Abstracts tagged "Angiogenesis"

Abstract Number: 0042 • ACR Convergence 2022
The Pathogenic Role of Lymphatic Vessels in Autoimmune Valvular Carditis
Amritha Yellamilli¹, Victoria Osinski², Maria Firulyova³, Jennifer Auger⁴, Lee Meier², Jessica Faragher⁵, Aubyn Marath⁶, Konstantin Zaitsev³ and Bryce Binstadt⁵, ¹Stanford University School of Medicine, Palo Alto, ²University of Minnesota School of Medicine, Minneapolis, MN, ³ITMO University, Saint Petersburg, Russia, ⁴University of Minnesota Medical School, Minneapolis, MN, ⁵University of Minnesota, Minneapolis, MN, ⁶CardioStart, Portland
Background/Purpose: Valvular carditis is a serious complication of systemic autoimmune diseases. Although endothelial cells are thought to play an important role in autoimmune valvular carditis,…
Abstract Number: 0620 • ACR Convergence 2022
Neovascularization Is Altered by Rheumatoid Arthritis Synovial Fibroblasts and Canstatin in Vitro and in Vivo
Corinna Heck¹, Daria Kürsammer¹, Klaus Frommer², Mona Arnold³, Stefan Rehart⁴, Ulf Müller-Ladner⁵ and Elena Neumann³, ¹Justus Liebig University Gießen, Department of Rheumatology and Clinical Immunology, Bad Nauheim, Germany, ²Justus Liebig University Gießen, Department of Rheumatology and Clinical Immunology, Campus Kerckhoff, Bad Nauheim, Germany, ³JLU Gießen, Campus Kerckhoff, Bad Nauheim, Germany, ⁴Agaplesion Markus Hospital, Dpt of Orthopaedics and Trauma Surgery, Frankfurt, Germany, ⁵JLU Campus KK, Bad Nauheim, Germany
Background/Purpose: In the pathogenesis of rheumatoid arthritis (RA), neovascularization is increased in the activated and inflamed synovium. RA synovial fibroblasts (RASF) are key players in…
Abstract Number: 1230 • ACR Convergence 2022
Diabetes Mellitus Nailfold Capillaroscopy Pattern: DM Pattern
Genessis Maldonado¹, Amala Chacko¹, Diana Franco¹, Lydia Robles¹, Deyger Navarrete¹, Madalina Ionescu¹ and Zineb Aouhab², ¹Loyola MacNeal Hospital, Berwyn, IL, ²Loyola University Medical Center, Maywood, IL
Background/Purpose: Recent data has shown the presence of nailfold architecture abnormalities in type 2 diabetes mellitus (T2DM), the changes has been associated with uncontrolled disease.…
Abstract Number: 0459 • ACR Convergence 2021
CCN1: An Angiogenic Actor Implicated in the Structural Damages of Rheumatoid Arthritis
Jerome Avouac¹, Alexia Steelandt², Olivia Amiar², Agathe Leblond², Cindy Orvain², Anne Cauvet², Virginie Gonzalez² and Yannick Allanore¹, ¹Université de Paris, Service de Rhumatologie, Hôpital Cochin, AP-HP.CUP, Paris, France, ²INSERM U1016, Institut Cochin, Paris, France
Background/Purpose: We have previously shown that decreased expression of the deacetylase sirtuin-1 (SIRT1) contributes to the proliferative, activated and proangiogenic profile of endothelial cells (EC)…
Abstract Number: 0512 • ACR Convergence 2021
Peficitinib and Filgotinib Inhibit Angiogenesis via Suppression of VEGF Production in Rheumatoid Arthritis Fibroblast-like Synoviocytes
Yuzo Ikari, Takeo Isozaki, Kuninobu Wakabayashi and Tsuyoshi Kasama, Division of Rheumatology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan
Background/Purpose: Peficitinib and filgotinib are novel Janus kinase (JAK) inhibitors developed for the treatment of rheumatoid arthritis (RA). Peficitinib inhibits all JAKs, especially JAK3. Filgotinib,…
Abstract Number: 0545 • ACR Convergence 2021
SIRT1 Modulates the Senescent Phenotype in Scleroderma Endothelial Cells
Ellen Model, Morgan Omara, Pamela Palisoc, Dinesh Khanna and Eliza Pei-Suen Tsou, University of Michigan, Ann Arbor, MI
Background/Purpose: Vascular abnormalities in systemic sclerosis (SSc) are characterized by injury to vascular wall and extensive damage of the microvessels. It has been shown that…
Abstract Number: 1246 • ACR Convergence 2021
The Effect of Tocilizumab on miR-146a-5p and EMMPRIN/CD147 in Rheumatoid Arthritis Patients
Devy Zisman¹, Mirna Safieh¹, Elina Simanovich¹, Joy Feld², Amalia Kinarty¹, Liron Zisman¹, Tal Gazitt³, Amir Haddad⁴, Muna Elias¹, Itzhak Rosner⁵, Lisa Kaly⁶ and Michal A Rahat⁷, ¹Carmel Medical Center, Haifa, Israel, ²Carmel and Zvulun Medical Centre, Haifa, Israel, ³Carmel Hospital, Haifa, Israel, ⁴Carmel Medical Centre, Haifa, Israel, ⁵Rheumatology Unit, Bnai Zion Medical Center, Haifa, Israel, ⁶Bnei Zion Medical Center, Haifa, Israel, ⁷Carmel Medical Center/Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
Background/Purpose: Angiogenesis is an important contributor to the development of rheumatoid arthritis (RA). Tocilizumab (TCZ), an anti-IL-6 receptor antibody used in the treatment of RA…
Abstract Number: 0791 • ACR Convergence 2020
Peficitinib Inhibits Angiogenesis via Suppression of VEGF Production in Rheumatoid Arthritis Fibroblast-like Synoviocytes
Yuzo Ikari¹, Takeo Isozaki¹, Kuninobu Wakabayashi¹ and Tsuyoshi Kasama², ¹Division of Rheumatology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan, ²Division of Rheumatology, Department of Medicine, Showa University School of Medicine, Koutou-ku Tokyo, Japan
Background/Purpose: Peficitinib is a novel Janus kinase (JAK) inhibitor developed for the treatment of rheumatoid arthritis (RA). Peficitinib has approved in 2019 in Japan, but…
Abstract Number: 0971 • ACR Convergence 2020
Single-cell Profiling of Synovial Stromal Cells Reveals an Angiocrine Endothelium in Rheumatoid Arthritis
Kevin Wei¹, Ilya Korsunsky², Jennifer Marshall³, Gerald Watts⁴, Triin Major³, Zhu Zhu⁴, Yuhong Li⁵, Christopher Buckley⁶, Soumya Raychaudhuri⁷ and Michael Brenner¹, ¹Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ²Brigham and Women's Hospital, Boston, MA, ³Rheumatology Research Group, Institute for Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Queen Elizabeth Hospital, Birmingham, United Kingdom, ⁴Brigam and Women's Hospital, Boston, ⁵Brigham and Women's Hospital, Boston, ⁶University of Birmingham, Birmingham, United Kingdom, ⁷Brigham and Women’s Hospital and Harvard Medical School, Boston, MA
Background/Purpose: Vascular endothelial cells that provide the structure for blood vessels have traditionally been perceived as passive, structural units that provide blood flow. We recently…
Abstract Number: 1527 • ACR Convergence 2020
Tofacitinib Inhibits Angiogenesis Through Its Opposite Effects on Pro- and Anti-angiogenic Factors
Devy Zisman¹, Maya Rahat², Elina Simanovich², Elizabeth Mellins³, Amir Haddad¹, Tal Gazitt¹, Joy Feld² and Michal Rahat², ¹Carmel Hospital, Haifa, Israel, ²Carmel Medical Center, Haifa, Israel, ³Stanford University, Stanford, CA
Background/Purpose: Angiogenesis plays a key role in the progression of rheumatoid arthritis (RA), but the mechanisms regulating this process are not fully elucidated. EMMPRIN is…
Abstract Number: 53 • 2019 ACR/ARP Annual Meeting
Activation of the Desacetylase Sirtuin-1 Counteracts the Activated and Proangiogenic Profile of Endothelial Cells in Rheumatoid Arthritis and Alleviates Experimental Arthritis
Agathe Leblond ¹, Sonia Pezet ¹, Anne Cauvet ¹, Claudine Casas ¹, Julie Pires Da Silva ², Roxane Herve ³, Luca Semerano ⁴, Christophe Lemaire ⁵, Yannick Allanore ⁶ and Jerome Avouac⁶, ¹INSERM U1016, Paris, France, ²Paris Sud University, Chateany Malabry, France, ³Paris 13 University, Bobigny, France, ⁴INSERM UMR 1125 , Université Paris 13, Bobigny, France, ⁵Paris Sud University, Chatenay malabry, France, ⁶Paris Descartes University, Cochin Hospital, Rheumatology department, Paris, France
Background/Purpose: To decipher the phenotype of endothelial cells (ECs) derived from circulating progenitors issued from patients with rheumatoid arthritis (RA).Methods: Proliferation capacities between RA and…
Abstract Number: 1999 • 2019 ACR/ARP Annual Meeting
NADPH Oxidase 4 Regulates the Migration and Invasion of Synoviocytes in Rheumatoid Arthritis Through Pro-angiogenic Factor Secretion
Ha-Reum Lee¹, Su-Jin Yoo ², Chan-Geol Park ², Jinhyun Kim ², In Seol Yoo ² and Seong Wook Kang ², ¹Chungnam National University Hospital,, Daejeon, Republic of Korea, ²Chungnam National University Hospital, Daejeon, Republic of Korea
Background/Purpose: Fibroblast-like synoviocytes (FLS) are key effector cells in the pathogenesis of rheumatoid arthritis (RA) through the increased cell migration, degradation of extracellular matrix, and…
Abstract Number: 2018 • 2019 ACR/ARP Annual Meeting
Elevated Serum Levels of Tie-1 in Patients with Rheumatoid Arthritis
Dylan Lee¹, Chandra Mohan ², Danielle Feger ³, Nancy Olsen ⁴ and Rayford June ⁴, ¹Pennsylvania State M.S. Hershey Medical Center, Hershey, PA, ²Department of Biomedical Engineering, University of Houston,, Houston, ³Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health,, Baltimore, ⁴Pennsylvania State M.S. Hershey Medical Center, Hershey
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease that primarily affects patients’ peripheral joints and can lead to severe personal disability from progressive articular joint…
Abstract Number: 2692 • 2018 ACR/ARHP Annual Meeting
High Frequency Ultrasound As a Novel Approach to Quantifying the Digital Microangiopathy of Systemic Sclerosis
Victoria Flower^1,2, Shaney Barratt^3,4, Darren Hart⁵, Amanda MacKenzie², Jacqueline Shipley⁵, Stephen Ward² and John Pauling^1,2, ¹Department of Rheumatology, Royal National Hospital for Rheumatic Diseases, Royal United Hospitals NHS Foundation Trusts, Bath, United Kingdom, ²Centre for Therapeutic Innovations & Department of Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom, ³North Bristol NHS Trust, Bristol, United Kingdom, ⁴Academic Respiratory Unit, School of Clinical Sciences, University of Bristol, Bristol, United Kingdom, ⁵Clinical Measurement Department, Royal National Hospital for Rheumatic Diseases, Royal United Hospitals NHS Foundation Trusts, Bath, United Kingdom
Background/Purpose: Structural and functional vascular abnormalities occur in Systemic Sclerosis (SSc). We report on the use of High Frequency Ultrasound (HFUS) with Superb Microvascular Imaging…
Abstract Number: 116 • 2018 ACR/ARHP Annual Meeting
Identifying Matricellular Protein CYR61 As a Potential Anti-Fibrotic and Pro-Angiogenic Mediator in Scleroderma
Pei-Suen Tsou¹, Dinesh Khanna² and Amr H Sawalha¹, ¹Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²Division of Rheumatology, University of Michigan Scleroderma Program, Ann Arbor, MI
Background/Purpose: Vascular abnormalities represent a fundamental event in the pathogenesis of scleroderma (SSc) in that endothelial cell (EC) damage triggers a self-fueling process ending in…

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