosis in Axial Spondyloarthritis: Evidence from a Nested-Case-Control Study

    Anthony Lichaa1, Pauline KRUG1 and Adrien Nzeusseu Toukap2, 1Cliniques universitaires St-Luc, Brussel, Belgium, 2Cliniques universitaires Saint-Luc,, St.-Lambrechts-Woluwe, Belgium

    Background/Purpose: Axial spondyloarthritis (axSpA) is a progressive disease, characterized by chronic inflammation and progressive structural damage. However, the kinetic of progression to ankylosis and much…
  • Abstract Number: 1054 • ACR Convergence 2024

    Utilization of Rehabilitation Services in Patients with Common Rheumatic Conditions: A Systematic Review

    Keri Geinosky1, Joel Thompson2, Joshua Torrey3 and Louise Thoma4, 1University of North Carolina at Chapel Hill, Chapel Hill, 2university of north carolina - chapel hill, Cary, NC, 3UNC Chapel Hill, Westmoreland, NH, 4University of North Carolina, Chapel Hill, NC

    Background/Purpose: Rehabilitation services, such as physical therapy (PT) and occupational therapy (OT), are recommended in the care of inflammatory arthritis and other rheumatic conditions. However, the…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

ACR Abstract Embargo Policy

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

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