Abstracts tagged "Animal models"

Abstract Number: 2707 • 2013 ACR/ARHP Annual Meeting
Downregulation Of KLF5 and Fli1 Cooperatively Contribute To Distinct Manifestations Of Systemic Sclerosis In Vitro and In Vivo
Shinji Noda¹, Yoshihide Asano¹, Katsuhito Fujiu², Ichiro Manabe², Ryozo Nagai², Kaname Akamata¹, Takashi Taniguchi¹, Takehiro Takahashi¹, Yohei Ichimura¹, Tetsuo Toyama¹, Daisuke Tsuruta³, Maria Trojanowska⁴ and Shinichi Sato¹, ¹Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan, ²Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan, ³Dermatology, Osaka City University Graduate School of Medicine, Osaka, Japan, ⁴Arthritis Center, Boston University, Boston, MA
Background/Purpose: Systemic sclerosis (SSc) is a multisystem autoimmune disease characterized by initial vascular injuries and resultant fibrosis of skin and certain internal organs. Although the…
Abstract Number: 1296 • 2013 ACR/ARHP Annual Meeting
Deletion Of RBP-J In a Murine Model Of Inflammatory Arthritis Reveals Pro-Inflammatory Cytokine Expression and Immunophenotypic Differences
Soumya D. Chakravarty¹, Karmen Au², Lionel B. Ivashkiv³ and Xiaoyu Hu⁴, ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Hospital for Special Surgery, New York, NY, ³Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, ⁴Arthritis Tissue Degeneration Program, Hospital for Special Surgery, New York, NY
Background/Purpose: RBP-J, a DNA-binding protein, serves as the central transcriptional regulator of the Notch signaling pathway. Prior in vitro work has demonstrated that RBP-J plays…
Abstract Number: 663 • 2013 ACR/ARHP Annual Meeting
Propylthiouracil Attenuates Aortic Vasculopathy In An Animal Model Of Systemic Sclerosis
Gianluca Bagnato¹, Alessandra Bitto², Gabriele Pizzino², Neal Roberts³, Domenica Altavilla², Francesco Squadrito², Gianfilippo Bagnato¹ and Antonino Saitta⁴, ¹Rheumatology, University of Messina, Messina, Italy, ²Pharmacology, University of Messina, Messina, Italy, ³University of Louisville, Louisville, KY, ⁴Internal Medicine, University of Messina, Messina, Italy
Background/Purpose: Systemic sclerosis (SSc) is a generalized connective tissue disorder of unknown etiology characterized by thickening and fibrosis of the skin and distinctive visceral involvement…
Abstract Number: 2233 • 2013 ACR/ARHP Annual Meeting
Porphyromonas Gingivalis peptidylarginine Deiminase Exacerbates Collagen-Induced Arthritis In C57BL/6 mice
Saba Alzabin^1,2, Anne-Marie Quirke², Elena B. Lugli², Muslima Choudhury^2,3, Peter J. Charles⁴, Richard O. Williams⁵ and Patrick Venables⁶, ¹Epistem Ltd., Manchester, United Kingdom, ²University of Oxford, Kennedy Institute of Rheumatology, Oxford, United Kingdom, ³Kennedy Institute of Rheumatology, London, United Kingdom, ⁴Oxford University, Kennedy Institute of Rheumatology, Oxford, United Kingdom, ⁵Kennedy Institute of Rheumatology, Oxford University, Oxford, United Kingdom, ⁶Kennedy Institute of Rheumatology, Oxford, United Kingdom
Background/Purpose: There is increasing molecular and epidemiological evidence linking Porphyromonas gingivalis to RA. P. gingivalis is unique amongst periodontal pathogens in possessing a citrullinating enzyme…
Abstract Number: 1278 • 2013 ACR/ARHP Annual Meeting
The Arthritis Severity and Joint Damage Locus Cia25/Pia42 Is a New Genetic Regulator of the Invasive Properties of Synovial Fibroblasts
Max Brenner^1,2, Teresina Laragione^1,2 and Percio Gulko^1,2, ¹Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, ²Molecular Medicine, Hosftra North Shore-LIJ School of Medicine, Manhasset, NY
Background/Purpose: Rheumatoid arthritis (RA) is a chronic and commonly disabling disease with a prevalence of 1% world-wide. Disease remission is rarely achieved with current treatments…
Abstract Number: 566 • 2013 ACR/ARHP Annual Meeting
A Human Monoclonal Antibody Against Domain I Of β2-Glycoprotein I prevents Clotting and Fetal Loss Induced By Polyclonal Anti-Phospholipid Antibodies In Animal Models
Chiara Agostinis¹, Paolo Durigutto², Daniele Sblattero², Maria Orietta Borghi^3,4, Claudia Grossi⁴, Roberta Bulla², Paolo Macor², Pier Luigi Meroni^3,5 and Francesco Tedesco², ¹Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy, ²Department of Life Sciences, University of Trieste, Trieste, Italy, ³Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy, ⁴Laboratory of Immuno-rheumatology, IRCCS Istituto Auxologico Italiano, Milan, Italy, ⁵Department of Clinical Sciences and Community Health, Division of Rheumatology, Istituto G. Pini, Milan, Italy
Background/Purpose: Anticoagulant, antiplatelet or immunosuppressive therapy are currently used to treat the clinical manifestations of the anti-phospholipid syndrome (APS). Side effects or recurrences in spite…
Abstract Number: 2235 • 2013 ACR/ARHP Annual Meeting
Fas Signaling In Macrophages Promotes Chronicity In K/BxN Serum Transfer Induced Arthritis
Qi Quan Huang¹, Robert Birkett², Renee E. Koessler¹, Carla M. Cuda³, J.-P. Jin⁴, Harris R. Perlman⁵ and Richard M. Pope⁶, ¹Medicine/Rheumatology, Northwestern University, Chicago, IL, ²Medicine/Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL, ³Medicine / Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Physiology, Wayne State University, Detroit, MI, ⁵Northwestern University Feinberg School of Medicine, Chicago, IL, ⁶Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL
Background/Purpose: A non-apoptotic role for Fas signaling has been implicated in the regulation of inflammation and innate immunity. These studies were performed to elucidate the…
Abstract Number: 1281 • 2013 ACR/ARHP Annual Meeting
Inadequate Glucocorticoid Secretion in Experimental Arthritis in Rats Is Closely Linked to Impaired Mitochondria and Reduced Lipid Breakdown in the Adrenal Cortex
Christine Wolff¹, Katharina Krinner¹, Josef Schröder² and Rainer H. Straub³, ¹Laboratory of Exp. Rheumatology and Neuroendocrino-Immunology, Department of Internal Medicine I, University Hospital, Regensburg, Germany, ²Department of Phatology, University Hospital, Regensburg, Germany, ³Department of Internal Medicine I, Laboratory of Exp. Rheumatology and Neuroendocrino-Immunology, University Hospital of Regensburg, Regensburg, Germany
Background/Purpose: In rheumatoid arthritis a functional deterioration of the HPA-axis in form of inadequately low secretion of glucocorticoids in relation to severity of inflammation can…
Abstract Number: 542 • 2013 ACR/ARHP Annual Meeting
Evidence For Involvement Of C5a Receptor in Human and Murine Lupus Nephritis
Constanze Hess¹, Ditte Tornehave², Peter Helding Kvist², Yvonne Sundström³, Louise Berg³, Iva Gunnarsson⁴, Søren Jacobsen⁵, Claus Haase¹ and Lars Hornum¹, ¹Department of Immunopharmacology, Novo Nordisk A/S, Måløv, Denmark, ²Department of Histology, Novo Nordisk A/S, Måløv, Denmark, ³Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, ⁴Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, ⁵Department of Rheumatology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
Background/Purpose: The complement system plays an important role in the pathogenesis of systemic lupus erythematosus (SLE). Apart from the activation of the early components of…
Abstract Number: 2236 • 2013 ACR/ARHP Annual Meeting
Articular Inflammation Is Protected By Fat-1 During The Acute Phase Of Arthritis In Mice
Sang-Il Lee¹, Yun-Hong Cheon², Ji-Min Kim³ and Won Seok Lee², ¹Division of Rheumatology, Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, South Korea, ²Rheumatology, Department of Internal Medicine, Chonbuk National University Medical School and Research Institute of Clinical Medicine, Jeonju, South Korea, ³Division of Rheumatology, Department of Internal Medicine, Keimyung University School of Medicine, Daegu, South Korea
Background/Purpose: Omega-3 polyunsaturated fatty acids (n-3 PUFA) are well known to exert anti-inflammatory effects. The Fat-1 transgenic (Fat-1 TG) mice are capable of producing n-3…
Abstract Number: 1285 • 2013 ACR/ARHP Annual Meeting
Choline Kinase: A Novel Target For Rheumatoid Arthritis
Monica Guma¹, Elsa Sanchez-Lopez², Alessia Lodi³, Stefano Tiziani⁴, Juan Carlos Lacal⁵, Michael Karin⁶ and Gary S. Firestein⁷, ¹Rheumatology, UCSD School of Medicine, La Jolla, CA, ²Pharmacology, UCSD School of Medicine, La Jolla, CA, ³nutritional Sciences, University of Texas at Austin, Austin, TX, ⁴Nutritional Sciences, University of Texas at Austin, Austin, TX, ⁵Oncology, University Hospital Fundacion Jimenez Diaz, Madrid, Spain, ⁶Departments of Pharmacology, UCSD School of Medicine, La Jolla, CA, ⁷Div of Rheumatology, UCSD School of Medicine, La Jolla, CA
Background/Purpose: Choline kinase (ChoKa) is an essential enzyme for phosphatidylcholine biosynthesis and is required for cell proliferation. The enzyme has also been implicated in cancer…
Abstract Number: 553 • 2013 ACR/ARHP Annual Meeting
Estrogen Receptor Alpha Deficiency Protects Against Development Of Cognitive Impairment In Murine Lupus
Melissa A. Cunningham¹, Jena Wirth¹, Heather A. Boger², Ann-Charlotte Granholm-Bentley³ and Gary S. Gilkeson⁴, ¹Med/Rheumatology, MUSC, Charleston, SC, ²Neuroscience, Medical University of SC, Charleston, SC, ³Neuroscience, MUSC, Charleston, SC, ⁴Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC
Background/Purpose: Up to 80% of SLE patients have cognitive defects or affective disorders. The mechanism of CNS injury responsible for cognitive impairment is unknown. Anti-dsDNA…
Abstract Number: 146 • 2013 ACR/ARHP Annual Meeting
The Arthritis Severity Locus Cia4 Is An Early Regulator of IL-6, IL-1β, and NFκB activators’ Expression in Pristane-Induced Arthritis
Max Brenner^1,2, Teresina Laragione^1,2 and Percio Gulko^1,2, ¹Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, ²Molecular Medicine, Hosftra North Shore-LIJ School of Medicine, Manhasset, NY
Background/Purpose: Cia4 is a quantitative trait locus on rat chromosome 7 that regulates disease severity and joint damage in three models of rheumatoid arthritis including…
Abstract Number: 2214 • 2013 ACR/ARHP Annual Meeting
STAT3 Blockade Suppresses Autoimmune Arthritis In Mice Via The Reciprocal Regulation Of Treg and Th17 Cells
Jennifer Lee¹, Jae Ho Lee¹, Seung Min Jung², Young Sun Suh¹, Jung Hee Koh¹, Soo Young Lee³, Dae Chul Jeong⁴, Mi-La Cho⁵, Seung-Ki Kwok¹, Ji Hyeon Ju¹, Kyung-Su Park¹ and Sung-Hwan Park⁶, ¹Division of Rheumatology, Department of Internal Medicine, School of Medicine, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, South Korea, ²Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea, ³Department of Pediatrics, School of Medicine, The Catholic University of Korea, Incheon St. Mary's Hospital, Incheon, South Korea, ⁴Division of Rheumatology, Department of Pediatrics, School of Medicine, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, South Korea, ⁵Rheumatism Research Center, Catholic Research Institute of Medical Science, Catholic University of Korea, Seoul, South Korea, ⁶Rheumatism Research Center, Catholic Research Institute of Medical Science, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, South Korea
Background/Purpose: IL-6-mediated STAT3 signaling which is essential to Th17 differentiation plays the central role in the pathogenesis of rheumatoid arthritis. To investigate the molecular mechanism…
Abstract Number: 1287 • 2013 ACR/ARHP Annual Meeting
Pre-Clinical Proof-Of-Concept Of ALX-0761, a Nanobody^® Neutralizing Both IL-17A and F In a Cynomolgus Monkey Collagen Induced Arthritis Model
Katrien Vanheusden¹, Laurent Detalle¹, Alex Hemeryck¹, Alain Vicari², Roland Grenningloh³, Sofie Poelmans¹, Heidi Wouters⁴ and Thomas Stöhr¹, ¹Pharmacology, Ablynx NV, Gent, Belgium, ²Calypso Biotech, Geneva, Switzerland, ³Pharmacology, Merck-Serono, Darmstadt, Germany, ⁴Clinical Development, Ablynx nv, Zwijnaarde, Belgium
Background/Purpose: Interleukin (IL)-17 and Th17 cells are implicated in many auto-immune diseases, such as rheumatoid arthritis (RA), psoriasis and multiple sclerosis. Although IL-17(A) is the…

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