Session Type: ACR Poster Session B
Session Time: 9:00AM-11:00AM
Background/Purpose: Osteoarthritis (OA) is characterized by severe cartilage destruction, with a putative role for synovial macrophages. Up to 50% of the patients also show low grade joint inflammation reflected by a thickened synovial lining and elevated release of macrophage-derived mediators like interleukin-1 (IL-1) and S100A8/A9. The deteriorating role of S100A8/A9 in OA has been studied extensively, but the contribution of IL-1 to OA pathology is still unclear. IL-1 mediates cartilage destruction by degrading existing proteoglycans through stimulating degradative enzyme production, and by inhibiting new formation of proteoglycans. However, treatment of OA patients with IL-1 inhibitors has so far been disappointing. Here we investigated the role of IL-1α and IL-1βin synovitis and cartilage destruction during collagenase-induced OA (CiOA).
Methods: CiOA was induced by intra-articular injection of collagenase in WT and IL-1αβ
Results: At early stage (day 7) of CiOA, gene expression of IL-1β within inflamed synovium was significantly elevated when compared to synovium of naïve control knees. In later stages (day 21 and 42), IL-1β expression levels showed a steep decline. This is in contrast to pro-inflammatory mediators like S100A8 and S100A9 which remained elevated on day 21. Remarkably, synovial inflammation on day 7 in IL-1αβ
Conclusion: IL-1α and IL-1β are not involved in synovial inflammation and cartilage destruction during collagenase-induced osteoarthritis, implicating that other mediators are responsible for the joint damage.
To cite this abstract in AMA style:van Dalen S, Blom A, Sloetjes A, Helsen MM, Roth J, Vogl T, van den Berg WB, van den Bosch M, van Lent PLEM. Interleukin-1 Is Not Involved in Synovial Inflammation and Cartilage Destruction in Collagenase-Induced Osteoarthritis [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/interleukin-1-is-not-involved-in-synovial-inflammation-and-cartilage-destruction-in-collagenase-induced-osteoarthritis/. Accessed March 25, 2019.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/interleukin-1-is-not-involved-in-synovial-inflammation-and-cartilage-destruction-in-collagenase-induced-osteoarthritis/