Abstracts tagged "Animal models"

Abstract Number: 991 • 2019 ACR/ARP Annual Meeting
Identification of Citrullinated Peptide Specific T-cells in Humanized Mice Immunized with Citrullinated Peptides
Matthew McElwee¹, Thamotharampillai Dileepan ¹ and Marc Jenkins ¹, ¹University of Minnesota, Minneapolis, MN
Background/Purpose: Seropositive rheumatoid arthritis (RA) is a T-cell mediated disease that is characterized by the presence of antibodies to proteins that have undergone the post-translational…
Abstract Number: 992 • 2019 ACR/ARP Annual Meeting
Identification of CJ-15314, a Novel Highly Selective JAK1 Inhibitor, for the Treatment of Rheumatoid Arthritis
So Young Ki¹, Dongkyu Kim ¹, Juhyun Lee ¹, Byoung Seok Moon ¹ and Shin-Young Ryu ¹, ¹CJ Healthcare, Icheon-si, Republic of Korea
Background/Purpose: Janus kinases (JAKs) play critical roles in mediating various cytokine signaling. First-generation non-selective JAK inhibitors such as tofacitinib and baricitinib are widely used for…
Abstract Number: 994 • 2019 ACR/ARP Annual Meeting
Increased Antibody and T-cell Responses Following Treatment of Collagen-Induced Arthritis in C57Bl/6 Mice with Organic Dust Inhalants
Michael Duryee¹, Jill Poole ¹, Amy Nelson ¹, Katherine Janike ¹, Kathryn Rentfro ¹, Lynell Klassen ¹, James O'Dell ², Bryant England ³, Geoffrey Thiele ² and Ted Mikuls ², ¹University of Nebraska Medical Center, Omaha, NE, ²VA Nebraska-Western IA Health Care System & University of Nebraska Medical Center, Omaha, NE, ³VA Nebraska-Western IA Health Care System & University of Nebraska Medical Center, Omaha
Background/Purpose: Increasing evidence suggests that inhalant exposures, such as tobacco smoke or silica, are implicated in the initiation of autoimmunity leading to rheumatoid arthritis (RA).…
Abstract Number: 55 • 2019 ACR/ARP Annual Meeting
A Novel Subclass of Intravascular Non-classical, Tissue Resident Synovial Monocyte Is Critical for Rheumatoid Arthritis Pathogenesis
Anna Montgomery ¹, Shang-Yang Chen ¹, Deborah Winter ² and Harris Perlman², ¹Northwestern University, Chicago, ²Northwestern University Feinberg School of Medicine, Division of Rheumatology, Chicago
Background/Purpose: There are at least three populations of circulating monocytes; classical, intermediate and non-classical. We demonstrated that circulating non-classical monocytes are required for the effector…
Abstract Number: 995 • 2019 ACR/ARP Annual Meeting
Inhibition of Endoplasmic Reticulum Stress Using 4-phenylbutyric Acid Ameliorates the Severity of Collagen-induced Arthritis in Mice via Attenuation of Proliferation and Inflammatory Responses of Synovial Fibroblasts
Wan-Hee Yoo¹, Yunjung Choi ², Eun-gyeong Lee ², Chang-hoon Lee ³ and Myeung-Su Lee ³, ¹Department of Internal Medicine, Chonbuk National University Medical School, Research Institute of Clinical Medicine of Chonbuk National University-Biomedical, Research Institute of Chonbuk National University Hospital, Jeonju, Korea, JeonJu, Republic of Korea, ²Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, JeonJu, Republic of Korea, ³Wonkwang University College of Medicine, Iksan, Republic of Korea
Background/Purpose: Several studies have recently revealed the pathological role of endoplasmic reticulum (ER) stress in the pathogenesis of inflammatory diseases. In addition, 4-phenylbutyric acid (4-PBA) was…
Abstract Number: 83 • 2019 ACR/ARP Annual Meeting
Dysfunction of TRIM21 Promotes Aberrant Plasmablast Differentiation in Systemic Lupus Erythematosus Due to the Reduction of TRIM21-mediated Ubiquitylation of IRF5
Yosuke Kunishita¹, Ryusuke Yoshimi ¹, Reikou Kamiyama ¹, Daiga Kishimoto ¹, Koji Yoshida ¹, Eijin Hashimoto ¹, Yumiko Sugiyama ², Takaaki Komiya ¹, Natsuki Sakurai ¹, Yohei Kirino ³ and Hideaki Nakajima ³, ¹Department of Stem Cell and Immune Regulation / Yokohama City University Graduate School of Medicine, Yokohama, Japan, ²Department of Rheumatic Diseases / Yokohama City University Medical Center, Yokohama, Japan, ³Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan
Background/Purpose: TRIM21 is a member of the tripartite motif family proteins and is one of the autoantigens which react with anti-SS-A antibody (Ab) present in…
Abstract Number: 996 • 2019 ACR/ARP Annual Meeting
The Role of Flip in Differentiation and Survival of Synovial Tissue Resident Macrophages
Qi Huang¹, Renee Doyle ¹, Shang-Yang Chen ², Alexander Misharin ³, Deborah Winter ⁴ and Richard Pope ⁵, ¹Northwestern University Feinberg School of Medicine, Chicago, IL, ²Northwestern University, Chicago, ³Northwestern University Feinberg School of Medicine, chicago, ⁴Northwestern University Feinberg School of Medicine, Division of Rheumatology, Chicago, ⁵Northwestern University Feinberg School of Medicine, Division of Rheumatology, chicago, IL
Background/Purpose: We previously identified that under homeostatic conditions Flip was necessary for macrophage (MΦ) survival. The mechanisms responsible for the differentiation of monocyte-derived MΦs into…
Abstract Number: 85 • 2019 ACR/ARP Annual Meeting
Selective Inhibition of the Immunoproteasome with KZR-616 Blocks Multiple Cell Signaling Pathways, Plasma Cell Signatures and Myeloid Cell Associated Damage in the NZB/W Lupus Nephritis Model
Tony Muchamuel¹, Janet Anderl ¹, R Andrea Fan ¹, Henry Johnson ¹, Dustin McMinn ¹ and Christopher Kirk ¹, ¹Kezar Life Sciences, South San Francisco, CA
Background/Purpose: The immunoproteasome is a distinct class of proteasome found predominantly in immune effector cells and has been shown to play a distinct role in…
Abstract Number: 998 • 2019 ACR/ARP Annual Meeting
Stimulation of Splenic Neurovascular Bundle Protect Mice from Developing Collagen-induced Arthritis
Thomas Simon¹, Clara Panzolini ², Julien Lavergne ², Arun Srihar ³, Margriet Vervoordeldonk ³, nicolas Glaichenhaus ² and Philippe Blancou ², ¹CNRS/IPMC, Valbonne, France, ²IPMC/CNRS, VALBONNE, France, ³Galvani Bioelectronics, Stevenage, United Kingdom
Background/Purpose: Vagus nerve (VN) stimulation has shown the potential to improve the disease development in animal models of arthritis and in patients with RA. However,…
Abstract Number: 89 • 2019 ACR/ARP Annual Meeting
Difference of Induced CD4+ and Natural Regulatory T Cells in Targeting Inflamed Synovial Tissues in Autoimmune Arthritis
Ximei Zhang¹, Julie Wang ², Nancy Olsen ³, Wael Jarjour ⁴ and Song Guo Zheng ⁴, ¹Ohio State College of Medicine, Columbus, ²Ohio State University, columbus, ³Penn State University, Hershey, PA, ⁴Ohio State College of Medicine, Columbus, OH
Background/Purpose: Enhanced evidence supports that autoimmune diseases often result from an imbalance between regulatory T cells (Tregs) and interleukin-17-producing T helper (Th17) cells. However, under…
Abstract Number: 999 • 2019 ACR/ARP Annual Meeting
Targeted Drug Delivery Using a Novel Joint-homing Peptide for Arthritis Therapy
Rakeshchandra Meka¹, Shivaprasad Venkatesha ¹, Bodhraj Acharya ¹ and Kamal Moudgil ¹, ¹University of Maryland School of Medicine and Baltimore VA Medical Center, Baltimore, Baltimore, MD
Background/Purpose: Rheumatoid arthritis (RA) is a chronic debilitating autoimmune disease characterized by inflammation of the synovial tissue of the joints, which if not controlled early…
Abstract Number: 100 • 2019 ACR/ARP Annual Meeting
Targeting ITK Signaling Ameliorates Collagen-Induced Arthritis via Shifting the Balance Between Th17 and Regulatory Th17 Cells
Ye Chen¹, Julie Wang ², Nancy Olsen ³, Wael Jarjour ⁴ and Song Guo Zheng ⁴, ¹Ohio State University, Columbus, OH, ²Ohio State University, columbus, ³Penn State University, Hershey, PA, ⁴Ohio State College of Medicine, Columbus, OH
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease that cannot be cured and current approaches have some severe side effects. Although the pathogenesis is…
Abstract Number: 1000 • 2019 ACR/ARP Annual Meeting
RKIP, as an Upstream Regulator of Intracellular Signaling, Exerts Anti-arthritic Effect in Fibroblast-like Synoviocyte and Collagen-induced Arthritis
Sang-Il Lee¹, Hae Sook Noh ² and Yun-Hong Cheon ¹, ¹Divison of Rheumatology, Gyeongsang National University Hospital, Jin-Ju, Republic of Korea, ²Gyeongsang University Hospital, Jinju, Republic of Korea
Background/Purpose: Nuclear factor-kappaB (NF-kappaB) and extracellular-signal-regulated kinase (ERK) have been implicated as a therapeutic target for the treatment of rheumatoid arthritis (RA). Raf kinase inhibitory…
Abstract Number: 144 • 2018 ACR/ARHP Annual Meeting
Small Molecule Inhibitor of Bcl-6 Reduces the Tfh Population in Peripheral Blood, Splenic Germinal Center and Ankle Joints in a Collagen-Induced Arthritis Mouse Model of RA
Nitasha Bhatia¹, Sedrick Bradley², Cara McLeod¹, Gbemi Olayemi¹, Robert Quinet¹, William E. Davis³, Jerald Zakem⁴ and Xin Zhang¹, ¹Ochsner Medical Center, New Orleans, LA, ²Ochsner Clinic Foundation, New Orleans, LA, ³University of Queensland School of Medicine, Brisbane, Australia, ⁴Ochsner Medical Center, New Orleans, LA
Background/Purpose: Rheumatoid arthritis (RA) is a common autoimmune disease characterized by chronic joint inflammation, synovial hyperplasia and progressive destruction of cartilage and bone. T follicular…
Abstract Number: 1952 • 2018 ACR/ARHP Annual Meeting
Experimental Tendinopathy Treatment with SM04755, a Topical Small Molecule Inhibitor of the Wnt Pathway
Vishal Deshmukh, Timothy Seo and Yusuf Yazici, Samumed, LLC, San Diego, CA
Background/Purpose: Tendinopathy is an inflammatory and degenerative disorder caused by injuries and overuse. The Wnt pathway is upregulated in chronic tendinopathy and involved in inflammation,…

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