Abstracts tagged "adipose tissue"

Abstract Number: 55 • 2018 ACR/ARHP Annual Meeting
Adipose Derived Stem Cell Suppressed Synovial Inflammation and Repaired Cartilage Destruction in Rheumatoid Arthritis Model Mice
Tadashi Okano¹, Kentaro Inui², Hideki Ueyama³, Kumi Orita³, Tatsuya Koike⁴ and Hiroaki Nakamura², ¹Orthopedic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan, ²Orthopaedic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan, ³Osaka City University Graduate School of Medicine, Osaka, Japan, ⁴Center for Senile Degenerative Disorders, Osaka City University Graduate School of Medicine, Osaka, Japan
Background/Purpose: Adipose derived stem cell (ADSC) is one of the stem cells produced by adipose tissue which can be collected easily and in large quantities.…
Abstract Number: 85 • 2018 ACR/ARHP Annual Meeting
Antibodies to Citrullinated Protein Antigens (ACPAs) Induce Adipose Tissue Dysfunction Contributing to the Cardiovascular Disease Risk in Rheumatoid Arthritis. Modulation By Biological Dmards
Nuria Barbarroja¹, Ivan Arias de la Rosa², Miriam Ruiz-Ponce³, Maria Dolores de la Rosa-Garrido³, Patricia Ruiz-Limon⁴, Yolanda Jiménez-Gómez¹, Carlos Perez-Sanchez¹, Maria Carmen Abalos-Aguilera², Rocio Guzman-Ruiz⁵, Maria del Mar Malagon⁶, Francisco Jose Tinahones⁷, Eduardo Collantes-Estévez¹, Chary Lopez-Pedrera³ and Alejandro Escudero-Contreras², ¹Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ²Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ³IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ⁴Research Group of Endocrine Diseases, Research Laboratory. Biomedical Research Institute of Malaga (IBIMA).Virgen de la Victoria Universitary Hospital, Malaga, Spain., Málaga, MA, Spain, ⁵Department of Cell Biology, Physiology, and Immunology,, IMIBIC/University of Córdoba/Reina Sofía University Hospital, Cordoba, Spain, ⁶Department of Cell Biology, Physiology, and Immunology,I, IMIBIC/University of Córdoba/Reina Sofía University Hospital, Cordoba, Spain, ⁷Department of Clinical Endocrinology and Nutrition, Institute of Biomedical Research of Málaga (IBIMA), Hospital of Málaga (Virgen de la Victoria), University of Málaga (UMA), Málaga, Spain; CIBER Fisiopatología Obesidad y Nutrición, Instituto de Salud Ca, Malaga, Spain
Background/Purpose: 1) To test the relationship among ACPAs and levels of adipocytokines and atherosclerosis in RA patients. 2) To analyze the effects of ACPAs on…
Abstract Number: 503 • 2018 ACR/ARHP Annual Meeting
Waist Circumference Based Abdominal Obesity Versus Body Mass Index in Rheumatoid Arthritis: Influence on the Risk of Diabetes and Cardiovascular Disease
Gulsen Ozen¹, Sofia Pedro² and Kaleb Michaud^1,2, ¹Rheumatology, University of Nebraska Medical Center, Omaha, NE, ²FORWARD, The National Databank for Rheumatic Diseases, Wichita, KS
Background/Purpose: Adipose tissue deposited around the mesentery is highly associated with insulin resistance and cardiovascular disease (CVD). Compared to BMI, waist circumference (WC) has been…
Abstract Number: 1618 • 2018 ACR/ARHP Annual Meeting
Adipose Tissue Inflammation in Psoriatic Arthritis: Overexpression of a Wide Array of Inflammatory Mediators and Associations with Disease and Treatment Characteristics
Jae Hee Yun¹, Robert Winchester², Hui-Zhu Zhang², Christopher Depender¹ and Jon T. Giles¹, ¹Medicine/Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, ²Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY
Background/Purpose: Obesity is associated with PsA risk, severity, and lack of response to DMARDs. However, no studies have explored adipose tissue inflammation at the molecular…
Abstract Number: 1766 • 2018 ACR/ARHP Annual Meeting
Abdominal Adipose Tissue Predicts Incident Major Cardiovascular Events in Systemic Necrotizing Vasculitis Patients: Data from a Prospective Cohort Study on 120 Patients
Soledad Henriquez¹, Bertrand Dunogué², Alexis Régent¹, Pascal Cohen³, Alice Bérezné¹, Sami Kolta⁴, Claire Le Jeunne¹, Luc Mouthon⁵, Christian Roux⁴, Loïc Guillevin⁶, Karine Briot⁷ and Benjamin Terrier⁸, ¹Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, ²Internal Medicine, Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, ³Department of Internal Medicine, INSERM Unité 1016, Centre de Référence pour les Maladies Auto-immunes Rares, Hôpital Cochin, Université Paris Descartes, Sorbonne Paris Cité, Paris, France, ⁴Department of Rheumatology, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, ⁵Department of Internal Medicine, INSERM Unité 1016, Centre de Référence pour les Maladies Auto-immunes Rares, National Referral Center for Rare Systemic Autoimmune Diseases, Paris Cochin, France, Paris, France, ⁶Medecine Interne, Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, ⁷Department of Rheumatology, Cochin Hospital and Epidemiology and Biostatistics Unit,Sorbonne Paris Cité Reserach Center,Paris Descartes University,INSERM U1153, Paris, France, ⁸National Referral Center for Rare Systemic Autoimmune Diseases, Paris Cochin, France, Paris, France
Background/Purpose: Cardiovascular (CV) events are highly prevalent in patients with systemic necrotizing vasculitides (SNV). The visceral/subcutaneous adipose tissue (VAT/SAT) ratio has been shown to be…
Abstract Number: 570 • 2017 ACR/ARHP Annual Meeting
Signalling Pathways Identified in Salivary Glands from Primary Sjögren’s Syndrome Patients Reveal Enhanced Adipose Tissue Development, As Demonstrated By Microarray Analysis, Real-Time PCR and Immunohistochemistry
Lara A Aqrawi¹, Janicke C Liaaen Jensen¹, Gunnvor Øijordsbakken², Ann-Kristin Ruus³, Ståle Nygård^4,5, Marit Holden⁶, Roland Jonsson^7,8, Hilde Kanli Galtung⁹ and Kathrine Skarstein^10,11, ¹Department of Oral Surgery and Oral Medicine, University of Oslo, Oslo, Norway, ²Department of Clinical Medicine, University of Bergen, Gade Laboratory for Pathology, Department of Clinical Medicine, University of Bergen, Bergen, Norway, ³Department of Oral Biology, University of Oslo, Oslo, Norway, ⁴Department of Informatics, University of Oslo, Oslo, Norway, ⁵Bioinformatics core facility, Institute for Cancer research, Oslo University Hospital, Oslo, Norway, ⁶Norwegian Computing Center, Oslo, Oslo, Norway, ⁷Broegelmann Research laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway, ⁸Department of Rheumatology, Haukeland University Hospital, Bergen, Bergen, Norway, ⁹Department of Oral Biology, University of Oslo, Oslo, Pakistan, ¹⁰Gade Laboratory for Pathology, Department of Clinical Medicine, University of Bergen, Bergen, Norway, ¹¹Department of Pathology, Haukeland University Hospital, Bergen, Bergen, Norway
Background/Purpose: : A characteristic feature of Sjögren’s syndrome (SS) is the destruction of salivary and lacrimal glands mediated by mononuclear cell infiltration. Adipocytes can also…
Abstract Number: 1961 • 2017 ACR/ARHP Annual Meeting
Risk Factors for Low Muscle MASS in Community-Dwelling Older Women: A Population-Based Prospective Cohort Study in Brazil. the São Paulo Ageing & Health Study
Ketty Machado¹, Diogo S Domiciano², Luana G Machado³, Jaqueline B Lopes⁴, Camille P Figueiredo⁵, Valéria F. Caparbo³, Liliam Takayama³, Paulo Menezes⁶ and Rosa M R Pereira², ¹Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ²Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil, ³Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ⁴Rheumatology Division, Rheumatology Division, Faculdade de Medicina da USP, São Paulo, Brazil, ⁵Rheumatology Division, Faculdade de Medicina da USP, São Paulo, Brazil, ⁶Preventive medicine, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
Background/Purpose: Sarcopenia is a syndrome characterized by progressive loss of skeletal muscle mass, which results in decreased muscle strength and impairment of functional capacity. Moreover,…
Abstract Number: 2372 • 2017 ACR/ARHP Annual Meeting
Obesity and the Impact on Treat to Target Goals and Functional Ability in RA. Results from Two Multi-Centre UK Inception Cohorts
Elena Nikiphorou¹, Sam Norton², Patrick Kiely³ and Adam Young⁴, ¹Academic Rheumatology Department, King's College London, London, United Kingdom, ²Academic Rheumatology, King´s College London, London, United Kingdom, ³St George's Hospital, London, United Kingdom, ⁴University of Hertfordshire, Hertford, United Kingdom
Background/Purpose: The links between inflammation, obesity and joint dysfunction are well established. How these translate into clinical disease activity and functional disability in rheumatoid arthritis…
Abstract Number: 2961 • 2017 ACR/ARHP Annual Meeting
Body Composition and Myokine Levels in Juvenile Dermatomyositis and Associations with Physical Function
Birgit Nomeland Witczak¹, Kristin Godang², Jens Bollerslev^2,3, Thomas Schwartz^4,5, Berit Flatø^3,6, Ivar Sjaastad^3,4,7 and Helga Sanner^6,8, ¹Oslo University Hospital, Institute for Experimental Medical Research, Oslo University Hospital, Oslo, Norway, Oslo, Norway, ²Section of Specialized Endocrinology, Department of Endocrinology, Oslo University Hospital, Rikshospitalet, Oslo, Norway, Oslo, Norway, ³Institute for Clinical Medicine, University of Oslo, Oslo, Norway, Oslo, Norway, ⁴Institute for Experimental Medical Research, Oslo University Hospital, Oslo, Norway, Oslo, Norway, ⁵Department of Infectious Diseases, Oslo University Hospital, Oslo, Norway, Oslo, Norway, ⁶Department of Rheumatology, Oslo University Hospital, Rikshospitalet, Oslo, Norway, Oslo, Norway, ⁷Department of Cardiology, Oslo University Hospital, Oslo, Norway, Oslo, Norway, ⁸Norwegian National Advisory Unit on Rheumatic Diseases in Children and Adolescents, Oslo University Hospital, Rikshospitalet, Oslo, Norway, Oslo, Norway
Background/Purpose: JDM presents with proximal muscle weakness and atrophy is frequent. Still, body composition (BC) in JDM has not been widely studied, but is known…
Abstract Number: 51 • 2017 ACR/ARHP Annual Meeting
Irisin Ameliorates Infrapatellar Adiposity in Knee Osteoarthritis Pathogenesis By Orchestrating Adipokine Signaling
Feng-Sheng Wang¹, Yi-Chih Sun¹ and Jih-Yang Ko², ¹Core Facility for Phenomics & Diagnostics, Department of Medical Research, Core Facility for Phenomics & Diagnostics, Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital, Taiwan, Kaohsiung, Taiwan, ²Department of Orthopedic Surgery, Department of Orthopedic Surgery, Kaohsiung Chang Gung Memorial Hospital, Taiwan, Kaohsiung, Taiwan
Background/Purpose: Aberrant infrapatellar fat metabolism is a prominent feature that exacerbates inflammation and fibrosis relative to joint deterioration during osteoarthritis (OA). Irisin, a secretory subunit…
Abstract Number: 54 • 2017 ACR/ARHP Annual Meeting
Maintaining Angiogenesis Prevents Glucocorticoid Induced Osteonecrosis
Alanna Dubrovsky¹, Wei Yao¹, Geetha Mohan¹, Mie Jin Lim¹, Yu-An Evan Lay¹, Donald Kimmel² and Nancy E. Lane^3,4,5,6,7,8, ¹UC Davis Center for Musculoskeletal Health, Sacramento, CA, ²Creighton University School of Medicine Osteoporosis Research Center, Omaha, NE, ³Center for Musculoskeletal Health, University of California, Davis School of Medicine, Sacramento, CA, ⁴Internal Medicine, Center for Musculoskeletal Health, UC Davis School of Medicine, Sacramento, CA, ⁵UC Davis Medical Center, Sacramento, CA, ⁶Center for Musculoskeletal Health, Univ of California at Davis, Sacramento, CA, ⁷Medicine, U.C. Davis, Sacramento, CA, ⁸UCDMC, Sacramento, CA
Background/Purpose: Atraumatic osteonecrosis (ON) results from reduced bone vascularity. Glucocorticoids (GC) are a major risk factor for ON, as GCs reduce vascular endothelial growth factor,…
Abstract Number: 521 • 2016 ACR/ARHP Annual Meeting
Subcutaneous Adipose Tissue from Rheumatoid Arthritis Patients Is Characterized By an Abundance of Macrophages That Are Associated with Autoantibodies, Systemic Inflammation, and Immunomodulation
Jon T. Giles¹, Anthony W Ferrante², Rachel Broderick³, Afshin Zartoshti⁴, Janine Rose³, Hui-Zhu Zhang³ and Robert Winchester³, ¹Division of Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, ²Endocrinology, Nutrition, and Preventive Medicine, Columbia University, College of Physicians & Surgeons, New York, NY, ³Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, ⁴Rheumatology, Columbia University, College of Physicians & Surgeons, New York city, NY
Background/Purpose: Adipose tissue macrophages (ATMs) are a potent source of inflammatory cytokines with profound effects on adipose tissue function and systemic inflammation, yet their potential…
Abstract Number: 542 • 2016 ACR/ARHP Annual Meeting
Changes on Body Composition in Women with Long-Standing Established Rheumatoid Arthritis: Differences By Level of Disease Activity
Gabriela Daffre Carvalho¹, Karina Bonfiglioli², Ana C. M. Ribeiro¹, Celio R. Gonçalves¹, Rosa M R Pereira³ and Diogo S Domiciano⁴, ¹Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ²Rheumatology Division, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil, ³Rheumatology Division, Faculdade de Medicina da USP, São Paulo, Brazil, ⁴Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
Background/Purpose: Studies on association between inflammatory activity and body composition changes in rheumatoid arthritis (RA) are controversial due to some limitations: use of low accuracy…
Abstract Number: 819 • 2016 ACR/ARHP Annual Meeting
Impaired Adiponectin Signaling in SSc Contributes to Myofibroblast Differentiation and Organ Fibrosis
Roberta Goncalves Marangoni¹, Benjamin Korman², Feng Fang¹, Monique Hinchcliff¹, Laszlo Otvos³, Philipp E. Scherer⁴, Warren Tourtellotte⁵ and John Varga⁶, ¹Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL, ²Department of Rheumatology, Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL, ³Temple University, Philadelphia, PA, ⁴University of Texas Southwestern Medical Center, Dallas, TX, ⁵Department of Pathology, Ward, Northwestern University, Chicago, IL, ⁶Rheumatology and Dermatology, Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL
Background/Purpose: In systemic sclerosis (SSc) patients, skin fibrosis is accompanied by involution of dermal white adipose tissue (dWAT), a prominent source of adiponectin (APN). We…
Abstract Number: 851 • 2016 ACR/ARHP Annual Meeting
Perioral Autologous FAT Transplantation Is More Effective THAN Hyaluronic Acid Filler on Scleroderma Skin Fibrosis: Results from a LONG TERM Controlled Study
Nicoletta Del Papa¹, Eleonora Zaccara¹, Romina Andracco¹, Wanda Maglione¹, Francesca Pignataro¹, Fabio Caviggioli², Gabriele Di Luca³, Antonina Prafioriti⁴ and Claudio Vitali⁵, ¹Dept. Rheumatology, G. Pini Hospital, Milano, Italy, ²UOC Chirurgia Plastica, UOC Chirurgia Plastica, Multimedica Holding SpA, Milano, Italy, ³UOS Chirurgia Vascolare,, Osp. G. Pini, Milano, Italy, ⁴Pathology Unit, Istituto G.Pini, Milan, Italy, ⁵Rheumatology Section, Istituto San Giuseppe, Como, Italy
Background/Purpose: Autologous fat tissue grafting (AFTG) has been successfully used in the treatment of different sclerotic conditions, including scleroderma. We evaluated in patients with SSc…