Abstracts tagged "Animal models"

Abstract Number: 500 • 2018 ACR/ARHP Annual Meeting
Impact of Inflammation and Biologic Treatments on Generation and Progression to Advanced Calcified Coronary Plaques in Rheumatoid Arthritis
George Karpouzas¹, Sarah Ormseth², Elizabeth Hernandez² and Matthew Budoff³, ¹Division of Rheumatology, Harbor-UCLA Medical Center, Torrance, CA, ²Rheumatology, Harbor-UCLA Medical Center, Torrance, CA, ³Cardiology, Harbor-UCLA Medical Center, Torrance, CA
Background/Purpose: In early atherogenesis inflammation drives and co-localizes with intimal calcification. In chronic, advanced plaques inflammation and calcification are inversely correlated and spatially distinct; advanced…
Abstract Number: 1994 • 2018 ACR/ARHP Annual Meeting
Osteoarthritis Severity Is Reduced By Intra-Articular Administration of Hydrogen Sulfide
Elena F. Burguera^1,2, Angela Vela-Anero³, Carlos Vaamonde-Garcia³, Tamara Hermida-Gómez^1,2, Purificacion Filgueira-Fernandez^1,2, Lucía Gato-Calvo², Rosa Meijide-Failde⁴ and Francisco J Blanco⁵, ¹CIBER-BBN, Madrid, Spain, ²Unidad de Medicina Regenerativa, Grupo de Investigación en Reumatología, Agrupación Estratégica CICA-INIBIC, Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas, Universidade de A Coruña (UDC), A Coruña, Spain, ³Department of Physiotherapy, Medicine and Biological sciences, Tissue Engineering and Regenerative Medicine group (University of A Coruña), A Coruña, Spain, ⁴Department of Physiotherapy, Medicine and Biological Sciences, Tissue Engineering and Regenerative Medicine group (University of A Coruña), A Coruña, Spain, ⁵Grupo de Investigación en Reumatología, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain
Background/Purpose: Hydrogen sulphide (H2S) is recognized as a therapeutic target in osteoarthritis (OA). Exogenous supplementation with synthetic salts in in vitro models of OA has…
Abstract Number: 840 • 2018 ACR/ARHP Annual Meeting
The CCL21/CCR7 Axis Drives Vascular, Inflammatory and Destructive Remodeling in Rheumatoid Arthritis
Katrien Van Raemdonck^1,2, Karol Palasiewicz^1,2, Sadiq Umar^1,2 and Shiva Shahrara², ¹Jesse Brown VA Medical Center, Chicago, IL, ²Medicine, Division of Rheumatology, University of Illinois at Chicago, Chicago, IL
Background/Purpose: The synovial tissue of rheumatoid arthritis (RA) patients exhibits abundant expression of CCL21, produced excessively by RA fibroblasts and macrophages. While CCR7 mediates CCL21-driven…
Abstract Number: 2059 • 2018 ACR/ARHP Annual Meeting
Inhibition of the Transcription Factor That Drives IL-17 Expression Suppresses Inflammation, Joint Damage, and New Bone Formation in Experimental Spondyloarthritis in HLA-B27 Transgenic Rats
Joel Taurog¹, Jiankun Zhu¹, Michael Kort², Shaughn Bryant³, Lucy Phillips³ and Wendy Waegell³, ¹Dept Int Med-Rheum Dis Div, University of Texas Southwestern Medical Center, Dallas, TX, ²AbbVie, Inc., North Chicago, IL, ³AbbVie, Inc., Worcester, MA
Background/Purpose: The IL-17 axis has been identified as a central pathway in SpA pathogenesis. Targeting this axis in AS and PsA significantly suppresses inflammation and…
Abstract Number: 845 • 2018 ACR/ARHP Annual Meeting
New Insights in Lupus Dermatitis: Differential Regulation and Roles of Tissue-Resident Dendritic Cell Subsets in the Pathogenesis of Autoimmune Skin Inflammation
Ram R. Singh, Miguel-Angel Gutierrez, Peter Kim, Darshan Randhawa, Rachael Philips, Jennifer K. King and Anna Eriksson, Autoimmunity and Tolerance Laboratory, Department of Medicine/Rheumatology, UCLA, Los Angeles, CA
Background/Purpose: Acquired or self antigens in tissues are taken to lymphoid organs to elicit protective immunity or tolerance, respectively. This is accomplished by dendritic cells…
Abstract Number: 2063 • 2018 ACR/ARHP Annual Meeting
Early Injection of TNF Inhibitor Prevents Spinal Inflammation and Deformity in Curdlan-Induced Spondyloarthritis Animal Model
Doo-Ho Lim¹, Eun-Ju Lee², Seokchan Hong², Yong-Gil Kim², Chang Keun Lee² and Bin Yoo², ¹Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Ulsan University Hospital, Ulsan, Korea, Republic of (South), ²Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea, Republic of (South)
Background/Purpose: TNF inhibitors are highly efficient in controlling disease activity and improving functional outcomes as well as quality of life in most ankylosing spondylitis patients;…
Abstract Number: 850 • 2018 ACR/ARHP Annual Meeting
Long Term Efficacy of Cartilage Repair Induced By scSOX9 in Situ with Bone Marrow-Derived Mesenchymal Stem Cells
Xiaowei Zhang^1,2, Shili Wu³, Yong Zhu³ and Cong-Qiu Chu^4,5, ¹Oregon Health & Science University, Portland, OR, ²VA Portland Health Care System, Portland, OR, ³VivoScript, Inc, Costa Mesa, CA, ⁴Rheumatology, Oregon Health & Science University, Portland, OR, ⁵Rheumatology, VA Portland Health Care System, Portland, OR
Background/Purpose: Microfracture induces fibrocartilage or fibro-hyaline cartilage both are biomechanically inferior to hyaline cartilage. We reported previously that a super positively charged SOX9 (scSOX9) improved…
Abstract Number: 2072 • 2018 ACR/ARHP Annual Meeting
Beneficial Effect of Combination Therapy of Etanercept with Non-Steroidal Anti-Inflammatory Drugs Compared to Etanercept Monotherapy in a Spondyloarthritis Animal Model
Seung-Cheol Shim¹, Ji-Young Kim², Seung Taek Song³, Jin-Sun Choi², Chan Keol Park⁴ and In-Seol Yoo¹, ¹Division of Rheumatology, Department of Internal Medicine, Daejeon Rheumatoid & Degenerative Arthritis Center, Chungnam National University Hospital, Daejeon, Korea, Republic of (South), ²Division of Rheumatology, Daejeon Rheumatoid & Degenerative Arthritis Center, Chungnam National University Hospital, Daejeon, Korea, Republic of (South), ³Department of Rheumatology, Cheongju St. Mary's Hospital, Cheongju, Korea, Republic of (South), ⁴Internal medicine, Daejeon Rheumatoid & Degenerative Arthritis Center, Chungnam National University Hospital, Daejeon, Korea, Republic of (South)
Background/Purpose: Non-steroidal anti-inflammatory drugs (NSAIDs) are recommended as first-line drug treatment of spondyloarthritis (SpA) which is frequently associated with inflammatory bowel disease. Biologic disease modifying…
Abstract Number: 1007 • 2018 ACR/ARHP Annual Meeting
Macrophage Mediators of Autoimmune Valvular Carditis and Fibrosis
Lee Meier¹, Mayra Gonzalez-Torres², Jennifer L. Auger², Aubyn Marath³ and Bryce A. Binstadt², ¹Department of Pediatrics and Center for Immunology, University of Minnesota, Minneapols, MN, ²Department of Pediatrics and Center for Immunology, University of Minnesota, Minneapolis, MN, ³CardioStart International, Tampa, FL
Background/Purpose: K/B.g7 TCR transgenic mice spontaneously develop both autoimmune arthritis and valvular carditis. We utilize this model to define mediators of rheumatic disease-associated cardiovascular inflammation…
Abstract Number: 2077 • 2018 ACR/ARHP Annual Meeting
Pathological Osteogenesis and Inflammation in Experimental Spondyloarthritis Are Associated with Aberrant Type H Blood Vessels and Development of High Endothelial Venules Accompanied By Ectopic Lymphoid Structures in Bone Marrow
Merlijn Kaaij¹, Jan Piet van Hamburg², George Kollias³, Dominique Baeten¹, Leonie van Duivenvoorde¹ and Sander W. Tas², ¹Department of Clinical Immunology & Rheumatology and Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ²Amsterdam Rheumatology & immunology Center | Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ³Department of Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece
Background/Purpose: Spondyloarthritis (SpA) is characterized by pathological osteogenesis, inflammation and extensive angiogenesis in inflamed tissues. TNF plays a central role in SpA pathology and transgenic…
Abstract Number: 1021 • 2018 ACR/ARHP Annual Meeting
Impact of TLR7 Ligation in RA Pathology
Sadiq Umar^1,2, Katrien Van Raemdonck^1,2, Karol Palasiewicz^1,2 and Shiva Shahrara¹, ¹Medicine, Division of Rheumatology, University of Illinois at Chicago, Chicago, IL, ²Jesse Brown VA Medical Center, Chicago, IL
Background/Purpose: Expression of Toll-like receptor 7 (TLR-7) is highly elevated in rheumatoid arthritis (RA) and osteoarthritis (OA) compared to normal (NL) synovial tissue lining and…
Abstract Number: 2082 • 2018 ACR/ARHP Annual Meeting
ERAP1 Deficiency Partially Relieves HLA-B27-Induced ER Stress and IL-23 Expression, but Does Not Restore Dendritic Cell Function in Experimental Spondyloarthritis
Tri Tran¹, Vance Holt², Tejpal Gill¹, Joshua R. Bennett², Joel Taurog³ and Robert Colbert⁴, ¹National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ²National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ³Dept Int Med-Rheum Dis Div, University of Texas Southwestern Medical Center, Dallas, TX, ⁴National Institute of Arthritis and Musculuskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD
Background/Purpose: Preliminary results suggest that endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1) deficiency partially protects HLA-B27/human b2m transgenic (B27-Tg) rats from spondyloarthritis (SpA) as evidenced by…
Abstract Number: 1033 • 2018 ACR/ARHP Annual Meeting
Comparison of Oral Administration of Diacerein, Intra-Articular Injection of Diacerein Solution, and Intra-Articular Injection of Diacerein-Loaded Nanoparticle in Osteoarthritis Rat Model
Jae Hyun Jung^1,2, Sung Jae Choi^1,3, Gwan Gyu Song^1,2, Sung Eun Kim⁴ and Hak-Jun Kim^5,6, ¹Internal Medicine, Korea University College of Medicine, Seoul, Korea, Republic of (South), ²Internal Medicine, Korea University Guro Hospital, Seoul, Korea, Republic of (South), ³Internal Medicine, Korea University Ansan Hospital, Ansan, Korea, Republic of (South), ⁴Orthopedic Surgery, Korea University Guro Hospitial, Seoul, Korea, Republic of (South), ⁵Orthopedic Surgery, Korea Univertisy College of Medicine, Seoul, Korea, Republic of (South), ⁶Orthopedic Surgery, Korea University Guro Hospital, Seoul, Korea, Republic of (South)
Background/Purpose: Osteoarthritis (OA) treatment is typically administered to control symptoms. Diacerein (DIA) reduces interleukin (IL)-1 receptor on chondrocytes and prevents structural degradation of joint tissue.…
Abstract Number: 2090 • 2018 ACR/ARHP Annual Meeting
Identification of a Role for Monocytes in Murine Lupus Associated Diffuse Alveolar Hemorrhage By Mass Cytometry
Nathan Nelson-Maney¹, Pui Lee², Anais Levescot³, Yuelong Huang⁴ and Peter Nigrovic⁵, ¹Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA, ²Harvard Medical School, Boston, MA, ³Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, boston, MA, ⁴Brigham and Women's Hospital, Boston, MA, ⁵Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA
Background/Purpose: Diffuse alveolar hemorrhage (DAH) is a life-threatening pulmonary complication of systemic lupus erythematosus. The inciting pathology is thought to be pulmonary capillaritis but the…
Abstract Number: 1034 • 2018 ACR/ARHP Annual Meeting
A Conplastic Mice Model of Aging Reveals That Mitochondrial DNA Variation Influences the Process of Joint Deterioration
Ignacio Rego-Pérez¹, Ana Victoria Lechuga-Vieco², Morena Scotece¹, Purificación Filgueira-Fernández¹, Sonia Pertega³, Jose Antonio Enríquez² and Francisco J Blanco⁴, ¹Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña. España, A Coruña, Spain, ²Grupo de Genética funcional del sistema de fosforilación oxidativa. Centro Nacional de Investigaciones Cardiovasculares (CNIC). C/Melchor Fernández de Almagro, 3, 2 Sur. 28029. Madrid, España, Madrid, Spain, ³Unidad de Epidemiología Clínica y Bioestadística. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain, ⁴Grupo de Investigación en Reumatología, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain
Background/Purpose: Different studies showed interesting genetic associations between mtDNA haplogroups and OA-related features, including prevalence, incidence and progression of the disease. The aim of this…

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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

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