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Abstracts tagged "Adipokines"

  • Abstract Number: 3054 • 2016 ACR/ARHP Annual Meeting

    The Impact of Obesity on Knee Osteoarthritis Symptoms and Related Biomarker Profiles in a Bariatric Surgery Cohort

    Thayer Mukherjee1, Fernando Bomfim2, Evan Wilder1, Lauren Browne3, Kayleigh Toth4, Shira Aharon4, Janice Lin4, Renata La Rocca Vieira5, Christine Ren-Fielding6, Manish Parikh7, Steven B. Abramson8, Mukundan Attur9 and Jonathan Samuels2, 1NYU Langone Medical Center, New York, NY, 2Rheumatology, NYU Langone Medical Center, New York, NY, 3NYU Langone Medical Center, Rheumat, New York, NY, 4NYU Langone Medical Center, Rheumatology, New York, NY, 5Department of Radiology, NYU Langone Medical Center, New York, NY, 6Department of Surgery, New York University School of Medicine, New York, NY, 7Department of Surgery, NYU Langone Medical Center, New York, NY, 8Dept of Rheumatology/Medicine, NYU Langone Medical Center, New York, NY, 9Rheumatology Research, NYU - Hospital for Joint Diseases, New York, NY

    Background/Purpose: Obesity is a common risk factor for knee osteoarthritis (KOA). While it is intuitive that bariatric weight loss improves knee pain, it is not…
  • Abstract Number: 3093 • 2016 ACR/ARHP Annual Meeting

    Comparison of Changes in Cardiovascular Risk-Associated Biomarkers in RA Patients Treated with Anti-TNF or Other Biological Agents: A Metabolic Study from a Randomized Trial

    Alexandre Virone1, Jean-Philippe Bastard2, Soraya Fellahi2, Jacqueline Capeau2, Stéphanie Rouanet3, Jean Sibilia4, Philippe Ravaud5, Francis Berenbaum6, Jacques-Eric Gottenberg7 and Jeremie Sellam6, 1Rheumatology, Rheumatology dept, APHP St-Antoine hospital, Univ Paris 06, Paris, France, Paris, France, 2APHP Hôpital Tenon, Sorbonne Universités, UPMC Univ Paris-6, Inserm UMR_S938, ICAN, DHU i2B, Paris, France, 3StatEthic, Levallois-Perret, France, 4Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France, 5Hôpital Hôtel Dieu, Paris, France, 6Rheumatology dept, APHP St-Antoine hospital, Univ Paris 06, Paris, France, Paris, France, 7Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France

    Background/Purpose: Considering the increased cardiovascular risk in RA patients and the influence of biologics, especially tocilizumab (TCZ) on the lipid profile, we aimed to investigate…
  • Abstract Number: 690 • 2016 ACR/ARHP Annual Meeting

    Increase in Serum Leptin Levels Is Associated with Radiographic Progression of Male Patients with Ankylosing Spondylitis: A 2-Year Longitudinal Study

    Seung-Geun Lee1, Eun-Kyoung Park2, Ji-Heh Park1, Hee-Sang Tag3 and Geun-Tae Kim4, 1Internal Medicine, Pusan National University School of Medicine, Pusan National University Hospital, Busan, Korea, The Republic of, 2Division of Rheumatology, Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea, The Republic of, 3Division of Rheumatology, Department of Internal Medicine, Kosin University College of Medicine, Busan, South Korea, 4Kosin University College of Medicine, Busan, South Korea

    Background/Purpose:  The immunomodulatory effects of adipokines have been extensively studied in rheumatic diseases, there is a paucity of information regarding their effects on bone metabolism.…
  • Abstract Number: 819 • 2016 ACR/ARHP Annual Meeting

    Impaired Adiponectin Signaling in SSc Contributes to Myofibroblast Differentiation and Organ Fibrosis

    Roberta Goncalves Marangoni1, Benjamin Korman2, Feng Fang1, Monique Hinchcliff1, Laszlo Otvos3, Philipp E. Scherer4, Warren Tourtellotte5 and John Varga6, 1Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL, 2Department of Rheumatology, Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL, 3Temple University, Philadelphia, PA, 4University of Texas Southwestern Medical Center, Dallas, TX, 5Department of Pathology, Ward, Northwestern University, Chicago, IL, 6Rheumatology and Dermatology, Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL

    Background/Purpose:  In systemic sclerosis (SSc) patients, skin fibrosis is accompanied by involution of dermal white adipose tissue (dWAT), a prominent source of adiponectin (APN). We…
  • Abstract Number: 4 • 2015 ACR/ARHP Annual Meeting

    The Influence of Adipokines on the Interaction of Rheumatoid Arthritis Synovial Fibroblasts with Endothelial Cells

    Rebecca Hasseli1, Klaus W. Frommer2, Thomas Dr. Umscheid3, Markus Prof. Dr. Schönburg4, Stefan Rehart5, Ulf Müller-Ladner2 and Elena Neumann2, 1Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, 2Internal Medicine and Rheumatology, Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, 3William Harvey Klinik; Bad Nauheim, Germany, Bad Nauheim, Germany, 4Department of Cardiac Surgery; Kerckhoff-Klinik, Bad Nauheim, Bad Nauheim, Germany, 5Orthopedics and Trauma Surgery, Markus-Hospital, Frankfurt, Germany

    Background/Purpose: Rheumatoid Arthritis (RA) is a systemic chronic inflammatory disease. Adipose tissue, being an endocrine organ, plays an important role in inflammatory processes. Adipokines are…
  • Abstract Number: 329 • 2015 ACR/ARHP Annual Meeting

    Serum Leptin and Risk of Knee Pain and Osteoarthritis: Multicenter Osteoarthritis Study

    Devyani Misra1, Jingbo Niu2, David T. Felson2, Michael C. Nevitt3, James Torner4, Cora E. Lewis5, Anyu Hu6, Sadao Jinno7 and Tuhina Neogi8, 1Medicine, Section of, BUSM, Boston, MA, 2Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, 3Epidemiology and Biostatistics, UCSF, San Francisco, CA, 4University of Iowa, UIowa, Iowa City, IA, 5Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL, 6Clinical Epidemiology Research Unit, Boston University School of Medicine, Boston, MA, 7BUSM, Boston, MA, 8Clinical Epidemiology, BUSM, Boston, MA

    Serum Leptin and Risk of Knee Pain and Osteoarthritis: Multicenter Osteoarthritis StudyD. Misra, J. Niu, D.T. Felson, M. Nevitt, J. Torner, C.E. Lewis, A. Hu,…
  • Abstract Number: 546 • 2015 ACR/ARHP Annual Meeting

    Adipokines and Insulin-like Growth Factor 1 As Predictors of Clinical and Radiographic Outcomes in Early Rheumatoid Arthritis

    Adrian Levitsky1, Kerstin Brismar2, Saedis Saevarsdottir3, Karen Hambardzumyan1, Anna Andersson1 and Ronald F. van Vollenhoven1, 1Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), The Karolinska Institute, Stockholm, Sweden, 2Department of Molecular Medicine and Surgery, Unit of Growth and Metabolism, The Karolinska Institute, Stockholm, Sweden, 3Department of Medicine, Rheumatology Unit, The Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden

    Background/Purpose: Adipokines are cytokines/hormones primarily synthesized in white adipose tissue. In rheumatoid arthritis (RA), some adipokines have been associated with worse outcomes (1-3). The aim…
  • Abstract Number: 1591 • 2015 ACR/ARHP Annual Meeting

    A Low Adiponectin Level in Rheumatoid Arthritis Is Associated with Coronary Artery Disease

    Jon Roger Eidet1, Ida G. Fostad2, Kelly J. Shields3, Torstein Lyberg1, Tor Paaske Utheim1, Anita Kåss4, Knut Mikkelsen5, Terje Veel6, Kjell Saatvedt7, Morten Wang Fagerland8, Matthew Liang9 and Ivana Hollan5, 1Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway, 2Department of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway, 3Medicine, Lupus Center of Excellence / Allegheny Health Network, Pittsburgh, PA, 4Rheumatology, Betanien Hospital, Skien, Norway, 5Lillehammer Hospital for Rheumatic Diseases, Lillehammer, Norway, 6Department of Cardiac Surgery, Feiring Heart Clinic, Feiring, Norway, 7Department of Cardiothoracic Surgery, Oslo University Hospital, Oslo, Norway, 8Department of Biostatistics, Oslo University Hospital, Oslo, Norway, 9Department of Rheumatology, Brigham and Women’ s Hospital, Boston, Boston, MA

    Background/Purpose: Adipokines exert pleiotropic actions, including immunoregulatory and matrix degrading effects. There is evidence of adipokine involvement in the pathogenesis of cardiovascular (CV) disease as…
  • Abstract Number: 1796 • 2015 ACR/ARHP Annual Meeting

    Progression of Atherosclerosis Might be Prevented By Decrease of Serum Resistin Level after Glucocorticoid Therapy in Patients with Systemic Autoimmune Disease

    Shotaro Masuoka, Nahoko Tanaka, Natsuko Kusunoki, Tatsuhiro Yamamoto, Kaichi Kaneko, Sei Muraoka, Makoto Kaburaki, Kotaro Shikano, Natsuki Fujio, Hiroshi Sato, Mai Kawazoe, Emiko Shindo, Soichi Yamada, Kenji Takagi, Toshihiro Nanki and Shinichi Kawai, Division of Rheumatology, Department of Internal Medicine, School of Medicine, Faculty of Medicine, Toho University, Tokyo, Japan

    Background/Purpose: Development of atherosclerosis is accelerated in patients with systemic autoimmune diseases. However, underlying mechanisms of accelerated atherosclerosis remains unknown, and the impact of pharmacotherapies…
  • Abstract Number: 1821 • 2015 ACR/ARHP Annual Meeting

    Leptin, Adiponectin, and Resistin As Serum Markers of Fatigue in Systemic Lupus Erythematosus: A Pilot Study

    Mary Mahieu1, Grace Ahn2, Joan S. Chmiel3, Dorothy D. Dunlop4, Irene Helenowski3, Pamela Semanik5, Jing Song4, Rowland W. Chang3 and Rosalind Ramsey-Goldman6, 1Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, 2Rheumatology, Falls Medical Specialists, Baltimore, MD, 3Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, 4Institute for Healthcare Studies, Northwestern University Feinberg School of Medicine, Chicago, IL, 5Nursing, Rush University College of Nursing, Chicago, IL, 6Northwestern University Feinberg School of Medicine, Chicago, IL

    Background/Purpose: Fatigue, a common symptom in systemic lupus erythematosus (SLE) patients, is ameliorated by physical activity. Adiposity and adipokines may be associated with patient-reported fatigue.…
  • Abstract Number: 1901 • 2015 ACR/ARHP Annual Meeting

    Association of Serum Adipokines Adipsin, Adiponectin, and Leptin/Adiponectin Ratio with Systemic Sclerosis

    Benjamin Korman1, Roberta Goncalves Marangoni1, Monique E. Hinchcliff2, Sanjiv Shah3, Mary A. Carns4, Rosalind Ramsey-Goldman5 and John Varga6, 1Division of Rheumatology, Northwestern University, Chicago, IL, 2Division of Rheumatology, Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, 3Northwestern University, Chicago, IL, 4Rheumatology, Northwestern University, Chicago, IL, 5Northwestern University Feinberg School of Medicine, Chicago, IL, 6Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL

    Background/Purpose: Patients with systemic sclerosis (SSc) display reductions in adipose tissue, particularly intradermal adipose tissue.  There are currently no well-validated serum biomarkers in SSc, and…
  • Abstract Number: 2991 • 2015 ACR/ARHP Annual Meeting

    Evaluation of Serum Levels of Adipokines and Interleukines in Pericardial Effusion Related to Systemic Sclerosis

    Angela Chialà1, Cinzia Rotondo1, Maria Grazia Anelli1, Emanuela Praino1, Luca Cantarini2, Crescenzio Scioscia1, Margherita Giannini1, Giovanni Lapadula1 and Florenzo Iannone1, 1DIM, Rheumatology Unit, Bari, Italy, 2Univ Siena, Siena, Italy

    Background/Purpose: Pericardial involvement is common in rheumatic disease, as rheumatoid arthritis, lupus erythematosus, mixed connective disease and systemic sclerosis. Few data are available about pathogenesis…
  • Abstract Number: 3014 • 2015 ACR/ARHP Annual Meeting

    Endotrophin: A Novel Adipokine Linking Adipose Tissue and Skin Fibrosis in Systemic Sclerosis

    Roberta Goncalves Marangoni1, Jun Wei2, Monique E. Hinchcliff1, Philipp E. Scherer3 and John Varga2, 1Division of Rheumatology, Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, 2Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, 3University of Texas Southwestern Medical Center, Dallas, TX

    Background/Purpose: Adipocytes and their progenitor cells are embedded in a network of extracellular matrix that plays a role in regulating its function. Type 6 collagen…
  • Abstract Number: 3059 • 2015 ACR/ARHP Annual Meeting

    Abnormal Body Composition in Takayasu Arteritis Patients: Role of Inflammatory Cytokines and Adipokines

    Thiago Ferreira da Silva, Mauricio Levy Neto, Valéria Caparbo, Liliam Takayama and Rosa M R Pereira, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

    Background/Purpose: Chronic inflammatory conditions including rheumatic diseases may alter body composition, especially lean and fat mass. In this process, adipokines and inflammatory cytokines appear to…
  • Abstract Number: 3102 • 2015 ACR/ARHP Annual Meeting

    Increasing Circulating Adiponectin after DMARD Initiation Is Associated with Radiographic Progression in Early Aggressive RA, Regardless of Treatment Strategy

    Jon T. Giles1, S. Louis Bridges Jr.2, James R. O'Dell3, Stacey Cofield4, George Howard5, Jeffrey R. Curtis6 and Larry W. Moreland7, 1Division of Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, 2Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 3Rheumatology, University of Nebraska Medical Center, Omaha, NE, 4School of Public Health, University of Alabama at Birmingham, Birmingham, AL, 5Biostatistics, The University of Alabama at Birmingham, Birmingham, AL, 6University of Alabama at Birmingham, Division of Clinical Immunology and Rheumatology, Birmingham, AL, 7Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Higher levels of circulating adiponectin have been linked to radiographic progression in RA in observational studies, but never studied in the context of early…
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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

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