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Abstracts tagged "ANCA associated vasculitis"

  • Abstract Number: 1440 • ACR Convergence 2020

    The Myeloperoxidase (MPO) Anti-Neutrophilic Cytoplasmic Antibody (ANCA) Binding Epitope, MPO447-459 Induces CD4 T-cell Proliferation in Patients with MPO-ANCA-associated Vasculitis

    Matthew Terrill1, Hendrik Nel2, Yassmin Musthaffa3, Wong Richard4, Ross Francis5, David Johnson5, Greg Keir6, David Gillis7 and Ranjeny Thomas8, 1University of Queensland Diamantina Institute and Princess Alexandra Hospital, Rheumatology Department, Brisbane- Australia, Moffat beach, Queensland, Australia, 2University of Queensland Diamantina Institute, Brisbane, Queensland, Australia, 3University of Queensland Diamantina Institute, Brisbane, Australia, 4Immunology Department, Princess Alexandra Hospital, Brisbane- Australia, Brisbane, Australia, 5Renal Department, Princess Alexandra Hospital, Brisbane- Australia., Brisbane, Queensland, Australia, 6Respiratory Department, Princess Alexandra Hospital, Brisbane- Australia., Brisbane, Queensland, Australia, 7Immunopathology Department, Royal Women’s and Children’s Hospital, Brisbane- Australia., Brisbane, Queensland, Australia, 8University of Queensland Diamantina Institute and Rheumatology Department, Princess Alexandra Hospital, Brisbane – Australia., Brisbane, Australia

    Background/Purpose: In Myeloperoxidase (MPO) Anti Neutrophilic Cytoplasmic Antibody (ANCA)-Associated Vasculitis (MPO-AAV), murine and human studies suggest that the MPO435-465 region, which includes ANCA-binding MPO447-459, the…
  • Abstract Number: 1419 • ACR Convergence 2020

    Clinical Disease Might Be Divided into Two Phenotypes in ANCA Associated Vasculitis; Results of a Cluster Analysis

    Elif Ediboglu1, Onay Gercik2, Emre Bilgin3, Dilek Solmaz4, Irfan Ocal5, Arzu Saglam6, Zeki Soypacacı2, Haluk Cinaklı5, Sedat Kiraz3, Ömer Karadağ7 and Servet Akar2, 1Izmir Katip Celebi University, Izmir, Izmir, Turkey, 2Izmir Katip Celebi University, Izmir, Turkey, 3Hacettepe University, Ankara, Turkey, 4Izmir Katip Celebi University, Department of Internal Medicine, Division of Rheumatology, Izmir, TURKEY, Izmir, Turkey, 5Izmir Katip Celebi University, Izmir, 6Hacettepe University, Ankara, 7Hacettepe University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Ankara,, Ankara, Turkey

    Background/Purpose: One of the controversial matters in ANCA associated vasculitis is the definition of disease based on clinical characteristics since there is a remarkable overlap…
  • Abstract Number: 1589 • ACR Convergence 2020

    An Initiative to Improve Timely Glucocorticoid Tapering in Vasculitis

    Arielle Mendel1, Daniel Ennis2, Shirley Lake3, Simon Carette4 and Christian Pagnoux5, 1Division of Rheumatology, McGill University, Montreal, QC, Canada, 2Division of Rheumatology, Vancouver General Hospital, University of British Columbia, Vancouver, BC, Canada, 3Division of Rheumatology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada, 4Division of Rheumatology, Mount Sinai Hospital and University Health Network, University of Toronto, Toronto, ON, Canada, 5Division of Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada

    Background/Purpose: Vasculitis guidelines recommend scheduled glucocorticoid (GC) tapering to avoid toxicity. In an audit of 130 consecutive new patients on GC assessed in our tertiary…
  • Abstract Number: 1420 • ACR Convergence 2020

    Characterization of ANCA-Associated Vasculitis Among African American Patients

    Sehris Khawaja1, Saloni Godbole1, Maryann Kimoto2, Virginia Steen3 and Kaitlin Quinn4, 1Georgetown University, Washington, DC, 2UCLA, Los Angeles, CA, 3Division of Rheumatology, Department of Medicine, MedStar Georgetown University Hospital, Washington, DC, 4National Institutes of Health, Washington, DC

    Background/Purpose: ANCA-associated vasculitis (AAV) comprises a group of disorders characterized by inflammation of small and medium-sized arteries.  Prevalence and phenotype of these diseases appear to…
  • Abstract Number: 1590 • ACR Convergence 2020

    Bone Health in ANCA – Associated Vasculitis Patients

    Deepa Ragesh Panikkath1, Sandy Lee2 and Christina Downey2, 1Loma Linda University Health, Department of Rheumatology, Loma Linda, CA, 2Loma Linda University Medical Center, Redlands, CA

    Background/Purpose: Glucocorticoids (GC) are an important mode of therapy in ANCA associated vasculitis (AAV), and osteoporosis (OP) and fractures are potential adverse effects seen. The…
  • Abstract Number: 1421 • ACR Convergence 2020

    Clinical Features, Disease Activity and Prognosis of ANCA-Associated Vasculitis in US African Americans

    Luis Palomino1, Angelo Gaffo2, Sebastian Sattui3 and Dongmei Sun2, 1University of Alabama at Birmingham Hospital, Birmingham, AL 2University of Alabama at Birmingham, Birmingham, AL, 3Hospital for Special Surgery, New York, NY

    Background/Purpose: ANCA-associated vasculitis (AAV), including Granulomatosis with Polyangiitis (GPA), Eosinophilic Granulomatosis with Polyangiitis (EGPA) and Microscopic Polyangiitis (MPA), affect mostly Caucasians of European descent. Clinical…
  • Abstract Number: 2048 • ACR Convergence 2020

    Comparison of Two Rituximab Regimens for Induction of Remission in Antineutrophil Cytoplasm Antibody-associated Vasculitis: Systematic Review and Meta-analysis

    Valerie Benard1, Cynthia Farhat2, Melissa Zarandi-Nowroozi2, Madeleine Durand3, Christian Pagnoux4, Pierre Charles5, Xavier Puechal6, Loïc Guillevin7 and Jean-Paul Makhzoum1, 1Vasculitis Clinic, Canadian Network for Research on Vasculitides (CanVasc), Department of Internal Medicine, Hopital du Sacre-Coeur de Montreal, University of Montreal, Montreal, QC, Canada, 2Department of Medecine, University of Montreal, Montreal, QC, Canada, 3Department of Internal Medicine, Centre Hospitalier de l’Universite de Montreal (CHUM) and Centre de Recherche du Centre Hospitalier de l’Universite de Montreal (CRCHUM), Montreal, QC, Canada, 4Vasculitis Clinic, Canadian Network for Research on Vasculitides (CanVasc), Department of Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, 5Department of Internal Medicine, Institut Mutualiste Montsouris, Paris, France, 6National Referral Center for Rare Systemic Autoimmune Diseases, Cochin Hospital, Paris-Descartes University, Paris, France, 7Department of Internal Medecine, National Referral Center for Rare Systemic Autoimmune Diseases, Cochin Hospital, Paris-Descartes University, Paris, France

    Background/Purpose: Organ or life-threatening granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA), two of the antineutrophil cytoplasm antibody-associated vasculitis (AAV), are treated with cyclophosphamide or…
  • Abstract Number: 1422 • ACR Convergence 2020

    Healthcare Utilization Among Patients Diagnosed with ANCA-Associated Vasculitis Between 2007 and 2014 in a Multi-Center Cohort Linked to Medicare Claims Data

    Zachary Wallace1, Xiaoqing Fu2, John Stone3, Hyon Choi4 and Rochelle Walensky2, 1Massachusetts General Hospital, Newton, MA, 2Massachusetts General Hospital, Boston, 3Massachusetts General Hospital, Concord, MA, 4Massachusetts General Hospital, Department of Medicine, Division of Rheumatology, Lexington, MA

    Background/Purpose: ANCA-associated vasculitis (AAV) leads to complications that contribute to poor quality of life and survival.  Systemic vasculitis is associated with high healthcare utilization but…
  • Abstract Number: 2050 • ACR Convergence 2020

    Autoantibodies Targeting Complement Receptors C3aR and C5aR1 Are Decreased in ANCA-associated Vasculitis and Correlate with a Higher Relapse Rate

    Sebastian Klapa1, Antje Müller2, Andreas Koch3, Anja Kerstein-Staehle4, Wataru Kaehler3, Harald Heidecke5, Susanne Schinke6, Markus Huber-Lang7, Martin Nitschke8, Silke Pitann9, Christian Karsten10, Gabriela Riemekasten11 and Peter Lamprecht2, 1University of Lübeck and Institute of Experimental Medicine, Christian-Albrechts-University of Kiel c/o German Naval Medical Institute, Department of Rheumatology and Clinical Immunology, Luebeck, Germany, 2University of Lübeck, Department of Rheumatology and Clinical Immunology, Lübeck, Germany, 3Institute of Experimental Immunology, Christian-Albrechts-University Kiel, c/o German Naval Medical Institute, Kronshagen, Germany, 4University of Lübeck, Dept Rheumatology and Clinical Immunology, Luebeck, Germany, 5CellTrend GmbH, Luckenwalde, Germany, 6University of Lübeck, Department of Rheumatology and Clinical Immunology, Luebeck, Germany, 7Institute of Clinical and Experimental Trauma Immunology, University Hospital Ulm, Ulm, Germany, 8Department of Internal Medicine I, Transplant Center, University of Lübeck, Luebeck, Germany, 9University of Lübeck, Department of Rheumatology and Clinical Immunology,, Luebeck, Germany, 10Institute of Systemic Inflammation Research, University of Lübeck, Luebeck, Germany, 11University of Lübeck, Department of Rheumatology and Clinical Immunology,, Lübeck, Germany

    Background/Purpose: Activation of the alternative and common terminal complement pathways has been shown in ANCA-associated vasculitis (AAV). Circulating titers of the anaphylatoxin C5a are increased…
  • Abstract Number: 1424 • ACR Convergence 2020

    Outcomes of Hospitalizations for Acute Myocardial Infarction in Patients with ANCA Associated Vasculitis from the National Inpatient Sample

    Atefeh Vafa1, Marielys Figueroa Sierra1, Omid Behnamfar2, Hamayon Babary1, Suraiya Afroz1 and Yih Chang Lin3, 1University of South Florida, Tampa, FL, 2University of California San Diego, La Jolla, CA, 3University of South Florida, Morsani College of Medicine, Tampa, FL

    Background/Purpose: Several studies in the past have shown significantly increased risks of cardiovascular disease in patients with ANCA associated vasculitis (AAV). This association is thought…
  • Abstract Number: 2051 • ACR Convergence 2020

    Localized versus Systemic Granulomatosis with Polyangiitis: Data from the French Vasculitis Study Group Database

    Michele Iudici1, Christian Pagnoux2, Delphine Courvoisier3, Pascal Cohen4, Mohamed Hamidou5, Achille Aouba6, François Lifermann7, Marc Ruivard8, Olivier Aumaitre9, Bernard Bonnotte10, Julien Campagne11, Olivier Decaux12, Eric Hachulla13, Alexandre Karras14, Chahéra Khouatra15, Noémie Jourde-Chiche16, Jean-François Viallard17, Pascal Godmer18, Claire Blanchard-Delaunay19, Alain Le Quellec20, Thomas Quéméneur21, Claire de Moreuil22, Alexis Regent4, Benjamin Terrier4, Luc Mouthon4, Loïc Guillevin4 and Xavier Puechal4, 1National Referral Center for Rare Systemic Autoimmune Diseases, Cochin Hospital, Paris-Descartes University and Geneva University Hospitals, Geneva, Switzerland, 2Division of Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, 3Division of rheumatology, Geneva University Hospitals, Geneva, Switzerland, 4National Referral Center for Rare Systemic Autoimmune Diseases, Cochin Hospital, Paris-Descartes University, Paris, France, 5Department of Internal Medicine, Hôtel-Dieu, CHU Nantes, Nantes, France, 6Department of Internal Medicine, CHU Côte de Nacre, Caen, France, 7Department of Internal Medicine, CH Côte d’Argent, Dax, France, 8Department of Internal Medicine, CHU Estaing, Clermont Ferrand, France, 9Department of Internal Medicine, CHU Gabriel Montpied, Clermont Ferrand, France, 10CHU Dijon, Dijon, France, 11Department of Internal Medicine, Hôpitaux Privés de Metz, Metz, France, 12CHU Rennes, Rennes, France, 13Department of Internal Medicine, CHRU, Lille Cedex, France, 14Department of Nephrology, Hôpital Européen Georges Pompidou, Paris, France, 15Department of Respiratory Medicine, CHU Louis Pradel, Lyon, France, 16Department of Nephrology, CHU de la Conception, Marseille, France, 17Department of Internal Medicine, CHU Haut-Lévêque, Bordeaux, France, 18Department of Internal Medicine, CH Bretagne Atlantique, Vannes, France, 19Department of Internal Medicine, CH, Niort, France, 20Department of Internal Medicine, CHU Saint Eloi, Montpellier, France, 21Department of Internal Medicine, CH, Valenciennes, France, 22Department of Internal Medicine, CHU Cavale Blanche, Brest, France

    Background/Purpose: The clinical picture at onset and evolution of localized forms of granulomatosis with polyangiitis (L-GPA) have already been investigated but, to our knowledge, have…
  • Abstract Number: 1426 • ACR Convergence 2020

    Prevalence of ANCA-associated Vasculitis and Spatial Association with Quarries in a French Northeast Region: A Capture-recapture and Geospatial Analysis

    Stéphane Giorgiutti1, Yannick Dieudonné1, Olivier Hinschberger2, Benoit Nespola3, Julien Campagne4, Hanta Nirina Rakotoarivelo5, Thierry Hannedouche6, Bruno Moulin6, Gilles Blaison5, Jean-Christophe Weber7, Marie-Caroline Dalmas8, Frederic De Blay9, Dan Lipsker10, Francois Chantrel11, Jacques-Eric Gottenberg12, Yves Dimitrov13, Olivier Imhoff14, Pierre-Edouard Gavand15, Emmanuel Andres16, Christian Debry17, Yves Hansmann18, Alexandre Klein19, Caroline Lohmann20, François Mathiaux21, Aurélien Guffroy1, Vincent Poindron1, Thierry Martin1, Anne-Sophie Korganow1 and Laurent Arnaud22, 1Department of Clinical Immunology and Internal Medicine, Hôpitaux Universitaires de Strasbourg, Strasbourg, France, 2Department of Internal Medicine, Hôpital Emile Muller, Mulhouse, Mulhouse, France, 3Department of Immunobiology, Hôpitaux Universitaires de Strasbourg, Strasbourg, France, 4Department of Internal Medicine, Hôpitaux Privés de Metz, Metz, France, 5Department of Internal Medicine, Hôpitaux Civils de Colmar, Colmar, France, 6Department of Nephrology, Hôpitaux Universitaires de Strasbourg, Strasbourg, France, 7Department of Internal Medicine, Hôpitaux Universitaires de Strasbourg, Strasbourg, France, 8Department of Internal Medicine Endocrinology and Nutrition, Hôpitaux Universitaires de Strasbourg, Strasbourg, France, 9Pneumology, Hôpitaux Universitaires de Strasbourg, Strasbourg, France, 10Department of Dermatology, Hôpitaux Universitaires de Strasbourg, Strasbourg, France, 11Department of Nephrology, Hôpital Emile Muller, Mulhouse, Strasbourg, France, 12Strasbourg University Hospital, Strasbourg, France, 13Department of Nephrology, Centre hospitalier de Haguenau, Haguenau, France, 14Department of Nephrology, Clinique Saint-Anne, Strasbourg, Strasbourg, France, 15Department of Internal Medicine, Clinique Rhena, Strasbourg, Strasbourg, France, 16Department of Internal Medicine, Diabete and Metabolic Diseases, Hôpitaux Universitaires de Strasbourg, Strasbourg, France, 17Department of Otorhinolaryngology, Hôpitaux Universitaires de Strasbourg, Strasbourg, France, 18Department of Infectious Diseases, Hôpitaux Universitaires de Strasbourg, Strasbourg, France, 19Department of Nephrology, Hôpitaux Civils de Colmar, Colmar, France, 20Department of Microbiology, Hôpital Emile Muller, Mulhouse, Mulhouse, France, 21Department of Biology, Hôpitaux Civils de Colmar, Strasbourg, France, 22Department of Rheumatology, Hôpitaux Universitaires de Strasbourg, Strasbourg, France

    Background/Purpose: Studies addressing the epidemiology of ANCA-associated vasculitides (AAV) in different countries reported various prevalence rates and suggested that incidence may have increased over the…
  • Abstract Number: 2052 • ACR Convergence 2020

    Extended Follow-Up of Patients Recruited to a Randomized, Controlled Trial of Rituximab versus Azathioprine After Induction of Remission with Rituximab for Patients with ANCA-Associated Vasculitis and Relapsing Disease

    Rona Smith1, David Jayne2 and Peter A. Merkel3, 1University of Cambridge, Cambridge, United Kingdom, 2Department of Medicine, Vasculitis and Lupus Research Group, University of Cambridge, Cambridge, UK, Cambridge, United Kingdom, 3Division of Rheumatology University of Pennsylvania, Philadelphia, PA

    Background/Purpose: Rituximab is an effective therapy for induction of remission in ANCA-associated vasculitis (AAV).  However, the effect of rituximab is not sustained, and subsequent relapse…
  • Abstract Number: 1430 • ACR Convergence 2020

    The Role of Lung Biopsy in Pediatric ANCA-associated Vasculitis

    Edouard Sayad1, Tiphanie Vogel1, David Moreno McNeill1, Nahir Cortes-Santiago1, David Spielberg1, Kalyani Patel1 and Manuel Silva Carmona1, 1Baylor College of Medicine/Texas Children's Hospital, Houston, TX

    Background/Purpose: Anca-associated vasculitis (AAV) is characterized by vascular inflammation in multiple organs. The diagnosis can be made clinically using a number of different criteria. The…
  • Abstract Number: PP02 • ACR Convergence 2020

    Low- and Hi-Tech Tools for Enhancing Patient-Hospital Care Team Communication in the Context of Rare Disease

    Ida Hakkarinen1, 1Vasculitis Patient-Powered Research Network (VPPRN) / Member, Vasculitis Foundation, Greenbelt, MD

    Background/Purpose: For over two years, I experienced a variety of disparate symptoms including:  joint aches, sinus congestion, shortness of breath and chronic cough. An episode…
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