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Abstracts tagged "Adipokines"

  • Abstract Number: 1267 • 2018 ACR/ARHP Annual Meeting

    The Association between Clinically Suspect Arthralgia and Adipokines in Obese Patients

    Taskin Senturk1, Reyhan Kose1, Gokhan Sargin1, Songul Cildag2, Mustafa Unubol3, Burçin İrem Abas4 and Cigdem Yenisey4, 1Rheumatology, Adnan Menderes University Medical School, Aydin, Turkey, 2Allergy and Immunology, Adnan Menderes University Medical School, Aydin, Turkey, 3Endocrinology and Metabolism, Adnan Menderes University Medical School, Aydin, Turkey, 4Biochemistry, Adnan Menderes University Medical School, Aydin, Turkey

    Background/Purpose: Obesity is a moderate low-grade chronic inflammatory condition. Also, it has been reported to be a risk factor for inflammatory rheumatic diseases, seronegative inflammatory…
  • Abstract Number: 1907 • 2018 ACR/ARHP Annual Meeting

    High Serum Adiponectin Associates with the Incidence of Rheumatoid Arthritis in Obese Subjects

    Cristina Maglio1, Yuan Zhang2, Christian Herder3, Anna Rudin4 and Lena Carlsson5, 1Dep. of Rheumatology and Inflammation Research and Wallenberg Centre for Molecular and Translational Medicine, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, 2Dep. of Rheumatology and Inflammation Research, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, 3German Diabetes Center, Düsseldorf, Germany, 4Dept of Rheumatology and Inflammation Research, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, 5Department of Molecular and Clinical Medicine, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

    Background/Purpose: Adiponectin, a cytokine mainly produced by the adipose tissue, plays an important role in several metabolic and inflammatory processes. In obese subjects, serum adiponectin…
  • Abstract Number: 1935 • 2017 ACR/ARHP Annual Meeting

    Influence of Adipokines on the Differentiation of Spongiosa-Derived Mesenchymal Stromal Cells from Osteoporosis and Osteoarthritis Patients

    Lali Tsiklauri1, Janina Werner2, Klaus W. Frommer1, Rosel Engel3, Stefan Rehart4, Sabine Wenisch2, Ulf Müller-Ladner5 and Elena Neumann1, 1Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad Nauheim, Germany, 2Justus-Liebig-University Giessen, Institute of Veterinary-Anatomy, -Histology and –Embryology, Clinic of Small Animals, Giessen Germany, Giessen, Germany, 3Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad nauheim, Germany, 4Orthopedic & Trauma Surgery, Agaplesion Markus-Hospital, Frankfurt, Frankfurt, Germany, 5Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad-Nauheim, Germany

    Background/Purpose: Osteoporosis predominantly affects elderly people and is characterized by bone loss, increased fracture risk and reduced regeneration ability. An inverse relationship between bone marrow…
  • Abstract Number: 2209 • 2017 ACR/ARHP Annual Meeting

    Leptin and Adiponectin Mediate the Association between Body Mass Index and Hand and Knee Osteoarthritis

    F.P.B. Kroon1, A. Veenbrink1, R. de Mutsert2, A.W. Visser1, Saskia le Cessie3, F.R. Rosendaal2 and M. Kloppenburg1,2, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands, 3Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: Associations between obesity and osteoarthritis (OA) in non-weight bearing joints suggest that systemic influences also contribute to OA. Systemically active substances secreted by adipose…
  • Abstract Number: 2984 • 2017 ACR/ARHP Annual Meeting

    Predictive Value of a Combined Index for Weight Loss in Systemic Sclerosis

    Gianluca Bagnato1, Erika Pigatto2, Alessandra Bitto1, Carmelo Pizzino1, Natasha Irrera1, Giuseppina Abignano3, MIchele Hutchinson4, Francesco Squadrito1, Maya H. Buch5, Sebastiano Gangemi1, William Neal Roberts6, Antonino Saitta1, Franco Cozzi7 and Francesco Del Galdo8, 1University of Messina, Messina, Italy, 2University of Padova, Padova, Italy, 3Rheumatology Department of Lucania,, Rheumatology Institute of Lucania (IReL), San Carlo Hospital of Potenza and Madonna delle Grazie Hospital of Matera,, Potenza, Italy, 4University of Leeds, Leeds, United Kingdom, 5NIHR-Leeds Musculoskeletal Biomedical Research Unit, Leeds, United Kingdom, 6University of Louisville, Louisville, LA, 7Division of Rheumatology, Rheumatology Unit, Department of Medicine, University of Padova, Padova, Italy, 8Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom

    Background/Purpose: Malnutrition and severe gastrointestinal (GI) dysfunction are the cause of mortality in 4-15% of systemic sclerosis (SSc) patients whereas overall GI involvement is observed…
  • Abstract Number: 51 • 2017 ACR/ARHP Annual Meeting

    Irisin Ameliorates Infrapatellar Adiposity in Knee Osteoarthritis Pathogenesis By Orchestrating Adipokine Signaling

    Feng-Sheng Wang1, Yi-Chih Sun1 and Jih-Yang Ko2, 1Core Facility for Phenomics & Diagnostics, Department of Medical Research, Core Facility for Phenomics & Diagnostics, Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital, Taiwan, Kaohsiung, Taiwan, 2Department of Orthopedic Surgery, Department of Orthopedic Surgery, Kaohsiung Chang Gung Memorial Hospital, Taiwan, Kaohsiung, Taiwan

    Background/Purpose: Aberrant infrapatellar fat metabolism is a prominent feature that exacerbates inflammation and fibrosis relative to joint deterioration during osteoarthritis (OA). Irisin, a secretory subunit…
  • Abstract Number: 1414 • 2017 ACR/ARHP Annual Meeting

    Stimulation with Resistin Upregulates Chemokine Production By Fibroblast-like Synoviocytes from Patients with Rheumtoid Arthritis

    Hiroshi Sato1, Sei Muraoka1, Natsuko Kusunoki1, Shotaro Masuoka1, Soichi Yamada1, Toshio Imai2, Shinichi Kawai3 and Toshihiro Nanki1, 1Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan, 2KAN Research Institute, Inc., Kobe, Japan, 3Department of Inflammation and Pain Control Research, Toho University School of Medicine, Tokyo, Japan

    Background/Purpose: Adipose tissue synthesizes and releases physiologically active molecules that are known as adipokines. Resistin, an adipokine, has been widely studied the regulation of glucose…
  • Abstract Number: 5 • 2017 Pediatric Rheumatology Symposium

    Effects of Puberty on Systemic Lupus Erythematosus:  Results of a multi-center prospective longitudinal observational study in children entering puberty with SLE

    Kathleen O'Neil1, Hermine Brunner2, Andrew Zeft3, Anne Stevens4, Suzanne Li5, Tracey Wright6, Emily von Scheven7, B. Anne Eberhard8, C. Egla Rabinovich9 and Deborah M. Levy10, 1Pediatrics, Indiana University, Indianapolis, IN, 2Rheumatology, PRCSG, Cincinnati, OH, 3Pediatrics Rheumatology, Cleveland Clinic, Cleveland, OH, 4University of Washington, Department of Pediatrics, Seattle, WA, 5Pediatrics, Joseph M Sanzari Children’s Hospital, Hackensack Meridian Health, Hackensack, NJ, 6Pediatrics/Rheumatology, University of TX Southwestern, Dallas, TX, 7Division of Rheumatology, Department of Pediatrics, University of California San Francisco, San Francisco, CA, 8Cohen Children's Medical Center of New York, New Hyde Park, NY, 9Pediatric Rheumatology, Duke University Medical Center, Durham, NC, 10Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada

    Background/Purpose:  Lupus often presents during puberty, and when it affects pre-pubertal children, disease activity is thought to increase at puberty. Sex hormones play some role…
  • Abstract Number: 690 • 2016 ACR/ARHP Annual Meeting

    Increase in Serum Leptin Levels Is Associated with Radiographic Progression of Male Patients with Ankylosing Spondylitis: A 2-Year Longitudinal Study

    Seung-Geun Lee1, Eun-Kyoung Park2, Ji-Heh Park1, Hee-Sang Tag3 and Geun-Tae Kim4, 1Internal Medicine, Pusan National University School of Medicine, Pusan National University Hospital, Busan, Korea, The Republic of, 2Division of Rheumatology, Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea, The Republic of, 3Division of Rheumatology, Department of Internal Medicine, Kosin University College of Medicine, Busan, South Korea, 4Kosin University College of Medicine, Busan, South Korea

    Background/Purpose:  The immunomodulatory effects of adipokines have been extensively studied in rheumatic diseases, there is a paucity of information regarding their effects on bone metabolism.…
  • Abstract Number: 819 • 2016 ACR/ARHP Annual Meeting

    Impaired Adiponectin Signaling in SSc Contributes to Myofibroblast Differentiation and Organ Fibrosis

    Roberta Goncalves Marangoni1, Benjamin Korman2, Feng Fang1, Monique Hinchcliff1, Laszlo Otvos3, Philipp E. Scherer4, Warren Tourtellotte5 and John Varga6, 1Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL, 2Department of Rheumatology, Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL, 3Temple University, Philadelphia, PA, 4University of Texas Southwestern Medical Center, Dallas, TX, 5Department of Pathology, Ward, Northwestern University, Chicago, IL, 6Rheumatology and Dermatology, Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL

    Background/Purpose:  In systemic sclerosis (SSc) patients, skin fibrosis is accompanied by involution of dermal white adipose tissue (dWAT), a prominent source of adiponectin (APN). We…
  • Abstract Number: 1102 • 2016 ACR/ARHP Annual Meeting

    Differentiation of Spongiosa-Derived Mesenchymal Stromal Cells from Osteoporosis and Osteoarthritis Patients Are Influenced By Adipokines

    Lali Tsiklauri1, Janina Werner2, Klaus W. Frommer1, Ulf Müller-Ladner3, Stefan Rehart4, Sabine Wenisch2 and Elena Neumann1, 1Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad Nauheim, Germany, 2Justus-Liebig-University Giessen, Institute of Veterinary-Anatomy, -Histology and –Embryology, Clinic of Small Animals, Giessen Germany, Giessen, Germany, 3Department of Internal Medicine and Rheumatology, Justus-Liebig-University Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, 4Orthopedic & Trauma Surgery, Agaplesion Markus-Hospital, Frankfurt, Frankfurt, Germany

    Background/Purpose: Osteoporosis is characterized by bone loss, increased fracture risk and reduced regeneration ability. Age-related bone loss leading to osteoporosis correlates with increased bone marrow…
  • Abstract Number: 1363 • 2016 ACR/ARHP Annual Meeting

    Serum Adipokines in Juvenile Dermatomyositis Are Associated with Disease Activities and Cardiac Function

    Birgit Nomeland Witczak1, Kristin Godang2, Thomas Schwartz3, Nicoleta Cristina Olarescu4, Berit Flatø5,6, Jens Bollerslev5,7, Ivar Sjaastad5,8,9 and Helga Sanner5,6, 1Oslo University Hospital, Institute for Experimental Medical Research, Oslo University Hospital, Oslo, Norway, Oslo, Norway, 2Department of Specialised Endocrinology, Oslo University Hospital, Section of Specialised Endocrinology, Department of Endocrinology, Oslo University Hospital, Rikshospitalet, Oslo, Norway, Oslo, Norway, 3Department of Infectious Diseases, Department of Infectious Diseases, Oslo University Hospital, Oslo, Norway, Oslo, Norway, 4Department of Endocrinology, Oslo University Hospital, Rikshospitalet, Oslo, Norway., Section of Specialised Endocrinology, Department of Endocrinology, Oslo University Hospital, Rikshospitalet, Oslo, Norway, Oslo, Norway, 5Institute for Clinical Medicine, University of Oslo, Oslo, Norway, Oslo, Norway, 6Department of Rheumatology, Oslo University Hospital, Rikshospitalet, Oslo, Norway, Oslo, Norway, 7Section of Specialised Endocrinology, Department of Endocrinology, Oslo University Hospital, Rikshospitalet, Oslo, Norway, Oslo, Norway, 8Department of Cardiology, Oslo University Hospital, Oslo, Norway, Oslo, Norway, 9Institute for Experimental Medical Research, Oslo University Hospital, Oslo, Norway, Oslo, Norway

    Background/Purpose: We have earlier demonstrated redistribution of adipose tissue in JDM patients. There is an increase in visceral adipose tissue (VAT), a highly active metabolic…
  • Abstract Number: 2149 • 2016 ACR/ARHP Annual Meeting

    Adipokines Alter the Interaction Between Rheumatoid Arthritis Synovial Fibroblasts Adhesion and Endothelial Cells

    Rebecca Hasseli1, Klaus W. Frommer2, Markus Prof. Dr. Schönburg3, Stefan Prof. Dr. Rehart4, Ulf Müller-Ladner5,6 and Elena Neumann2, 1Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, 2Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad Nauheim, Germany, 3Department of Cardiac Surgery; Kerckhoff-Klinik, Bad Nauheim, Bad Nauheim, Germany, 4Department of Orthopedics and Trauma Surgery, Markus Hospital, Frankfurt, Frankfurt, Germany, 5Department of Internal Medicine and Rheumatology, Justus-Liebig-University Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, 6Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad-Nauheim, Germany

    Background/Purpose: Synovial fibroblast plays a key role in rheumatoid arthritis (RA), which is a chronic polyarticular inflammatory disease. SF are able to migrate long distances…
  • Abstract Number: 3054 • 2016 ACR/ARHP Annual Meeting

    The Impact of Obesity on Knee Osteoarthritis Symptoms and Related Biomarker Profiles in a Bariatric Surgery Cohort

    Thayer Mukherjee1, Fernando Bomfim2, Evan Wilder1, Lauren Browne3, Kayleigh Toth4, Shira Aharon4, Janice Lin4, Renata La Rocca Vieira5, Christine Ren-Fielding6, Manish Parikh7, Steven B. Abramson8, Mukundan Attur9 and Jonathan Samuels2, 1NYU Langone Medical Center, New York, NY, 2Rheumatology, NYU Langone Medical Center, New York, NY, 3NYU Langone Medical Center, Rheumat, New York, NY, 4NYU Langone Medical Center, Rheumatology, New York, NY, 5Department of Radiology, NYU Langone Medical Center, New York, NY, 6Department of Surgery, New York University School of Medicine, New York, NY, 7Department of Surgery, NYU Langone Medical Center, New York, NY, 8Dept of Rheumatology/Medicine, NYU Langone Medical Center, New York, NY, 9Rheumatology Research, NYU - Hospital for Joint Diseases, New York, NY

    Background/Purpose: Obesity is a common risk factor for knee osteoarthritis (KOA). While it is intuitive that bariatric weight loss improves knee pain, it is not…
  • Abstract Number: 3093 • 2016 ACR/ARHP Annual Meeting

    Comparison of Changes in Cardiovascular Risk-Associated Biomarkers in RA Patients Treated with Anti-TNF or Other Biological Agents: A Metabolic Study from a Randomized Trial

    Alexandre Virone1, Jean-Philippe Bastard2, Soraya Fellahi2, Jacqueline Capeau2, Stéphanie Rouanet3, Jean Sibilia4, Philippe Ravaud5, Francis Berenbaum6, Jacques-Eric Gottenberg7 and Jeremie Sellam6, 1Rheumatology, Rheumatology dept, APHP St-Antoine hospital, Univ Paris 06, Paris, France, Paris, France, 2APHP Hôpital Tenon, Sorbonne Universités, UPMC Univ Paris-6, Inserm UMR_S938, ICAN, DHU i2B, Paris, France, 3StatEthic, Levallois-Perret, France, 4Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France, 5Hôpital Hôtel Dieu, Paris, France, 6Rheumatology dept, APHP St-Antoine hospital, Univ Paris 06, Paris, France, Paris, France, 7Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France

    Background/Purpose: Considering the increased cardiovascular risk in RA patients and the influence of biologics, especially tocilizumab (TCZ) on the lipid profile, we aimed to investigate…
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