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Abstracts tagged "Angiogenesis"

  • Abstract Number: 0042 • ACR Convergence 2022

    The Pathogenic Role of Lymphatic Vessels in Autoimmune Valvular Carditis

    Amritha Yellamilli1, Victoria Osinski2, Maria Firulyova3, Jennifer Auger4, Lee Meier2, Jessica Faragher5, Aubyn Marath6, Konstantin Zaitsev3 and Bryce Binstadt5, 1Stanford University School of Medicine, Palo Alto, 2University of Minnesota School of Medicine, Minneapolis, MN, 3ITMO University, Saint Petersburg, Russia, 4University of Minnesota Medical School, Minneapolis, MN, 5University of Minnesota, Minneapolis, MN, 6CardioStart, Portland

    Background/Purpose: Valvular carditis is a serious complication of systemic autoimmune diseases. Although endothelial cells are thought to play an important role in autoimmune valvular carditis,…
  • Abstract Number: 0620 • ACR Convergence 2022

    Neovascularization Is Altered by Rheumatoid Arthritis Synovial Fibroblasts and Canstatin in Vitro and in Vivo

    Corinna Heck1, Daria Kürsammer1, Klaus Frommer2, Mona Arnold3, Stefan Rehart4, Ulf Müller-Ladner5 and Elena Neumann3, 1Justus Liebig University Gießen, Department of Rheumatology and Clinical Immunology, Bad Nauheim, Germany, 2Justus Liebig University Gießen, Department of Rheumatology and Clinical Immunology, Campus Kerckhoff, Bad Nauheim, Germany, 3JLU Gießen, Campus Kerckhoff, Bad Nauheim, Germany, 4Agaplesion Markus Hospital, Dpt of Orthopaedics and Trauma Surgery, Frankfurt, Germany, 5JLU Campus KK, Bad Nauheim, Germany

    Background/Purpose: In the pathogenesis of rheumatoid arthritis (RA), neovascularization is increased in the activated and inflamed synovium. RA synovial fibroblasts (RASF) are key players in…
  • Abstract Number: 1230 • ACR Convergence 2022

    Diabetes Mellitus Nailfold Capillaroscopy Pattern: DM Pattern

    Genessis Maldonado1, Amala Chacko1, Diana Franco1, Lydia Robles1, Deyger Navarrete1, Madalina Ionescu1 and Zineb Aouhab2, 1Loyola MacNeal Hospital, Berwyn, IL, 2Loyola University Medical Center, Maywood, IL

    Background/Purpose: Recent data has shown the presence of nailfold architecture abnormalities in type 2 diabetes mellitus (T2DM), the changes has been associated with uncontrolled disease.…
  • Abstract Number: 0459 • ACR Convergence 2021

    CCN1: An Angiogenic Actor Implicated in the Structural Damages of Rheumatoid Arthritis

    Jerome Avouac1, Alexia Steelandt2, Olivia Amiar2, Agathe Leblond2, Cindy Orvain2, Anne Cauvet2, Virginie Gonzalez2 and Yannick Allanore1, 1Université de Paris, Service de Rhumatologie, Hôpital Cochin, AP-HP.CUP, Paris, France, 2INSERM U1016, Institut Cochin, Paris, France

    Background/Purpose: We have previously shown that decreased expression of the deacetylase sirtuin-1 (SIRT1) contributes to the proliferative, activated and proangiogenic profile of endothelial cells (EC)…
  • Abstract Number: 0512 • ACR Convergence 2021

    Peficitinib and Filgotinib Inhibit Angiogenesis via Suppression of VEGF Production in Rheumatoid Arthritis Fibroblast-like Synoviocytes

    Yuzo Ikari, Takeo Isozaki, Kuninobu Wakabayashi and Tsuyoshi Kasama, Division of Rheumatology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan

    Background/Purpose: Peficitinib and filgotinib are novel Janus kinase (JAK) inhibitors developed for the treatment of rheumatoid arthritis (RA). Peficitinib inhibits all JAKs, especially JAK3. Filgotinib,…
  • Abstract Number: 0545 • ACR Convergence 2021

    SIRT1 Modulates the Senescent Phenotype in Scleroderma Endothelial Cells

    Ellen Model, Morgan Omara, Pamela Palisoc, Dinesh Khanna and Eliza Pei-Suen Tsou, University of Michigan, Ann Arbor, MI

    Background/Purpose: Vascular abnormalities in systemic sclerosis (SSc) are characterized by injury to vascular wall and extensive damage of the microvessels. It has been shown that…
  • Abstract Number: 1246 • ACR Convergence 2021

    The Effect of Tocilizumab on miR-146a-5p and EMMPRIN/CD147 in Rheumatoid Arthritis Patients

    Devy Zisman1, Mirna Safieh1, Elina Simanovich1, Joy Feld2, Amalia Kinarty1, Liron Zisman1, Tal Gazitt3, Amir Haddad4, Muna Elias1, Itzhak Rosner5, Lisa Kaly6 and Michal A Rahat7, 1Carmel Medical Center, Haifa, Israel, 2Carmel and Zvulun Medical Centre, Haifa, Israel, 3Carmel Hospital, Haifa, Israel, 4Carmel Medical Centre, Haifa, Israel, 5Rheumatology Unit, Bnai Zion Medical Center, Haifa, Israel, 6Bnei Zion Medical Center, Haifa, Israel, 7Carmel Medical Center/Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel

    Background/Purpose: Angiogenesis is an important contributor to the development of rheumatoid arthritis (RA). Tocilizumab (TCZ), an anti-IL-6 receptor antibody used in the treatment of RA…
  • Abstract Number: 0791 • ACR Convergence 2020

    Peficitinib Inhibits Angiogenesis via Suppression of VEGF Production in Rheumatoid Arthritis Fibroblast-like Synoviocytes

    Yuzo Ikari1, Takeo Isozaki1, Kuninobu Wakabayashi1 and Tsuyoshi Kasama2, 1Division of Rheumatology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan, 2Division of Rheumatology, Department of Medicine, Showa University School of Medicine, Koutou-ku Tokyo, Japan

    Background/Purpose: Peficitinib is a novel Janus kinase (JAK) inhibitor developed for the treatment of rheumatoid arthritis (RA). Peficitinib has approved in 2019 in Japan, but…
  • Abstract Number: 0971 • ACR Convergence 2020

    Single-cell Profiling of Synovial Stromal Cells Reveals an Angiocrine Endothelium in Rheumatoid Arthritis

    Kevin Wei1, Ilya Korsunsky2, Jennifer Marshall3, Gerald Watts4, Triin Major3, Zhu Zhu4, Yuhong Li5, Christopher Buckley6, Soumya Raychaudhuri7 and Michael Brenner1, 1Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 2Brigham and Women's Hospital, Boston, MA, 3Rheumatology Research Group, Institute for Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Queen Elizabeth Hospital, Birmingham, United Kingdom, 4Brigam and Women's Hospital, Boston, 5Brigham and Women's Hospital, Boston, 6University of Birmingham, Birmingham, United Kingdom, 7Brigham and Women’s Hospital and Harvard Medical School, Boston, MA

    Background/Purpose: Vascular endothelial cells that provide the structure for blood vessels have traditionally been perceived as passive, structural units that provide blood flow. We recently…
  • Abstract Number: 1527 • ACR Convergence 2020

    Tofacitinib Inhibits Angiogenesis Through Its Opposite Effects on Pro- and Anti-angiogenic Factors

    Devy Zisman1, Maya Rahat2, Elina Simanovich2, Elizabeth Mellins3, Amir Haddad1, Tal Gazitt1, Joy Feld2 and Michal Rahat2, 1Carmel Hospital, Haifa, Israel, 2Carmel Medical Center, Haifa, Israel, 3Stanford University, Stanford, CA

    Background/Purpose: Angiogenesis plays a key role in the progression of rheumatoid arthritis (RA), but the mechanisms regulating this process are not fully elucidated. EMMPRIN is…
  • Abstract Number: 53 • 2019 ACR/ARP Annual Meeting

    Activation of the Desacetylase Sirtuin-1 Counteracts the Activated and Proangiogenic Profile of Endothelial Cells in Rheumatoid Arthritis and Alleviates Experimental Arthritis

    Agathe Leblond 1, Sonia Pezet 1, Anne Cauvet 1, Claudine Casas 1, Julie Pires Da Silva 2, Roxane Herve 3, Luca Semerano 4, Christophe Lemaire 5, Yannick Allanore 6 and Jerome Avouac6, 1INSERM U1016, Paris, France, 2Paris Sud University, Chateany Malabry, France, 3Paris 13 University, Bobigny, France, 4INSERM UMR 1125 , Université Paris 13, Bobigny, France, 5Paris Sud University, Chatenay malabry, France, 6Paris Descartes University, Cochin Hospital, Rheumatology department, Paris, France

    Background/Purpose: To decipher the phenotype of endothelial cells (ECs) derived from circulating progenitors issued from patients with rheumatoid arthritis (RA).Methods: Proliferation capacities between RA and…
  • Abstract Number: 1999 • 2019 ACR/ARP Annual Meeting

    NADPH Oxidase 4 Regulates the Migration and Invasion of Synoviocytes in Rheumatoid Arthritis Through Pro-angiogenic Factor Secretion

    Ha-Reum Lee1, Su-Jin Yoo 2, Chan-Geol Park 2, Jinhyun Kim 2, In Seol Yoo 2 and Seong Wook Kang 2, 1Chungnam National University Hospital,, Daejeon, Republic of Korea, 2Chungnam National University Hospital, Daejeon, Republic of Korea

    Background/Purpose: Fibroblast-like synoviocytes (FLS) are key effector cells in the pathogenesis of rheumatoid arthritis (RA) through the increased cell migration, degradation of extracellular matrix, and…
  • Abstract Number: 2018 • 2019 ACR/ARP Annual Meeting

    Elevated Serum Levels of Tie-1 in Patients with Rheumatoid Arthritis

    Dylan Lee1, Chandra Mohan 2, Danielle Feger 3, Nancy Olsen 4 and Rayford June 4, 1Pennsylvania State M.S. Hershey Medical Center, Hershey, PA, 2Department of Biomedical Engineering, University of Houston,, Houston, 3Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health,, Baltimore, 4Pennsylvania State M.S. Hershey Medical Center, Hershey

    Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease that primarily affects patients’ peripheral joints and can lead to severe personal disability from progressive articular joint…
  • Abstract Number: 2692 • 2018 ACR/ARHP Annual Meeting

    High Frequency Ultrasound As a Novel Approach to Quantifying the Digital Microangiopathy of Systemic Sclerosis

    Victoria Flower1,2, Shaney Barratt3,4, Darren Hart5, Amanda MacKenzie2, Jacqueline Shipley5, Stephen Ward2 and John Pauling1,2, 1Department of Rheumatology, Royal National Hospital for Rheumatic Diseases, Royal United Hospitals NHS Foundation Trusts, Bath, United Kingdom, 2Centre for Therapeutic Innovations & Department of Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom, 3North Bristol NHS Trust, Bristol, United Kingdom, 4Academic Respiratory Unit, School of Clinical Sciences, University of Bristol, Bristol, United Kingdom, 5Clinical Measurement Department, Royal National Hospital for Rheumatic Diseases, Royal United Hospitals NHS Foundation Trusts, Bath, United Kingdom

    Background/Purpose: Structural and functional vascular abnormalities occur in Systemic Sclerosis (SSc). We report on the use of High Frequency Ultrasound (HFUS) with Superb Microvascular Imaging…
  • Abstract Number: 116 • 2018 ACR/ARHP Annual Meeting

    Identifying Matricellular Protein CYR61 As a Potential Anti-Fibrotic and Pro-Angiogenic Mediator in Scleroderma

    Pei-Suen Tsou1, Dinesh Khanna2 and Amr H Sawalha1, 1Division of Rheumatology, University of Michigan, Ann Arbor, MI, 2Division of Rheumatology, University of Michigan Scleroderma Program, Ann Arbor, MI

    Background/Purpose: Vascular abnormalities represent a fundamental event in the pathogenesis of scleroderma (SSc) in that endothelial cell (EC) damage triggers a self-fueling process ending in…
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