Abstracts tagged "Animal models"

Abstract Number: 936 • 2014 ACR/ARHP Annual Meeting
Active Invasion of Periodontal Bacteria into Synovial Joint Exacerbates Collagen-Induced Arthritis in Disease-Prone B10 Riii Mice
Sasanka Chukkapalli¹, Mercedes Rivera-Kweh¹, Irina Velsko¹, Indraneel Bhattacharyya², S. John Calise³, Edward Chan⁴, Minoru Satoh⁵ and Lakshmyya Kesavalu¹, ¹Periodontology, College of Dentistry, University of Florida, Gainesville, FL, ²Oral Diagnostic Sciences, College of Dentistry, University of Florida, Gainesville, FL, ³Oral Biology, University of Florida, Gainesville, FL, ⁴Oral Biology, College of Dentistry, University of Florida, Gainesville, FL, ⁵Clinical Nursing, Univ. Occupational and Environmental Health, Kitakyushu, Fukuoka, FL, Japan
Background/Purpose: Periodontitis (PD) is a chronic immunoinflammatory disease caused by complex subgingival periodontal bacteria. Rheumatoid Arthritis (RA) and PD both are chronic inflammatory disorders characterized…
Abstract Number: 607 • 2014 ACR/ARHP Annual Meeting
The HLA-B27 Peptidome in Vivo in Transgenic Rats
Joel D. Taurog¹, Yael Haimovich², Eilon Barnea³, Michal Bassani-Sternberg³, Shira Yair-Sabag², Martha L. Dorris¹, Nimman Satumtira¹, Mylinh Nguyen⁴, Robert E. Hammer⁴, Tri M. Tran⁵, Robert A. Colbert⁵ and Arie Admon³, ¹Internal Medicine, Rheumatic Diseases Division, UT Southwestern Medical Center, Dallas, TX, ²Technion-Israel Institute of Technology, Haifa, Israel, ³Biology, Technion-Israel Institute of Technology, Haifa, Israel, ⁴Biochemistry, UT Southwestern Medical Center, Dallas, TX, ⁵NIAMS/NIH, Bethesda, MD
Background/Purpose . In all current hypotheses for the association of B27 with SpA, the B27 peptide repertoire (peptidome) is likely to play a key role.…
Abstract Number: 2344 • 2014 ACR/ARHP Annual Meeting
Amelioration of Collagen-Induced Arthritis By Water-Soluble Fullerene C60(OH)₃₆ Nanoparticles through the Inhibition of Angiogenesis
Chia-Tse Weng^1,2, Shih-Yao Chen³, Yu-Hung Chen⁴, Chao-Liang Wu³, Ming-Fei Liu^1,2, Ai-Li Shiau⁵ and Chrong-Reen Wang^1,2, ¹Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan, ²Internal Medicine, National Cheng Kung University Medical College, Tainan, Taiwan, ³Biochemistry and Molecular Biology, National Cheng Kung University Medical College, Tainan, Taiwan, ⁴Medicine, National Cheng Kung University Medical College, Tainan, Taiwan, ⁵Microbiology and Immunology, National Cheng Kung University Medical College, Tainan, Taiwan
Background/Purpose Our previous study has shown that injection of 13-nm gold nanoparticles ameliorates collagen-induced arthritis (CIA) through the inhibition of angiogenesis by binding to VEGF.…
Abstract Number: 935 • 2014 ACR/ARHP Annual Meeting
Targeting Glycolysis in Rheumatoid Arthritis
Monica Guma¹, Alessia Lodi², Ajit Divakaruni³, Anne Murphy³, Stefano Tiziani⁴ and Gary S. Firestein⁵, ¹Division of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA, ²nutritional Sciences, University of Texas at Austin, Austin, TX, ³Pharmacology, University of California, San Diego, La Jolla, CA, ⁴Nutritional Sciences, University of Texas at Austin, Austin, TX, ⁵Division of Rheumatology, Allergy and Immunology, University of California at San Diego School of Medicine, La Jolla, CA
Background/Purpose: Many of the signaling pathways activated in inflammation have a profound effect on cell metabolism. However, little is known about metabolome in rheumatoid arthritis…
Abstract Number: 346 • 2014 ACR/ARHP Annual Meeting
Treatment of Collagen Induced Artritis with Human Embrionic Stem Cell-Derived Multipotent Mesenchymal Stromal Cells (hESC-MSC)
Gabriel Criado¹, María J. Pérez-Lorenzo¹, María Galindo², Jose L. Pablos², Pablo Menéndez³ and Elena Gonzalo-Gil⁴, ¹Grupo de Enfermedades Inflamatorias y Autoinmunes, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, ²Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, ³Josep Carreras Leukemia Research Insitute, Barcelona, Spain, ⁴Grupo de Investigación en Enfermedades Inflamatorias y Autoinmunes, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain
Background/Purpose Inhibition of TGFβ signaling in human Embryonic Stem Cells (hESC) generates mesenchymal stromal cells (hESC-MSC) with osteogenic, adipogenic and chondrogenic potential. These cells have…
Abstract Number: 2347 • 2014 ACR/ARHP Annual Meeting
Therapeutic Effect of a Novel Histone Deacetylase 6 Inhibitor, CKD-L, on Collagen Induced Arthritis and Peripheral Blood Mononuclear Cells from Patients with Rheumatoid Arthritis
Bo Ram Oh¹, Hyojin Lim², Daekwon Bae², Nina Ha², Young il Choi², Hyun Jung Yoo^3,4, Jin Kyun Park³, Eun Young Lee⁵, Eun Bong Lee³ and Yeong Wook Song^3,4, ¹Division of Rheumatology, Department of Molecular Medicine and Biophamaceutical Sciences, BK 21 plus Graduate School of Convergence Science Technology, Colleage of Medicine, Seoul National University, Seoul, South Korea, ²Department of Pharmacology and Toxicology, CKD Research Institute, CKD Pharmaceutical Company, Seoul, South Korea, ³Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea, ⁴Department of Molecular Medicine and Biophamaceutical Sciences, BK 21 plus Graduate School of Convergence Science Technology, Colleage of Medicine, Seoul National University, Seoul, South Korea, ⁵Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea
Background/Purpose Epigenetic regulation plays an important role in inflammatory arthritis, including rheumatoid arthritis (RA). Histone deacetylase inhibitor (HDACi) has been recently reported to have therapeutic…
Abstract Number: 934 • 2014 ACR/ARHP Annual Meeting
Amelioration of Inflammatory Arthritis By Anti-TNF Therapy Is Associated with Restoration of Lymphatic Contraction
Echoe M. Bouta¹, Igor Kuzin², Karen de Mesy-Bentley¹, Ronald Wood³, Homaira Rahimi⁴, Rui-Cheng Ji⁵, Christopher T. Ritchlin⁶, Andrea Bottaro², Lianping Xing⁷ and Edward M. Schwarz⁸, ¹University of Rochester, Rochester, NY, ²Cooper Medical School, Camden, NJ, ³Department of Urology, University of Rochester Medical Center, Rochester, NY, ⁴Rheumatology, University of Rochester/Golisano Children's Hospit, Rochester, NY, ⁵Department of Anatomy, Biology and Medicine, Oita University, Oita, Japan, ⁶Allergy Immunology & Rheumatology, University of Rochester Medical Center, Rochester, NY, ⁷Pathology & Lab Medicine, University of Rochester, Rochester, NY, ⁸Center for Musculoskeletal Research, University of Rochester, Rochester, NY
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory joint disease with episodic flares. In tumor necrosis factor transgenic (TNF-Tg) mice, a model of inflammatory-erosive arthritis,…
Abstract Number: 344 • 2014 ACR/ARHP Annual Meeting
Reduced Macrophages in the Synovium Contribute to the Effective Treatment of Spontanneous Arthritis Observeded in Human TNF-Transgenic Mice
Robert Birkett¹, Qi Quan Huang¹, Bo Shi² and Richard Pope³, ¹Medicine/Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL, ²Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL, ³Medicine/Rheumatology Div, Northwestern University Feinberg school of Medicine, Chicago, IL
Background/Purpose Macrophages in rheumatoid arthritis (RA) synovial tissue (ST) produce high levels of inflammatory cytokines/chemokines and exhibit enhanced differentiation into osteoclasts in the pannus, playing…
Abstract Number: 3004 • 2014 ACR/ARHP Annual Meeting
Autoantibody-Mediated Raynaud’s Phenomenon: Animal Model and Human Disease
Dana P. Ascherman^1,2, Yunjuan Zang³, Laisel Martinez⁴, Judith Pignac-Kobinger⁵, Irina Fernandez³ and Eric L. Greidinger^3,4, ¹Medicine/Rheumatology, University of Miami, Miami, FL, ²Rheumatology, Miami VAMC, Miami, FL, ³Rheumatology, University of Miami, Miami, FL, ⁴Miami VAMC, Miami, FL, ⁵University of Miami, Miami, FL
Background/Purpose: Raynaud’s Phenomenon (RP) is frequently seen in autoimmune conditions, but an autoimmune basis for RP has not been established. Methods: Sera derived from anti-RNP+…
Abstract Number: 2351 • 2014 ACR/ARHP Annual Meeting
Ligand of Glucocorticoid-Induced Tumor Necrosis Factor Receptor Enhances Th17 Cells Response in Collagen-Induced Arthritis Via P38 MAPK and STAT3 Pathway
Xinyi Tang¹ and Shengjun Wang², ¹Department of Laboratory Medicine, Jiangsu University Affi�liated People’s Hospital, Zhenjiang, China, ²Department of Laboratory Medicine, Jiangsu University Affiliated People’s Hospital, Zhenjiang, China
Background/Purpose Helper T lymphocyte-17 (Th17) has recognized to be an important factor in rheumatoid arthritis (RA) pathogenesis. The natural ligand of glucocorticoid-induced tumor necrosis factor…
Abstract Number: 856 • 2014 ACR/ARHP Annual Meeting
A Pathogenic Role for the Gut Microbiota in Murine Antiphospholipid Syndrome and Lupus
Silvio M. Vieira¹, Andrew Yu¹, Michael Hiltesperger¹, Odelya E. Pagovich¹, Eleni Tiniakou¹, William Ruff², John Sterpka¹ and Martin Kriegel^2,3, ¹Yale School of Medicine, New Haven, CT, ²Immunobiology, Yale School of Medicine, New Haven, CT, ³Medicine, Section of Rheumatology, Yale School of Medicine, New Haven, CT
Background/Purpose: The etiology of lupus-associated antiphospholipid syndrome (APS) is unknown but microbial triggers have been implicated in transient antiphospholipid antibody production in both mice and…
Abstract Number: 343 • 2014 ACR/ARHP Annual Meeting
The Caspase 8/RIPK3 Signaling Axis Has Opposing Roles in Myeloid and Dendritic Cells during Progression of a Murine Model of Acute Inflammatory Arthritis
Carla M. Cuda¹, Alexander Misharin², George Kenneth Haines III³ and Harris R. Perlman⁴, ¹Medicine / Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Northwestern University, Chicago, IL, ³Pathology, The Mount Sinai Hospital, New York, NY, ⁴Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose Rheumatoid arthritis (RA) manifests in persistent synovial inflammation, cellular infiltration and pro-inflammatory cytokine production, and results in progressive joint destruction. Both myeloid cells and…
Abstract Number: 2873 • 2013 ACR/ARHP Annual Meeting
The Ion Channel TRPV2 Is New Suppressor of Arthritis Severity and Joint Damage
Teresina Laragione^1,2, Max Brenner^1,2, Christine Beeton³ and Percio Gulko^1,2, ¹Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, ²Molecular Medicine, Hosftra North Shore-LIJ School of Medicine, Manhasset, NY, ³Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX
Background/Purpose: Rheumatoid arthritis (RA) is a common and chronic disease associated with increased risk of developing disability. Disease remission is still rarely achieved and better…
Abstract Number: 1832 • 2013 ACR/ARHP Annual Meeting
Discovery of MicroRNAs in the Regulation of Inflammation and Bone Erosion in Rheumatoid Arthritis
Ellen M. Gravallese¹, Yukiko Maeda¹, Nicholas Farina², Paul Fanning³ and Jane Lian², ¹Department of Medicine, Division of Rheumatology, University of Massachusetts Medical School, Worcester, MA, ²Department of Biochemistry, University of Vermont College of Medicine, Burlington, VT, ³Department of Orthopedics, University of Massachusetts Medical School, worcester, MA
Background/Purpose: Focal articular bone erosion in rheumatoid arthritis (RA) is mediated by osteoclasts and repair of erosion by osteoblasts is uncommon, despite the use of…
Abstract Number: 1152 • 2013 ACR/ARHP Annual Meeting
Ligation Of TLR5 Promotes Myeloid Cell Infiltration and Differentiation Into Mature Osteoclasts In RA Patients and Experimental Arthritis
Seung-jae Kim¹, Zhenlong Chen¹, Nathan D. Chamberlain¹, Michael V. Volin², Suncica Volkov¹, William Swedler³, Shiva Arami⁴, Anjali Mehta⁵, Nadera J. Sweiss⁶ and Shiva Shahrara¹, ¹Medicine/Rheumatology, University of Illinois at Chicago, Chicago, IL, ²Department of Microbiology and Immunology, Chicago College of Osteopathic Medicine Midwestern University, Downers Grove, IL, ³Section of Rheumatology, University of Illinois at Chicago, Chicago, IL, ⁴Medicine - Rheumatology, University of Illinois at Chicago, Chicago, IL, ⁵University of Illinois at Chicago, Chicago, IL, ⁶internal medicine section of rheumatology, University of Illinois at Chicago, Chicago, IL
Background/Purpose: The aim of this study was to examine the importance of TLR5 ligation in the pathogenesis of rheumatoid arthritis (RA) and experimental arthritis. Methods:…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].