Abstracts tagged "Animal models"

Abstract Number: 1639 • 2012 ACR/ARHP Annual Meeting
FLIP in Macrophages Promotes the Progression of Serum Transfer-Induced Arthritis
Qi Quan Huang¹, Robert Birkett², Renee E. Koessler¹, G. Kenneth Haines III³, Harris R. Perlman⁴ and Richard M. Pope⁵, ¹Medicine/Rheumatology, Northwestern University, Chicago, IL, ²Division of Rheumatology, Department od Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Department of Pathology, Yale University, New Haven, CT, ⁴Feinberg School of Medicine, Northwestern University, Chicago, IL, ⁵Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL
Background/Purpose: Flip is well known as an anti-apoptotic protein induced by chronic inflammation that protects against death receptor-mediated apoptosis. Employing a FLIP myeloid lineage knock-out…
Abstract Number: 856 • 2012 ACR/ARHP Annual Meeting
Am80, a Retinoic Acid Receptor Agonist, Ameliorates Murine Vasculitisthrough the Suppression of Neutrophil Migration and Activation
Chie Miyabe¹, Yoshishige Miyabe¹, Noriko Miura², Kei Takahashi³, Yuya Terashima⁴, Etsuko Toda⁴, Fumiko Honda⁵, Tomohiro Morio⁵, Naohito Ohno², Jun-ichi Suzuki⁶, Mitsuaki Isobe⁷, Kouji Matsushima⁴, Ryoji Tsuboi⁸, Nobuyuki Miyasaka¹ and Toshihiro Nanki⁹, ¹Department of Medicine and Rheumatology, Tokyo Medical and Dental University, Tokyo, Japan, ²Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Tokyo, Japan, ³Department of Pathology, Toho University Ohashi Medical Center, Tokyo, Japan, ⁴Department of Molecular Preventive Medicine, The University of Tokyo, Tokyo, Japan, ⁵Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, Tokyo, Japan, ⁶Department of Advanced Clinical Science and Therapeutics, The University of Tokyo, Tokyo, Japan, ⁷Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan, ⁸Department of Dermatology, Tokyo Medical University, Tokyo, Japan, ⁹Department of Rheumatology, Tokyo Medical and Dental University, Tokyo, Japan
Background/Purpose: Vasculitis is characterized by leukocyte infiltration in the vessel walls with destructive damage to mural structures. Retinoids are compounds that bind to retinoic acid…
Abstract Number: 311 • 2012 ACR/ARHP Annual Meeting
The DEK Autoantigen Regulates Formation of Neutrophil Extracellular Traps and Zymosan Induced Arthritis in Mice
Nirit Mor-Vaknin¹, Anjan K. Saha², Maureen Legendre¹, Marta J. Gonzalez-Hernandez³, M. Asif Amin⁴, Bradley J. Rabquer⁵, Julie M. Jorns⁶, Mariana J. Kaplan⁷, Barbara S. Adams⁸, David A. Fox⁹, Alisa E. Koch¹⁰ and David Markovitz¹, ¹Internal Medicine, University of Michigan, Ann Arbor, MI, ²Medical School, University of Michigan, Ann Arbor, MI, ³Graduate Program in Immunology, University of Michigan, Ann Arbor, MI, ⁴Department of Medicine, University of Michigan Medical School, Ann Arbor, MI, ⁵University of Michigan Medical School, Ann Arbor, MI, ⁶Pathology, Ann Arbor, MI, ⁷Systemic Autoimmunity Branch, National Institutes of Health/NIAMS, Bethesda, MD, ⁸University of Michigan, Ann Arbor, MI, ⁹Rheumatology/Int Medicine, Univ of Michigan Med Ctr, Ann Arbor, MI, ¹⁰Internal Medicine - Rheumatology, University of Michigan Medical School, Ann Arbor, MI
Background/Purpose: The nuclear oncoprotein DEK is a known autoantigen associated with juvenile idiopathic arthritis (JIA) and other autoimmune diseases. DEK is actively secreted by human…
Abstract Number: 2290 • 2012 ACR/ARHP Annual Meeting
Type I Interferon Associated Gene IRF7 in the Pathogenesis of Fibrosis in Systemic Sclerosis (SSc)
Minghua Wu¹, Michael R. Blackburn², Shervin Assassi¹, Xiaochun Liu¹, John D. Reveille¹, Filemon K. Tan¹, Sandeep K. Agarwal³ and Maureen D. Mayes¹, ¹Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ²Biochemistry and Molecular Biology, The University of Texas Medical School at Houston, Houston, TX, ³Medicine, Section of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, TX
Background/Purpose: Fibrosis in Systemic Sclerosis is characterized by excessive collagen production and accumulation in the skin and lungs. It has been increasingly appreciated that a…
Abstract Number: 1634 • 2012 ACR/ARHP Annual Meeting
Delivering Mesenchymal Stem Cells to Arthritic Joints with Nano-Fiber Scaffold Resulted in Inhibition of Arthritis and Joint Damage in Arthritis Models
Xiangmei Zhang¹, Kunihiro Yamaoka¹, Koshiro Sonomoto¹, Masahiro Kondo¹, Shunsuke Fukuyo¹, Makoto Satake², Hiroaki Kaneko², Kazuhisa Nakano¹, Shingo Nakayamada³, Yosuke Okada¹ and Yoshiya Tanaka¹, ¹The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ²The Third Laboratory, Integrative Technology Research Institute, Teijin Limited, Tokyo, Japan, ³First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan
Background/Purpose: Even though treatment of rheumatoid arthritis (RA) has emerged, aiming bone repair is still a challenge. Mesenchymal stem cells (MSCs) possess immunoregulatory function with…
Abstract Number: 785 • 2012 ACR/ARHP Annual Meeting
Resident Lung Fibroblast Gene Expression Signatures Predict Susceptibility or Resistance to Experimental Lung Fibrosis
Emma Derrett-Smith¹, Rachel Hoyles¹, Korsa Khan², David J. Abraham³ and Christopher P. Denton², ¹Centre for Rheumatology and Connective Tissue Diseases,, UCL Medical School, London, United Kingdom, ²Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom, ³UCL Medical School, London, United Kingdom
Background/Purpose: In scleroderma (SSc), lung fibrosis is linked to epithelial damage and dysregulated repair mechanisms. Resident lung fibroblasts may affect multiple cell types including…
Abstract Number: 326 • 2012 ACR/ARHP Annual Meeting
Silencing Intraarticular Snail Expression Ameliorates Rat Collagen-Induced Arthritis Through Induction of Mesenchymal-Epithelial Transition in Synovial Fibroblasts
Chrong-Reen Wang¹, Shih-Yao Chen², Ai-Li Shiau³, Yuan-Tsung Li⁴, Ming-Fei Liu⁵ and Chao-Liang Wu², ¹Section of Rheumatology and Immunology, Department of Internal Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ²Biochemistry and Molecular Biology, National Cheng Kung University Medical College, Tainan, Taiwan, ³Microbiology and Immunology, National Cheng Kung University Medical College, Tainan, Taiwan, ⁴Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ⁵Internal Medicine, National Cheng Kung University Medical College, Tainan, Taiwan
Background/Purpose: Morphological characteristics of rheumatoid arthritis (RA) synovial fibroblasts (SF) are similar to transformed cells. We hypothesized that epithelial-mesenchymal transition (EMT) of SF regulated by…

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