Abstracts tagged "Aging"

Abstract Number: 1592 • ACR Convergence 2023
Memantine Attenuates the Development of Osteoarthritis by Blocking NMDA Receptor Mediated Calcium Overload and Chondrocyte Senescence
Ning Wang¹, Qingmei Cheng¹, Xiaoxiao Li², ke he¹, Junyu Zhu¹, Hui Li³ and Jie Wei⁴, ¹中南大学湘雅医院, Changsha, China, ²Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Xiangya Hospital, Central South University, Changsha, China, ³Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China, ⁴Health Management Center, Xiangya Hospital Central South University, Changsha, China
Background/Purpose: Memantine is an FDA proved drug utilized for the treatment of dementia and exerts its function by blocking the NMDA (N-methyl-D-aspartate) receptor, a calcium…
Abstract Number: 1628 • ACR Convergence 2023
The Impact of Cardiovascular and Cerebrovascular Disease on the Risk of Dementia in Rheumatoid Arthritis. a Mediation Analysis
Edward Lovering¹, Chanakya Kodishala², Rakesh Kumar¹, Cynthia Crowson¹, Ryan Lennon¹, John Davis¹ and Elena Myasoedova¹, ¹Mayo Clinic, Rochester, MN, ²Mayo Clinic Rochester Minnesota, Rochester, MN
Background/Purpose: Alzheimer's disease and related dementias have an immense disease burden, with predicted continuous increase in incidence and prevalence. Systemic inflammation plays a major role…
Abstract Number: 1850 • ACR Convergence 2023
Long-term Glucocorticoid Use in a Cohort of Elderly Early Rheumatoid Arthritis Patients: A Joint Analysis of Medicare and the Rheumatology Informatics System for Effectiveness (RISE) Data
Andriko Palmowski¹, Eric Roberts², Jing Li², Emma Kersey², Rachael Stovall², Frank Buttgereit³, Jinoos Yazdany⁴ and Gabriela Schmajuk⁵, ¹Charité - Universitätsmedizin Berlin, Berlin, Germany, ²University of California San Francisco, San Francisco, CA, ³Charité Universitätsmedizin, Dept. Rheumatology, Berlin, Germany, ⁴University of California, General Department of Medicine, Division of Rheumatology, San Francisco, CA, ⁵UCSF / SFVA, San Francisco, CA
Background/Purpose: According to recent ACR and EULAR rheumatoid arthritis (RA) guidelines, glucocorticoids (GCs) should only be used for brief periods or not at all. Our…
Abstract Number: 0311 • ACR Convergence 2023
Heterogeneity and Natural History of Medial Fixed Joint Space Width in Healthy Knees Among Women and Men: Data from Three Large Cohort Studies
Kent Kwoh¹, Erin Ashbeck², Edward Bedrick¹, Yvonne Golightly³, Zong-Ming Li¹, Jean liew⁴, Amanda Nelson⁵, Tuhina Neogi⁶, Xiaoxiao Sun¹ and Jeffrey Duryea⁷, ¹University of Arizona, Tucson, AZ, ²University of Arizona Arthritis Center, Tucson, AZ, ³University of Nebraska Medical Center, Omaha, NE, ⁴Boston University, Boston, MA, ⁵University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁶Boston University School of Medicine, Boston, MA, ⁷Brigham and Women's Hospital, Boston, MA
Background/Purpose: Radiographic joint space width (JSW) is commonly used to assess structural progression in randomized controlled trials and observational studies of knee osteoarthritis (KOA). No…
Abstract Number: 2091 • ACR Convergence 2023
Reach and Representativeness of Participants in an Evidence-Based, Community-Delivered Physical Activity Intervention in Adults with Arthritis
Dina Jones¹ and Jennifer Hootman², ¹West Virginia University, Morgantown, WV, ²Centers for Disease Control and Prevention, Atlanta, GA
Background/Purpose: It is imperative that adults with arthritis and other chronic conditions are active enough to maintain health. Enhance®Fitness (EF) is an evidence-based physical activity…
Abstract Number: 0403 • ACR Convergence 2023
Disease Activity Is Associated with Frailty in Veterans with Rheumatoid Arthritis
Courtney Loecker¹, Bryant England², Punyasha Roul², Namrata Singh³, Kaleb Michaud², Lani Zimmerman⁴, Myra Schmaderer⁴, Grant Cannon⁵, Ted R Mikuls⁶, Gary Kunkel⁷, Ariela Orkaby⁸, Joshua Baker⁹ and K Wysham¹⁰, ¹University of Nebraska Medical Center;VA Nebraska-Western Iowa Health Care System, Lincoln, NE, ²University of Nebraska Medical Center, Omaha, NE, ³University of Washington, Bellevue, WA, ⁴University of Nebraska Medical Center, Lincoln, NE, ⁵University of Utah and Salt Lake City VA, Salt Lake City, UT, ⁶Division of Rheumatology and Immunology, University of Nebraska Medical Center, Omaha, NE, ⁷VA Salt Lake City & University of Utah, Salt Lake City, UT, ⁸Veterans Affairs Boston Healthcare System & Brigham and Women’s Hospital, Harvard Medical School, Boston, MA; VA Geriatric Research Education and Clinical Center, Boston, MA, ⁹University of Pennsylvania, Philadelphia, PA, ¹⁰VA Puget Sound/University of Washington, Seattle, WA
Background/Purpose: Frailty, defined as an increased vulnerability to stressors and adverse health outcomes, is an emerging concept in RA. Active RA disease gives rise to…
Abstract Number: 2117 • ACR Convergence 2023
Frailty Is Associated with Mortality in Veterans with Rheumatoid Arthritis
Sayuli Bhide¹, Punyasha Roul², Namrata Singh³, Grant Cannon⁴, Gary Kunkel⁵, Ted R Mikuls⁶, Bryant England², Dolores Shoback⁷, Patti Katz⁸, Jose Garcia⁹, Ariela Orkaby¹⁰, Joshua Baker¹¹ and K Wysham¹², ¹University of Washington, Seattle, WA, ²University of Nebraska Medical Center, Omaha, NE, ³University of Washington, Bellevue, WA, ⁴University of Utah and Salt Lake City VA, Salt Lake City, UT, ⁵University of Utah, Salt Lake City, UT, ⁶Division of Rheumatology and Immunology, University of Nebraska Medical Center, Omaha, NE, ⁷San Francisco VA Medical Center, San Francisco, CA, ⁸University of California San Francisco, San Rafael, CA, ⁹VA Puget Sound Healthcare System, Seattle, WA, ¹⁰Veterans Affairs Boston Healthcare System & Brigham and Women’s Hospital, Harvard Medical School, Boston, MA; VA Geriatric Research Education and Clinical Center, Boston, MA, ¹¹University of Pennsylvania, Philadelphia, PA, ¹²VA Puget Sound/University of Washington, Seattle, WA
Background/Purpose: Frailty is established as an important predictor of mortality in the general population.1Rheumatoid arthritis (RA) is associated with higher rates of frailty than the…
Abstract Number: 0431 • ACR Convergence 2023
Senescence and Cell Exhaustion in CD4+ and CD8+ Lymphocytes in Rheumatoid Arthritis Patients in Remission Without Treatment
Rodolfo Jiménez-Soto¹, Luis llorente², Guadalupe Lima¹, Luisa Alanis Saenz¹, Amairani Gomez Rodriguez¹, Hilda Marin Lopez¹, Erik Cimé-Aké¹ and Juan Jakez-Ocampo¹, ¹Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ²Departamento de Inmunología y Reumatología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Background/Purpose: T cells are important among the several risk factors and immunological markers implicated in rheumatoid arthritis (RA). The goal of this study was to…
Abstract Number: 2127 • ACR Convergence 2023
Associations Between Rheumatoid Arthritis, Frailty Status and Mortality in Older Adults with Bladder Cancer
Maya Swaminathan¹, Sarah Holt², John Gore², Yaw Nyame², Jonathan Wright², George Schade², Ami Shah³, Jeffrey Sparks⁴, Una Makris⁵, Petros Grivas⁶, Maria Suarez-Almazor⁷, Sarah Psutka² and Namrata Singh⁸, ¹University of Washington, Seattle, WA, ²Department of Urology, University of Washington, Seattle, WA, ³Department of Medicine, Division of Rheumatology, Johns Hopkins University School of Medicine, Ellicott City, MD, ⁴Division of Rheumatology, Inflammation, and Immunity, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, ⁵UT Southwestern Medical Center and Dallas VA, Dallas, TX, ⁶Division of Medical Oncology, Dept. of Medicine, UW; Clinical Research Division; Fred Hutchinson Cancer Center, Seattle, WA, ⁷MD Anderson Cancer Center, Houston, TX, ⁸University of Washington, Bellevue, WA
Background/Purpose: Rheumatoid arthritis (RA) is associated with an increased risk of developing certain cancers, including bladder cancer (Beydon et al. 20231). However, few studies have…
Abstract Number: 0433 • ACR Convergence 2023
DMARD Initiation in Older Adults with New Diagnosis of Late-Onset Rheumatoid Arthritis
Jiha Lee¹, Jonathan Martindale¹, Una Makris², Namrata Singh³, Raymond Yung⁴ and Julie Bynum¹, ¹University of Michigan, Ann Arbor, MI, ²UT Southwestern Medical Center and Dallas VA, Dallas, TX, ³University of Washington, Bellevue, WA, ⁴Michigan Medicine, Ann Arbor, MI
Background/Purpose: The number of older adults living with rheumatoid arthritis (RA) is growing as the world population is aging. Up to one-third of the older…
Abstract Number: 2138 • ACR Convergence 2023
Frailty Is a Predictor of Incident Osteoporotic Fractures in Veterans with Rheumatoid Arthritis
K Wysham¹, Hannah Brubeck², Aaron Baraff³, Punyasha Roul⁴, Namrata Singh⁵, James Andrews⁶, Grant Cannon⁷, Gary Kunkel⁸, Ted R Mikuls⁹, Bryant England⁴, Dolores Shoback¹⁰, Patti Katz¹¹, Jose Garcia¹², Ariela Orkaby¹³ and Joshua Baker¹⁴, ¹VA Puget Sound/University of Washington, Seattle, WA, ²VA Puget Sound Health Care System, Seattle, WA, ³VA Puget Sound Seattle, Seattle, WA, ⁴University of Nebraska Medical Center, Omaha, NE, ⁵University of Washington, Bellevue, WA, ⁶University of Washington, Seattle, WA, ⁷University of Utah and Salt Lake City VA, Salt Lake City, UT, ⁸University of Utah, Salt Lake City, UT, ⁹Division of Rheumatology and Immunology, University of Nebraska Medical Center, Omaha, NE, ¹⁰San Francisco VA Medical Center, San Francisco, CA, ¹¹University of California San Francisco, San Rafael, CA, ¹²VA Puget Sound Healthcare System, Seattle, WA, ¹³Veterans Affairs Boston Healthcare System & Brigham and Women’s Hospital, Harvard Medical School, Boston, MA; VA Geriatric Research Education and Clinical Center, Boston, MA, ¹⁴University of Pennsylvania, Philadelphia, PA
Background/Purpose: Frailty occurs prematurely in RA. Levels of frailty are higher in Veteran populations than civilians1. Frailty has been shown to predict osteoporotic fractures in…
Abstract Number: 0720 • ACR Convergence 2023
Cognitive Function and Its Associated Factors in Polymyalgia Rheumatica
Patricia Harkins¹, Sharon Cowley², David Kane³ and Richard Conway⁴, ¹St James's Hospital, Dublin, Ireland, ²Tallaght University Hospital, Dublin, Dublin, Ireland, ³Tallaght University Hospital & Trinity College Dublin, Dublin, Ireland, ⁴Trinity College Dublin, Dublin, Ireland
Background/Purpose: Over the past decade our understanding of the prevalence, and indeed impact of cognitive impairment in rheumatic diseases has increased. Intact cognitive function is…
Abstract Number: 2377 • ACR Convergence 2023
The Impact of Chronologic versus Biologic Age on the Risk of Severe Infection, End-Stage Renal Disease, and Death in Older Adults with ANCA-Associated Vasculitis
Sebastian Sattui¹, Xiaoqing Fu², Claire Cook², Shruthi Srivatsan², Yuqing Zhang² and Zachary Wallace³, ¹University of Pittsburgh, Pittsburgh, PA, ²Massachusetts General Hospital, Boston, MA, ³Massachusetts General Hospital, Newton, MA
Background/Purpose: Older adults with ANCA-associated vasculitis (AAV) have distinct clinical presentations and outcomes when compared to younger adults. Despite a high incidence of AAV in…
Abstract Number: 0805 • ACR Convergence 2023
De-escalation of Anti-TNFs in Older Adults with Rheumatoid Arthritis
Jiha Lee¹, Navasuja Kumar¹, Mohammed Kabeto¹, Andrzej Galecki¹, Chiang-Hua Chang¹, Namrata Singh², Raymond Yung³, Una Makris⁴ and Julie Bynum¹, ¹University of Michigan, Ann Arbor, MI, ²University of Washington, Bellevue, WA, ³Michigan Medicine, Ann Arbor, MI, ⁴UT Southwestern Medical Center and Dallas VA, Dallas, TX
Background/Purpose: Biologic disease modifying anti-rheumatic drugs (bDMARDs) such as anti-tumor necrosis factors(anti-TNFs) improve clinical and radiographic outcomes in rheumatoid arthritis (RA). However, their use is…
Abstract Number: 2457 • ACR Convergence 2023
Ageism in Rheumatology: The Health Care Professional’s Perspective
Aaron Smith¹, Pooja Achanta¹ and Una Makris², ¹UT Southwestern, Dallas, TX, ²UT Southwestern Medical Center and Dallas VA, Dallas, TX
Background/Purpose: Ageism (stereotypes, prejudice or discrimination based on age) is highly prevalent and has been linked to reduced lifespan, prolonged disability, and accelerated cognitive decline…

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