Abstracts tagged "Animal models"

Abstract Number: 2950 • 2014 ACR/ARHP Annual Meeting
Synovial Macrophages Promote TGF-β Activation after Intra-Articular Injections of Oxidized LDL in Naïve Murine Knee Joints, Preventing Production of Pro-Inflammatory Factors S100A8/9, Chemokines and Aggrecanase-Induced Neo-Epitopes
Wouter de Munter, Peter M. van der Kraan, Wim B. van den Berg and Peter L. van Lent, Experimental Rheumatology (272), Radboud university medical center, Nijmegen, Netherlands
Background/Purpose: In previous studies we found that synovial macrophages regulate joint pathology during experimental osteoarthritis (OA). Recently, we found that high systemic levels of LDL…
Abstract Number: 1971 • 2014 ACR/ARHP Annual Meeting
The Role of the Proinflammatory Mediator High-Mobility Group Box Protein 1 (HMGB1) in Anti-Collagen-Antibody-Induced Arthritis Is Dependent on Vascular Endothelial Growth Factor (VEGF)
Federico Biscetti¹, Andrea Flex², Giovanni Pecorini², Flavia Angelini², Vincenzo Arena³, Egidio Stigliano³, Barbara Tolusso¹, Elisa Gremese¹ and Gianfranco Ferraccioli¹, ¹Division of Rheumatology, Institute of Rheumatology and Affine Sciences, Catholic University of the Sacred Heart, Rome, Italy, ²Laboratory of Vascular Biology and Genetics, Catholic University School of Medicine, Rome, Italy, ³Department of Pathology, Catholic University School of Medicine, Rome, Italy
Background/Purpose High-mobility group box 1 (HMGB1) is a non-histone nuclear protein that is released extracellulary and has been implicated in rheumatoid arthritis (RA) and angiogenesis.…
Abstract Number: 773 • 2014 ACR/ARHP Annual Meeting
Functional Autoantibodies from Patients with Systemic Sclerosis Reactive to Angiotensin II Type 1and Endothelin-1 Type a Receptor Induce Inflammatory Lymphocyte Infiltration into Lungs of Mice
Angela Kill¹, Clement Braesch¹, Anja Kühl², Jeannine Guenther³, Mike O. Becker⁴, Gerd Burmester⁵, Thomas Walther⁶ and Gabriela Riemekasten⁷, ¹Rheumatology and clinical Immunology, Charité University Hospital, German Rheumatology Research Center, a Leibniz Institute, Berlin, Germany, ²Department of Internal Medicine, Charité University Hospital, Berlin, Germany, ³Rheumatology and Clinical Immunology, Charité University Hospital, German Rheumatology Research Center, a Leibniz Institute, Berlin, Germany, ⁴Rheumatology and Clinical Immunology, Charité University Hospital, Berlin, Germany, ⁵Department of Rheumatology and Clinical Immunology, Charité University Medicine, Berlin, Germany, ⁶Pharmacology & Therapeutics, University College Cork, Cork, Ireland, ⁷Charité University Hospital and German Rheumatism Research Centre, a Leibniz Institute, Berlin, Germany
Background/Purpose Functional autoantibodies reactive to the angiotensin II type 1 receptor (AT1R) and endothelin 1 type A receptor (ETAR) were found in elevated levels in…
Abstract Number: 327 • 2014 ACR/ARHP Annual Meeting
AMPK Activation in Inflammatory Arthritis
Monica Guma¹, Yun Wang² and Ru Liu-Bryan², ¹Division of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA, ²UCSD/VAMC, La Jolla, CA
Background/Purpose: AMP-activated protein kinase (AMPK) is a serine/threonine protein kinase involved in the regulation of cellular energy homeostasis. It is a central regulator of both…
Abstract Number: 2951 • 2014 ACR/ARHP Annual Meeting
Syndecan-4 Regulates Chondrocyte Phenotype and Cartilage Homeostasis Via the WNT Signaling Pathway
Charlotte Kimberley Clarke¹, Annelena Held¹, Richard Stange², Uwe Hansen³, Lars Godmann⁴, Jessica Bertrand⁵, Thomas Pap⁶, Giovanna Nalesso⁷, Frank Echtermeyer⁸, Francesco Dell'Accio⁹ and Joanna Sherwood⁷, ¹University Hospital Muenster, Institute of Experimental Musculoskeletal Medicine (IEMM), Muenster, 48149, Germany, ²Dept. of Trauma, Hand and Reconstructive Surgery, University Hospital Münster, Münster, Germany, ³Institute for Physiological Chemistry & Pathobiochemistry, University Hospital Münster, Münster, Germany, ⁴Institute of Experimental Muskuloskeletal Medicine, University Hospital Münster, Münster, Germany, ⁵Institute of Experimental Musculoskeletal Medicine, University Hospital Münster, Münster, Germany, ⁶Institute of Experimental Musculoskeletal Medicine, University Hospital Muenster, Muenster, Germany, ⁷Centre for Experimental Medicine and Rheumatology, Queen Mary University London, London, United Kingdom, ⁸Dept. of Anaesthesiology and Intensive Care Medicine, University Hospital Hannover, Hanover, Germany, ⁹William Harvey Research Institute, Barts and the London Queen Mary's School of Medicine and Dentistry, Centre for Experimental Medicine and Rheumatology, London, United Kingdom
Background/Purpose Syndecan-4 (Sdc4), family member of type I transmembrane heparan sulfate proteoglycans (HSPGs), is a regulator of various cartilage-related processes including osteoarthritis (OA). Blockade of…
Abstract Number: 1916 • 2014 ACR/ARHP Annual Meeting
Stromal Overexpression of Transmembrane TNF Induces Spa-like Arthritis and Spondylitis in Mice
Leonie M. van Duivenvoorde^1,2, Melissa N. van Tok³ and Dominique L. Baeten^1,4, ¹Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ²Experimental Immunology, Department of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands, ³Department of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands, ⁴Experimental Immunology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: The immunopathology of spondyloarthritis (SpA) is determined by inflammation and structural damage, in particular osteoproliferation, of axial and peripheral joints. The failure of TNF…
Abstract Number: 771 • 2014 ACR/ARHP Annual Meeting
Development of a Bifluorescent Lineage Tracker Reporter Mouse Strain to Analyze the Phenotypic Conversion of Endothelial Cells into Myofibroblasts in Vivo. Application to Study the Synergistic Effects of Endothelin-1 on TGF-β1-Induced Endothelial-to-Mesenchymal Transition
Peter J. Wermuth and Sergio A. Jimenez, Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center,Thomas Jefferson University, Philadelphia, PA
Background/Purpose: Endothelial-to-mesenchymal transition (EndoMT) may be a crucial pathway in generating activated myofibroblasts, cells that play a pivotal role in the development of tissue and…
Abstract Number: 324 • 2014 ACR/ARHP Annual Meeting
Regulation of TNF-α-Mediated Activation of Rheumatoid Synovial Fibroblasts By Transcription Factor Snail
Chrong-Reen Wang^1,2, Shih-Yao Chen³, Ai-Li Shiau⁴, I-Ming Jou^5,6, Ming-Fei Liu^1,2 and Chao-Liang Wu³, ¹Internal Medicine, National Cheng Kung University Medical College, Tainan, Taiwan, ²Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan, ³Biochemistry and Molecular Biology, National Cheng Kung University Medical College, Tainan, Taiwan, ⁴Microbiology and Immunology, National Cheng Kung University Medical College, Tainan, Taiwan, ⁵Orthopedics, National Cheng Kung University Medical College, Tainan, Taiwan, ⁶Orthopedics, National Cheng Kung University Hospital, Tainan, Taiwan
Background/Purpose: Transcription factor Snail plays active roles in various biological functions and is involved in many disease states. We hypothesized that this molecule regulates TNF-α-mediated…
Abstract Number: 2952 • 2014 ACR/ARHP Annual Meeting
S100A9 Inhibitor Paquinimod (ABR-215757) reduces Joint Destruction in Experimental Osteoarthritis and Blocks Activating Effects of S100A9 in OA Synovium
Peter L. van Lent¹, Rik Schelbergen², Arjen B. Blom¹, Tomas Leanderson³, Helena Eriksson⁴ and Wim B. van den Berg⁵, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Radboud university medical center, Nijmegen, Netherlands, ³Immunology Group, Lund University, Lund, Sweden, ⁴BioScience, Active Biotech AB, Lund, Sweden, ⁵Experimental Rheumatology (272), Radboud university medical center, Nijmegen, Netherlands
Background/Purpose Synovial activation is present in more than 50% of osteoarthritis (OA) patients and it is thought to be involved in the development of OA…
Abstract Number: 1725 • 2014 ACR/ARHP Annual Meeting
The SYK Inhibitor Fostamatinib Limits Tissue Damage and Fibrosis in a Bleomycin-Induced Scleroderma MOUSE MODEL
Omer Nuri Pamuk¹, Guray Can², Suleyman Ayvaz³, Turan Karaca⁴, Gulsum Pamuk⁵, Selim Demirtas⁶ and George C. Tsokos⁷, ¹Rheumatology, Trakya University Medical Faculty, Edirne, Turkey, ²Gastroenterology, Trakya University Medical Faculty, Edirne, Turkey, ³Pediatric Surgery, Trakya University Medical Faculty, Edirne, Turkey, ⁴Histology, Trakya University Medical Faculty, Edirne, Turkey, ⁵Hematology, Trakya University Medical Faculty, Edirne, Turkey, ⁶Trakya University Medical Faculty, Edirne, Turkey, ⁷Rheumatology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA
Background/Purpose The possible antifibrotic effects of various kinase inhibitors has been studied before in SSc. Spleen tyrosine kinase (Syk) is a protein tyrosine kinase which…
Abstract Number: 766 • 2014 ACR/ARHP Annual Meeting
Endothelial Fli1 Deficiency Delays Wound Healing Due to Impaired Anastomosis of Newly Formed Vessels – a Possible Mechanism of Refractory Skin Ulcers in Systemic Sclerosis
Yoshihide Asano¹ and Maria Trojanowska², ¹Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan, ²Arthritis Center, Boston University, Boston, MA
Background/Purpose Systemic sclerosis (SSc) is a multisystem inflammatory and vascular disease resulting in fibrosis of the skin and certain internal organs. Although the pathogenesis of…
Abstract Number: 337 • 2014 ACR/ARHP Annual Meeting
Effect of Etanercept on Endothelial Dysfunction in Rat Adjuvant-Induced Arthritis
Perle Totoson¹, Katy Maguin-Gaté¹, Daniel Wendling² and Céline Demougeot¹, ¹EA 4267 « Fonctions et Dysfonctions Epithéliales » , Faculté de Médecine-Pharmacie, Besançon, France, ²Service de Rhumatologie, CHU J Minjoz, Besancon, France
Background/Purpose Growing evidence indicate that Rheumatoid Arthritis (RA)-associated increase in cardiovascular risk is secondary to the presence of endothelial dysfunction (ED). Although Tumor Necrosis Factor…
Abstract Number: 2696 • 2013 ACR/ARHP Annual Meeting
Impaired Bacterial Clearance and An Exuberant Inflammatory Response Promote Chlamydia-Induced Reactive Arthritis In SKG Mice
Athan Baillet¹, Linda Rehaume², Helen Benham², Connor O'Meara³, Charles Armitage⁴, Marina Harvie⁴, Geraldine Brizard⁵, Jared Velasco², John V. Forrester⁶, Mariapia Degli-Esposti⁵, Kenneth Beagley⁴ and Ranjeny Thomas², ¹Diamantina Institute, The University of Queensland, Brisbane, Australia, ²University of Queensland Diamantina Institute, Brisbane, Australia, ³Institute of Health & Biomedical Innovation, Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, Australia, ⁴Institute of Health & Biomedical Innovation, Brisbane, Australia, ⁵Lions Eye Institute, Nedlands, Australia, ⁶Lions Eye Institute, Nedlands, Bahrain
Background/Purpose: The sterile inflammatory arthritis associated with spondylitis, uveitis and rash, known as reactive arthritis, commences weeks after certain gastrointestinal or genitourinary infections, including Salmonella…
Abstract Number: 1374 • 2013 ACR/ARHP Annual Meeting
NR1D1 Is a New Suppressor of Rheumatoid Arthritis Fibroblast-Like Synoviocyte Invasion
Teresina Laragione^1,2 and Percio Gulko^1,2, ¹Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, ²Molecular Medicine, Hosftra North Shore-LIJ School of Medicine, Manhasset, NY
Background/Purpose: Rheumatoid arthritis (RA) is a common and chronic autoimmune disease. Arthritis severity and joint damage predict clinical outcome and the risk for disability in…
Abstract Number: 714 • 2013 ACR/ARHP Annual Meeting
Combination Blocking Of Interleukin-6 and Interleukin-21 In Experimental Arthritis Inhibits Their Redundant Role In T Helper 17-Driven Joint Pathology
Debbie M. Roeleveld¹, Marije I. Koenders², Renoud J. Marijnissen^1,3, Cheryl L. Nickerson-Nutter⁴, Fons A. van de Loo¹ and Wim B. van den Berg⁵, ¹Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ²Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands, ³Rheumatology and Clinical Immunology, University Medical Centre Utrecht, Utrecht, Netherlands, ⁴Immunology and Autoimmunity, Pfizer, Cambridge, MA, ⁵Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
Background/Purpose: Both IL-6 and IL-21 have been described to drive in vitro Th17 differentiation in the presence of TGF-β. We explored whether also in vivo…

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