Abstracts tagged "Animal models"

Abstract Number: 2091 • 2012 ACR/ARHP Annual Meeting
The Effect of Pretreatment with Capsaicin On Measurement of Arthritis Pain by Dynamic Weight Bearing and Evoked Pain Responses in an Acute Murine Arthritis Model
Hollis E. Krug¹, Christopher W. Dorman², Sandra Frizelle² and Maren L. Mahowald³, ¹Medicine, VA Health Care System, Minneapolis, MN, ²Research, Minneapolis VA Health Care System, Minneapolis, MN, ³Medicine, University of Minnesota Medical School and Minneapolis VA Health Care System, Minneapolis, MN

Background/Purpose: Murine models are important to study arthritis pain and new analgesics, however measuring pain in mice is challenging. The Dynamic Weight Bearing (DWB) device…
Abstract Number: 1442 • 2012 ACR/ARHP Annual Meeting
IRF-1 Deficient Lupus-Prone MRL/Lpr Mice Show Reduced Glomerulonephritis but Develop Severe Interstitial Nephritis, Renal Vasculitis and Pulmonary Granulomas with Propensity for Th2 Polarity
Hidemaru Sekine¹, Takeshi Machida¹, Natsumi Sakamoto¹, Eiji Suzuki², Xian Zhang³, Christopher Reilly⁴ and Gary S. Gilkeson⁵, ¹Immunology, Fukushima Medical University School of Medicine, Fukushima, Japan, ²Medicine, Medical University of South Carolina, Charleston, SC, ³Medicine, Medical University of South Carolina and Ralph H. Johnson VA Medical Center, Charleston, SC, ⁴Virginia Tech, Blacksburg, VA, ⁵Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC
Background/Purpose: The transcription factor interferon regulatory factor-4 (IRF-4) and -1 (IRF-1) are members of the IRF family of transcription regulators and involved in the development…
Abstract Number: 519 • 2012 ACR/ARHP Annual Meeting
Sex-Specific Regulatory T Cell Dysfunction in a Mouse Model of Sjögren Syndrome
Scott M. Lieberman¹, Portia A. Kreiger² and Gary A. Koretzky³, ¹Pediatrics, Div Rheumatology, The Children's Hospital of Philadelphia, Philadelphia, PA, ²Pathology, Nemours/A.I. DuPont Hospital for Children, Wilmington, DE, ³Medicine, University Pennsylvania, Philadelphia, PA
Background/Purpose: CD4+Foxp3+ regulatory T cells (Tregs) are a specialized population of lymphocytes which prevent autoimmunity in normal hosts. Treg dysfunction has been implicated in autoimmunity; however results…
Abstract Number: 2069 • 2012 ACR/ARHP Annual Meeting
Proteinase Activated Receptor-4 Stimulation Promotes Leukocyte Adhesion in the Rat Knee Joint
Jason J. McDougall, Departments of Pharmacology and Anaesthesia, Dalhousie University, Halifax, NS, Canada
Background/Purpose: Proteinase activated receptors (PARs) are a family of G protein-coupled receptors that signal by enzymatic cleavage of the receptor in a specific extracellular domain.…
Abstract Number: 1450 • 2012 ACR/ARHP Annual Meeting
MEDI-551 Depletes a Majority of Murine B Cells and Reduces Serum Titers of Autoantibodies in the SLE1-huCD19 TG Mice
Sandra Gallagher¹, Yue Wang¹, Isharat Yusuf¹, Thomas McCaughtry¹, Ronald Herbst² and Laura Carter¹, ¹Respiratory, Inflammation and Autoimmune, MedImmune, Gaithersburg, MD, ²Respiration, Inflammation and Autoimmunity, MedImmune, Gaithersburg, MD
Background/Purpose: Systemic Lupus Erythematosus (SLE) is characterized by chronic inflammation that can affect various organs. Hyperactive B cells appear to be key drivers in SLE…
Abstract Number: 438 • 2012 ACR/ARHP Annual Meeting
Methyl Supplementation of Rheumatoid Arthritis Synovial Fibroblasts Regulates the Expression of Transcription Factors and Matrix Metalloproteinases
Edvardas Bagdonas¹, Emmanuel Karouzakis², Astrid Jungel², Caroline Ospelt¹, Renate E. Gay¹, Steffen Gay¹, Beat A. Michel¹ and Michel Neidhart¹, ¹Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Center of Experimental Rheumatology, University Hospital Zurich and Zurich Center of Integrative Human Physiology (ZIHP), Zurich, Switzerland
Background/Purpose: Previously we reported that methyl supplementation can reverse the global hypomethylation of rheumatoid arthritis synovial fibroblasts (RASF) and attenuate their aggressive behaviour. Now we…
Abstract Number: 2680 • 2012 ACR/ARHP Annual Meeting
Soluble Receptor for Advanced Glycation End Products Alleviates Nephritis in NZB/WF1 Mice
Sang-Won Lee¹, Kyu-Hyoung Park¹, Sungha Park², Ji-Hye Kim¹, Sung-You Hong², Soo Kon Lee³, Donghoon Choi² and Yong-Beom Park⁴, ¹Internal Medicine, Yonse University College of Medicine, Seoul, South Korea, ²Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea, ³Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea, ⁴Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea
Background/Purpose: The receptor for advanced glycation end products (RAGE) is a pattern-recognition receptor that interacts with multiple ligands such as high mobility group box 1…

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