Abstracts tagged "Adipokines"

Abstract Number: 1267 • 2018 ACR/ARHP Annual Meeting
The Association between Clinically Suspect Arthralgia and Adipokines in Obese Patients
Taskin Senturk¹, Reyhan Kose¹, Gokhan Sargin¹, Songul Cildag², Mustafa Unubol³, Burçin İrem Abas⁴ and Cigdem Yenisey⁴, ¹Rheumatology, Adnan Menderes University Medical School, Aydin, Turkey, ²Allergy and Immunology, Adnan Menderes University Medical School, Aydin, Turkey, ³Endocrinology and Metabolism, Adnan Menderes University Medical School, Aydin, Turkey, ⁴Biochemistry, Adnan Menderes University Medical School, Aydin, Turkey
Background/Purpose: Obesity is a moderate low-grade chronic inflammatory condition. Also, it has been reported to be a risk factor for inflammatory rheumatic diseases, seronegative inflammatory…
Abstract Number: 1907 • 2018 ACR/ARHP Annual Meeting
High Serum Adiponectin Associates with the Incidence of Rheumatoid Arthritis in Obese Subjects
Cristina Maglio¹, Yuan Zhang², Christian Herder³, Anna Rudin⁴ and Lena Carlsson⁵, ¹Dep. of Rheumatology and Inflammation Research and Wallenberg Centre for Molecular and Translational Medicine, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, ²Dep. of Rheumatology and Inflammation Research, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, ³German Diabetes Center, Düsseldorf, Germany, ⁴Dept of Rheumatology and Inflammation Research, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, ⁵Department of Molecular and Clinical Medicine, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
Background/Purpose: Adiponectin, a cytokine mainly produced by the adipose tissue, plays an important role in several metabolic and inflammatory processes. In obese subjects, serum adiponectin…
Abstract Number: 1935 • 2017 ACR/ARHP Annual Meeting
Influence of Adipokines on the Differentiation of Spongiosa-Derived Mesenchymal Stromal Cells from Osteoporosis and Osteoarthritis Patients
Lali Tsiklauri¹, Janina Werner², Klaus W. Frommer¹, Rosel Engel³, Stefan Rehart⁴, Sabine Wenisch², Ulf Müller-Ladner⁵ and Elena Neumann¹, ¹Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad Nauheim, Germany, ²Justus-Liebig-University Giessen, Institute of Veterinary-Anatomy, -Histology and –Embryology, Clinic of Small Animals, Giessen Germany, Giessen, Germany, ³Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad nauheim, Germany, ⁴Orthopedic & Trauma Surgery, Agaplesion Markus-Hospital, Frankfurt, Frankfurt, Germany, ⁵Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad-Nauheim, Germany
Background/Purpose: Osteoporosis predominantly affects elderly people and is characterized by bone loss, increased fracture risk and reduced regeneration ability. An inverse relationship between bone marrow…
Abstract Number: 2209 • 2017 ACR/ARHP Annual Meeting
Leptin and Adiponectin Mediate the Association between Body Mass Index and Hand and Knee Osteoarthritis
F.P.B. Kroon¹, A. Veenbrink¹, R. de Mutsert², A.W. Visser¹, Saskia le Cessie³, F.R. Rosendaal² and M. Kloppenburg^1,2, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands, ³Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Associations between obesity and osteoarthritis (OA) in non-weight bearing joints suggest that systemic influences also contribute to OA. Systemically active substances secreted by adipose…
Abstract Number: 2984 • 2017 ACR/ARHP Annual Meeting
Predictive Value of a Combined Index for Weight Loss in Systemic Sclerosis
Gianluca Bagnato¹, Erika Pigatto², Alessandra Bitto¹, Carmelo Pizzino¹, Natasha Irrera¹, Giuseppina Abignano³, MIchele Hutchinson⁴, Francesco Squadrito¹, Maya H. Buch⁵, Sebastiano Gangemi¹, William Neal Roberts⁶, Antonino Saitta¹, Franco Cozzi⁷ and Francesco Del Galdo⁸, ¹University of Messina, Messina, Italy, ²University of Padova, Padova, Italy, ³Rheumatology Department of Lucania,, Rheumatology Institute of Lucania (IReL), San Carlo Hospital of Potenza and Madonna delle Grazie Hospital of Matera,, Potenza, Italy, ⁴University of Leeds, Leeds, United Kingdom, ⁵NIHR-Leeds Musculoskeletal Biomedical Research Unit, Leeds, United Kingdom, ⁶University of Louisville, Louisville, LA, ⁷Division of Rheumatology, Rheumatology Unit, Department of Medicine, University of Padova, Padova, Italy, ⁸Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
Background/Purpose: Malnutrition and severe gastrointestinal (GI) dysfunction are the cause of mortality in 4-15% of systemic sclerosis (SSc) patients whereas overall GI involvement is observed…
Abstract Number: 51 • 2017 ACR/ARHP Annual Meeting
Irisin Ameliorates Infrapatellar Adiposity in Knee Osteoarthritis Pathogenesis By Orchestrating Adipokine Signaling
Feng-Sheng Wang¹, Yi-Chih Sun¹ and Jih-Yang Ko², ¹Core Facility for Phenomics & Diagnostics, Department of Medical Research, Core Facility for Phenomics & Diagnostics, Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital, Taiwan, Kaohsiung, Taiwan, ²Department of Orthopedic Surgery, Department of Orthopedic Surgery, Kaohsiung Chang Gung Memorial Hospital, Taiwan, Kaohsiung, Taiwan
Background/Purpose: Aberrant infrapatellar fat metabolism is a prominent feature that exacerbates inflammation and fibrosis relative to joint deterioration during osteoarthritis (OA). Irisin, a secretory subunit…
Abstract Number: 1414 • 2017 ACR/ARHP Annual Meeting
Stimulation with Resistin Upregulates Chemokine Production By Fibroblast-like Synoviocytes from Patients with Rheumtoid Arthritis
Hiroshi Sato¹, Sei Muraoka¹, Natsuko Kusunoki¹, Shotaro Masuoka¹, Soichi Yamada¹, Toshio Imai², Shinichi Kawai³ and Toshihiro Nanki¹, ¹Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan, ²KAN Research Institute, Inc., Kobe, Japan, ³Department of Inflammation and Pain Control Research, Toho University School of Medicine, Tokyo, Japan
Background/Purpose: Adipose tissue synthesizes and releases physiologically active molecules that are known as adipokines. Resistin, an adipokine, has been widely studied the regulation of glucose…
Abstract Number: 5 • 2017 Pediatric Rheumatology Symposium
Effects of Puberty on Systemic Lupus Erythematosus: Results of a multi-center prospective longitudinal observational study in children entering puberty with SLE
Kathleen O'Neil¹, Hermine Brunner², Andrew Zeft³, Anne Stevens⁴, Suzanne Li⁵, Tracey Wright⁶, Emily von Scheven⁷, B. Anne Eberhard⁸, C. Egla Rabinovich⁹ and Deborah M. Levy¹⁰, ¹Pediatrics, Indiana University, Indianapolis, IN, ²Rheumatology, PRCSG, Cincinnati, OH, ³Pediatrics Rheumatology, Cleveland Clinic, Cleveland, OH, ⁴University of Washington, Department of Pediatrics, Seattle, WA, ⁵Pediatrics, Joseph M Sanzari Children’s Hospital, Hackensack Meridian Health, Hackensack, NJ, ⁶Pediatrics/Rheumatology, University of TX Southwestern, Dallas, TX, ⁷Division of Rheumatology, Department of Pediatrics, University of California San Francisco, San Francisco, CA, ⁸Cohen Children's Medical Center of New York, New Hyde Park, NY, ⁹Pediatric Rheumatology, Duke University Medical Center, Durham, NC, ¹⁰Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada
Background/Purpose: Lupus often presents during puberty, and when it affects pre-pubertal children, disease activity is thought to increase at puberty. Sex hormones play some role…
Abstract Number: 690 • 2016 ACR/ARHP Annual Meeting
Increase in Serum Leptin Levels Is Associated with Radiographic Progression of Male Patients with Ankylosing Spondylitis: A 2-Year Longitudinal Study
Seung-Geun Lee¹, Eun-Kyoung Park², Ji-Heh Park¹, Hee-Sang Tag³ and Geun-Tae Kim⁴, ¹Internal Medicine, Pusan National University School of Medicine, Pusan National University Hospital, Busan, Korea, The Republic of, ²Division of Rheumatology, Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea, The Republic of, ³Division of Rheumatology, Department of Internal Medicine, Kosin University College of Medicine, Busan, South Korea, ⁴Kosin University College of Medicine, Busan, South Korea
Background/Purpose: The immunomodulatory effects of adipokines have been extensively studied in rheumatic diseases, there is a paucity of information regarding their effects on bone metabolism.…
Abstract Number: 819 • 2016 ACR/ARHP Annual Meeting
Impaired Adiponectin Signaling in SSc Contributes to Myofibroblast Differentiation and Organ Fibrosis
Roberta Goncalves Marangoni¹, Benjamin Korman², Feng Fang¹, Monique Hinchcliff¹, Laszlo Otvos³, Philipp E. Scherer⁴, Warren Tourtellotte⁵ and John Varga⁶, ¹Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL, ²Department of Rheumatology, Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL, ³Temple University, Philadelphia, PA, ⁴University of Texas Southwestern Medical Center, Dallas, TX, ⁵Department of Pathology, Ward, Northwestern University, Chicago, IL, ⁶Rheumatology and Dermatology, Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL
Background/Purpose: In systemic sclerosis (SSc) patients, skin fibrosis is accompanied by involution of dermal white adipose tissue (dWAT), a prominent source of adiponectin (APN). We…
Abstract Number: 1102 • 2016 ACR/ARHP Annual Meeting
Differentiation of Spongiosa-Derived Mesenchymal Stromal Cells from Osteoporosis and Osteoarthritis Patients Are Influenced By Adipokines
Lali Tsiklauri¹, Janina Werner², Klaus W. Frommer¹, Ulf Müller-Ladner³, Stefan Rehart⁴, Sabine Wenisch² and Elena Neumann¹, ¹Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad Nauheim, Germany, ²Justus-Liebig-University Giessen, Institute of Veterinary-Anatomy, -Histology and –Embryology, Clinic of Small Animals, Giessen Germany, Giessen, Germany, ³Department of Internal Medicine and Rheumatology, Justus-Liebig-University Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, ⁴Orthopedic & Trauma Surgery, Agaplesion Markus-Hospital, Frankfurt, Frankfurt, Germany
Background/Purpose: Osteoporosis is characterized by bone loss, increased fracture risk and reduced regeneration ability. Age-related bone loss leading to osteoporosis correlates with increased bone marrow…
Abstract Number: 1363 • 2016 ACR/ARHP Annual Meeting
Serum Adipokines in Juvenile Dermatomyositis Are Associated with Disease Activities and Cardiac Function
Birgit Nomeland Witczak¹, Kristin Godang², Thomas Schwartz³, Nicoleta Cristina Olarescu⁴, Berit Flatø^5,6, Jens Bollerslev^5,7, Ivar Sjaastad^5,8,9 and Helga Sanner^5,6, ¹Oslo University Hospital, Institute for Experimental Medical Research, Oslo University Hospital, Oslo, Norway, Oslo, Norway, ²Department of Specialised Endocrinology, Oslo University Hospital, Section of Specialised Endocrinology, Department of Endocrinology, Oslo University Hospital, Rikshospitalet, Oslo, Norway, Oslo, Norway, ³Department of Infectious Diseases, Department of Infectious Diseases, Oslo University Hospital, Oslo, Norway, Oslo, Norway, ⁴Department of Endocrinology, Oslo University Hospital, Rikshospitalet, Oslo, Norway., Section of Specialised Endocrinology, Department of Endocrinology, Oslo University Hospital, Rikshospitalet, Oslo, Norway, Oslo, Norway, ⁵Institute for Clinical Medicine, University of Oslo, Oslo, Norway, Oslo, Norway, ⁶Department of Rheumatology, Oslo University Hospital, Rikshospitalet, Oslo, Norway, Oslo, Norway, ⁷Section of Specialised Endocrinology, Department of Endocrinology, Oslo University Hospital, Rikshospitalet, Oslo, Norway, Oslo, Norway, ⁸Department of Cardiology, Oslo University Hospital, Oslo, Norway, Oslo, Norway, ⁹Institute for Experimental Medical Research, Oslo University Hospital, Oslo, Norway, Oslo, Norway
Background/Purpose: We have earlier demonstrated redistribution of adipose tissue in JDM patients. There is an increase in visceral adipose tissue (VAT), a highly active metabolic…
Abstract Number: 2149 • 2016 ACR/ARHP Annual Meeting
Adipokines Alter the Interaction Between Rheumatoid Arthritis Synovial Fibroblasts Adhesion and Endothelial Cells
Rebecca Hasseli¹, Klaus W. Frommer², Markus Prof. Dr. Schönburg³, Stefan Prof. Dr. Rehart⁴, Ulf Müller-Ladner^5,6 and Elena Neumann², ¹Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, ²Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad Nauheim, Germany, ³Department of Cardiac Surgery; Kerckhoff-Klinik, Bad Nauheim, Bad Nauheim, Germany, ⁴Department of Orthopedics and Trauma Surgery, Markus Hospital, Frankfurt, Frankfurt, Germany, ⁵Department of Internal Medicine and Rheumatology, Justus-Liebig-University Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, ⁶Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad-Nauheim, Germany
Background/Purpose: Synovial fibroblast plays a key role in rheumatoid arthritis (RA), which is a chronic polyarticular inflammatory disease. SF are able to migrate long distances…
Abstract Number: 3054 • 2016 ACR/ARHP Annual Meeting
The Impact of Obesity on Knee Osteoarthritis Symptoms and Related Biomarker Profiles in a Bariatric Surgery Cohort
Thayer Mukherjee¹, Fernando Bomfim², Evan Wilder¹, Lauren Browne³, Kayleigh Toth⁴, Shira Aharon⁴, Janice Lin⁴, Renata La Rocca Vieira⁵, Christine Ren-Fielding⁶, Manish Parikh⁷, Steven B. Abramson⁸, Mukundan Attur⁹ and Jonathan Samuels², ¹NYU Langone Medical Center, New York, NY, ²Rheumatology, NYU Langone Medical Center, New York, NY, ³NYU Langone Medical Center, Rheumat, New York, NY, ⁴NYU Langone Medical Center, Rheumatology, New York, NY, ⁵Department of Radiology, NYU Langone Medical Center, New York, NY, ⁶Department of Surgery, New York University School of Medicine, New York, NY, ⁷Department of Surgery, NYU Langone Medical Center, New York, NY, ⁸Dept of Rheumatology/Medicine, NYU Langone Medical Center, New York, NY, ⁹Rheumatology Research, NYU - Hospital for Joint Diseases, New York, NY
Background/Purpose: Obesity is a common risk factor for knee osteoarthritis (KOA). While it is intuitive that bariatric weight loss improves knee pain, it is not…
Abstract Number: 3093 • 2016 ACR/ARHP Annual Meeting
Comparison of Changes in Cardiovascular Risk-Associated Biomarkers in RA Patients Treated with Anti-TNF or Other Biological Agents: A Metabolic Study from a Randomized Trial
Alexandre Virone¹, Jean-Philippe Bastard², Soraya Fellahi², Jacqueline Capeau², Stéphanie Rouanet³, Jean Sibilia⁴, Philippe Ravaud⁵, Francis Berenbaum⁶, Jacques-Eric Gottenberg⁷ and Jeremie Sellam⁶, ¹Rheumatology, Rheumatology dept, APHP St-Antoine hospital, Univ Paris 06, Paris, France, Paris, France, ²APHP Hôpital Tenon, Sorbonne Universités, UPMC Univ Paris-6, Inserm UMR_S938, ICAN, DHU i2B, Paris, France, ³StatEthic, Levallois-Perret, France, ⁴Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France, ⁵Hôpital Hôtel Dieu, Paris, France, ⁶Rheumatology dept, APHP St-Antoine hospital, Univ Paris 06, Paris, France, Paris, France, ⁷Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France
Background/Purpose: Considering the increased cardiovascular risk in RA patients and the influence of biologics, especially tocilizumab (TCZ) on the lipid profile, we aimed to investigate…