Abstracts tagged "Animal models"

Abstract Number: 1462 • 2016 ACR/ARHP Annual Meeting
Magnesium Is a New Mediator Arthritis Severity and Joint Damage
Teresina Laragione, Nasim Azizgolshani, Carolyn Harris, Erjing Gao and Percio Gulko, Medicine/Rheumatology, Icahn School of Medicine at Mount Sinai, New York, NY
Background/Purpose: Given the effects of magnesium supplementation in suppressing components of the innate immunity in short-term studies, we examined the effect of dietary magnesium modifications…
Abstract Number: 374 • 2016 ACR/ARHP Annual Meeting
Anxiolytic Effects of the Novel α2δ Ligand Mirogabalin (DS-5565) in Sluka Model, an Experimental Animal Model of Fibromyalgia
Yuki Domon¹, Naohisa Arakawa¹, Hiroyasu Murasawa², Hiroyuki Kobayashi², Kensuke Saeki² and Yutaka Kitano¹, ¹Pain & Neuroscience Laboratories, Daiichi Sankyo Co., Ltd., Tokyo, Japan, ²Nihon Bioresearch Inc., Hashima, Japan
Anxiolytic Effects of the Novel Alpha-2-Delta Ligand Mirogabalin (DS-5565) in Sluka Model, an Experimental Animal Model of Fibromyalgia Yuki Domona, Naohisa Arakawaa, Hiroyasu Murasawab, Hiroyuki…
Abstract Number: 1122 • 2016 ACR/ARHP Annual Meeting
Infliximab Suppresses the Monocyte Chemotaxis in Human TNF-Transgenic Mice
Qi Quan Huang¹, Robert Birkett¹, Elyssa L Roberts² and Richard M. Pope³, ¹Medicine/Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL, ²northwestern University, Chicago, IL, ³Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Macrophages in rheumatoid arthritis (RA) synovium produce high levels of inflammatory cytokines/chemokines and play the pivotal role in promoting inflammation and joint destruction. Treatment…
Abstract Number: 1851 • 2016 ACR/ARHP Annual Meeting
The Effect of Narrow Band Ultraviolet A1 Light on Bleomycin-Induced Mouse Model of Scleroderma
Diana Karpec^1,2, Romualdas Rudys², Laima Leonaviciene², Zygmunt Mackiewicz², Ruta Bradunaite², Gailute Kirdaite², Rita Rugiene² and Algirdas Venalis^2,3, ¹Clinics of Rheumatology, Traumatology-Orthopedics and Reconstructive Surgery, Vilnius University Hospital Santariskiu Klinikos, Vilnius, Lithuania, ²State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania, ³Vilnius University Hospital Santariskiu Klinikos, Vilnius, Lithuania
Background/Purpose: Ultraviolet A1 (UVA1) phototherapy implications for systemic sclerosis still remain the area of research. The aim of the study was to evaluate narrow band…
Abstract Number: 457 • 2016 ACR/ARHP Annual Meeting
Novel Mechanism Mediated By the IL-23/Th17 Axis Contributing to Auto-Immune Arthritis
René Pfeifle¹, Tobias Rothe¹, Natacha Ipseiz¹, Stephan Culemann¹, Ulrike Harre², Gerhard Krönke³ and Georg Schett⁴, ¹Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²Department of Internal Medicine 3 and Institute for Clinical Immunology, Friedrich-Alexander-University Erlangen-Nuremberg (FAU), Erlangen, Germany, ³Universitätsklinikum Erlangen, Erlangen, Austria, ⁴Department of Internal Medicine III, Institute for Clinical Immunology,, Friedrich-Alexander-University Erlangen-Nuremberg (FAU), Erlangen, Germany
Background/Purpose: Checkpoints and mechanisms regulating the onset of rheumatoid arthritis (RA) remain largely elusive. Apart from B cells and auto-antibodies, Th17 cells were shown to…
Abstract Number: 1126 • 2016 ACR/ARHP Annual Meeting
Interleukin-1 Is Not Involved in Synovial Inflammation and Cartilage Destruction in Collagenase-Induced Osteoarthritis
Stephanie van Dalen¹, Arjen Blom¹, Annet Sloetjes¹, Monique M. Helsen¹, Johannes Roth², Thomas Vogl², Wim B. van den Berg¹, Martijn van den Bosch¹ and Peter L. E. M. van Lent¹, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Institute of Immunology, University of Münster, Münster, Germany
Background/Purpose: Osteoarthritis (OA) is characterized by severe cartilage destruction, with a putative role for synovial macrophages. Up to 50% of the patients also show low…
Abstract Number: 1859 • 2016 ACR/ARHP Annual Meeting
Fucosyltransferase-1 Mediated Fucosylation of TGF-βR1 Is Critical to TGF-β Signaling in Scleroderma and in Bleomycin-Induced Fibrosis
W. Alexander Stinson¹, Pei-Suen Tsou^1,2, Yuxuan Du³, Huadong Cui¹, Ellen Cealey³, Nicholas Lepore⁴, Ray A. Ohara¹, Gautam Edhayan¹, Sarah Arwani¹, Rachel Morgan¹, Dinesh Khanna^1,2, David A. Fox¹ and M. Asif Amin⁵, ¹Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ²University of Michigan Scleroderma Program, Ann Arbor, MI, ³Rheumatology, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ⁴University of Michigan, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ⁵Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI
Background/Purpose: Systemic sclerosis (SSc) is a connective tissue disease characterized by systemic fibrosis. The dysregulation of transforming growth factor-β (TGF-β) signaling causes proliferation of myofibroblasts…
Abstract Number: 458 • 2016 ACR/ARHP Annual Meeting
The TAM Receptors Axl and Mer Play a Protective Role in a Temporal and Spatial Manner in Inflammatory Arthritis
Claire E.J. Waterborg¹, Paqui G. Través², Silke Beermann¹, Marije I. Koenders¹, Greg Lemke² and Fons A.J. van de Loo¹, ¹Experimental Rheumatology, Radboudumc, Nijmegen, Netherlands, ²Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA
Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by an unrestrained inflammatory response in selective, anatomically distinct synovial joints. The innate immune system…
Abstract Number: 1128 • 2016 ACR/ARHP Annual Meeting
Anti-Fractalkine Monoclonal Antibody Inhibits Cartilage Destruction and Bone Erosion in Collagen-Induced Arthritis Model
Kana Hoshino¹, Masayoshi Ohkuro², Wataru Ikeda¹, Tomoya Nakatani¹, Yoshikazu Kuboi³, Naoto Ishii¹, Toshihiko Yamauchi¹, Nobuyuki Yasuda¹ and Toshio Imai¹, ¹KAN Research Institute Inc., Chuo-ku, Kobe-shi, Japan, ²Research Project Promotion Group, EA Pharma Co., Ltd., Kawasaki-ku, Kawasaki-shi, Japan, ³Medicine Creation. Neuro Business Group, Eisai Co., Ltd., Tsukuba-shi, Japan
Background/Purpose: Rheumatoid arthritis (RA) is a chronic disease leading to joint destruction. In the previous Phase 1/2 clinical study, E6011, a novel humanized anti-fractalkine (FKN)…
Abstract Number: 1866 • 2016 ACR/ARHP Annual Meeting
Human and Experimental Tracheal Stenosis Is Characterized By a TGF-β-Dependent Fibrotic Component
Alicia Usategui¹, Juan L. Antón-Pacheco², Carmen M. García-Herrero¹, Manuel J. Del Rey¹, Vanessa Miranda¹, Iván Martínez³, Antonio P Gámez³ and Jose L. Pablos¹, ¹Grupo de Enfermedades Inflamatorias y Autoinmunes, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain, ²Servicio de Cirugía Pediátrica, Hospital 12 de Octubre, Madrid, Spain, ³Servicio de Cirugía Torácica, Hospital 12 de Octubre, Madrid, Spain
Background/Purpose: Acquired tracheal stenosis (ATS) is an unusual disease secondary to inflammatory diseases or to prolonged mechanical trauma. Tracheal mucosa undergoes inflammation and granulation tissue…
Abstract Number: 464 • 2016 ACR/ARHP Annual Meeting
an Anti-Fima Antibody Attenuates Porphyromonas Gingivalis-Associated Experimental Arthritis
Sang Hoon Jeong¹, Jennifer Lee², Seo Hwa Kim³, Haneul Kim⁴, Seung-Ki Kwok⁵, Sung-Hwan Park⁶ and Ji Hyeon Ju⁷, ¹The Catholic University of Korea, Seoul, Korea, The Republic of, ²Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of, ³Division of Rheumatology,, Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea, The Republic of, ⁴Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea, The Republic of, ⁵[email protected], Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea, ⁶Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea, ⁷Division of Rheumatology, Department of Internal Medicine,, College of Medicine, The Catholic University of Korea, Seoul, South Korea
Background/Purpose: Evidence suggests that periodontal infection by Porphyromonas gingivalis(Pg) exacerbates rheumatoid arthritis (RA); however, the underlying mechanisms remain unknown. Here, we examined the pathogenic and therapeutic…
Abstract Number: 1435 • 2016 ACR/ARHP Annual Meeting
KCa1.1 Potassium Channels Are a Novel Therapeutic Target on Fibroblast-like Synoviocytes in Rheumatoid Arthritis
Mark Tanner¹, Redwan Huq¹, Rajeev Tajhya¹, Michael Pennington², Teresina Laragione³, Pércio Gulko⁴ and Christine Beeton⁵, ¹Molecular Physiology & Biophysics, Baylor College of Medicine, Houston, TX, ²Peptides International, Louisville, KY, ³Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, ⁴Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, ⁵Department of Molecular Physiology & Biophysics, Baylor College of Medicine, Houston, TX
Background/Purpose: Fibroblast-like synoviocytes (FLS) develop a high degree of invasiveness during rheumatoid arthritis (RA), leading to joint degradation. There are currently no therapeutics that specifically…
Abstract Number: 1914 • 2016 ACR/ARHP Annual Meeting
Immune Recognition of a Novel Citrullinated Epitope of Cartilage Proteoglycan Aggrecan in Mice with Proteoglycan-Induced Arthritis and in Patients with Rheumatoid Arthritis
Adrienn Markovics¹, Timea Ocsko¹, Robert S. Katz², Edit I Buzas³, Tibor T. Glant¹ and Katalin Mikecz¹, ¹Orthopedic Surgery, Rush University Medical Center, Chicago, IL, ²Rush University Medical Center, Chicago, IL, ³Semmelweis University, Budapest, Hungary
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease leading to the inflammatory destruction of synovial joints. Anti-citrullinated protein antibodies (ACPA) are frequently detected in the…
Abstract Number: 467 • 2016 ACR/ARHP Annual Meeting
Interleukin-21-Signaling in B Cells, but Not in T Cells, Is Indispensable for Development of Collagen-Induced Arthritis in Mice
Koji Sakuraba^1,2, Kenjiro Fujimura^1,2, Hisaaki Miyahara¹ and Hisakata Yamada², ¹Clinical Research Center, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan, ²Division of Host Defense, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
Background/Purpose: IL-21 is a T cell-derived cytokine whose receptor is expressed on variety of cells in immune system. IL-21was reported to be involved in the…
Abstract Number: 1437 • 2016 ACR/ARHP Annual Meeting
Netrin-1 and Its Receptor Unc5b Are Novel Targets for the Treatment of Inflammatory Arthritis
Aranzazu Mediero¹, Tuere Wilder², Bhama Ramkhelawon³, Kathryn Moore³ and Bruce Cronstein⁴, ¹Medicine, Divison of Translational Medicine, NYU School of Medicine, New York City, NY, ²Department of Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY, ³Leon H. Charney Division of Cardiology, Department of Medicine,, NYU School of Medicine, New York, NY, ⁴Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation and destruction of joints. Netrin-1, a laminin-like matrix protein that acts as a…

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