Abstracts tagged "Aging"

Abstract Number: 1049 • ACR Convergence 2021
Multimorbidity Differences Between Systemic Lupus Erythematosus Patients and Comparators in Different Age Groups: A Large Nationwide US Study
Ali Duarte-Garcia¹, Herbert Heien¹, Nilay Shah¹ and Cynthia Crowson², ¹Mayo Clinic, Rochester, MN, ²Mayo Clinic, Eyota, MN
Background/Purpose: Patients with Systemic Lupus Erythematosus (SLE) have an increased burden of multimorbidity. Age is strongly associated with accumulation of comorbidities. Patients with SLE may…
Abstract Number: 1059 • ACR Convergence 2021
The Association of Pain and Sleep in Relation to Depressive Symptoms Among Older Adults with Arthritis
Uyen-Sa Nguyen¹, Cameron Zielke² and Noah Peeri³, ¹University of North Texas Health Science Center, School of Public Health, Arlington, TX, ²University of Illinois-Chicago, Fort Worth, TX, ³University of North Texas Health Science Center, Fort Worth
Background/Purpose: The primary symptom of arthritis is chronic pain which has widespread consequences on an individual’s sleep and mental health. Research suggests that sleep and…
Abstract Number: 1091 • ACR Convergence 2021
Serum Metabolomic Profiling Identifies Potential Biomarkers in Arthritis in the Elderly
Martha Cedeno¹, Jessica Murillo Saich¹, Roxana Coras², Anahy Maria Brandy-Garcia³, Agueda Prior-Español⁴, Lourdes Mateo⁵, Melania Martinez-Morillo⁵ and Monica Guma⁶, ¹University of California San Diego, La Jolla, CA, ²University of California San Diego/Department of Medicine, Autonomous University of Barcelona, San Diego, CA, ³Hospital Germans Trias i Pujol, Badalona, Spain, ⁴Department of Rheumatology, Germans Trias i Pujol. University Hospital, Badalona, Spain, ⁵Department of Rheumatology, Germans Trias i Pujol. University Hospital, Barcelona, Spain, ⁶University of California San Diego/San Diego VA Healthcare Service/Department of Medicine, Autonomous University of Barcelona, La Jolla, CA
Background/Purpose: Elderly-onset RA (EORA) and polymyalgia rheumatica (PMR) are common rheumatic diseases in the elderly, but their pathogenesis is not yet fully understood. Seronegative EORAneg…
Abstract Number: 1145 • ACR Convergence 2021
Prevalence of and Risk Factors for Vertebral Fractures and Low Bone Mass Density Among Women Aging with HIV in Peru
Diego Cabrera¹, Mijahil P. Cornejo², Rebecca Slotkin³, Yvett Pinedo⁴, Wei Yu⁵, Wenmin Guan⁵, Patricia J. Garcia⁶ and Evelyn Hsieh⁷, ¹Yale School of Medicine, Lima, Peru, ²Grunenthal peruana, Lima, Peru, ³Yale New Haven Hospital, New Haven, CT, ⁴Hospital Nacional Arzobispo Loayza, Lima, Peru, ⁵Department of Radiology, Chinese Academy of Medicine Sciences and Peking Union Medical College Hospital, Beijing, China (People's Republic), ⁶Universidad Peruana Cayetano Heredia, Lima, Peru, ⁷Yale School of Medicine, New Haven, CT
Background/Purpose: Few studies in Latin America and the Caribbean have evaluated osteoporosis and fracture epidemiology among populations at increased risk for secondary osteoporosis, such as…
Abstract Number: 1147 • ACR Convergence 2021
Therapeutic Inertia and Low Patient Compliance: Major Contributors to Low Treatment Rates in Patients with Osteoporosis with Clinical Vertebral Compression Fractures
Shiva Malaty, Paramvir Sidhu, Rustan Sharer and Soo Yeon Kim, HonorHealth Internal Medicine Residency, Scottsdale, AZ
Background/Purpose: Treatment rates with pharmacologic therapy after osteoporotic vertebral fracture are very low in the United States. Underlying causes of these low treatment rates are…
Abstract Number: 1392 • ACR Convergence 2021
Assessment of a Patient Self-Report Frailty Tool in Patients with Polymyalgia Rheumatica
Sebastian Sattui, Deanna Jannat-Khah, Lindsay Lally, Sarah Lieber, Lisa Mandl and Robert Spiera, Hospital for Special Surgery, New York, NY
Background/Purpose: Frailty, a syndrome characterized by decreased physiologic reserve, is associated with chronic inflammation. We have shown a high prevalence of frailty in patients with…
Abstract Number: 1514 • ACR Convergence 2021
Age-related Metabolic Reprogramming of Memory CD4+ T Cells Is Associated with Reactive Oxygen Species-induced Immune Cell Dysfunction
Yuling Chen¹, Pierre-Louis Krau², Pelle Löwe³, Moritz Pfeiffenberger⁴, Lisa Ehlers³, Alexandra Damerau⁴, Paula Hoff³, Frank Buttgereit⁵ and Timo Gaber⁴, ¹Charité University Medicine Berlin, Berlin, Germany, ²Charit Universittsmedizin Berlin, corporate member of Freie Universitt Berlin, Humboldt-Universitt zu Berlin, and Berlin Institute of Health, Department of Rheumatology and Clinical Immunology, Berlin, Germany, ³Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Department of Rheumatology and Clinical Immunology, Berlin, Germany, ⁴Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, ⁵Charité – Universitätsmedizin Berlin, Berlin, Germany
Background/Purpose: Inflamm-aging is a sterile, low-grade, chronic systemic inflammatory state characterized by an increase in proinflammatory cytokines involved in the development of most age-related diseases…
Abstract Number: 0158 • ACR Convergence 2021
The Influence of Age on the Prevalence of Inflammatory and Post-inflammatory MRI Lesions in the Sacroiliac Joints of Patients with and Without Axial Spondyloarthritis
Xenofon Baraliakos, Styliani Tsiami, Anna Kühn, Martin Fruth and Jürgen Braun, Rheumazentrum Ruhrgebiet Herne, Ruhr-Universität Bochum, Herne, Germany
Background/Purpose: Axial spondyloarthritis (axSpA) is clinically characterized by chronic inflammatory back pain and by inflammatory and structural changes in the sacroiliac joint (SIJ) as assessed…
Abstract Number: 1678 • ACR Convergence 2021
Favorable Balance of Benefit and Harm of Long-Term, Low Dose Prednisolone Added to Standard Treatment in Rheumatoid Arthritis Patients Aged 65+: The Pragmatic, Multicenter, Placebo-Controlled GLORIA Trial
Maarten Boers¹, Linda Hartman¹, Daniela Opris-Belinski², Reinhard Bos³, Marc Kok⁴, Jose Pereira da Silva⁵, Ed Griep⁶, Ruth Klaasen⁷, Cornelia F. Allaart⁸, Paul Baudoin⁹, Hennie Raterman¹⁰, Zoltan Szekanecz¹¹, Frank Buttgereit¹², Pavol Masaryk¹³, L. Thomas Klausch¹, Sabrina Paolino¹⁴, Annemarie Schilder³, Willem Lems¹⁵ and Maurizio Cutolo¹⁴, ¹Amsterdam UMC, Vrije Universiteit, Amsterdam, Netherlands, ²Carol Davila University, Bucharest, Romania, ³Medical Center Leeuwarden, Leeuwarden, Netherlands, ⁴Maasstad Hospital, Rotterdam, Netherlands, ⁵University of Coimbra | UC · Clínica Universitária de Reumatologia. Faculty of Medicine, Columbia, Portugal, ⁶Antonius Hospital, Sneek, Netherlands, ⁷Meander Medical Center, Amersfoort, Netherlands, ⁸Leiden University Medical Center, Leiden, Netherlands, ⁹Reumazorg Flevoland, Emmeloord, Netherlands, ¹⁰Northwest Clinics, Alkmaar, Netherlands, ¹¹Division of Rheumatology, University of Debrecen, Faculty of Medicine, Debrecen, Hungary, ¹²Charité – Universitätsmedizin Berlin, Berlin, Germany, ¹³National Institute for the Rheumatic Diseases, Bratislava, Slovakia, ¹⁴Laboratory of Experimental Rheumatology and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS Polyclinic San Martino Hospital, Genoa, Italy, ¹⁵VUmc, Amsterdam, Netherlands
Background/Purpose: Low-dose glucocorticoid (GC) therapy is widely used in rheumatoid arthritis (RA) but the balance of benefit and harm is still unclear. We studied the…
Abstract Number: 0352 • ACR Convergence 2021
Native American and African American Rheumatic Disease Patients Exhibit Accelerated Biological Aging Compared to European Americans
Joseph Kheir, Carla Guthridge, Nicolas Dominguez, Wade DeJager, Sarah Cooper, Joel Guthridge and Judith James, Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: The universal process of aging is associated with increased risk of disease and death as a result of changing physiologic and molecular processes. In…
Abstract Number: 1862 • ACR Convergence 2021
Clonal Hematopoiesis Across the Age Spectrum in Patients with Systemic Vasculitis
Kristina Wells¹, Fernanda Gutierrez-Rodrigues², Bhavisha Patel², Kaitlin Quinn³, Keith Sikora¹, Neal Young⁴ and Peter Grayson⁵, ¹National Institute of Arthritis, Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, ²National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD, ³National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Washington, DC, ⁴National Heart, Lung, and Blood Institute (NHLBI), National Institues of Health, Bethesda, MD, ⁵National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD
Background/Purpose: Clonal hematopoiesis (CH) is a pre-malignant state characterized by somatic mutations in hematologic precursor cells in genes associated with myeloid malignancies. Incidence of CH…
Abstract Number: 0375 • ACR Convergence 2021
Optimizing a Referral Strategy for Patients with a High Probability of Axial Spondyloarthritis:the Role of Age and Symptom Duration
Fabian Proft¹, Laura Spiller¹, Burkhard Muche², Mikhail Protopopov¹, Judith Rademacher¹, Valeria Rios Rodriguez¹, Murat Torgutalp¹, Denis Poddubnyy³ and Imke Redeker⁴, ¹Charité University Medicine Berlin, Berlin, Germany, ²Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Gastroenterology, Infectiology and Rheumatology (including Nutrition Medicine), Berlin, Germany, ³Department of Rheumatology, Charité – Universitätsmedizin, Berlin, Germany, ⁴German Rheumatism Research Centre (DRFZ), Berlin, Germany
Background/Purpose: One of the most important prerequisites for a timely diagnosis of axial spondyloarthritis (axSpA) is the early referral of a patient with back pain…
Abstract Number: 0624 • ACR Convergence 2020
Association of Regional Body Composition and Physical Function Using the Short Physical Performance Battery Among Peruvian Women with HIV
Diego Cabrera¹, Mijahil Pavel Cornejo Ortega², Yvett Pinedo³, Patricia Garcia⁴ and Evelyn Hsieh⁵, ¹Yale University, Universidad Peruana Cayetano Heredia, Lima, Peru, ²Hospital Nacional Arzobispo Loayza, Lima, Peru, ³Hospital Nacional Arzobispo Loayza, Lima, ⁴Universidad Peruana Cayetano Heredia, Lima, Peru, ⁵Yale University School of Medicine; West Haven VA, New Haven, CT
Background/Purpose: The musculoskeletal (MSK) system is significantly affected by HIV and its treatment. Changes in body composition can reflect important changes in bone and MSK…
Abstract Number: 0693 • ACR Convergence 2020
Effect of Physical Activity on Cartilage Degradation and Inflammation in Individuals with Lumbar Spinal Stenosis
Gustavo Almeida¹, Samannaaz Khoja², Lauren Terhorst³, Gwendolyn Sowa⁴, Sara Piva² and Michael Schneider², ¹Department of Physical Therapy, UT HEALTH SAN ANTONIO, San Antonio, TX, ²Department of Physical Therapy, University of Pittsburgh, Pittsburgh, PA, ³Department of Occupational Therapy, University of Pittsburgh, Pittsburgh, PA, ⁴Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Guidelines recommend 150 minutes a week in moderate-intensity physical activity (MPA) to improve health in individuals with chronic disease such as those with lumbar…
Abstract Number: 0694 • ACR Convergence 2020
Relationships Among Adherence and Patient Outcomes in a Cognitive Behavioral Plus Physical Activity Intervention for Older Adults with Osteoarthritis and Hypertension
Xiaojun Shi¹, Elizabeth Schlenk² and Susan Sereika¹, ¹University of Pittsburgh School of Nursing, Pittsburgh, ²University of Pittsburgh School of Nursing, Pittsburgh, PA
Background/Purpose: Osteoarthritis of the knee (OAK) affects nearly 14 million older adults and more than half are diagnosed with hypertension (HTN). Cognitive behavior therapy (CBT)…

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