Abstracts tagged "Adipokines"

Abstract Number: 1935 • 2017 ACR/ARHP Annual Meeting
Influence of Adipokines on the Differentiation of Spongiosa-Derived Mesenchymal Stromal Cells from Osteoporosis and Osteoarthritis Patients
Lali Tsiklauri¹, Janina Werner², Klaus W. Frommer¹, Rosel Engel³, Stefan Rehart⁴, Sabine Wenisch², Ulf Müller-Ladner⁵ and Elena Neumann¹, ¹Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad Nauheim, Germany, ²Justus-Liebig-University Giessen, Institute of Veterinary-Anatomy, -Histology and –Embryology, Clinic of Small Animals, Giessen Germany, Giessen, Germany, ³Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad nauheim, Germany, ⁴Orthopedic & Trauma Surgery, Agaplesion Markus-Hospital, Frankfurt, Frankfurt, Germany, ⁵Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad-Nauheim, Germany
Background/Purpose: Osteoporosis predominantly affects elderly people and is characterized by bone loss, increased fracture risk and reduced regeneration ability. An inverse relationship between bone marrow…
Abstract Number: 2209 • 2017 ACR/ARHP Annual Meeting
Leptin and Adiponectin Mediate the Association between Body Mass Index and Hand and Knee Osteoarthritis
F.P.B. Kroon¹, A. Veenbrink¹, R. de Mutsert², A.W. Visser¹, Saskia le Cessie³, F.R. Rosendaal² and M. Kloppenburg^1,2, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands, ³Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Associations between obesity and osteoarthritis (OA) in non-weight bearing joints suggest that systemic influences also contribute to OA. Systemically active substances secreted by adipose…
Abstract Number: 2984 • 2017 ACR/ARHP Annual Meeting
Predictive Value of a Combined Index for Weight Loss in Systemic Sclerosis
Gianluca Bagnato¹, Erika Pigatto², Alessandra Bitto¹, Carmelo Pizzino¹, Natasha Irrera¹, Giuseppina Abignano³, MIchele Hutchinson⁴, Francesco Squadrito¹, Maya H. Buch⁵, Sebastiano Gangemi¹, William Neal Roberts⁶, Antonino Saitta¹, Franco Cozzi⁷ and Francesco Del Galdo⁸, ¹University of Messina, Messina, Italy, ²University of Padova, Padova, Italy, ³Rheumatology Department of Lucania,, Rheumatology Institute of Lucania (IReL), San Carlo Hospital of Potenza and Madonna delle Grazie Hospital of Matera,, Potenza, Italy, ⁴University of Leeds, Leeds, United Kingdom, ⁵NIHR-Leeds Musculoskeletal Biomedical Research Unit, Leeds, United Kingdom, ⁶University of Louisville, Louisville, LA, ⁷Division of Rheumatology, Rheumatology Unit, Department of Medicine, University of Padova, Padova, Italy, ⁸Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
Background/Purpose: Malnutrition and severe gastrointestinal (GI) dysfunction are the cause of mortality in 4-15% of systemic sclerosis (SSc) patients whereas overall GI involvement is observed…
Abstract Number: 51 • 2017 ACR/ARHP Annual Meeting
Irisin Ameliorates Infrapatellar Adiposity in Knee Osteoarthritis Pathogenesis By Orchestrating Adipokine Signaling
Feng-Sheng Wang¹, Yi-Chih Sun¹ and Jih-Yang Ko², ¹Core Facility for Phenomics & Diagnostics, Department of Medical Research, Core Facility for Phenomics & Diagnostics, Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital, Taiwan, Kaohsiung, Taiwan, ²Department of Orthopedic Surgery, Department of Orthopedic Surgery, Kaohsiung Chang Gung Memorial Hospital, Taiwan, Kaohsiung, Taiwan
Background/Purpose: Aberrant infrapatellar fat metabolism is a prominent feature that exacerbates inflammation and fibrosis relative to joint deterioration during osteoarthritis (OA). Irisin, a secretory subunit…
Abstract Number: 1414 • 2017 ACR/ARHP Annual Meeting
Stimulation with Resistin Upregulates Chemokine Production By Fibroblast-like Synoviocytes from Patients with Rheumtoid Arthritis
Hiroshi Sato¹, Sei Muraoka¹, Natsuko Kusunoki¹, Shotaro Masuoka¹, Soichi Yamada¹, Toshio Imai², Shinichi Kawai³ and Toshihiro Nanki¹, ¹Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan, ²KAN Research Institute, Inc., Kobe, Japan, ³Department of Inflammation and Pain Control Research, Toho University School of Medicine, Tokyo, Japan
Background/Purpose: Adipose tissue synthesizes and releases physiologically active molecules that are known as adipokines. Resistin, an adipokine, has been widely studied the regulation of glucose…
Abstract Number: 5 • 2017 Pediatric Rheumatology Symposium
Effects of Puberty on Systemic Lupus Erythematosus: Results of a multi-center prospective longitudinal observational study in children entering puberty with SLE
Kathleen O'Neil¹, Hermine Brunner², Andrew Zeft³, Anne Stevens⁴, Suzanne Li⁵, Tracey Wright⁶, Emily von Scheven⁷, B. Anne Eberhard⁸, C. Egla Rabinovich⁹ and Deborah M. Levy¹⁰, ¹Pediatrics, Indiana University, Indianapolis, IN, ²Rheumatology, PRCSG, Cincinnati, OH, ³Pediatrics Rheumatology, Cleveland Clinic, Cleveland, OH, ⁴University of Washington, Department of Pediatrics, Seattle, WA, ⁵Pediatrics, Joseph M Sanzari Children’s Hospital, Hackensack Meridian Health, Hackensack, NJ, ⁶Pediatrics/Rheumatology, University of TX Southwestern, Dallas, TX, ⁷Division of Rheumatology, Department of Pediatrics, University of California San Francisco, San Francisco, CA, ⁸Cohen Children's Medical Center of New York, New Hyde Park, NY, ⁹Pediatric Rheumatology, Duke University Medical Center, Durham, NC, ¹⁰Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada
Background/Purpose: Lupus often presents during puberty, and when it affects pre-pubertal children, disease activity is thought to increase at puberty. Sex hormones play some role…
Abstract Number: 690 • 2016 ACR/ARHP Annual Meeting
Increase in Serum Leptin Levels Is Associated with Radiographic Progression of Male Patients with Ankylosing Spondylitis: A 2-Year Longitudinal Study
Seung-Geun Lee¹, Eun-Kyoung Park², Ji-Heh Park¹, Hee-Sang Tag³ and Geun-Tae Kim⁴, ¹Internal Medicine, Pusan National University School of Medicine, Pusan National University Hospital, Busan, Korea, The Republic of, ²Division of Rheumatology, Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea, The Republic of, ³Division of Rheumatology, Department of Internal Medicine, Kosin University College of Medicine, Busan, South Korea, ⁴Kosin University College of Medicine, Busan, South Korea
Background/Purpose: The immunomodulatory effects of adipokines have been extensively studied in rheumatic diseases, there is a paucity of information regarding their effects on bone metabolism.…
Abstract Number: 819 • 2016 ACR/ARHP Annual Meeting
Impaired Adiponectin Signaling in SSc Contributes to Myofibroblast Differentiation and Organ Fibrosis
Roberta Goncalves Marangoni¹, Benjamin Korman², Feng Fang¹, Monique Hinchcliff¹, Laszlo Otvos³, Philipp E. Scherer⁴, Warren Tourtellotte⁵ and John Varga⁶, ¹Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL, ²Department of Rheumatology, Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL, ³Temple University, Philadelphia, PA, ⁴University of Texas Southwestern Medical Center, Dallas, TX, ⁵Department of Pathology, Ward, Northwestern University, Chicago, IL, ⁶Rheumatology and Dermatology, Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL
Background/Purpose: In systemic sclerosis (SSc) patients, skin fibrosis is accompanied by involution of dermal white adipose tissue (dWAT), a prominent source of adiponectin (APN). We…
Abstract Number: 1102 • 2016 ACR/ARHP Annual Meeting
Differentiation of Spongiosa-Derived Mesenchymal Stromal Cells from Osteoporosis and Osteoarthritis Patients Are Influenced By Adipokines
Lali Tsiklauri¹, Janina Werner², Klaus W. Frommer¹, Ulf Müller-Ladner³, Stefan Rehart⁴, Sabine Wenisch² and Elena Neumann¹, ¹Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad Nauheim, Germany, ²Justus-Liebig-University Giessen, Institute of Veterinary-Anatomy, -Histology and –Embryology, Clinic of Small Animals, Giessen Germany, Giessen, Germany, ³Department of Internal Medicine and Rheumatology, Justus-Liebig-University Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, ⁴Orthopedic & Trauma Surgery, Agaplesion Markus-Hospital, Frankfurt, Frankfurt, Germany
Background/Purpose: Osteoporosis is characterized by bone loss, increased fracture risk and reduced regeneration ability. Age-related bone loss leading to osteoporosis correlates with increased bone marrow…
Abstract Number: 1363 • 2016 ACR/ARHP Annual Meeting
Serum Adipokines in Juvenile Dermatomyositis Are Associated with Disease Activities and Cardiac Function
Birgit Nomeland Witczak¹, Kristin Godang², Thomas Schwartz³, Nicoleta Cristina Olarescu⁴, Berit Flatø^5,6, Jens Bollerslev^5,7, Ivar Sjaastad^5,8,9 and Helga Sanner^5,6, ¹Oslo University Hospital, Institute for Experimental Medical Research, Oslo University Hospital, Oslo, Norway, Oslo, Norway, ²Department of Specialised Endocrinology, Oslo University Hospital, Section of Specialised Endocrinology, Department of Endocrinology, Oslo University Hospital, Rikshospitalet, Oslo, Norway, Oslo, Norway, ³Department of Infectious Diseases, Department of Infectious Diseases, Oslo University Hospital, Oslo, Norway, Oslo, Norway, ⁴Department of Endocrinology, Oslo University Hospital, Rikshospitalet, Oslo, Norway., Section of Specialised Endocrinology, Department of Endocrinology, Oslo University Hospital, Rikshospitalet, Oslo, Norway, Oslo, Norway, ⁵Institute for Clinical Medicine, University of Oslo, Oslo, Norway, Oslo, Norway, ⁶Department of Rheumatology, Oslo University Hospital, Rikshospitalet, Oslo, Norway, Oslo, Norway, ⁷Section of Specialised Endocrinology, Department of Endocrinology, Oslo University Hospital, Rikshospitalet, Oslo, Norway, Oslo, Norway, ⁸Department of Cardiology, Oslo University Hospital, Oslo, Norway, Oslo, Norway, ⁹Institute for Experimental Medical Research, Oslo University Hospital, Oslo, Norway, Oslo, Norway
Background/Purpose: We have earlier demonstrated redistribution of adipose tissue in JDM patients. There is an increase in visceral adipose tissue (VAT), a highly active metabolic…
Abstract Number: 2149 • 2016 ACR/ARHP Annual Meeting
Adipokines Alter the Interaction Between Rheumatoid Arthritis Synovial Fibroblasts Adhesion and Endothelial Cells
Rebecca Hasseli¹, Klaus W. Frommer², Markus Prof. Dr. Schönburg³, Stefan Prof. Dr. Rehart⁴, Ulf Müller-Ladner^5,6 and Elena Neumann², ¹Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, ²Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad Nauheim, Germany, ³Department of Cardiac Surgery; Kerckhoff-Klinik, Bad Nauheim, Bad Nauheim, Germany, ⁴Department of Orthopedics and Trauma Surgery, Markus Hospital, Frankfurt, Frankfurt, Germany, ⁵Department of Internal Medicine and Rheumatology, Justus-Liebig-University Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, ⁶Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad-Nauheim, Germany
Background/Purpose: Synovial fibroblast plays a key role in rheumatoid arthritis (RA), which is a chronic polyarticular inflammatory disease. SF are able to migrate long distances…
Abstract Number: 3054 • 2016 ACR/ARHP Annual Meeting
The Impact of Obesity on Knee Osteoarthritis Symptoms and Related Biomarker Profiles in a Bariatric Surgery Cohort
Thayer Mukherjee¹, Fernando Bomfim², Evan Wilder¹, Lauren Browne³, Kayleigh Toth⁴, Shira Aharon⁴, Janice Lin⁴, Renata La Rocca Vieira⁵, Christine Ren-Fielding⁶, Manish Parikh⁷, Steven B. Abramson⁸, Mukundan Attur⁹ and Jonathan Samuels², ¹NYU Langone Medical Center, New York, NY, ²Rheumatology, NYU Langone Medical Center, New York, NY, ³NYU Langone Medical Center, Rheumat, New York, NY, ⁴NYU Langone Medical Center, Rheumatology, New York, NY, ⁵Department of Radiology, NYU Langone Medical Center, New York, NY, ⁶Department of Surgery, New York University School of Medicine, New York, NY, ⁷Department of Surgery, NYU Langone Medical Center, New York, NY, ⁸Dept of Rheumatology/Medicine, NYU Langone Medical Center, New York, NY, ⁹Rheumatology Research, NYU - Hospital for Joint Diseases, New York, NY
Background/Purpose: Obesity is a common risk factor for knee osteoarthritis (KOA). While it is intuitive that bariatric weight loss improves knee pain, it is not…
Abstract Number: 3093 • 2016 ACR/ARHP Annual Meeting
Comparison of Changes in Cardiovascular Risk-Associated Biomarkers in RA Patients Treated with Anti-TNF or Other Biological Agents: A Metabolic Study from a Randomized Trial
Alexandre Virone¹, Jean-Philippe Bastard², Soraya Fellahi², Jacqueline Capeau², Stéphanie Rouanet³, Jean Sibilia⁴, Philippe Ravaud⁵, Francis Berenbaum⁶, Jacques-Eric Gottenberg⁷ and Jeremie Sellam⁶, ¹Rheumatology, Rheumatology dept, APHP St-Antoine hospital, Univ Paris 06, Paris, France, Paris, France, ²APHP Hôpital Tenon, Sorbonne Universités, UPMC Univ Paris-6, Inserm UMR_S938, ICAN, DHU i2B, Paris, France, ³StatEthic, Levallois-Perret, France, ⁴Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France, ⁵Hôpital Hôtel Dieu, Paris, France, ⁶Rheumatology dept, APHP St-Antoine hospital, Univ Paris 06, Paris, France, Paris, France, ⁷Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France
Background/Purpose: Considering the increased cardiovascular risk in RA patients and the influence of biologics, especially tocilizumab (TCZ) on the lipid profile, we aimed to investigate…
Abstract Number: 1821 • 2015 ACR/ARHP Annual Meeting
Leptin, Adiponectin, and Resistin As Serum Markers of Fatigue in Systemic Lupus Erythematosus: A Pilot Study
Mary Mahieu¹, Grace Ahn², Joan S. Chmiel³, Dorothy D. Dunlop⁴, Irene Helenowski³, Pamela Semanik⁵, Jing Song⁴, Rowland W. Chang³ and Rosalind Ramsey-Goldman⁶, ¹Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Rheumatology, Falls Medical Specialists, Baltimore, MD, ³Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Institute for Healthcare Studies, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵Nursing, Rush University College of Nursing, Chicago, IL, ⁶Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Fatigue, a common symptom in systemic lupus erythematosus (SLE) patients, is ameliorated by physical activity. Adiposity and adipokines may be associated with patient-reported fatigue.…
Abstract Number: 1796 • 2015 ACR/ARHP Annual Meeting
Progression of Atherosclerosis Might be Prevented By Decrease of Serum Resistin Level after Glucocorticoid Therapy in Patients with Systemic Autoimmune Disease
Shotaro Masuoka, Nahoko Tanaka, Natsuko Kusunoki, Tatsuhiro Yamamoto, Kaichi Kaneko, Sei Muraoka, Makoto Kaburaki, Kotaro Shikano, Natsuki Fujio, Hiroshi Sato, Mai Kawazoe, Emiko Shindo, Soichi Yamada, Kenji Takagi, Toshihiro Nanki and Shinichi Kawai, Division of Rheumatology, Department of Internal Medicine, School of Medicine, Faculty of Medicine, Toho University, Tokyo, Japan
Background/Purpose: Development of atherosclerosis is accelerated in patients with systemic autoimmune diseases. However, underlying mechanisms of accelerated atherosclerosis remains unknown, and the impact of pharmacotherapies…