Abstracts tagged "ACPA"

Abstract Number: 836 • 2017 ACR/ARHP Annual Meeting
B Cell Receptor Sequencing of Anti-Citrullinated Protein Antibody Expressing B Cells Indicates a Selective Advantage for the Introduction of N-Glycosylation Sites during Somatic Hypermutation
Rochelle D. Vergroesen¹, Linda Slot¹, Lise Hafkenscheid¹, Marvyn T. Koning², Ellen I.H. van der Voort³, Christine A. Grooff¹, George Zervakis², Tom W.J. Huizinga¹, Theo Rispens⁴, Hendrik Veelken², Rene E.M. Toes¹ and Hans U. Scherer³, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Hematology, Leiden University Medical Center, Leiden, Netherlands, ³Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁴Immunopathology, Sanquin Research, Amsterdam, Netherlands
Background/Purpose: The vast majority (>90%) of anti-citrullinated protein antibodies (ACPA) of the IgG isotype in serum and synovial fluid of patients with rheumatoid arthritis carry…
Abstract Number: 970 • 2017 ACR/ARHP Annual Meeting
ACPA Activate Challenged Synovial Fibroblasts through a PAD Dependent Mechanism: A Potential Explanation of the “Second Hit Model” in RA
Meng Sun¹, Vijay Joshua¹, Akilan Krishnamurthy¹, Aase Hensvold¹, Yanying Liu², Sergiu-Bogdan Catrina³, Caroline Ospelt⁴, Vivianne Malmström¹, Johanna Steen¹, Marianne Engström¹, Heidi Wähämaa¹, Bence Rethi¹ and Anca I. Catrina¹, ¹Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden, ²Rheumatology Unit, Department of Medicine, Peking University People's Hospital, Beijing, China, ³Molecular Medicine and Surgery, Molecular Medicine and Surgery, Stockholm, Sweden, ⁴Center of Experimental Rheumatology, University Hospital Zürich, Zurich, Switzerland
Background/Purpose: Anti-citrullinated proteins antibodies (ACPAs) injected in mice induce IL-8 dependent bone loss and arthralgia, but no synovial changes. We hypothesized that additional stimulus, sensitizing…
Abstract Number: 990 • 2017 ACR/ARHP Annual Meeting
Higher Omega-6 to Omega-3 Fatty Acid Ratio Is Associated with Increased Odds of Inflammatory Arthritis in a Health Fair Population Positive for Anti-Citrullinated Protein Antibodies (ACPA)
Kristen J. Polinski¹, Ryan W. Gan², Elizabeth A. Bemis¹, M. Kristen Demoruelle³, Michael J. Clare-Salzler⁴, V. Michael Holers⁵, Kevin D. Deane⁶ and Jill M. Norris⁷, ¹Epidemiology, Colorado School of Public Health, Aurora, CO, ²Colorado School of Public Health, University of Colorado Denver, Aurora, CO, ³1775 Aurora Ct, 1775 Aurora Ct, Aurora, CO, ⁴Experimental Pathology, University of Florida, College of Medicine, Gainesville, FL, ⁵Rheumatology Division, University of Colorado School of Medicine, Aurora, CO, ⁶Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ⁷Department of Epidemiology, Colorado School of Public Health, Aurora, CO
Background/Purpose: We previously found that lower levels of omega-3 fatty acids (n-3 FA) were associated with the presence of inflammatory arthritis (IA) as well as…
Abstract Number: 583 • 2016 ACR/ARHP Annual Meeting
Associations of Serum Anti-Citrullinated Proteins and Cytokines with Radiographic Scores in African-American Rheumatoid Arthritis Patients
Dongmei Sun¹, William H Robinson², Xiangqin Cui³, Vincent A. Laufer⁴, Maria I. Danila⁵, Richard J. Reynolds⁶, Chander Raman⁷, Stephanie Ledbetter⁸, Alexander Szalai⁹ and S. Louis Bridges Jr.⁹, ¹Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ²Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ³Biostatistics, University of Alabama at Birmingham, Birmingham, AL, ⁴Division of Clinical Rheumatology and Immunology, University of Alabama at Birmingham, Birmingham, AL, ⁵University of Alabama at Birmingham, Birmingham, AL, ⁶Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁷Medicine/Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁸1825 University Blvd., University of Alabama at Birmingham, Birmingham, AL, ⁹Rheumatology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Serum anti-citrullinated proteins (ACPA, including anti-CCP antibodies) and rheumatoid factor (RF) are critical diagnostic markers for RA, and are associated with more severe radiographic…
Abstract Number: 2612 • 2016 ACR/ARHP Annual Meeting
Sero-Positivity for Rheumatoid Factor Is an Independent Predictor for Achievement of Good EULAR Response at 24 Weeks in ACPA Positive Rheumatoid Arthritis Patients Treated with Abatacept: Results from Japanese Multicenter Registry
Nobunori Takahashi¹, Toshihisa Kojima¹, Shuji Asai¹ and Naoki Ishiguro², ¹Department of Orthopedic Surgery, Nagoya University Hospital, Nagoya, Japan, ²Nagoya University, Nagoya, Japan
Background/Purpose: Abatacept is a new class of biologic agent for the treatment of rheumatoid arthritis (RA) that inhibits T cell activation by binding to CD80/86.…
Abstract Number: 584 • 2016 ACR/ARHP Annual Meeting
Glycoprotein VI: A Potential Target for ACPA-Mediated Platelet Activation?
John Stack¹, Anne Madigan², Laura Helbert¹, Niamh Redmond¹, Eimear Dunne³, Dermot Kenny³ and Geraldine M. McCarthy², ¹Rheumatology, Mater Misericordiae University Hospital, Dublin, Ireland, ²Rheumatology, Mater Misericordiae University Hospital, Dublin 7, Ireland, ³Molecular and Cellular Therapeutics, RCSI, Dublin 2, Ireland
Background/Purpose: Arterial thrombosis is a major cause of mortality in rheumatoid arthritis (RA),especially in anti-citrullinated protein antibody (ACPA)-positive patients Recent studies suggest that platelet activation…
Abstract Number: 2613 • 2016 ACR/ARHP Annual Meeting
Seropositivity for RF or ACPA Predicts Long Term Drug Retention with Rituximab, but Not with Abatacept and Tocilizumab : Long-Term Registry Data in 4498 Patients with Rheumatoid Arthritis
Jacques-Eric Gottenberg¹, Jacques Morel², Arnaud Constantin³, Thomas Bardin⁴, Alain G. Cantagrel⁵, Bernard Combe⁶, Maxime Dougados⁷, Rene-Marc Flipo⁸, Alain Saraux⁹, Thierry Schaeverbeke¹⁰, Jean Sibilia¹¹, Martin Soubrier¹², Olivier Vittecoq¹³, Elodie Perrodeau¹⁴, Philippe Ravaud¹⁵, Xavier Mariette¹⁶ and on behalf of the French Society of Rheumatology and of all the investigators participating to the AIR, ORA and REGATE registries, ¹Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France, ²Rheumatology, Department of Rheumatology, Montpellier University Hospital, Montpellier, France, ³Rheumatology, CHU Purpan - Hopital Pierre-Paul Riquet, Toulouse, France, ⁴Clinique de Rhumatologie, Hopital Lariboisiere, Paris Cedex 10, France, ⁵Rheumatology, Centre Hospitalier Universitaire, Toulouse Purpan, Toulouse, France, ⁶Département Rhumatologie, Hôpital Lapeyronie, Montpellier, France, ⁷Rheumatology, Paris Descartes University, Paris, France, ⁸Rheumatology, University Hospital, Lille, France, ⁹Rheumatology, Brest University Hospital, Brest, France, ¹⁰Rheumatology, CHU Bordeaux, Bordeaux, France, ¹¹Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France, ¹²Rheumatology, Department of Rheumatology, CHU Gabriel Montpied, Clermont-Ferrand, France, ¹³Rheumatology, Rouen University Hospital &INSERM U905, Rouen, France, ¹⁴Epidemiology, Hopital Hotel Dieu, Paris Descartes University, Paris, France, ¹⁵Epidemiologist, PARIS, France, ¹⁶Rheumatology, Rheumatology department, Bicetre Hospital, Paris-Sud University, Le Kremlin Bicetre, France
Background/Purpose: Seropositivity for RF or ACPA is associated with a better short-term effectiveness and drug retention of abatacept (ABA) and rituximab (RTX). Data are very…
Abstract Number: 585 • 2016 ACR/ARHP Annual Meeting
Disease Associated Anti-Citrullinated Protein Memory B Cells in Rheumatoid Arthritis Persist in DAS Remission
Adam J. Pelzek¹, Caroline Grönwall², Lelise Getu³, Pamela Rosenthal⁴, Jeffrey D. Greenberg⁵, Mandy J. McGeachy⁶, Larry W. Moreland⁷ and Gregg J. Silverman⁸, ¹New York University School of Medicine, New York, NY, ²Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, ³Department of Medicine, New York University School of Medicine, New York, NY, ⁴Rheumatology, New York University School of Medicine, New York, NY, ⁵New York University School of Medicine, Millburn, NJ, ⁶Medicine, University of Pittsburgh, Pittsburgh, PA, ⁷Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁸Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY
Background/Purpose: B cells are central drivers of seropositive RA, and B cells that express anti-citrullinated protein antibodies (ACPA) may arise from past and/or ongoing breaches…
Abstract Number: 586 • 2016 ACR/ARHP Annual Meeting
Association Between ACPA Fine Specificity and High Resolution Computed Tomography Lung Changes in Patients with Early Rheumatoid Arthritis
Vijay Joshua¹, Katerina Chatzidionysiou¹, Gudrun Reynisdottir¹, Aase Hensvold¹, Monika Hansson¹, Leonor Nogueira², Guy Serre², Johan Grunewald³ and Anca I Catrina¹, ¹Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden, ²Unité Différenciation Épidermique et Autoimmunité Rhumatoïde, Unité Mixte de Recherche, INSERM, Toulouse, France, ³Division of Respiratory Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Airways abnormalities that are consistent with inflammation are common in anti-CCP2 positive subjects without inflammatory arthritis. Anti-CCP2 antibodies are associated with high-resolution computed tomography…
Abstract Number: 587 • 2016 ACR/ARHP Annual Meeting
Synovial Immunophenotype and Anti-Citrullinated Protein Antibodies in Rheumatoid Arthritis Patients: Relationship to Treatment Response and Radiological Prognosis
Carl Orr¹, Aurélie Najm², Monika Biniecka³, Francis Young¹, Ursula Fearon⁴ and Douglas J. Veale¹, ¹Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin 4, Ireland, ²Rheumatology, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin, Ireland, ³St. Vincent's University Hospital, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin, Ireland, ⁴Trinity College Dublin, Department of Molecular Rheumatology, Trinity College Dublin, Dublin, Ireland
Background/Purpose: Circulating anti-citrullinated peptide antibodies (ACPA) have been proposed as an important clinical test for stratification of patients presenting with rheumatoid arthritis (RA). ACPA may…
Abstract Number: 590 • 2016 ACR/ARHP Annual Meeting
Microvesicles in the Lungs of Early Rheumatoid Arthritis
Vijay Joshua¹, Fariborz Mobarrez¹, Gudrun Reynisdottir¹, Johan Öckinger², Jan Wahlström², Johan Grunewald², Heidi Wähämaa¹ and Anca I Catrina¹, ¹Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden, ²Division of Respiratory Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Structural changes, increased tissue citrullination and signs of local inflammation are present in the pulmonary compartment of early seropositive RA and seropositive individuals at…
Abstract Number: 1035 • 2016 ACR/ARHP Annual Meeting
The Prognostic Value of Different Auto-Antibodies for Arthritis Development in Patients with Clinically Suspect Arthralgia
Robin M ten Brinck¹, Hanna W van Steenbergen¹, Marije K. Verheul¹, Leendert A. Trouw² and Annette HM van der Helm-van Mil³, ¹Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ³Rheumatology, Rheumatology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Previous longitudinal studies in arthralgia patients studied Rheumatoid Factor (IgM-RF) and Anti-Citrullinated Protein Antibodies (ACPA) in relation to arthritis development. Participants in these studies…
Abstract Number: 6 • 2016 ACR/ARHP Annual Meeting
Lower Omega-3 Fatty Acid Biomarkers Are Associated with Inflammatory Arthritis in a Population Positive for Anti-Citrullinated Protein Antibodies
Ryan W. Gan¹, Elizabeth A. Bemis¹, M. Kristen Demoruelle², Kevin D. Deane², Christopher C. Striebich³, James H. Goddard⁴, Stacey A. Brake⁴, Michael J. Clare-Salzler⁵, V. Michael Holers⁶ and Jill M. Norris¹, ¹Epidemiology, Colorado School of Public Health, Aurora, CO, ²Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ³Division of Rhuematology, University of Colorado School of Medicine, Aurora, CO, ⁴Nine Health Services, Inc., Denver, CO, ⁵Experimental Pathology, University of Florida, College of Medicine, Gainesville, FL, ⁶Rheumatology Division, University of Colorado School of Medicine, Aurora, CO
Background/Purpose: Antibodies to citrullinated protein antigens (ACPA) can be elevated prior to onset of inflammatory arthritis (IA) and RA. However, understanding of factors related to…
Abstract Number: 1108 • 2016 ACR/ARHP Annual Meeting
Protein Citrullinations By PAD Enzymes Promote Dendritic Cell Transdifferentiation into Osteoclast and Generate Targets for RA-Specific Antibodies
Akilan Krishnamurthy¹, Jimmy Ytterberg², Meng Sun¹, Vijay Joshua¹, Heidi Wähämaa¹, Nataliya Tarasova², Khaled Amara¹, Johanna Steen¹, Vivianne Malmström¹, Bence Rethi¹ and Anca I Catrina¹, ¹Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden, ²Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Immature dendritic cells (DCs) can develop into osteoclasts (OCs), however, the mechanisms regulating this differentiation switch are not yet understood. We have shown that…
Abstract Number: 130 • 2016 ACR/ARHP Annual Meeting
Anti-CCP Status Determines the Power Doppler Oscillation Pattern in Rheumatoid Arthritis – a Prospective Study
Ottar Gadeholt¹, Tobias Wech², Sebastian Schuh¹, Eva Christina Scharbatke¹, Eva Niederle¹, Hans-Peter Tony³ and Marc Schmalzing⁴, ¹Rheumatology/Immunology, Medical Clinic II, University Clinic Wuerzburg, Wuerzburg, Germany, ²Experimental Rradiology, University Clinic Wuerzburg, Wuerzburg, Germany, ³Rheumatology/Immunology, Medical Clinic II, University Clinic Wuerzburg, Würzburg, Germany, ⁴Rheumatology/Clinical Immunology, Medical Clinic II, University Clinic Wuerzburg, Würzburg, Germany
Title: Anti-CCP Status Determines the Power Doppler Oscillation Pattern in Rheumatoid Arthritis – a Prospective Study Abstract: Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory…

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