Abstracts tagged "Animal models"

Abstract Number: 2520 • 2016 ACR/ARHP Annual Meeting
Multi-Biomarker Disease Activity (MBDA) Score and Prediction of Radiographic Progression in a Randomized Study of Patients with Early RA Treated with Methotrexate Alone or with Adalimumab
Cecilie Heegaard Brahe¹, Mikkel Østergaard², Julia Sidenius Johansen³, Nadine A. Defranoux⁴, Ching Chang Hwang⁵, Xingbin Wang⁴, Rebecca J. Bolce⁴, Eric H. Sasso⁴, Kim Hørslev-Petersen⁶, Kristian Stengaard-Pedersen⁷, Lykke Midtbøll Ørnbjerg⁸, Peter Junker⁹, Torkell Ellingsen¹⁰, Palle Ahlquist¹¹, Hanne Lindegaard¹², Asta Linauskas¹³, Annette Schlemmer¹⁴, Mette Yde Dam¹⁵, Ib Tønder Hansen¹⁶, Tine Lottenburger¹¹, Christian G. Ammitzbøll¹⁷, Anette Jørgensen¹⁷, Sophine B. Krintel⁸, Johnny Lillelund Raun¹⁸ and Merete Lund Hetland^3,19, ¹Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Denmark, Glostrup, Denmark, ²Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Denmark, Copenhagen, Denmark, ³Danish Rheumatologic Biobank and DANBIO registry, Rigshospitalet, Glostrup, Gentofte and Herlev University Hospital, Copenhagen, Denmark, ⁴Crescendo Bioscience Inc., South San Francisco, CA, ⁵Biostatistics, Crescendo Bioscience Inc., South San Francisco, CA, ⁶King Christian X Hospital for Rheumatic Diseases, Graasten, Denmark, ⁷Rigshospitalet (Glostrup and Blegdamsvej), Århus University Hospital, Odense University Hospital, Herlev/Gentofte Hospital, Slagelse Sygehus, Chr X hospital (University of South Denmark) and Zitelab Aps, DANBIO Registry and Departments of Rheumatology, Copenhagen, Denmark, ⁸Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark, ⁹Department of Rheumatology C, Odense University Hospital, Odense, Denmark, ¹⁰Department of Rheumatology, Odense University Hospital, Odense, DK, Odense, Denmark, ¹¹Department of Medicine, Vejle Regional Hospital, Vejle, Denmark, ¹²The DANBIO registry and the Danish Departments of Rheumatology, Odense, Denmark, ¹³The DANBIO registry and the Danish Departments of Rheumatology, Copenhagen, Denmark, ¹⁴9Department of Rheumatology, Aalborg University Hospital, Aalborg, Denmark, ¹⁵Diagnostic Centre, Silkeborg Regional Hospital, Silkeborg, Denmark, ¹⁶Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ¹⁷Department of Rheumatology, Institute of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark, ¹⁸King Christian X Hospital for Rheumatic Diseases, South Jutland Hospital, Graasten, Denmark, ¹⁹Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Denmark,, Copenhagen, Denmark
Background/Purpose: The multi-biomarker disease activity (MBDA) score, which combines 12 serum biomarkers to measure RA disease activity on a scale of 1−100, has been found…
Abstract Number: 474 • 2016 ACR/ARHP Annual Meeting
Impaired Cognition Is Linked to Brain Depletion in Brain-Derived Neurotrophic Factor Levels in a Rat Model of Rheumatoid Arthritis
Martin Pedard¹, Perle Totoson², Clément Prati^3,4, Céline Demougeot² and Christine Marie⁵, ¹CHU François Mitterrand and INSERM U1093 Cognition, Action et Plasticité Sensorimotrice, Dijon, France, ²EA 4267 FDE, FHU INCREASE, Université de Bourgogne Franche-Comté, Besançon, France, ³Service de Rhumatologie, CHRU J Minjoz, Besançon, France, ⁴Hopital Jean Minjoz and EA 4267 FDE, FHU INCREASE, Université de Bourgogne Franche-Comté, Besançon, France, ⁵INSERM U1093, Université de Bourgogne Franche-Comté, Dijon, France
Background/Purpose: Cognitive dysfunction including depression-like symptoms is a frequent comorbidity of rheumatoid arthritis (RA)1. Mechanisms that have been linked to cognitive impairments in the general…
Abstract Number: 1445 • 2016 ACR/ARHP Annual Meeting
Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Ameliorate Rheumatoid Arthritis Via Regulation of Macrophage Activation and Polarization
Tae-Hoon Shin¹, Kichul Shin², Hyung-Sik Kim^3,4 and Kyung-Sun Kang⁵, ¹Adult Stem Cell Research Center, College of Veterinary Medicine, Seoul National University, Seoul, Korea, The Republic of, ²Kyungnam villa #102, Division of Rheumatology, Department of Internal Medicine, SMG-SNU Boramae Medical Center, Seoul, Korea, Republic of, ³Busan National University School of Medicine, Busan, Korea, The Republic of, ⁴Biomedical Research Institute, Busan National University Hospital, Busan, Korea, The Republic of, ⁵Institute for Stem cell Regenerative Medicine, Kangstem Biotech, Seoul, Korea, The Republic of
Background/Purpose: Immunomodulatory properties enable mesenchymal stem cells (MSCs) to be a promising alternative for the treatment of a wide range of immune-related diseases including rheumatoid…
Abstract Number: 2782 • 2016 ACR/ARHP Annual Meeting
Bortezomib Treatment Prevents Glomerulosclerosis Associated with Lupus Nephritis in a Murine Model through Suppressive Effects on the Immune and Renin-Angiotensin Systems
Kazuhisa Nozawa¹, Yuko Matsuki², Ken Yamaji³, Naoto Tamura⁴ and Yoshinari Takasaki³, ¹2-1-1 Hongo Bunkyo-ku, Juntendo University, Tokyo, Japan, ²Department of Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, ³Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, ⁴Rheumatology, Juntendo University, Tokyo, Japan
Background/Purpose: Lupus nephritis (LN) is one of the main causes of morbidity and mortality in SLE. Although a combination therapy using steroids and immunosuppressant…
Abstract Number: 582 • 2016 ACR/ARHP Annual Meeting
ACPA Induce Pathogenic Cytokines Expression in PBMC of ACPA+-RA Patients and Inhibition of Its Effect By Cit-ME a Synthetic Citrullinated Peptide
Smadar Gertel¹, Gidi Karmon², Eszter Szarka³, , Esther Houri-Levi⁴, Edna mozes⁵, Yehuda Shoenfeld⁴ and Howard Amital^6,7, ¹Sheba Medical Center, Zabludowicz Center for Autoimmune Diseases, affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Ramat Gan, Israel, ²Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Israel, ³Department of Immunology,, Eötvös Loránd University, Budapest,, Budapest, Hungary, ⁴Zabludowicz Center For Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel, Ramat-Gan, Israel, ⁵Department of Immunology,, The Weizmann Institute of Science, Rehovot, Israel., Rehovot, Israel, ⁶Department of Medicine B, Center for Autoimmune Diseases, Sheba Medical Center, Tel-hashomer, Israel, ⁷Department of Internal Medicine 'D', Sackler Faculty of Medicine, Tel-Aviv University, Kfar-Saba, Israel
ACPA induce pathogenic cytokines expression in PBMC of ACPA+-RA patients and inhibition of its effect by Cit-ME a synthetic citrullinated peptide.Smadar Gertel1, Gidi Karmon1, Eszter…
Abstract Number: 1447 • 2016 ACR/ARHP Annual Meeting
Therapeutic Blockade of Interleukin-6 Trans-Signalling Restores Vascular Function in Murine Collagen Induced Arthritis
Ruth Davies¹, Jessica O Williams², Katie Sime², Ellyn Hughes², Lauren A. Jordan², Charlotte Rawlings², Derek Lang³, Stefan Rose-John⁴, Simon A. Jones⁵, Anwen S. Williams² and Ernest H. Choy^6,7, ¹CREATE Centre, Division of Infection and Immunity, Cardiff University, Cardiff, United Kingdom, ²Institute of Infection and Immunity, Cardiff University, Cardiff, United Kingdom, ³Institute of Molecular and Experimental Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom, ⁴Institute of Biochemistry, Christian Albrechts University, Kiel, Germany, ⁵Infection, Immunity and Biochemistry, School of Medicine, Cardiff University, Cardiff, Wales, ⁶Section of Rheumatology, Cardiff University, Cardiff, Great Britain, ⁷CREATE Center, Division of Infection and Immunity,, Cardiff University, Cardiff, United Kingdom
Background/Purpose: Mortality is increased in rheumatoid arthritis (RA), mainly due to cardiovascular disease (CVD). While molecular mechanisms underlining this clinical observation are unknown, systemic elevations…
Abstract Number: 2791 • 2016 ACR/ARHP Annual Meeting
Targeting Micro-RNAs Derived from Extracellular Vesicles to Inhibit of TLR7 and TLR8 Signaling Suppresses Inflammation in a Novel Human-Mouse Chimeric Model of Systemic Lupus Erythematosus
Nicholas A. Young¹, Giancarlo R. Valiente², Holly Steigelman³, Jeffrey Hampton⁴ and Wael N. Jarjour⁵, ¹Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ²Rheumatology & Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, ³The Ohio State University, Columbus, OH, ⁴Immunology and Rheumatoloty, The Ohio State University Wexner Medical Center, Columbus, OH, ⁵Department of Rheumatology/Medicine, Ohio State University, Columbus, OH
Background/Purpose: Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease displaying a heavy female predominance during reproductive years. We have previously shown that toll-like receptor…
Abstract Number: 801 • 2016 ACR/ARHP Annual Meeting
Multi-Tissue Gene Expression Pathway Analysis of Emerging Therapeutics in a TGFβ Dependent Mouse Model of Systemic Sclerosis
Emma C. Derrett-Smith^1,2, Shiwen Xu³, Rachel K. Hoyles⁴ and Christopher Denton⁵, ¹Centre for Rheumatology and Connective Tissue Diseases, UCL Division of Medicine, London, United Kingdom, ²Rheumatology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom, ³Division of Medicine, Centre for Rheumatology and Connective tissue disease, University College London, London, United Kingdom, ⁴Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom, ⁵Division of Medicine, Centre for Rheumatology and Connective Tissue Disease, University College London, London, United Kingdom
Background/Purpose: We have previously investigated the interplay between TGFβ, BMP, VEGF and endothelin in SSc using the TβRIIΔk-fib strain, a transgenic mouse model in…
Abstract Number: 1451 • 2016 ACR/ARHP Annual Meeting
Glutamine Metabolism Plays a Crucial Role in the Pathogenesis of Rheumatoid Arthritis
Soshi Takahashi¹, Jun Saegusa², Ikuko Naka³, Kosaku Tsuda³, Takaichi Okano⁴, Kengo Akashi³, Sho Sendo², Yo Ueda³, Akira Onishi⁵, Yoshinori Kogata² and Akio Morinobu², ¹Department of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, ²Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, ³Kobe University Graduate School of Medicine, Kobe, Japan, ⁴Rheumatology and Clinical immunology, Kobe University Graduate School of Medicine, Kobe, Japan, ⁵Rheumaology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan
Background/Purpose: Many signaling pathways activated under inflammatory and hypoxic conditions have profound effects on intracellular metabolism to support cell growth and survival. Cancer cells consume…
Abstract Number: 3018 • 2016 ACR/ARHP Annual Meeting
The Analysis of Severity of Arthritis in the Intestinal Microbiota-Humanized Mice
Yuichi Maeda¹, Masato Matsushita², Masashi Narazaki³, Yukihiko Saeki^4,5, Atsushi Kumanogoh⁶ and Kiyoshi Takeda⁷, ¹Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Graduate School of Medicine, Suita, Japan, ²Rheumatology, Osaka Minami Medical Center, Osaka, Japan, ³Osaka University Graduate School of Medicine, Suita, Japan, ⁴Dept of Clinical research, Osaka-Minami Medical Ctr, Osaka, Japan, ⁵Dept of Clinical Research, Osaka-Minami Medical Center, Kawachinagano City, Japan, ⁶Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Graduate School of Medicine, Suita, Japan, ⁷Department of Microbiology and Immunology, Osaka University Graduate School of Medicine, Suita, Japan
Background/Purpose: Although various genetic factors have been implicated in susceptibility to rheumatoid arthritis (RA), environmental factors including smoking, periodontal disease and hormones are also necessary…
Abstract Number: 1008 • 2016 ACR/ARHP Annual Meeting
Advantageous Effect of an Endogenous Retroviral Envelope Protein in Systemic Lupus Erythematosus with Ex Vivo and In Vivo Anti-Inflammatory Potential
Anne Troldborg^1,2, Magdalena Janina Laska³, Ellen-Margrethe Hauge^4,5, Shervin Bahrami⁶ and Kristian Stengaard-Pedersen^7,8, ¹clinical medicine, Aarhus University, Aarhus, Denmark, ²Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ³Biomedicine, Aarhus University, Aarhus, Denmark, ⁴Dept. of Anatomy, Aarhus University, Aarhus, Denmark, ⁵Rheumatology, Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ⁶Clinical Medicine, Aarhus University, Aarhus, Denmark, ⁷Clinical medicine, Aarhus University, Aarhus, Denmark, ⁸Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark
Background/Purpose: Human Endogenous Retroviruses (HERVs) are remnants of retroviral infections in the human germline. Most, but not all, HERV genes have become inactive by accumulation…
Abstract Number: 1452 • 2016 ACR/ARHP Annual Meeting
18 F-FDG PET Imaging: An In Vivo quantitative Drug Screening Tool for Novel Antiinflammatory Therapies
Siba P. Raychaudhuri¹, Smriti K. Raychaudhuri², Anupam Mitra³ and Abhijit Chaudhari⁴, ¹Davis, CA, ²Rheumatology/Immunology, VA Sacramento Medical Center, Davis, CA, ³Dermatology, UC Davis School of Medicine, Davis, CA, ⁴Radiology, UC Davis School of Medicine, Sacramento, CA
Background/Purpose: Collagen induced arthritis (CIA) mouse model is used for screening of new drugs for autoimmune arthritis. The conventional read outs of this model are…
Abstract Number: 3124 • 2016 ACR/ARHP Annual Meeting
Huntingtin Interacting Protein 1 (Hip1) Is a New Arthritis Severity Gene
Teresina Laragione¹, Percio Gulko¹ and Max Brenner², ¹Medicine/Rheumatology, Icahn School of Medicine at Mount Sinai, New York, NY, ²Feinstein Institute for Medical Research, Manhasset, NY
Background/Purpose: Cia25/Pia42 is an arthritis severity and joint damage quantitative trait locus on rat chromosome 12 previously identified in an intercross between MHC identical but…
Abstract Number: 1031 • 2016 ACR/ARHP Annual Meeting
Glucocorticoid Receptor Dimerization in Stromal Cells Modulates Macrophage Polarization during Serum Transfer-Induced Arthritis
Mascha Koenen¹, Ulrike Baschant^2,3, Stephan Culemann^3,4, Tobias Kockmann⁵, Hans-Michael Kaltenbach⁶, Sabine Vettorazzi^1,3, Paolo Nanni⁷, Bernd Roschitzki⁸, Ulrich Auf dem Keller⁹ and Jan P. Tuckermann^1,3, ¹Institute for Comparative Molecular Endocrinology, University of Ulm, Ulm, Germany, ²Dep. of Medicine III, TU Dresden, Dresden, Germany, ³Leibniz Institute on Aging, FLI Jena, Jena, Germany, ⁴Dep. of Internal Medicine 3, Universitätsklinikum Erlangen, Erlangen, Germany, ⁵Institute for Molecular Health Sciences, ETH Zürich, Zürich, Switzerland, ⁶Dep. of Biosystems Science and Engineering, ETH Zürich, Zürich, Germany, ⁷Functional Genomics Center Zurich, University and ETH Zurich, Zürich, Switzerland, ⁸Functional Genomics Center Zurich, University and ETH Zurich, Zurich, Switzerland, ⁹Institute for Molecular Health Sciences, ETH Zürich, Zürich, Germany
Background/Purpose: Rheumatoid arthritis is commonly treated with potent anti-inflammatory glucocorticoids (GC), despite severe side effects such as osteoporosis and insulin resistance associated with chronic dosing…
Abstract Number: 1454 • 2016 ACR/ARHP Annual Meeting
Combination of the SYK Inhibitor, GS-9876, with a JAK Inhibitor Increases Efficacy in a Chronic Rat Model of Collagen-Induced Arthritis
Julie Di Paolo¹, David Alonzo², Christian Franci³, Terry Gentzler¹, Li Li⁴, Bernard Murray⁵ and Jim Zheng⁵, ¹Biology, Gilead Sciences, Foster City, CA, ²FPD, Gilead Sciences, Foster City, CA, ³Biology, Gilead Sciences, Foster, CA, ⁴Gilead Sciences, South San Francisco, CA, ⁵DMPK, Gilead Sciences, Foster City, CA
Background/Purpose: Here we demonstrate that 1) the single agent activity of GS-9876 is efficacious in a late stage rat model of collagen-induced arthritis (CIA);…

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