Abstracts tagged "Adipokines"

Abstract Number: 1102 • 2016 ACR/ARHP Annual Meeting
Differentiation of Spongiosa-Derived Mesenchymal Stromal Cells from Osteoporosis and Osteoarthritis Patients Are Influenced By Adipokines
Lali Tsiklauri¹, Janina Werner², Klaus W. Frommer¹, Ulf Müller-Ladner³, Stefan Rehart⁴, Sabine Wenisch² and Elena Neumann¹, ¹Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad Nauheim, Germany, ²Justus-Liebig-University Giessen, Institute of Veterinary-Anatomy, -Histology and –Embryology, Clinic of Small Animals, Giessen Germany, Giessen, Germany, ³Department of Internal Medicine and Rheumatology, Justus-Liebig-University Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, ⁴Orthopedic & Trauma Surgery, Agaplesion Markus-Hospital, Frankfurt, Frankfurt, Germany
Background/Purpose: Osteoporosis is characterized by bone loss, increased fracture risk and reduced regeneration ability. Age-related bone loss leading to osteoporosis correlates with increased bone marrow…
Abstract Number: 1363 • 2016 ACR/ARHP Annual Meeting
Serum Adipokines in Juvenile Dermatomyositis Are Associated with Disease Activities and Cardiac Function
Birgit Nomeland Witczak¹, Kristin Godang², Thomas Schwartz³, Nicoleta Cristina Olarescu⁴, Berit Flatø^5,6, Jens Bollerslev^5,7, Ivar Sjaastad^5,8,9 and Helga Sanner^5,6, ¹Oslo University Hospital, Institute for Experimental Medical Research, Oslo University Hospital, Oslo, Norway, Oslo, Norway, ²Department of Specialised Endocrinology, Oslo University Hospital, Section of Specialised Endocrinology, Department of Endocrinology, Oslo University Hospital, Rikshospitalet, Oslo, Norway, Oslo, Norway, ³Department of Infectious Diseases, Department of Infectious Diseases, Oslo University Hospital, Oslo, Norway, Oslo, Norway, ⁴Department of Endocrinology, Oslo University Hospital, Rikshospitalet, Oslo, Norway., Section of Specialised Endocrinology, Department of Endocrinology, Oslo University Hospital, Rikshospitalet, Oslo, Norway, Oslo, Norway, ⁵Institute for Clinical Medicine, University of Oslo, Oslo, Norway, Oslo, Norway, ⁶Department of Rheumatology, Oslo University Hospital, Rikshospitalet, Oslo, Norway, Oslo, Norway, ⁷Section of Specialised Endocrinology, Department of Endocrinology, Oslo University Hospital, Rikshospitalet, Oslo, Norway, Oslo, Norway, ⁸Department of Cardiology, Oslo University Hospital, Oslo, Norway, Oslo, Norway, ⁹Institute for Experimental Medical Research, Oslo University Hospital, Oslo, Norway, Oslo, Norway
Background/Purpose: We have earlier demonstrated redistribution of adipose tissue in JDM patients. There is an increase in visceral adipose tissue (VAT), a highly active metabolic…
Abstract Number: 2149 • 2016 ACR/ARHP Annual Meeting
Adipokines Alter the Interaction Between Rheumatoid Arthritis Synovial Fibroblasts Adhesion and Endothelial Cells
Rebecca Hasseli¹, Klaus W. Frommer², Markus Prof. Dr. Schönburg³, Stefan Prof. Dr. Rehart⁴, Ulf Müller-Ladner^5,6 and Elena Neumann², ¹Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, ²Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad Nauheim, Germany, ³Department of Cardiac Surgery; Kerckhoff-Klinik, Bad Nauheim, Bad Nauheim, Germany, ⁴Department of Orthopedics and Trauma Surgery, Markus Hospital, Frankfurt, Frankfurt, Germany, ⁵Department of Internal Medicine and Rheumatology, Justus-Liebig-University Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, ⁶Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad-Nauheim, Germany
Background/Purpose: Synovial fibroblast plays a key role in rheumatoid arthritis (RA), which is a chronic polyarticular inflammatory disease. SF are able to migrate long distances…
Abstract Number: 3054 • 2016 ACR/ARHP Annual Meeting
The Impact of Obesity on Knee Osteoarthritis Symptoms and Related Biomarker Profiles in a Bariatric Surgery Cohort
Thayer Mukherjee¹, Fernando Bomfim², Evan Wilder¹, Lauren Browne³, Kayleigh Toth⁴, Shira Aharon⁴, Janice Lin⁴, Renata La Rocca Vieira⁵, Christine Ren-Fielding⁶, Manish Parikh⁷, Steven B. Abramson⁸, Mukundan Attur⁹ and Jonathan Samuels², ¹NYU Langone Medical Center, New York, NY, ²Rheumatology, NYU Langone Medical Center, New York, NY, ³NYU Langone Medical Center, Rheumat, New York, NY, ⁴NYU Langone Medical Center, Rheumatology, New York, NY, ⁵Department of Radiology, NYU Langone Medical Center, New York, NY, ⁶Department of Surgery, New York University School of Medicine, New York, NY, ⁷Department of Surgery, NYU Langone Medical Center, New York, NY, ⁸Dept of Rheumatology/Medicine, NYU Langone Medical Center, New York, NY, ⁹Rheumatology Research, NYU - Hospital for Joint Diseases, New York, NY
Background/Purpose: Obesity is a common risk factor for knee osteoarthritis (KOA). While it is intuitive that bariatric weight loss improves knee pain, it is not…
Abstract Number: 546 • 2015 ACR/ARHP Annual Meeting
Adipokines and Insulin-like Growth Factor 1 As Predictors of Clinical and Radiographic Outcomes in Early Rheumatoid Arthritis
Adrian Levitsky¹, Kerstin Brismar², Saedis Saevarsdottir³, Karen Hambardzumyan¹, Anna Andersson¹ and Ronald F. van Vollenhoven¹, ¹Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), The Karolinska Institute, Stockholm, Sweden, ²Department of Molecular Medicine and Surgery, Unit of Growth and Metabolism, The Karolinska Institute, Stockholm, Sweden, ³Department of Medicine, Rheumatology Unit, The Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden
Background/Purpose: Adipokines are cytokines/hormones primarily synthesized in white adipose tissue. In rheumatoid arthritis (RA), some adipokines have been associated with worse outcomes (1-3). The aim…
Abstract Number: 1591 • 2015 ACR/ARHP Annual Meeting
A Low Adiponectin Level in Rheumatoid Arthritis Is Associated with Coronary Artery Disease
Jon Roger Eidet¹, Ida G. Fostad², Kelly J. Shields³, Torstein Lyberg¹, Tor Paaske Utheim¹, Anita Kåss⁴, Knut Mikkelsen⁵, Terje Veel⁶, Kjell Saatvedt⁷, Morten Wang Fagerland⁸, Matthew Liang⁹ and Ivana Hollan⁵, ¹Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway, ²Department of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway, ³Medicine, Lupus Center of Excellence / Allegheny Health Network, Pittsburgh, PA, ⁴Rheumatology, Betanien Hospital, Skien, Norway, ⁵Lillehammer Hospital for Rheumatic Diseases, Lillehammer, Norway, ⁶Department of Cardiac Surgery, Feiring Heart Clinic, Feiring, Norway, ⁷Department of Cardiothoracic Surgery, Oslo University Hospital, Oslo, Norway, ⁸Department of Biostatistics, Oslo University Hospital, Oslo, Norway, ⁹Department of Rheumatology, Brigham and Women’ s Hospital, Boston, Boston, MA
Background/Purpose: Adipokines exert pleiotropic actions, including immunoregulatory and matrix degrading effects. There is evidence of adipokine involvement in the pathogenesis of cardiovascular (CV) disease as…
Abstract Number: 1796 • 2015 ACR/ARHP Annual Meeting
Progression of Atherosclerosis Might be Prevented By Decrease of Serum Resistin Level after Glucocorticoid Therapy in Patients with Systemic Autoimmune Disease
Shotaro Masuoka, Nahoko Tanaka, Natsuko Kusunoki, Tatsuhiro Yamamoto, Kaichi Kaneko, Sei Muraoka, Makoto Kaburaki, Kotaro Shikano, Natsuki Fujio, Hiroshi Sato, Mai Kawazoe, Emiko Shindo, Soichi Yamada, Kenji Takagi, Toshihiro Nanki and Shinichi Kawai, Division of Rheumatology, Department of Internal Medicine, School of Medicine, Faculty of Medicine, Toho University, Tokyo, Japan
Background/Purpose: Development of atherosclerosis is accelerated in patients with systemic autoimmune diseases. However, underlying mechanisms of accelerated atherosclerosis remains unknown, and the impact of pharmacotherapies…
Abstract Number: 1821 • 2015 ACR/ARHP Annual Meeting
Leptin, Adiponectin, and Resistin As Serum Markers of Fatigue in Systemic Lupus Erythematosus: A Pilot Study
Mary Mahieu¹, Grace Ahn², Joan S. Chmiel³, Dorothy D. Dunlop⁴, Irene Helenowski³, Pamela Semanik⁵, Jing Song⁴, Rowland W. Chang³ and Rosalind Ramsey-Goldman⁶, ¹Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Rheumatology, Falls Medical Specialists, Baltimore, MD, ³Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Institute for Healthcare Studies, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵Nursing, Rush University College of Nursing, Chicago, IL, ⁶Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Fatigue, a common symptom in systemic lupus erythematosus (SLE) patients, is ameliorated by physical activity. Adiposity and adipokines may be associated with patient-reported fatigue.…
Abstract Number: 1901 • 2015 ACR/ARHP Annual Meeting
Association of Serum Adipokines Adipsin, Adiponectin, and Leptin/Adiponectin Ratio with Systemic Sclerosis
Benjamin Korman¹, Roberta Goncalves Marangoni¹, Monique E. Hinchcliff², Sanjiv Shah³, Mary A. Carns⁴, Rosalind Ramsey-Goldman⁵ and John Varga⁶, ¹Division of Rheumatology, Northwestern University, Chicago, IL, ²Division of Rheumatology, Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ³Northwestern University, Chicago, IL, ⁴Rheumatology, Northwestern University, Chicago, IL, ⁵Northwestern University Feinberg School of Medicine, Chicago, IL, ⁶Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL
Background/Purpose: Patients with systemic sclerosis (SSc) display reductions in adipose tissue, particularly intradermal adipose tissue. There are currently no well-validated serum biomarkers in SSc, and…
Abstract Number: 2991 • 2015 ACR/ARHP Annual Meeting
Evaluation of Serum Levels of Adipokines and Interleukines in Pericardial Effusion Related to Systemic Sclerosis
Angela Chialà¹, Cinzia Rotondo¹, Maria Grazia Anelli¹, Emanuela Praino¹, Luca Cantarini², Crescenzio Scioscia¹, Margherita Giannini¹, Giovanni Lapadula¹ and Florenzo Iannone¹, ¹DIM, Rheumatology Unit, Bari, Italy, ²Univ Siena, Siena, Italy
Background/Purpose: Pericardial involvement is common in rheumatic disease, as rheumatoid arthritis, lupus erythematosus, mixed connective disease and systemic sclerosis. Few data are available about pathogenesis…
Abstract Number: 3014 • 2015 ACR/ARHP Annual Meeting
Endotrophin: A Novel Adipokine Linking Adipose Tissue and Skin Fibrosis in Systemic Sclerosis
Roberta Goncalves Marangoni¹, Jun Wei², Monique E. Hinchcliff¹, Philipp E. Scherer³ and John Varga², ¹Division of Rheumatology, Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ²Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ³University of Texas Southwestern Medical Center, Dallas, TX
Background/Purpose: Adipocytes and their progenitor cells are embedded in a network of extracellular matrix that plays a role in regulating its function. Type 6 collagen…
Abstract Number: 3059 • 2015 ACR/ARHP Annual Meeting
Abnormal Body Composition in Takayasu Arteritis Patients: Role of Inflammatory Cytokines and Adipokines
Thiago Ferreira da Silva, Mauricio Levy Neto, Valéria Caparbo, Liliam Takayama and Rosa M R Pereira, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
Background/Purpose: Chronic inflammatory conditions including rheumatic diseases may alter body composition, especially lean and fat mass. In this process, adipokines and inflammatory cytokines appear to…
Abstract Number: 3102 • 2015 ACR/ARHP Annual Meeting
Increasing Circulating Adiponectin after DMARD Initiation Is Associated with Radiographic Progression in Early Aggressive RA, Regardless of Treatment Strategy
Jon T. Giles¹, S. Louis Bridges Jr.², James R. O'Dell³, Stacey Cofield⁴, George Howard⁵, Jeffrey R. Curtis⁶ and Larry W. Moreland⁷, ¹Division of Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, ²Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ³Rheumatology, University of Nebraska Medical Center, Omaha, NE, ⁴School of Public Health, University of Alabama at Birmingham, Birmingham, AL, ⁵Biostatistics, The University of Alabama at Birmingham, Birmingham, AL, ⁶University of Alabama at Birmingham, Division of Clinical Immunology and Rheumatology, Birmingham, AL, ⁷Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Higher levels of circulating adiponectin have been linked to radiographic progression in RA in observational studies, but never studied in the context of early…
Abstract Number: 3250 • 2015 ACR/ARHP Annual Meeting
Systemic Inflammation and Pain Sensitization in Knee Osteoarthritis: The Multicenter Osteoarthritis Study
Tuhina Neogi¹, Laura Frey-Law², Devyani Misra¹, Michael C. Nevitt³, Lars Arendt-Nielsen⁴, Emily K. Quinn⁵ and Cora E. Lewis⁶, ¹Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ²UIowa, Iowa City, IA, ³Epidemiology and Biostatistics, UCSF, San Francisco, CA, ⁴Aalborg University, Aalborg, Denmark, ⁵Data Coordinating Center, Boston University School of Public Health, Boston, MA, ⁶Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Pain sensitization is associated with pain severity in knee osteoarthritis (OA), but its cause in humans is not well-understood. We recently demonstrated that local…
Abstract Number: 4 • 2015 ACR/ARHP Annual Meeting
The Influence of Adipokines on the Interaction of Rheumatoid Arthritis Synovial Fibroblasts with Endothelial Cells
Rebecca Hasseli¹, Klaus W. Frommer², Thomas Dr. Umscheid³, Markus Prof. Dr. Schönburg⁴, Stefan Rehart⁵, Ulf Müller-Ladner² and Elena Neumann², ¹Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, ²Internal Medicine and Rheumatology, Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, ³William Harvey Klinik; Bad Nauheim, Germany, Bad Nauheim, Germany, ⁴Department of Cardiac Surgery; Kerckhoff-Klinik, Bad Nauheim, Bad Nauheim, Germany, ⁵Orthopedics and Trauma Surgery, Markus-Hospital, Frankfurt, Germany
Background/Purpose: Rheumatoid Arthritis (RA) is a systemic chronic inflammatory disease. Adipose tissue, being an endocrine organ, plays an important role in inflammatory processes. Adipokines are…

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