ACR Meeting Abstracts

ACR Meeting Abstracts

  • Home
  • Meetings Archive
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP PRSYM
    • 2016-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • Register
    • View and print all favorites
    • Clear all your favorites
  • Meeting Resource Center

Abstract Number: 1363

Serum Adipokines in Juvenile Dermatomyositis Are Associated with Disease Activities and Cardiac Function

Birgit Nomeland Witczak1, Kristin Godang2, Thomas Schwartz3, Nicoleta Cristina Olarescu4, Berit Flatø5,6, Jens Bollerslev5,7, Ivar Sjaastad5,8,9 and Helga Sanner5,6, 1Oslo University Hospital, Institute for Experimental Medical Research, Oslo University Hospital, Oslo, Norway, Oslo, Norway, 2Department of Specialised Endocrinology, Oslo University Hospital, Section of Specialised Endocrinology, Department of Endocrinology, Oslo University Hospital, Rikshospitalet, Oslo, Norway, Oslo, Norway, 3Department of Infectious Diseases, Department of Infectious Diseases, Oslo University Hospital, Oslo, Norway, Oslo, Norway, 4Department of Endocrinology, Oslo University Hospital, Rikshospitalet, Oslo, Norway., Section of Specialised Endocrinology, Department of Endocrinology, Oslo University Hospital, Rikshospitalet, Oslo, Norway, Oslo, Norway, 5Institute for Clinical Medicine, University of Oslo, Oslo, Norway, Oslo, Norway, 6Department of Rheumatology, Oslo University Hospital, Rikshospitalet, Oslo, Norway, Oslo, Norway, 7Section of Specialised Endocrinology, Department of Endocrinology, Oslo University Hospital, Rikshospitalet, Oslo, Norway, Oslo, Norway, 8Department of Cardiology, Oslo University Hospital, Oslo, Norway, Oslo, Norway, 9Institute for Experimental Medical Research, Oslo University Hospital, Oslo, Norway, Oslo, Norway

Meeting: 2016 ACR/ARHP Annual Meeting

Date of first publication: September 28, 2016

Keywords: Adipokines, adipose tissue, cardiovascular disease and juvenile dermatomyositis

  • Tweet
  • Email
  • Print
Save to PDF
Session Information

Date: Monday, November 14, 2016

Session Title: Pediatric Rheumatology – Clinical and Therapeutic Aspects - Poster II: Myositis, Systemic Lupus Erythematosus, Sjögren's Syndrome

Session Type: ACR Poster Session B

Session Time: 9:00AM-11:00AM

Background/Purpose: We have earlier demonstrated redistribution of adipose tissue in JDM patients. There is an increase in visceral adipose tissue (VAT), a highly active metabolic organ producing adipokines which are involved in many inflammatory responses and cardiovascular complications. We aimed to investigate serum adipokine levels in JDM patients and controls, and explore the associations with disease activity and damage, VAT and cardiac function.

Methods: Fifty-nine patients with JDM and 59 age- and sex matched controls were included in a cross sectional study median 16.8years after disease onset. Body composition was analyzed by total body dual-energy X-ray absorptiometry (DXA). VAT (g) was quantified (DXA) only in individuals above 18 years. Serum adipokines, including pro-inflammatory (leptin and visfatin) and anti-inflammatory (adiponectin and apelin-12) analyzed by ELISA, were measured in serum drawn at follow-up. Long axis strain (LAS) and early diastolic tissue velocity (E’) assessed by echocardiography were used as markers for systolic and diastolic cardiac function, respectively. Inactive disease was measured by the PRINTO criteria, disease activity by DAS and disease damage by myositis damage index (MDI).

Results:  Leptin levels were higher in patients compared with controls (11.0ng/ml (IQR 4.4-25.2) vs 5.8ng/ml (IQR 3,0-14.7), p=0.010). Adiponectin was lower, but not significant in patients vs. controls (IQR 4.3microgr/ml (IQR 2.7-6.1) vs 5.5microgr/ml (IQR 3.7-6.9), p 0.091). Apelin-12 (0.8 ng/ml (IQR 0.7-1.3) vs 0.7 (IQR 0.6-0.9), p=0.005) and visfatin levels (5.7ng/ml (IQR 4.1-8.1) vs 4.2 (IQR 4.0-6.0), p=0.032) were higher in patients with active than inactive disease. Disease duration, lipodystrophy and calcinosis at follow-up correlated negatively with adiponectin (rsp-0.464, p=0.000; rsp -0.447, p=0.000 and rsp-0.358, p=0.005). Leptin correlated with DAS muscle at follow-up (rsp 0.284, p=0.029). MDI total at follow-up correlated negatively with adiponectin (rsp -0.315, p=0.015). VAT correlated negatively with adiponectin in all patients, with active and inactive disease and also with controls (rsp -0.578, p=0.000; rsp -0.647, p=0.004; rsp -0.492, p=0.028 and rsp -0.445, p=0.007 respectively). LAS and E’ correlated positively with both adiponectin (rsp 0.534, p=0.008 and rsp 0.435, p=0.001) and apelin-12 (rsp 0.347, p=0.007 and rsp 0.279, p=0.034). Leptin correlated with diastolic blood pressure (BP), whereas adiponectin correlated negatively with systolic and diastolic BP, numbers not given.

Conclusion: The pro-inflammatory adipokines leptin and visfatin are elevated in JDM patients and in the subgroup with active disease, respectively. Leptin is associated with higher DAS and elevated blood pressure. Lower levels of anti-inflammatory adipokines (adiponectin and apelin-12) were associated with higher VAT, higher disease activity, higher BP and impaired cardiac function. Our finding suggests that increased VAT and imbalanced adipokine secretion is involved in disease activity and cardiovascular abnormalities in JDM.


Disclosure: B. N. Witczak, None; K. Godang, None; T. Schwartz, None; N. C. Olarescu, None; B. Flatø, None; J. Bollerslev, None; I. Sjaastad, None; H. Sanner, None.

To cite this abstract in AMA style:

Witczak BN, Godang K, Schwartz T, Olarescu NC, Flatø B, Bollerslev J, Sjaastad I, Sanner H. Serum Adipokines in Juvenile Dermatomyositis Are Associated with Disease Activities and Cardiac Function [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/serum-adipokines-in-juvenile-dermatomyositis-are-associated-with-disease-activities-and-cardiac-function/. Accessed March 1, 2021.
  • Tweet
  • Email
  • Print
Save to PDF

« Back to 2016 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/serum-adipokines-in-juvenile-dermatomyositis-are-associated-with-disease-activities-and-cardiac-function/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

© COPYRIGHT 2021 AMERICAN COLLEGE OF RHEUMATOLOGY

Wiley

  • Home
  • Meetings Archive
  • Advanced Search
  • Meeting Resource Center
  • Online Journal
  • Privacy Policy
  • Permissions Policies
loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.