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Abstracts tagged "Angiogenesis"

  • Abstract Number: 1373 • 2013 ACR/ARHP Annual Meeting

    Connective Tissue Growth Factor Promotes Angiogenesis Through Increased Notch-1 Signaling in Rheumatoid Arthritis

    Kazuhisa Nozawa1, Maki Fujishiro2, Ayako Yamaguchi1, Mikiko Kawasaki2, Kazuhisa Iwabuchi2, Mitsuaki Yanagida2, Keigo Ikeda3, Shinji Morimoto4, Yoshinari Takasaki5 and Iwao Sekigawa3, 1Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, 2Institute for Environment and Gender Specific Medicine, Juntendo University Graduate School of Medicine, Chiba, Japan, 3Internal Medicine 2, Juntendo University Urayasu Hospital, Tomioka, Urayasu, Chiba, Japan, 4Juntendo University Urayasu Hospital, Tokyo, Japan, 5Division of Rheumatology, Department of Internal Medicine, Juntendo University, Tokyo, Japan

    Background/Purpose:  Increased angiogenesis has been associated with various inflammatory disease states including rheumatoid arthritis (RA), and it has been considered as one of main factors…
  • Abstract Number: 932 • 2013 ACR/ARHP Annual Meeting

    Hypoxia and Signal Transducer and Activator Of Transcription 3 Signalling Interactions Regulate Pro-Inflammatory Pathways In Rheumatoid Arthritis

    Wei Gao1, Jennifer McCormick1, Mary Connolly2, Emese Balogh2, Douglas J. Veale1 and Ursula Fearon1, 1Dublin Academic Medical Centre, Translational Rheumatology Research Group, Dublin, Ireland, 2Rheumatology, Translation Research Group, Dublin Academic Medical Centre, St. Vincent's University Hospital, Dublin, Ireland

    Background/Purpose: Signal Transducer and Activator of Transcription 3 (STAT3), a critical transcription activator in angiogenesis, plays a crucial role in the pathogenesis of Rheumatoid Arthritis…
  • Abstract Number: 933 • 2013 ACR/ARHP Annual Meeting

    Characterizing The Expression and Function Of CCL28 and Its Corresponding Receptor CCR10 In The Pathogenesis Of RA

    Zhenlong Chen1, Seung-jae Kim1, Michael V. Volin2, Suncica Volkov1, William Swedler3, Nadera J. Sweiss4 and Shiva Shahrara1, 1Medicine/Rheumatology, University of Illinois at Chicago, Chicago, IL, 2Department of Microbiology and Immunology, Chicago College of Osteopathic Medicine Midwestern University, Downers Grove, IL, 3Section of Rheumatology, University of Illinois at Chicago, Chicago, IL, 4internal medicine section of rheumatology, University of Illinois at Chicago, Chicago, IL

    Background/Purpose: This study was conducted to determine the expression pattern and function of CCL28 and its corresponding receptor CCR10 in the pathogenesis of rheumatoid arthritis…
  • Abstract Number: 937 • 2013 ACR/ARHP Annual Meeting

    Inhibitor Of DNA Binding 1 Mediates Angiogenesis In Rheumatoid Arthritis By Recruitment Of Endothelial Progenitor Cells

    Takeo Isozaki1, Alisa E. Koch2, M. Asif Amin1, Ali S. Arbab3, Gautam Edhayan4, Christine M. Ha4, Pei-Suen Tsou4, Sean C. Friday4, David A. Fox4 and Jeffrey H. Ruth4, 1Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, 2University of Michigan Medical School, Ann Arbor, MI, 3Diagnostic Radiology, Henry Ford Hospital and Medical Centers, Detroit, MI, 4Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI

    Background/Purpose: Endothelial progenitor cells (EPCs) are known to induce vasculoproliferative responses within rheumatoid arthritis (RA) synovial tissue (ST). Inhibitor of DNA-Binding 1 (Id1) is a…
  • Abstract Number: 946 • 2013 ACR/ARHP Annual Meeting

    Interleukin-34 Regulates Angiogenesis and Cell Proliferation In Inflammatory Arthritis, This Effect Is Potentiated By Hypoxia

    Emese Balogh1, Mary Connolly1, Monika Biniecka1, Jennifer McCormick2, Douglas J. Veale3 and Ursula Fearon2, 1Rheumatology, Translation Research Group, Dublin Academic Medical Centre, St. Vincent's University Hospital, Dublin, Ireland, 2Dublin Academic Medical Centre, Translational Rheumatology Research Group, Dublin, Ireland, 3Rheumatology, St. Vincent's University Hospital, Dublin 4, Ireland

    Background/Purpose: Interleukin-34 (IL-34) is a cytokine implicated in macrophage differentiation, angiogenesis and osteoclastogenesis in inflammatory arthritis (IA). IA is characterized by synovial hypoxia, increased oxidative…
  • Abstract Number: 777 • 2013 ACR/ARHP Annual Meeting

    A Unique Role For Galectin-9 In Angiogenesis and Inflammatory Arthritis

    Martin O'Brien1, Qiang Shu2, Pei-Suen Tsou3, William Stinson4, Jeffrey H. Ruth3, Takeo Isozaki5, Alisa E. Koch6, David A. Fox5 and M. Asif Amin5, 1Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, 2Department of Internal Medicine, University of Michigan Medical School and Qilu Hospital of Shandong University, Ann Arbor, MI, 3Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, 4Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, 5Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, 6VA Medical Service, Ann Arbor, MI

    Background/Purpose: Galectin-9 (Gal-9) is a mammalian lectin which contributes to T-cell autoimmunity and tumor biology. Here, we examined the contribution of Gal-9 in angiogenesis and…
  • Abstract Number: 658 • 2013 ACR/ARHP Annual Meeting

    Elevated 8-Isoprostane In Scleroderma: Implications Of Its Role In Inhibiting Vascular Endothelial Growth Factor-Induced Angiogenesis

    Pei-Suen Tsou1, George Zakhem2, Beatrix Balogh2, M. Asif Amin3, Phillip Campbell4, Gautam Edhayan1, Ray Ohara2, Elena Schiopu5, Dinesh Khanna6, Alisa E. Koch3,7 and David A. Fox1, 1Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, 2University of Michigan Medical School, Ann Arbor, MI, 3Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, 4Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, 5Rheumatology/Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, 6Division of Rheumatology, University of Michigan, Ann Arbor, MI, 7Department of Veteran's Affairs and University of Michigan, Ann Arbor, MI

    Background/Purpose: Scleroderma (SSc) is a complex disease characterized by inflammation, vasculopathy, and excessive disposition of extracellular matrix. Various studies have demonstrated a paradoxical increase in…
  • Abstract Number: 641 • 2013 ACR/ARHP Annual Meeting

    Vitamin D Increases The Number and Function Of Myeloid Angiogenic Cells In Systemic Lupus Erythematosus

    John A. Reynolds1, David W. Ray2, Terence O'Neill3, M. Yvonne Alexander4 and Ian N. Bruce5, 1Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute of Inflammation and repair, Manchester Academic Health Science Centre, The University of Manchester, United Kingdom, Manchester, United Kingdom, 2Institute of Human Development, Institute of Human Development, The University of Manchester, Manchester, United Kingdom, 3Arthritis Research UK Centre for Epidemiology, Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom, 4Healthcare Science Research Institute, Faculty of Science and Engineering, Healthcare Science Research Institute, Manchester Metropolitan University, Manchester, United Kingdom, 5Manchester Academic Health Science Centre, Arthritis Research UK Epidemiology Unit and NIHR Manchester Musculoskeletal Biomedical Research Unit, The University of Manchester, Manchester, United Kingdom

    Background/Purpose: Patients with Systemic Lupus Erythematosus (SLE) have an increased prevalence of cardiovascular disease (CVD).  Vitamin D deficiency is common in SLE and an independent…
  • Abstract Number: 2870 • 2013 ACR/ARHP Annual Meeting

    Higher Disease Activity and Serum Levels Of Angiogenic Factors In Patients With Rheumatoid Arthritis In Clinical Remission With Synovitis On Ultrasound

    Julio Ramirez1, Virginia Ruiz-Esquide2, Isaac Pomés3, Raquel Celis4, Jaume Pomés3, Sonia Cabrera1, M. Victoria Hernández5, Oscar M Epis6, Jose L. Pablos7, Raimon Sanmarti1 and Juan D. Cañete2, 1Arthritis Unit. Rheumatology Department, Hospital Clínic of Barcelona, Barcelona, Spain, 2Rheumatology, Hospital Clinic, Barcelona, Spain, 3Radiology, Hospital Clínic, Barcelona, Spain, 4Arthritis Unit, Rheumatology Department, Arthritis Unit, Rheumatology Dpt, Hospital Clinic of Barcelona and IDIBAPS, Barcelona, Spain, 5Arthritis Unit, Department of Rheumatology, Hospital Clinic, Barcelona, Barcelona, Spain, 6A.O. Ospedale Niguarda Cà Granda, Milan, Italy, 7Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain

    Background/Purpose: To identify and characterize subclinical synovitis in patients with rheumatoid arthritis in clinical remission using power Doppler ultrasound and serum levels of angiogenic factors.…
  • Abstract Number: 2571 • 2013 ACR/ARHP Annual Meeting

    Pigment Epithelium Derived Factor Secreted By Activated Fibroblasts Can Contribute To Impaired Angio and Vasculogenesis In Scleroderma

    Vasiliki Liakouli1,2, Georgia Mavria3, Justin Gillespie4, Margherita Scarcia3, Paola Cipriani2, Roberto Giacomelli2, Paul Emery5 and Francesco Del Galdo5, 1Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK., Leeds, United Kingdom, 2Rheumatology Unit, University of Aquila, L'Aquila, IT, L'Aquila, Italy, 3Signal Transduction and Angiogenesis group, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK, Leeds, United Kingdom, 4Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 5Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom

    Background/Purpose: Systemic Sclerosis (SSc) is an autoimmune disorder characterized by tissue fibrosis and vasculopathy. This latter comprises both neointima proliferation and defective angio and vasculogenesis.…
  • Abstract Number: 2219 • 2013 ACR/ARHP Annual Meeting

    Active Immunization Against VEGF-Derived Oligopeptides Improves Joint Inflammation and Destruction In Collagen-Induced Arthritis

    Emilie Duvallet1, Laure Foulboeuf1, Luca Semerano2, Nadia Belmellat1, Marc Lecouvey3, Eric Assier1, Sylviane Muller4 and Marie-Christophe Boissier5, 1EA4222, Li2P, University Paris 13, Sorbonne Paris Cité, EA4222, Li2P, University Paris 13, Sorbonne Paris Cité, Bobigny, France, 2INSERM UMR U1125, University Paris 13, Sorbonne Paris Cité, Bobigny, France, 3CSPBAT Paris 13 University, Bobigny, France, 4Institut de Biologie Moléculaire et Cellulaire, CNRS, Strasbourg, France, 5INSERM UMR 1125, Li2P, University Paris 13, Sorbonne Paris Cité, Bobigny, France

    Background/Purpose: We have demonstrated in experimental models the efficacy of vaccination against cytokines, using a heterocomplex of keyhole limpet hemocyanin (KLH) and human TNF, called…
  • Abstract Number: 1846 • 2013 ACR/ARHP Annual Meeting

    Mitochondrial Dysfunction Induces An Inflammatory, Tissue-Degrading, and Angiogenic Response In Normal Human Synoviocytes

    M. Noa Valcárcel-Ares1, Romina R. Riveiro-Naveira1, Jesus Loureiro1, Carlos Vaamonde-García1, Laura Hermida-Carballo1, Francisco J. Blanco2 and Maria J. López-Armada1, 1Aging and Inflammation Research Lab, INIBIC-CHU A Coruña, A Coruña, Spain, 2Osteoarticular and Aging Res. Lab. CIBER-BBN. INIBIC- University of A Coruña, A Coruña, Spain

    Background/Purpose: Tissues affected with inflammatory arthritis (IA) are subjected to great levels of oxidative stress. Synoviocytes from IA patients present a higher rate of mitochondrial…
  • Abstract Number: 1666 • 2013 ACR/ARHP Annual Meeting

    Negative Temporal Artery Biopsies: Pathologic Findings Of Patients With Biopsy-Negative Giant Cell Arteritis Compared To Those Of Patients Without Arteritis

    Francesco Muratore1, Alberto Lo Gullo1, Alberto Cavazza2, Giuseppe Germanò1, Luigi Boiardi1 and Carlo Salvarani3, 1Rheumatology Service, Arcispedale S Maria Nuova, IRCCS, Reggio Emilia, Italy, 2Pathology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, 3Rheumatology, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy

    Background/Purpose: Temporal artery biopsy (TAB) showing transmural inflammation is considered the gold  standard for the diagnosis of giant cell arteritis (GCA). A negative TAB does…
  • Abstract Number: 1777 • 2012 ACR/ARHP Annual Meeting

    The Bioenergetic Role of HIF-1 and HIF-2 During Angiogenesis of Human Microvascular Endothelial Cells

    Martin Hahne1, Cindy Strehl1, Manuela Jakstadt1, Paula Hoff1, Timo Gaber1, Gerd Burmester1 and Frank Buttgereit2, 1Department of Rheumatology and Clinical Immunology, Charité University Medicine, Berlin, Germany, 2Charité - Universitätsmedizin Berlin, Berlin, Germany

    Background/Purpose: Hypoxia and angiogenesis are features of inflamed and injured tissues. The transcription factors Hypoxia inducible factor (HIF)-1 and (HIF)-2 control cellular metabolic response to…
  • Abstract Number: 1599 • 2012 ACR/ARHP Annual Meeting

    NF-Kb Inducing Kinase (NIK) Is a Key Regulator of Inflammation-Induced Angiogenesis

    A.R. Noort1, K.P.M. van Zoest1, P. Koolwijk2, D.V. Novack3, M.J. Siemerink4, P. P. Tak5 and S.W. Tas6, 1Division of Clinical Immunology & Rheumatology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, 2Physiology, Institute for Cardiovascular Research (ICaR-VU) / VU University Medical Center, Amsterdam, Netherlands, 3Division of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, MO, 4Department of Ophthalmology and Department of Cell Biology and Histology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, 5Division of Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam and GlaxoSmithKline, Amsterdam, Netherlands, 6Division of Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands

    Background/Purpose: In rheumatoid arthritis (RA) synovial tissue (ST) angiogenesis can be observed already in the earliest phase of disease, which may be critical in the…
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