Abstracts tagged "Angiogenesis"

Abstract Number: 1508 • 2016 ACR/ARHP Annual Meeting
Prevalence and Clinical Characteristics of Rheumatoid Arthritis in Sickle Cell Patients: A Cross-Sectional Analysis
David J. Ozeri¹, Joshy Pathiparampil², Randolph Sanchez² and Isabel M. McFarlane³, ¹Rheumatology, SUNY Downstate Medical Center, brooklyn, NY, ²Internal Medicine, SUNY Downstate Medical Center, Brooklyn, NY, ³Rheumatology, SUNY Downstate Medical Center, Brooklyn, NY
Title: Prevalence and Clinical Characteristics of Rheumatoid Arthritis in Sickle Cell Patients Background/Purpose: Rheumatoid arthritis (RA) has been rarely reported in association with sickle cell…
Abstract Number: 1572 • 2016 ACR/ARHP Annual Meeting
Relationship Between KDR (VEGFR2) Gene Polymorphisms and Serum KDR Protein Levels in Patients with Rheumatoid Arthritis
Agnieszka Paradowska-Gorycka¹, Barbara Stypinska², Andrzej Pawlik³, Damian Malinowski³, Katarzyna Romanowska-Próchnicka⁴, Ewa Haladyj⁵, Malgorzata Manczak⁶ and Marzena Olesinska⁷, ¹Department of Biochemistry and Molecular Biology, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland, ²Department of Biochemistry and Molecular Biology, National Institute of geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland, ³Department of Pharmacology, Pomeranian Medical University, Szczecin, Poland, ⁴Department of Pathophysiology, Medical University of Warsaw and Department of Connective Tissue Diseases, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland, ⁵Department of Connective Tissue Diseases, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland, ⁶Department of Epidemiology and Health Promotion, National Institute of geriatrics, Rheumatology and Rehabilitation,, Warsaw, Poland, ⁷Department of Connective Tissue Disease, National Institute of Geriatrics, Rheumatology and Rehabilitation,, Warsaw, Poland
Background/Purpose: Rheumatoid arthritis (RA) is one of the chronic autoimmune diseases, with genetic and environmental predisposition, and synovial angiogenesis is considered to be a notable…
Abstract Number: 1858 • 2016 ACR/ARHP Annual Meeting
Phenotypical and Functional Characteristics of in Vitro Expanded Adipose-Derived Mesenchymal Stem Cells from Patients with Systemic Sclerosis
Nicoletta Del Papa¹, Chiara Capelli², Eleonora Zaccara¹, Paola Cipriani³, Paola Di Benedetto⁴, Wanda Maglione¹, Romina Andracco¹, Francesca Pignataro¹, Roberto Giacomelli⁴, Martino Introna⁵ and Claudio Vitali⁶, ¹Dept. Rheumatology, G. Pini Hospital, Milano, Italy, ²Laboratorio di Terapia Cellulare e Genica "G. Lanzani",, Ospedali Riuniti di Bergamo, Bergamo, Italy, ³Department of Biotechnological and Applied Clinical Science, Rheumatology Unit, School of Medicine, University of L’Aquila, L'Aquila, Italy, ⁴Department of Biotechnological and Applied Clinical Science, Rheumatology Unit, School of Medicine, University of L’Aquila, L’Aquila, Italy, ⁵Laboratorio di Terapia Cellulare e Genica "G. Lanzani", Ospedali Riuniti di Bergamo, Bergamo, Italy, ⁶Rheumatology Section, Istituto San Giuseppe, Como, Italy
Background/Purpose: Adult stem cells, namely those of mesenchymal origin (MSCs), have received attention as an ideal source of regenerative cells because of their multi-potential ability…
Abstract Number: 2997 • 2016 ACR/ARHP Annual Meeting
Microrna-29a Curtails Synovitis in the Development of Knee Osteoarthritis By Disrupting VEGF
Feng-Sheng Wang¹, Yi-Chih Sun¹, Yu-Shan Chen¹ and Jih-Yang Ko², ¹Core Facility for Phenomics & Diagnostics, Department of Medical Research, Core Facility for Phenomics & Diagnostics, Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital, Taiwan, Kaohsiung, Taiwan, ²Department of Orthopedic Surgery, Department of Orthopedic Surgery, Kaohsiung Chang Gung Memorial Hospital, Taiwan, Kaohsiung, Taiwan
Background/Purpose: Intensive synovitis is a prominent feature that progressively aggravated excessive fibrosis reactions relative to joint stiffness in the pathogenesis of osteoarthritis (OA). MicroRNA-29a (miR-29a)…
Abstract Number: 2015 • 2015 ACR/ARHP Annual Meeting
Targeting Non-Canonical NF-Kappa B Signaling Inhibits Angiogenesis in a Novel 3D Model of Rheumatoid Arthritis Synovial Angiogenesis
Chrissta X. Maracle¹, Paulina Kucharzewska², Boy Helder¹, Arjan W. Griffioen³, Henric K. Olsson² and Sander W. Tas⁴, ¹Clinical Immunology and Rheumatology, Amsterdam Rheumatology and immunology Center | Academic Medical Center, Amsterdam, Netherlands, ²Astra Zeneca, Mölndal, Sweden, ³Medical Oncology, VU University Medical Center, Amsterdam, Netherlands, ⁴Clinical Immunology and Rheumatology, Amsterdam Rheumatology and immunology Center | Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: Pathological angiogenesis is a crucial part of disease progression in rheumatoid arthritis (RA) and is often considered the switch from acute to chronic inflammation.…
Abstract Number: 2134 • 2015 ACR/ARHP Annual Meeting
Metabolic Reprogramming in the Inflamed Joint Inhibits Pro-Inflammatory Mechanisms
Monika Biniecka¹, Mary Canavan¹, Chin Teck Ng², Wei Gao¹, Thomas Smith³, Trudy McGarry⁴, Douglas J. Veale⁵ and Ursula Fearon⁴, ¹St. Vincent's University Hospital, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, Dublin, Ireland, ²Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia, ³Department of Endocrinology, St Vincent’s University Hospital, Dublin, Ireland, ⁴St. Vincent's University Hospital, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, Dublin 4, Ireland, ⁵St Vincent's University Hospital, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, Dublin 4, Ireland
Background/Purpose: To examine the relationship between synovial hypoxia, cellular bioenergetics and mitochondrial dysfunction with synovial inflammation. Methods: Primary RASFC were cultured with 3% hypoxia, DMOG…
Abstract Number: 2963 • 2015 ACR/ARHP Annual Meeting
Correlations Between Microvasculature Changes and Angiogenic Factors in Systemic Sclerosis – Data from a Single Center Registry
Radim Becvar¹, Simona Skacelova², Jiri Stork³, Hana Hulejová⁴, Ivana Putova⁵, Michal Tomcik⁶ and Marie Jachymova⁷, ¹Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, ²Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Prague, Czech Republic, ³Clinic of Dermatology and Venerology, Prague, Czech Republic, ⁴Institute of Rheumatology, Department of Rheumatology of the First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic, ⁵Institute of Rheumatology and Department of Rheumatology of the 1st Faculty of Medicine, Charles University, Prague 2, Czech Republic, ⁶Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Prague, Czech Republic, ⁷Second Internal Clinic – Clinic of Cardiology and Angiology, General University Hospital,, Prague, Czech Republic
Background/Purpose: Histopathological hallmarks of systemic sclerosis (SSc) are perivascular infiltrates and a reduced capillary density, which precede the excessive accumulation of extracellular matrix components in…
Abstract Number: 3099 • 2015 ACR/ARHP Annual Meeting
Differential Effects of IL-6 Blockade Tocilizumab and TNF Inhibitors on the Reduced Angiogenesis and Lining Layer Degeneration in Synovial Tissues from Patients with Rheumatoid Arthritis
Hirohata Shunsei¹, Asami Abe^2,3, Akira Murasawa³, Tetsuya Tomita⁴ and Hideki Yoshikawa⁴, ¹Rheumatology and infectious diseases, Kitasato University School of Medicine, Kanagawa, Japan, ²Rheumatplogy, Niigata Rheumatic Center, Shibata, Japan, ³Rheumatology, Niigata Rheumatic Center, Shibata, Japan, ⁴Department of Orthopedics, Osaka University Graduate School of Medicine, Suita Osaka, Japan
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by hyperplasia of synovial tissues, leading to the destruction of joint structures. TNF inhibitors, including…
Abstract Number: 3132 • 2015 ACR/ARHP Annual Meeting
Histone Deacetylase 5 Is Overexpressed in Scleroderma Endothelial Cells and Impairs Angiogenesis Via Repressing Pro-Angiogenic Factors
Pei-Suen Tsou^1,2, M. Asif Amin³, Elena Schiopu^2,4, David A. Fox³, Dinesh Khanna^1,2 and Amr H. Sawalha¹, ¹Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²University of Michigan Scleroderma Program, Ann Arbor, MI, ³Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ⁴Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI
Background/Purpose: Scleroderma (SSc) is a complex disease characterized by inflammation, vascular complications, and excessive deposition of extracellular matrix. Vascular dysfunction represents a disease initiating event…
Abstract Number: 3143 • 2015 ACR/ARHP Annual Meeting
Mapping the Back-Door Routes into the Vascular Wall: 3D Microscopic Reconstruction of Microvasculature in the Normal Temporal Artery and in Giant Cell Arteritis
Daniel Drayton¹, Aruna Chakrabarty², Ann Morgan³, Darren Treanor⁴ and Sarah Mackie⁵, ¹School of Medicine, University of Leeds, Leeds, United Kingdom, ²Department of Cellular Pathology, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ³Leeds Institute of Rheumatic and Musculoskeletal Medicine and NIHR-Leeds Musculoskeletal Biomedical Research Unit, University of Leeds, Leeds, United Kingdom, ⁴Leeds Institute of Cancer and Pathology, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ⁵NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, University of Leeds, Leeds, United Kingdom
Background/Purpose: The arterial wall is nourished by microvessels (vasa vasorum), which are a potential route of entry for inflammatory cells in vasculitis. Little is known…
Abstract Number: 188 • 2015 ACR/ARHP Annual Meeting
Whole-Body Synovial Uptake of a 99mtc-Labelled RGD Peptide Is Highly Correlated with Power Doppler Ultrasound
Toby Garrood¹, Matthew Morrison², Dharsha Shivapatham³, Khaldoun Chaabo¹, Fahim Ul-Hassan⁴, Jim Ballinger⁴, Gary Cook⁵ and Andrew P. Cope⁶, ¹Rheumatology, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom, ²GE Healthcare, Amersham, United Kingdom, ³Department of Rheumatology, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom, ⁴Nuclear Medicine, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom, ⁵Imaging Sciences, Kings College London, London, United Kingdom, ⁶Academic Department of Rheumatology, King´s College London, London, United Kingdom
Background/Purpose: Musculoskeletal ultrasound, and specifically power Doppler ultrasound (PDUS), is more sensitive than clinical examination for the assessment of active synovitis in patients with rheumatoid…
Abstract Number: 282 • 2015 ACR/ARHP Annual Meeting
Angiogenesis in Fasciitis Associated with Dermatomyositis
Ken Yoshida, Kentaro Noda, Taro Ukichi, Kazuhiro Furuya, Kenichiro Hirai, Isamu Kingetsu and Daitaro Kurosaka, Division of Rheumatology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
Background/Purpose: We have previously demonstrated that fasciitis is a common lesion of dermatomyositis (DM) detectable early after disease onset. Furthermore, en bloc biopsy showed that the…
Abstract Number: 902 • 2015 ACR/ARHP Annual Meeting
Inhibitor of DNA Binding 1 As a Fibroblast Derived Inflammatory Angiogenic Agonist in Rheumatoid Arthritis
Gautam Edhayan¹, Christine M. Ha¹, Ray A. Ohara¹, Takeo Isozaki¹, M. Asif Amin¹, Ali S. Arbab², Phillip L. Campbell¹, Rachel Morgan¹, W. Alexander Stinson³, Sean C. Friday¹, David A. Fox¹ and Jeffrey H. Ruth¹, ¹Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ²Georgia Regents University, Augusta, GA, ³Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI
Background/Purpose: Inhibitor of DNA binding 1 (Id1) is a nuclear protein containing a basic helix-loop-helix (bHLH) domain that regulates cell growth by selective binding and…
Abstract Number: 905 • 2015 ACR/ARHP Annual Meeting
Citrullinated Epithelial-Derived Neutrophil-Activating Peptide 78 (ENA-78/CXCL5) Induces Monocyte Migration Via JNK and NFκB Signaling Pathways
Ray A. Ohara¹, Nicholas Lepore², W. Alexander Stinson³, Gautam Edhayan³, Phillip L. Campbell¹, Sarah Arwani¹, Rachel Morgan¹, Jeffrey H. Ruth¹, Alisa E. Koch^1,4, David A. Fox¹ and M. Asif Amin¹, ¹Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ²University of Michigan, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ³Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ⁴Eli Lilly and Company, Indianapolis, IN
Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by monocyte (MN) infiltration into the synovium. Citrullination is a post-translational modification of arginine to…
Abstract Number: 1158 • 2015 ACR/ARHP Annual Meeting
Active Non-Canonical NF-Kappab Signaling in Microvessels of Atherosclerotic Lesions in Coronary Arteries Is Associated with Inflammatory Cell Infiltration and Myocardial Infarction
Chrissta X. Maracle¹, Rabia Agca², Boy Helder¹, Hans W. Niessen³, Mike T. Nurmohamed² and Sander W. Tas⁴, ¹Clinical Immunology and Rheumatology, Amsterdam Rheumatology and immunology Center | Academic Medical Center, Amsterdam, Netherlands, ²Rheumatology, Amsterdam Rheumatology and immunology Center, VU University medical center, Amsterdam, Netherlands, ³Pathology, VU University Medical Center, Amsterdam, Netherlands, ⁴Clinical Immunology and Rheumatology, Amsterdam Rheumatology and immunology Center | Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: Patients with chronic inflammatory diseases (CID) have higher risk of developing cardiovascular disease which may be in part due to increased systemic inflammatory burden.…

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