ACR Meeting Abstracts

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Abstracts tagged "Aging"

  • Abstract Number: 0873 • ACR Convergence 2023

    FOXO Activators as Drugs for Osteoarthritis

    Ichiro Kurakazu, Merissa Olmer, Kevin Myers and Martin K Lotz, Scripps Research Institute, La Jolla, CA

    Background/Purpose: Forkhead box O (FOXO) proteins are a family of transcription factors involved in lifespan, aging, and autophagy. FOXO are essential for maintaining cartilage homeostasis…
  • Abstract Number: 2521 • ACR Convergence 2023

    Understanding Age as a Risk Factor for Complications After Total Knee Arthroplasty: What Can We Learn from Machine Learning?

    Bella Mehta1, Yi Yiyuan2, Chloe Heiting3, Kaylee Ho2, Susan Goodman3, Peter Sculco3, Fei Wang2, Rich Caruana4, Peter cram5 and Said Ibrahim6, 1Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, 2Weill Cornell Medicine, New York, NY, 3Hospital for Special Surgery, New York, NY, 4Microsoft, Redmond, WA, 5The University of Texas Medical Branch, Galveston, TX, 6Northwell Health, New Hyde Park, NY

    Background/Purpose: Rates of total knee arthroplasty (TKA) in the United Stateshave risen, coupled with increasing demand for TKAs in younger patients.1Althoughrates of postoperative complications in…
  • Abstract Number: 0998 • ACR Convergence 2023

    Barriers and Facilitators for Osteoporosis and Sarcopenia Care for Persons Living with HIV in Peru: HIV Physician and Coordinator Perspectives

    Rebecca Slotkin1, Daniel Granda Calderón2, Joselito Malca Hernandez2, Diego Cabrera3, Carlos Manuel Benites Villafane4, Patricia Jannet García5 and Evelyn Hsieh6, 1Yale University, Department of Medicine, Section of Rheumatology; Yale School of Public Health, New Haven, CT, 2Facultad de Medicina Alberto Hurtado de la Universidad Peruana Cayetano Heredia, Lima, Peru, 3Yale University, Department of Medicine, Section of Rheumatology; Department of Internal Medicine, Waterbury Hospital, New Haven, CT, 4Ministerio de Salud, Peru, Lima, Peru, 5Epidemiology, STD, and HIV Unit, School of Public Health, Universidad Peruana Cayetano Heredia, Lima, Peru, 6Yale University, Department of Medicine, Section of Rheumatology; Yale School of Public Health; Section of Rheumatology, VA Connecticut Healthcare System, Westport, CT

    Background/Purpose: Persons living with HIV (PLWH) have a higher risk of developing age-related non-communicable diseases (NCDs), such as osteoporosis and sarcopenia. In Peru, HIV providers…
  • Abstract Number: 2604 • ACR Convergence 2023

    Premature Vascular Smooth Muscle Cells Senescence Driven by Interleukin-6-Mitochondrial STAT3-Mitofusin 2 Signaling in Takayasu’s Arteritis

    Chenglong Fang1, Lihong Du1, Lili Li2, Yuexin Chen3, Zuoguan Chen4, Yongjun Li4, Jing Li1, Mengtao Li5, xiaofeng Zeng6 and Xinping Tian5, 1Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China, 2The State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing, China, 3Department of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China, 4Department of Vascular Surgery, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China, 5Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, 6Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

    Background/Purpose: Takayasu’s arteritis (TAK) is characterized by persistent vascular inflammation involving aorta and its main branches, which is an important prosenescent factor that in turn…
  • Abstract Number: 1063 • ACR Convergence 2023

    Impact of Aging on Rheumatic Immune-related Adverse Events Secondary to Immune Checkpoint Inhibitors: Experience from the Canadian Research Group of Rheumatology in Immuno-Oncology (CanRIO)

    Jenny Li1, Marie Hudson2, Carrie Ye3, Janet Roberts4, Aurore Fifi-Mah5, May Choi5, Sabrina Hoa6, Thomas Appleton7, Janet Pope7, Nancy Maltez8, Lourdes Gonzalez Arreola9, Anthony Obrzut9 and Shahin Jamal10, 1University of British Columbia, Vancouver, BC, Canada, 2McGill University, Montréal, QC, Canada, 3University of Alberta, Edmonton, AB, Canada, 4Dalhousie University, Halifax, NS, Canada, 5University of Calgary, Calgary, AB, Canada, 6University of Montreal, Brossard, QC, Canada, 7University of Western Ontario, London, ON, Canada, 8The Ottawa Hospital, Ottawa, ON, Canada, 9Arthritis Research Canada, Vancouver, BC, Canada, 10Vancouver Coastal Health, Vancouver, BC, Canada

    Background/Purpose: Immune checkpoint inhibitors (ICI) have revolutionized cancer therapy. Their use is complicated by development of immune-related adverse effects (irAEs), including rheumatic irAEs (Rh-irAE). Aging…
  • Abstract Number: 1201 • ACR Convergence 2023

    Frailty and Its Impact on Patient Reported Outcomes in Polymyalgia Rheumatica

    Patricia Harkins1, Sharon Cowley2, David Kane3 and Richard Conway4, 1St James's Hospital, Dublin, Ireland, 2Tallaght University Hospital, Dublin, Dublin, Ireland, 3Tallaght University Hospital & Trinity College Dublin, Dublin, Ireland, 4Trinity College Dublin, Dublin, Ireland

    Background/Purpose: Frailty is an increasingly important construct in the field of rheumatology, aiding the identification of individuals with increased vulnerability to accelerated clinical decline and…
  • Abstract Number: 1206 • ACR Convergence 2023

    Self-Perceptions of Aging and Physical Activity in Older Adults with Arthritis: Does General Health Matter?

    Sarah Lieber1, Jerad Moxley2, Lisa Mandl1, M. Carrington Reid2 and Sara Czaja2, 1Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, 2Weill Cornell Medicine, New York, NY

    Background/Purpose: Negative self-perceptions of aging are generally associated with decreased physical function in older adults. Whether self-perceptions of aging (i.e., "awareness of age-related change" including…
  • Abstract Number: 1288 • ACR Convergence 2023

    Frailty Is Associated with Higher Risk of Readmission in Patients with Rheumatoid Arthritis

    Waqas Tahir1, Yenny Rosli2, Christopher Leung3, K Wysham4, Jiha Lee5, Radjiv Goulabchand6, Una Makris7, Siddharth Singh8 and Namrata Singh9, 1Mayo Clinic, Jacksonville, FL, 2University of Washington, Seattle, WA, 3Georgetown University School of Medicine, Washington, DC, 4VA Puget Sound/University of Washington, Seattle, WA, 5University of Michigan, Ann Arbor, MI, 6University of California San Diego, La Jolla, CA, 7UT Southwestern Medical Center and Dallas VA, Dallas, TX, 8University of California San Diego, San Diego, CA, 9University of Washington, Bellevue, WA

    Background/Purpose: With the advent of new therapies and increasing life expectancy, there is a rising number of older adults living with rheumatoid arthritis (RA). Patients…
  • Abstract Number: 1592 • ACR Convergence 2023

    Memantine Attenuates the Development of Osteoarthritis by Blocking NMDA Receptor Mediated Calcium Overload and Chondrocyte Senescence

    Ning Wang1, Qingmei Cheng1, Xiaoxiao Li2, ke he1, Junyu Zhu1, Hui Li3 and Jie Wei4, 1中南大学湘雅医院, Changsha, China, 2Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Xiangya Hospital, Central South University, Changsha, China, 3Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China, 4Health Management Center, Xiangya Hospital Central South University, Changsha, China

    Background/Purpose: Memantine is an FDA proved drug utilized for the treatment of dementia and exerts its function by blocking the NMDA (N-methyl-D-aspartate) receptor, a calcium…
  • Abstract Number: 1628 • ACR Convergence 2023

    The Impact of Cardiovascular and Cerebrovascular Disease on the Risk of Dementia in Rheumatoid Arthritis. a Mediation Analysis

    Edward Lovering1, Chanakya Kodishala2, Rakesh Kumar1, Cynthia Crowson1, Ryan Lennon1, John Davis1 and Elena Myasoedova1, 1Mayo Clinic, Rochester, MN, 2Mayo Clinic Rochester Minnesota, Rochester, MN

    Background/Purpose: Alzheimer's disease and related dementias have an immense disease burden, with predicted continuous increase in incidence and prevalence. Systemic inflammation plays a major role…
  • Abstract Number: 1850 • ACR Convergence 2023

    Long-term Glucocorticoid Use in a Cohort of Elderly Early Rheumatoid Arthritis Patients: A Joint Analysis of Medicare and the Rheumatology Informatics System for Effectiveness (RISE) Data

    Andriko Palmowski1, Eric Roberts2, Jing Li2, Emma Kersey2, Rachael Stovall2, Frank Buttgereit3, Jinoos Yazdany4 and Gabriela Schmajuk5, 1Charité - Universitätsmedizin Berlin, Berlin, Germany, 2University of California San Francisco, San Francisco, CA, 3Charité Universitätsmedizin, Dept. Rheumatology, Berlin, Germany, 4University of California, General Department of Medicine, Division of Rheumatology, San Francisco, CA, 5UCSF / SFVA, San Francisco, CA

    Background/Purpose: According to recent ACR and EULAR rheumatoid arthritis (RA) guidelines, glucocorticoids (GCs) should only be used for brief periods or not at all. Our…
  • Abstract Number: 0311 • ACR Convergence 2023

    Heterogeneity and Natural History of Medial Fixed Joint Space Width in Healthy Knees Among Women and Men: Data from Three Large Cohort Studies

    Kent Kwoh1, Erin Ashbeck2, Edward Bedrick1, Yvonne Golightly3, Zong-Ming Li1, Jean liew4, Amanda Nelson5, Tuhina Neogi6, Xiaoxiao Sun1 and Jeffrey Duryea7, 1University of Arizona, Tucson, AZ, 2University of Arizona Arthritis Center, Tucson, AZ, 3University of Nebraska Medical Center, Omaha, NE, 4Boston University, Boston, MA, 5University of North Carolina at Chapel Hill, Chapel Hill, NC, 6Boston University School of Medicine, Boston, MA, 7Brigham and Women's Hospital, Boston, MA

    Background/Purpose: Radiographic joint space width (JSW) is commonly used to assess structural progression in randomized controlled trials and observational studies of knee osteoarthritis (KOA). No…
  • Abstract Number: 2091 • ACR Convergence 2023

    Reach and Representativeness of Participants in an Evidence-Based, Community-Delivered Physical Activity Intervention in Adults with Arthritis

    Dina Jones1 and Jennifer Hootman2, 1West Virginia University, Morgantown, WV, 2Centers for Disease Control and Prevention, Atlanta, GA

    Background/Purpose: It is imperative that adults with arthritis and other chronic conditions are active enough to maintain health. Enhance®Fitness (EF) is an evidence-based physical activity…
  • Abstract Number: 0403 • ACR Convergence 2023

    Disease Activity Is Associated with Frailty in Veterans with Rheumatoid Arthritis

    Courtney Loecker1, Bryant England2, Punyasha Roul2, Namrata Singh3, Kaleb Michaud2, Lani Zimmerman4, Myra Schmaderer4, Grant Cannon5, Ted R Mikuls6, Gary Kunkel7, Ariela Orkaby8, Joshua Baker9 and K Wysham10, 1University of Nebraska Medical Center;VA Nebraska-Western Iowa Health Care System, Lincoln, NE, 2University of Nebraska Medical Center, Omaha, NE, 3University of Washington, Bellevue, WA, 4University of Nebraska Medical Center, Lincoln, NE, 5University of Utah and Salt Lake City VA, Salt Lake City, UT, 6Division of Rheumatology and Immunology, University of Nebraska Medical Center, Omaha, NE, 7VA Salt Lake City & University of Utah, Salt Lake City, UT, 8Veterans Affairs Boston Healthcare System & Brigham and Women’s Hospital, Harvard Medical School, Boston, MA; VA Geriatric Research Education and Clinical Center, Boston, MA, 9University of Pennsylvania, Philadelphia, PA, 10VA Puget Sound/University of Washington, Seattle, WA

    Background/Purpose: Frailty, defined as an increased vulnerability to stressors and adverse health outcomes, is an emerging concept in RA. Active RA disease gives rise to…
  • Abstract Number: 2117 • ACR Convergence 2023

    Frailty Is Associated with Mortality in Veterans with Rheumatoid Arthritis

    Sayuli Bhide1, Punyasha Roul2, Namrata Singh3, Grant Cannon4, Gary Kunkel5, Ted R Mikuls6, Bryant England2, Dolores Shoback7, Patti Katz8, Jose Garcia9, Ariela Orkaby10, Joshua Baker11 and K Wysham12, 1University of Washington, Seattle, WA, 2University of Nebraska Medical Center, Omaha, NE, 3University of Washington, Bellevue, WA, 4University of Utah and Salt Lake City VA, Salt Lake City, UT, 5University of Utah, Salt Lake City, UT, 6Division of Rheumatology and Immunology, University of Nebraska Medical Center, Omaha, NE, 7San Francisco VA Medical Center, San Francisco, CA, 8University of California San Francisco, San Rafael, CA, 9VA Puget Sound Healthcare System, Seattle, WA, 10Veterans Affairs Boston Healthcare System & Brigham and Women’s Hospital, Harvard Medical School, Boston, MA; VA Geriatric Research Education and Clinical Center, Boston, MA, 11University of Pennsylvania, Philadelphia, PA, 12VA Puget Sound/University of Washington, Seattle, WA

    Background/Purpose: Frailty is established as an important predictor of mortality in the general population.1Rheumatoid arthritis (RA) is associated with higher rates of frailty than the…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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