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Abstracts tagged "ANCA associated vasculitis"

  • Abstract Number: L14 • ACR Convergence 2021

    Effect of Avacopan, a Selective C5a Receptor Inhibitor, on Kidney Function in Patients with ANCA-Associated Vasculitis

    David Jayne1, Peter Merkel2, Annette Bruchfeld3, Duvuru Geetha4, Alexandre Karras5, John Niles6 and Pirow Bekker7, 1University of Cambridge, Cambridge, United Kingdom, 2University of Pennsylvania, Philadelphia, PA, 3Linköping University, Linköping, Sweden, 4Johns Hopkins University, Baltimore, MD, 5Hopital Europeen Georges Pompidou, Paris, France, 6Massachusetts General Hospital, Boston, MA, 7ChemoCentryx, Inc., San Carlos, CA

    Background/Purpose: Anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis is a life- or organ-threatening condition in which patients experience severe inflammation of small blood vessels; renal disease is…
  • Abstract Number: 0414 • ACR Convergence 2021

    Effect of Induction Therapies on Ear, Nose and Throat Involvement in Anti-neutrophil Cytoplasmic Antibody Associated Vasculitis: Results from a Multi-center Cohort Study

    Roline Krol1, Caroline Schaap1, Paco Welsing1, Ruth Klaasen2, Hilde Remmelts2, Chris Hagen2, Franka van Reekum1, Marloes Heijstek1 and Julia Spierings1, 1University Medical Center Utrecht, Utrecht, Netherlands, 2Meander Medical Center, Amersfoort, Netherlands

    Background/Purpose: Up to 87% of patients with anti-neutrophil cytoplasmic antibody (ANCA)- associated vasculitis (AAV) have ear, nose and throat (ENT) involvement, which can lead to…
  • Abstract Number: 0433 • ACR Convergence 2021

    Use of 2-Mercaptoethane Sodium Sulfonate Prophylaxis in Cyclophosphamide-Treated Patients with ANCA-Associated Vasculitis: Results of an Electronic Survey

    Lukas Joos1, Solange Gonzalez Chiappe1, Thomas Neumann1 and Alfred Mahr2, 1Kantonsspital St.Gallen, St.Gallen, Switzerland, 2Kantonsspital St. Gallen, St.Gallen, Switzerland

    Background/Purpose: Co-prescribing mesna with CYC for AAV aims to prevent the potential urotoxic effects of CYC. We investigated current clinical practice related to prescribing mesna…
  • Abstract Number: 0415 • ACR Convergence 2021

    Utility of the 22-Item Sinonasal Outcome Test Patient-Reported Outcome Instrument in ANCA-Associated Vasculitis

    Ellen Romich, Sherry Chou and Rennie Rhee, University of Pennsylvania, Philadelphia, PA

    Background/Purpose: ANCA-associated vasculitis (AAV) causes sinus symptoms that impact quality of life. The 22-item Sinonasal Outcome Test (SNOT-22) is a patient-reported outcome measure to assess…
  • Abstract Number: 0434 • ACR Convergence 2021

    Protein Profiling in Pre-dating Samples Separate MPO-ANCA Vasculitis from PR3-ANCA Vasculitis

    Mikael Brink1, Ewa Berglin1, Aladdin Mohammad2, Andrey Alexeyenko3, Kristina Lejon1 and Solbritt Rantapaa-Dahlqvist4, 1Umeå Universitet, Umeå, Sweden, 2Lund University, Lund, Sweden, 3Karolinska Institutet, Stockholm, Sweden, 4Ume University, Umea, Sweden

    Background/Purpose: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is considered a chronic relapsing condition, with unknown etiology. This study was undertaken to gain insight to the…
  • Abstract Number: 0417 • ACR Convergence 2021

    Neurologic Involvement in ANCA-associated Vasculitis: Data from Multicenter Longitudinal Observational Study

    Rula Hajj-Ali1, Robert Butler2, Carol Langford3, Leonard Calabrese2, David Cuthbertson4, Nader Khalidi5, CURRY LEE MD KOENING6, Carol McAlear7, Paul Monach8, Larry Moreland9, Christian Pagnoux10, Philip Seo11, Ulrich Specks12, Antoine Sreih7, Kenneth Warrington13 and Peter Merkel7, 1Cleveland Clinic, Hunting Valley, OH, 2Cleveland Clinic, Cleveland, OH, 3Cleveland Clinic, Moreland Hills, OH, 4University of South Florida, Tampa, FL, 5McMaster University, Hamilton, ON, Canada, 6LIMITED TO OFFICIAL UNIVERSITY DUTIES ONLY, Salt Lake City, UT, 7University of Pennsylvania, Philadelphia, PA, 8Brigham and Women's Hospital, Boston, MA, 9University of Colorado, Denver, CO, 10Mount Sinai Hospital, Toronto, ON, Canada, 11Johns Hopkins University, Baltimore, MD, 12Mayo Clinic, Rochester, MN, 13Mayo Clinic, Rochester, Minnesota

    Background/Purpose: The prevalence of neurologic involvement (NI) in ANCA-associated vasculitis (AAV), especially central nervous system (CNS) involvement, is not well characterized. This project aimed to…
  • Abstract Number: 0435 • ACR Convergence 2021

    Myeloperoxidase Activity in Individuals with Antineutrophil Cytoplasmic Antibodies (ANCA) Can Be Inhibited by RLS-0071

    Parvathi Kumar1, Pamela Hair1, Ulrich Thienel1, Kenji Cunnion1, Neel Krishna2 and Christos Gabriel3, 1ReAlta Life Sciences Inc, Norfolk, VA, 2ReAlta Life Sciences Inc., Norfolk, VA, 3Children's Hospital of The King's Daughters, Norfolk

    Background/Purpose: Anti-neutrophil cytoplasm antibodies (ANCA) are immunoglobulin G (IgG) autoantibodies directed against constituents of primary neutrophil granules (Davies, Moran et al. 1982). There is strong…
  • Abstract Number: 0419 • ACR Convergence 2021

    Post-induction ANCA Titer Does Not Predict Mortality or Renal Outcomes: A Target Trial Emulation Study

    Gregory McDermott1, Xiaoqing Fu2, Claire Cook3, John Stone4, Yuqing Zhang5 and Zachary Wallace6, 1Brigham and Women's Hospital, Brookline, MA, 2Massachusetts General Hospital, Boston, MA, 3Division of Rheumatology, Allergy, and Immunology, Mass General Hospital, Boston, MA, 4Massachusetts General Hospital Rheumatology Unit, Harvard Medical School, Boston, MA, 5Division of Rheumatology, Allergy, and Immunology, Mass General Hospital, Harvard Medical School, Boston, MA, 6Massachusetts General Hospital, Newton, MA

    Background/Purpose: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is associated with increased risk of end-stage renal disease (ESRD) and death. In most cases, circulating ANCA targeting…
  • Abstract Number: 0436 • ACR Convergence 2021

    Ocular and Orbital Manifestations of Granulomatosis with Polyangiitis: A Systematic Review of Published Cases

    Madeleine Yeakle1, Allen Tsiyer1, Daniel Bishev1, Kayvon Moin1, Victoria Garofalo1, Allison Parrill1, Alexander Hatsis2, Tyler Wickas2 and Prachi Anand3, 1American University of the Caribbean School of Medicine, Cupecoy, Netherlands Antilles, 2Department of Ophthalmology, Nassau University Medical Center, East Meadow, NY, 3Department of Rheumatology, Nassau University Medical Center, East Meadow, NY

    Background/Purpose: Granulomatosis with polyangiitis (GPA), formerly known as Wegener’s Granulomatosis, is a systemic autoimmune condition caused by granulomatous inflammation of small and medium arteries, arterioles…
  • Abstract Number: 0420 • ACR Convergence 2021

    Development and Validation of a Simulation Model for Maintenance Treatment in ANCA-Associated Vasculitis

    Zachary Wallace1, John Stone2, Hyon K. Choi3 and Emily Hyle4, 1Massachusetts General Hospital, Newton, MA, 2Massachusetts General Hospital Rheumatology Unit, Harvard Medical School, Boston, MA, 3Massachusetts General Hospital, Lexington, MA, 4Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA

    Background/Purpose: ANCA-associated vasculitis (AAV) care has evolved over the last two decades with several approaches to remission maintenance. However, these approaches have trade-offs regarding the…
  • Abstract Number: 0437 • ACR Convergence 2021

    Factors Associated with Reduced Immunogenicity of the BNT162b2 mRNA COVID-19 Vaccine in Patients with Autoimmune Inflammatory Rheumatic Diseases (AIIRD) Treated with Rituximab

    Victoria Furer1, Tali Eviatar2, Devy Zisman3, Hagit Peleg4, Daphna Paran5, David Levartovsky1, Ilana Kaufman6, Michael Zisapel1, Ofir Elalouf7, Roni Meidan1, Adi Broyde8, Ari Polachek9, Jonathan Wollman7, Katya Meridor10, Hila Nochomovitz1, Adi Silberman1, Dana Rosenberg1, Joy Feld11, Amir Haddad12, Tal Gazitt13, Muna Elias3, Nizar Hijaze14, Fadi Kharouf4, Gabi Shefer1, Orly Sharon1, Sara Pel1, Sharon Nevo1 and Ori Elkayam15, 1Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, 2Tel Aviv Sourasky Medical Center, Givataim, Israel, 3Carmel Medical Center, Haifa, Israel, 4Hadassah Medical Center, Jerusalem, Israel, 5Tel Aviv Sourasky Medical Center-Ichilov Hospital, Even Yehuda, Israel, 6Tel Aviv Sourasky Medical Center, Petach Tiqwa, Israel, 7Tel Aviv Medical Center, Herzliya, Israel, 8Tel Aviv Sourasky Medical Center, KIBBUTZ GIVAT HAIM I, Israel, 9Sourasky Medical Center, Petah-Tikva, Israel, 10Tel Aviv Sourasky Medical Center, Kfar Saba, Israel, 11Carmel and Zvulun Medical Centre, Haifa, Israel, 12Carmel Medical Centre, Haifa, Israel, 13Carmel Hospital, Haifa, Israel, 14Carmel medical centre, Tamra, Israel, 15Tel Aviv Medical Center, Tel Aviv, Israel

    Background/Purpose: Rituximab (RTX) has been associated with impaired humoral response to vaccination. This study aim was to identify the predictors for a lack of humoral…
  • Abstract Number: 0421 • ACR Convergence 2021

    Negative vs. Positive Antineutrophil Cytoplasmic Antibody Granulomatosis with Polyangiitis, a Case-control Study

    Marta Casal Moura, Samuel D. Falde, Ulrich Specks and Misbah Baqir, Mayo Clinic, Rochester, MN

    Background/Purpose: Antineutrophil cytoplasmic antibody (ANCA) negative granulomatosis with polyangiitis (GPA) is a challenging diagnosis. There is paucity of literature regarding the clinical course of ANCA-negative…
  • Abstract Number: 0525 • ACR Convergence 2021

    STEAP3, FZD2 and EGFLAM Are Novel Genetic Risk Loci for Granulomatosis with Polyangitis: A Genome Wide Association Study from UK Biobank

    Mehmet Hocaoglu1, Jamal Mikdashi2, Yi-Ju Chen2, James Perry2 and Charles Hong2, 1University of Maryland Medical Center, Midtown Campus, Baltimore, MD, 2University of Maryland School of Medicine, Baltimore, MD

    Background/Purpose: Granulomatosis with Polyangitis (GPA) is a systemic ANCA associated small vessel vasculitis. Prior genetic studies demonstrated a strong association of HLA Class II region…
  • Abstract Number: 0422 • ACR Convergence 2021

    Cancer in Patients with ANCA-associated Vasculitis: Which Came First, the Chicken or the Egg?

    Elif Ediboglu1, Riza Can Kardas2, Ertugrul Cagri bolek3, Resit Yildirim4, DenizCan Guven5, Saadettin Kilickap5, Omer Dizdar5, Melek Yalcin Mutlu6, Ozan Cemal Icacan7, Gizem Ayan8, Emre Bilgin8, Nazife Sule Yasar Bilge9, Levent Kilic8, Timucin Kasifoglu4, Cemal Bes10, Servet Akar11 and Omer Karadag12, 1Izmir Katip Celebi University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, İzmir, Turkey, 2Hacettepe University Faculty of Medicine, Department of Internal Medicine, Ankara, Turkey, 3Vasculitis Translational Research Program, NIAMS, NIH, US, Lanham, MD, 4Eskisehir Osmangazi University, Department of Internal Medicine, Division of Rheumatology, Eskisehir, Turkey, 5Hacettepe University Medical Faculty, Department of Medical Oncology, Ankara, Turkey, 6University of Health Sciences, Istanbul, 7University of Health Sciences, Istanbul, Turkey, 8Hacettepe University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Ankara, Turkey, 9Eskisehir Osmangazi University Medical Faculty, Eskisehir, Turkey, 10Saglik Bilimleri University, Basaksehir Cam and Sakura State Hospital – Istanbul, Turkey, Istanbul, Turkey, 11Izmir Katip Celebi University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Izmir, Turkey, 12Hacettepe University, Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Ankara, Turkey

    Background/Purpose: Many studies linking vasculitis to the development of malignancy based on chronic inflammation, cytotoxicity, emergence of vasculitis as a paraneoplastic disease. Even previous studies…
  • Abstract Number: 0533 • ACR Convergence 2021

    Identification of a Novel Susceptibility Locus for Small Vessel Vasculitis with Autoantibodies Against Myeloperoxidase

    Johanna Dahlqvist1, Diana Ekman2, Bengt Sennblad2, Sergey Kozyrev3, Jessika Nordin2, Åsa Karlsson3, Jennifer Meadows3, Erik Hellbacher1, Solbritt Rantapaa-Dahlqvist4, Ewa Berglin5, Bernd Stegmayr5, Bo Baslund6, Øyvind Palm7, Hilde Haukeland7, Iva Gunnarsson8, Annette Bruchfeld8, Mårten Segelmark9, Sophie Ohlsson9, Aladdin Mohammad9, Anna Svärd10, Rille Pullerits11, Hans Herlitz11, Annika Söderbergh12, Gerli Rosengren Pielberg3, Fabiana Farias3, Lina Hultin Rosenberg3, Matteo Bianchi3, Eva Muren3, Roald Omdal13, Roland Jonsson14, Maija-Leena Eloranta3, Lars Ronnblom3, Peter Söderkvist15, Ann Knight16, Per Eriksson15 and Kerstin Lindblad-Toh17, 1Uppsala University and University Hospital, Uppsala, Sweden, 2Science for Life Laboratory, Uppsala University, Uppsala, Sweden, 3Uppsala University, Uppsala, Sweden, 4Ume University, Umea, Sweden, 5Umeå University and University Hospital, Umeå, Sweden, 6University of Copenhagen, Copenhagen, Denmark, 7Oslo University, Oslo, Norway, 8Karolinska Institute, Stockholm, Sweden, 9Lund University, Lund, Sweden, 10Uppsala University, Falun, Sweden, 11Gothenburg University and Sahlgrenska Hospital, Gothenburg, Sweden, 12Dept. of Rheumatology, Örebro University Hospital, Örebro, Sweden, 13Stavanger University Hospital and University of Bergen, Stavanger, Norway, 14University of Bergen, Bergen, Norway, 15Linköping University, Linköping, Sweden, 16Rheumatology, Institute of Medical Sciences, Uppsala University, Uppsala, Sweden, 17Broad Institute of MIT and Harvard; and Uppsala University, Boston, MA

    Background/Purpose: ANCA-associated vasculitides (AAV) are rare but aggressive autoimmune disorders. The pathogenesis of the disorders is complex and still poorly understood; only a few genetic…
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