Abstracts tagged "Animal models"

Abstract Number: 2080 • 2012 ACR/ARHP Annual Meeting
IL-20 Is Not Involved in Mouse Collagen Induced Arthritis
Christina Andersson¹, Kyle Serikawa², Hermann Pelzer³, Peter Thygesen³, Patricia Smith², Kim Kruse², Shameek Biswas², Brian Fox², Anders Milner⁴, Peter Kvist⁵, Josephine Hebsgaard⁶, Jesper Pass⁷ and John Rømer⁸, ¹AID Models, Immunopharmacology, Biopharmaceutical Research Unit, Novo Nordisk A/S, Måløv, Denmark, ²Molecular Immunology, Biopharmaceutical Research Unit, Novo Nordisk A/S, Seattle, WA, ³Exploratory ADME, Biopharmaceutical Research Unit, Novo Nordisk A/S, Måløv, Denmark, ⁴DMPK, Cell and Antibody Analysis, Biopharmaceutical Research Unit, Novo Nordisk A/S, Måløv, Denmark, ⁵Histology, Novo Nordisk A/S, Måløv, Denmark, ⁶Histology, Biopharmaceutical Research Unit, Novo Nordisk A/S, Måløv, Denmark, ⁷Antibody Thechnology, Biopharmaceutical Research Unit, Novo Nordisk A/S, Måløv, Denmark, ⁸Inflammation Science, Biopharmaceutical Research Unit, Novo Nordisk A/S, Måløv, Denmark
Background/Purpose: Interleukin-20 (IL-20) is a pro-inflammatory cytokine involved in the pathogenesis of rheumatoid arthritis (RA). Clinical phase 2a testing has shown that treatment with an…
Abstract Number: 1059 • 2012 ACR/ARHP Annual Meeting
Endogenous Complement Factor H Plays an Important Role in Controlling Immune Complex-Induced Inflammatory Arthritis
Nirmal K. Banda¹, Gaurav Mehta², Viviana P. Ferreira³, Claudio Cortes³, Michael K. Pangburn⁴, William P. Arend² and V. Michael Holers², ¹University of Colorado School of Medicine, Aurora, CO, ²Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ³Department of Medical Microbiology and Immunology, University of Toledo Health Science Campus, Toledo, OH, ⁴Department of Biochemistry, University of Texas Health Sciences Center, Tyler, TX
Background/Purpose: The complement system, a major component of innate immunity, likely plays an important role in the pathogenesis of rheumatoid arthritis (RA). Factor H (fH)…
Abstract Number: 335 • 2012 ACR/ARHP Annual Meeting
Treatment with Bgp-15, a Novel Insulin Sensitizer Attenuates Collagen-Induced Arthritis in DBA/1 Mice
Peter Mandl¹, Silvia Hayer², Stephan Blüml³, Victoria Saferding¹, Despoina Sykoutri¹, Kurt Redlich² and Josef S. Smolen⁴, ¹Rheumatology, Medical University of Vienna, Vienna, Austria, ²Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ³Department of Rheumatology, Medical University of Vienna, Vienna, Austria, ⁴Department of Rheumatology, Medical University of Vienna and Hietzing Hospital, Vienna, Austria
Background/Purpose: BGP-15, a small synthetic hydroxylamine derivative is a member of a new class of insulin-sensitizing medications also known as chaperone-inducers. Beside its beneficial effects…
Abstract Number: 2308 • 2012 ACR/ARHP Annual Meeting
CD11c⁺ Cells Are Necessary for Myofibroblast Maintenance in Bleomycin-Induced Cutaneous Fibrosis
Jennifer J. Chia¹, Sha Tian² and Theresa T. Lu², ¹Weill Cornell/Rockefeller/Sloan-Kettering Tri-Institutional MD-PhD Program, New York, NY, ²Research Division, Hospital for Special Surgery, New York, NY
Background/Purpose: Systemic sclerosis (SSc) is a heterogeneous connective tissue disease that has significant mortality and morbidity secondary to internal and cutaneous fibrosis. Though the exact…
Abstract Number: 1810 • 2012 ACR/ARHP Annual Meeting
Identification and Characterization of Synthetic Small Molecule Macrocycle Antagonists of Human IL17A
David Livingston, Sethu Alexander, Julian Bond, Timothy Briggs, Andrew Fraley, Stephen Hale, Tanya Landsman, Richard Martinelli, Kelley Shortsleeves, Nick Terrett and Nathan Walsh, Ensemble Therapeutics, Cambridge, MA
Background/Purpose: : IL17A has been demonstrated to be a key pro-inflammatory cytokine in human rheumatoid arthritis and in several rodent models of arthritis. Synthetic macrocycles…
Abstract Number: 1061 • 2012 ACR/ARHP Annual Meeting
Generation of Myeloid-Derived Suppressor Cells in Vitro From Murine Bone Marrow Precursors
Julia Kurko¹, Beata Tryniszewska¹, Tibor A. Rauch¹, Colt Egelston², Tibor T. Glant¹ and Katalin Mikecz¹, ¹Orthopedic Surgery, Rush University Medical Center, Chicago, IL, ²Immunology, Rush University Medical Center, Chicago, IL
Background/Purpose: Myeloid-derived suppressor cells (MDSCs) are innate immune cells that expand under pathological conditions (such as cancer and autoimmune diseases) in response to local growth…
Abstract Number: 340 • 2012 ACR/ARHP Annual Meeting
Myeloid Deletion of SIRT1 Aggravates Inflammatory Arthritis Via Nuclear Factor-Kappab Activation in Animal Model of Rheumatoid Arthritis
Sang-il Lee and Yun-Hong Cheon, Division of Rheumatology, Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, South Korea
Background/Purpose: The nuclear factor-kappaB (NF-kB) activation plays a pivotal role and macrophages are of central importance in the pathogenesis of rheumatoid arthritis (RA). The SirT1,…

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