ACR Meeting Abstracts

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Abstracts tagged "Angiogenesis"

  • Abstract Number: 54 • 2017 ACR/ARHP Annual Meeting

    Maintaining Angiogenesis Prevents Glucocorticoid Induced Osteonecrosis

    Alanna Dubrovsky1, Wei Yao1, Geetha Mohan1, Mie Jin Lim1, Yu-An Evan Lay1, Donald Kimmel2 and Nancy E. Lane3,4,5,6,7,8, 1UC Davis Center for Musculoskeletal Health, Sacramento, CA, 2Creighton University School of Medicine Osteoporosis Research Center, Omaha, NE, 3Center for Musculoskeletal Health, University of California, Davis School of Medicine, Sacramento, CA, 4Internal Medicine, Center for Musculoskeletal Health, UC Davis School of Medicine, Sacramento, CA, 5UC Davis Medical Center, Sacramento, CA, 6Center for Musculoskeletal Health, Univ of California at Davis, Sacramento, CA, 7Medicine, U.C. Davis, Sacramento, CA, 8UCDMC, Sacramento, CA

    Background/Purpose: Atraumatic osteonecrosis (ON) results from reduced bone vascularity. Glucocorticoids (GC) are a major risk factor for ON, as GCs reduce vascular endothelial growth factor,…
  • Abstract Number: 71 • 2017 ACR/ARHP Annual Meeting

    The Critical Role of Interleukin-33 in Promoting Angiogenesis and Regulates Inflammation through Mast Cells in Takayasu Arteritis

    Anne-Claire Desbois1, Patrice Cacoub2, Aurélie LEROYER3, Edwige Tellier4, Marlène Garrido5, Anna Maciejewski-Duval6, Cloé Comarmond7, Stéphane Barete6, Michel Arock6, Patrick Bruneval8, Jean-Marie Launay9, Pierre Fouret10, Ulrich Blank11, Michelle Rosenzwajg6, David Klatzman12, Mohamed Jarraya13, Philippe Cluzel14, Fabien Koskas15, Gilles Kaplanski16 and David Saadoun17, 1Hôpital Pitié-Salpêtrière, Internal Medicine and Clinical Immunology, Paris, France, 2Department of Internal Medicine and Clinical Immunology, Groupe Hospitalier Pitié-Salpêtrière, Paris, France, 3Faculté de Pharmacie, Marseille, France, 4Université Marseille, Marseille, France, 5I3 laboratory, Pitié-Salpétrière, Paris, France, 6GHPS, Paris, France, 7DHU 2iB Internal Medicine Referal Center for Autoimmune diseases Pitie Hospital, Paris, France, 8HEGP, Paris, France, 9Hôpital lariboisière, Paris, France, 10Hôpital La Pitié Salpétrière, Paris, France, 11Hôpital Bichat, Paris, France, 12UPMC Université Paris 06, UMR 7211, Paris, France, 13Hôpital Saint Louis, Paris, France, 14Department of cardiovascular imagery, Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Hospitalier Pitié Salpétrière, 83 Boulevard de l'Hôpital, 75013, Paris, France., Paris, France, 15Department of vascular surgery, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France, 16Aix-Marseille Université - Internal Medicine hopital conception - F-13000 Marseilles, Marseille, France, 17Sorbonne Universités, UPMC Univ Paris 06, UMR 7211, and Inflammation-Immunopathology-Biotherapy Department (DHU i2B), F-75005, Paris, France; INSERM, UMR_S 959, F-75013, Paris, France; CNRS, FRE3632, F-75005, Paris, France; AP-HP, Groupe Hospitalier, Paris, France

    Background/Purpose: Large vessel vasculitis (LVV) include Takayasu arteritis (TA) and giant cell arteritis (GCA). Arterial lesions in LVV result from chronic inflammation and neoangiogenesis. IL-33,…
  • Abstract Number: 772 • 2017 ACR/ARHP Annual Meeting

    Molecular Mechanism for the Therapeutic Effect of Extracorporeal Shock Wave Therapy on Digital Ulcers of Systemic Sclerosis

    Yukiko Kamogawa1, Hiroshi Fujii1, Tsuyoshi Shirai1, Tomonori Ishii2 and Hideo Harigae1, 1Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan, 2Clinical Research, Innovation and Education Center, Tohoku University Hospital, Sendai, Japan

    Background/Purpose: Digital ulcers (DUs) are the most common skin manifestations in systemic sclerosis (SSc). DUs in SSc are not usually caused by vasculitis and are…
  • Abstract Number: 956 • 2017 ACR/ARHP Annual Meeting

    Inhibition of Fucosylation in Endothelial Cells Reduces Rheumatoid Arthritis Angiogenesis

    Takeo Isozaki, Airi Nishimi, Shinichiro Nishimi, Sho Ishii, Takahiro Tokunaga, Hidekazu Furuya, Kuninobu Wakabayashi and Tsuyoshi Kasama, Div of Rheumatology, Showa University School of Med, Shinagawa-ku Tokyo, Japan

    Background/Purpose: Glycosylation has been reported to associate with tumor invasion and metastasis. Fucosylation is involved the biological functions of adhesion molecules and growth factor receptors.…
  • Abstract Number: 957 • 2017 ACR/ARHP Annual Meeting

    A Disintegrin and Metalloprotease 15 Is Expressed on Rheumatoid Arthritis Synovial Tissue Endothelial Cells and Mediates Angiogenesis

    Shinichiro Nishimi, Takeo Isozaki, Airi Nishimi, Sho Ishii, Takahiro Tokunaga, Hidekazu Furuya, Kuninobu Wakabayashi and Tsuyoshi Kasama, Div of Rheumatology, Showa University School of Med, Shinagawa-ku Tokyo, Japan

    Background/Purpose: A disintegrin and metalloproteases (ADAMs) are reported that membrane-anchored glycoproteins composed of multiple distinct protein modules. ADAM-15 is one of them and is reported…
  • Abstract Number: 967 • 2017 ACR/ARHP Annual Meeting

    NF-κb-Inducing Kinase Regulates LTβR-Driven NF-κb Signaling and Inflammatory Activation of Endothelium

    Paulina Kucharzewska1, Chrissta Maracle2, Jan Piet van Hamburg2, Kim Jeucken2, Henric Olsson1 and Sander W. Tas3, 1Bioscience, AstraZeneca, Göteborg, Sweden, 22Department of Clinical Immunology & Rheumatology and Laboratory for Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, 3Department of Clinical Immunology & Rheumatology and Laboratory for Experimental Immunology, ARC | Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands

    Background/Purpose: Sites of chronic inflammation, such as rheumatoid arthritis synovial tissue, are characterized by neovascularization and often contain tertiary lymphoid structures with characteristic features of…
  • Abstract Number: 1705 • 2017 ACR/ARHP Annual Meeting

    Inhibition of EZH2 Stops Fibrosis and Improves Angiogenesis in Scleroderma

    Pei-Suen Tsou1, Phillip L. Campbell2, M. Asif Amin3, Patrick Coit1, David Fox4, Dinesh Khanna5 and Amr H Sawalha1, 1Division of Rheumatology, University of Michigan, Ann Arbor, MI, 2Rheumatology, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, 3Division of Rheumatology and Clinical Autoimmune Center of Excellence, University of Michigan, Ann Arbor, MI, Ann Arbor, MI, 4Department of Medicine [Division of Rheumatology], University of Michigan Medical System, Ann Arbor, MI, 5University of Michigan, Ann Arbor, MI

    Background/Purpose: Scleroderma (SSc) is a complex disease that involves activation of the immune system, vascular complications, and tissue fibrosis. Although the pathogenesis of this disease…
  • Abstract Number: 1719 • 2017 ACR/ARHP Annual Meeting

    Accelerated Wound Healing in Megakaryocyte/Platelet-Specific Fli1 Knockout Mice Due to the up-Regulated Expression of Interferon-γ

    Megumi Hirabayashi1, Yoshihide Asano2, Takashi Yamashita1, Ryosuke Saigusa1, Shunsuke Miura3, Kouki Nakamura1, Takuya Miyagawa1, Takashi Taniguchi1, Ayumi Yoshizaki1 and Shinichi Sato4, 1Dermatology, University of Tokyo, Graduate School of Medicine, Tokyo, Japan, 2Applied Chemistry, University of Tokyo, Graduate School of Medicine, Tokyo, Japan, 3University of Tokyo, Graduate School of Medicine, Tokyo, Japan, 4Department of Dermatology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Japan

    Background/Purpose: Fli1 deficiency, a potential predisposing factor of systemic sclerosis (SSc), induces SSc-like phenotypes in dermal fibroblasts, endothelial cells, keratinocytes, and macrophages. However, it is…
  • Abstract Number: 2132 • 2017 ACR/ARHP Annual Meeting

    Angiogenesis and VEGF-Expressing Cells Are Identified Predominantly in the Fascia Rather Than the Muscle in the Early Phase of Dermatomyositis

    Ken Yoshida1,2, Haruyasu Ito1, Kazuhiro Furuya1, Taro Ukichi1, Kentaro Noda1 and Daitaro Kurosaka1, 1Division of Rheumatology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan, 2Internal Medicine, Jikei University School of Medicine, Tokyo, Japan

    Background/Purpose: We previously showed that fasciitis is a frequent manifestation of the disease in dermatomyositis (DM) but not in polymyositis (PM) and that DM-associated fasciitis…
  • Abstract Number: 275 • 2016 ACR/ARHP Annual Meeting

    In Vitro Activation of Type I Interferon Pathway Reproduces the Characteristics Damages Observed in Dermatomyositis Patients

    Leandro Ladislau1,2,3, Xavier Suárez-Calvet1,4, Claudia Benjamin3, Ségolène Toquet1, Benjamin Terrier5, Flore Rozenberg6, Vincent Mouly1, Gillian Butler Browne7, Werner Stenzel8, Olivier Benveniste9 and Yves Allenbach10, 1Sorbonne Universités, UPMC Univ Paris 06, INSERM UMRS_974, CNRS FRE 3617, Center of Research in Myology., Paris, France, 2Programa de Ciências Biomédicas, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil, 3Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil, 4Neuromuscular Diseases Unit, Neurology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona and Institut de Recerca Sant Pau., Barcelona, Spain, 5Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, 6Departement de Virologie, Hôpital Cochin, Paris Descartes Universités, Paris, France, 7Sorbonne Universités UPMC Univ Paris 06, Myology research center, INSERM UMRS974, CNRS FRE3617, Pitié-Salpêtrière University Hospital, Paris, France, Paris, France, 8Charité-Universitätsmedizin Berlin, Berlin, Germany, 9Pitié-Salpêtrière University Hospital, Paris, France, 10Internal Medicine, Pitié-Salpêtrière University Hospital, Paris, France

    Background/Purpose: The type I interferons (IFN-I) including IFN-a, and IFN-b are key cytokines involved in innate immune response to viral infection. Almost all cells can…
  • Abstract Number: 808 • 2016 ACR/ARHP Annual Meeting

    Down-Regulation of microRNA-126 in Scleroderma Microvascular Endothelial Cells (MVECs) Is Associated with Impaired Responses to Vascular Endothelial Growth Factor (VEGF) and Defective Angiogenesis

    bashar kahaleh1, Nezam Altorok2, Yongqing Wang3, Shadia Nada2, Mohammed Madkhali3 and John Sun3, 1Rheumatology, University of Toledo, Toledo, OH, 2Medicine/Rheumatology, University of Toledo, Toledo, OH, 3University of Toledo, Toledo, OH

    Background/Purpose: Impaired angiogenesis in SSc is a crucial component of disease pathology that occurs in spite of upregulation of VEGF and other proangiogenic factors. MicroRNA-126…
  • Abstract Number: 820 • 2016 ACR/ARHP Annual Meeting

    EZH2 Modulates Angiogenesis and Fibrosis in Scleroderma

    Pei-Suen Tsou, Patrick Coit, Dinesh Khanna and Amr H Sawalha, Division of Rheumatology, University of Michigan, Ann Arbor, MI

    Background/Purpose:  Scleroderma (SSc) is a complex disease that involves activation of the immune system, vascular complications, and tissue fibrosis. Although the pathogenesis of this disease…
  • Abstract Number: 871 • 2016 ACR/ARHP Annual Meeting

    Interleukin 33 Critically Regulates Angiogenesis and Inflammation in Large Vessels Vasculitis

    Anne-Claire Desbois1, Aurélie LEROYER2, Marlène Garrido3, Julien Gaudric4, Cloé Comarmond5, David Klatzman6, Philippe Cluzel7, Pierre Fouret8, Laurent Chiche9, Fabien Koskas10, Gilles Kaplanski11, Patrice Cacoub12 and David Saadoun13, 1Hôpital Pitié-Salpêtrière, Internal Medicine and Clinical Immunology, Paris, France, 2Faculté de Pharmacie, Marseille, France, 3I3 laboratory, Pitié-Salpétrière, Paris, France, 4Department of Vascular surgery GHPS, Paris, France, 5DHU 2iB Internal Medicine Referal Center for Autoimmune diseases Pitie Hospital, Paris, France, 6UPMC Université Paris 06, UMR 7211, Paris, France, 7Cadiovascular Imaging and Interventional Radiology, Pitié-Salpétrière, Paris, France, 8Hôpital La Pitié Salpétrière, Paris, France, 9Service de Chirurgie Vasculaire, Groupe Hospitalier Pitié-Salpêtrière, Paris, France, 10Department of Internal Medicine and 2Laboratory I3 « Immunology, Immunopathology, Immunotherapy », UMR CNRS 7211, INSERM U959, Groupe Hospitalier Pitié-Salpetrière, Université Pierre et Marie Curie, Paris 6, Paris, France, Paris, France, 11Aix-Marseille Université - Internal Medicine hopital conception - F-13000 Marseilles, Marseille, France, 12Internal Medicine Department, University Hospital “Pitié-Salpêtrière”, “Pierre et Marie Curie Paris VI” University, Paris, France, 13Department of Internal Medicine and clinical Immunology. French National Reference Center for Autoimmune Diseases. DHU I2B (Inflammation, Immunotherapy and Biotherapy), UPMC, Paris VI, Hôpital Pitié Salpétrière, AP-HP, UPMC, Univ Paris 06, Paris, France

    Background/Purpose: Large vessels vasculitis (LVV) include Takayasu disease (TD) and Giant Cell Arteritis (GCA). Interleukin 33 (IL-33) is a cytokine which controls immune responses and…
  • Abstract Number: 1127 • 2016 ACR/ARHP Annual Meeting

    Extracellular Macrophage Migration Inhibitory Factor Is Essential for Hypoxia-Induced Angiogenesis in a Hypoxia Inducible Factor Independent Manner

    Mathias Mursell1,2, Martin Hahne1,2,3, Peggy Kunath1,2, Cindy Strehl1,2, Paula Hoff1,2, Frank Buttgereit2 and Timo Gaber1,2, 1German Rheumatism Research Center (DRFZ), Berlin, Germany, 2Department of Rheumatology and Clinical Immunology, Charité – Universitätsmedizin Berlin, Berlin, Germany, 3Miltenyi Biotec GmbH, Bergisch Gladbach, Germany

    Background/Purpose: Angiogenesis is a hallmark of the pathogenesis of rheumatoid arthritis (RA) but also of other inflammatory processes, tissue regeneration and progressing tumors. In RA,…
  • Abstract Number: 1131 • 2016 ACR/ARHP Annual Meeting

    Regulation of Rheumatoid Arthritis Synovial Fibroblast Cytokine Production By Inhibitor of DNA Binding-1 Via Crispr/Cas9 Transfection

    Ray A. Ohara1, Gautam Edhayan1, Thomas L. Saunders2, Thomas M. Lanigan3, Rachel Morgan1, W. Alexander Stinson4, Phillip L. Campbell5, Jerry Graham4, David A. Fox5 and Jeffrey H. Ruth5, 1Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, 2Molecular Medicine and Genetics, University of Michigan Medical School, Ann Arbor, MI, 3Vector Core, University of Michigan Medical School, Ann Arbor, MI, 4Division of Rheumatology, University of Michigan Medical School, Ann Arbor, MI, 5Internal Medicine, Division of Rheumatology, University of Michigan Medical School, Ann Arbor, MI

    Background/Purpose: Inhibitor of DNA binding-1 (Id1) is a nuclear protein actively transcribed in endothelial progenitor cells (EPCs) and synovial fibroblasts. We previously identified Id1 as…
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