ACR Meeting Abstracts

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Abstracts tagged "ACPA"

  • Abstract Number: 2450 • 2017 ACR/ARHP Annual Meeting

    Comparative Effectiveness of Abatacept Versus TNFi in Patients with RA Who Are CCP+ in the United States Corrona Registry

    Leslie R Harrold1, Heather J. Litman2, SE Connolly3, E Alemao3, K Price3, S Kelly3, Sabrina Rebello4, W Hua2 and Joel Kremer5, 1University of Massachusetts, Worcester, MA, 2Corrona, Southborough, MA, 3Bristol-Myers Squibb, Princeton, NJ, 4Corrona, LLC, Southborough, MA, 5Albany Medical College and The Center for Rheumatology, Albany, NY

    Background/Purpose: Anti-cyclic citrullinated peptide positivity (CCP+) is associated with a better response to abatacept than anti-CCP negativity in patients with RA1,2; however, there are no…
  • Abstract Number: 487 • 2017 ACR/ARHP Annual Meeting

    ARE ANTI-Citrullinated Protein Antibody Levels Associated with Periodontal Disease in Rheumatoid Arthritis?

    Jerián González Febles1, Fernando Sánchez-Alonso2, Jorge Luis Garnier Rodríguez3, Mariano Sanz Alonso1, Federico Díaz-González4 and Beatriz Rodriguez Lozano5,6, 1Periodontology, Universidad Complutense de Madrid, Madrid, Spain, 2Unidad de Investigación, Spanish Society of Rheumatology, Madrid, Spain, 3Odontology, Dental Clinic Garnier, S/C Tenerife, Spain, 4Servicio de Reumatología. Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain, 5Rheumatology, Rheumatology Department. Hospital Universitario de Canarias, S/C TENERIFE, Spain, 6Rheumatology, Hospital de Canarias, S/C Tenerife, Spain

    Background/Purpose: Positivity of anti-citrullinated peptides antibodies (ACPA) indicates severity in Rheumatoid Arthritis (RA). There is evidence for chronic periodontitis (PD) in RA autoimmune response by…
  • Abstract Number: 2791 • 2017 ACR/ARHP Annual Meeting

    Receptor Activator of Nuclear Factor Kappa-B Ligand (RANKL) and Marginal Jawbone Loss Predates the Onset of Rheumatoid Arthritis

    Elin Kindstedt1, Linda Johansson2, Py Palmqvist3, Cecilia Koskinen Holm1, Heidi Kokkonen4, Ingegerd Johansson3, Pernilla Lundberg3 and Solbritt Rantapaa-Dahlqvist5, 11Department of Odontology/Molecular Periodontology, Umeå University, Umeå, Sweden, 2Public Health and Clinical Medicine/Rheumatology, Umeå University, Umeå, Sweden, 3Department of Odontology/Molecular Periodontology, Umeå University, Umeå, Sweden, 4Public Health and Clinical Medicine/ Rheumatology, Umeå University, Umeå, Sweden, 5Dept of Public Health and Clinical Medicine/Rheumatology, Umeå University, Sweden, Umeå, Sweden

    Background/Purpose: Previous studies have shown a higher incidence of alveolar bone loss in patients with rheumatoid arthritis (RA) and that patients with periodontitis are at…
  • Abstract Number: 55 • 2016 ACR/ARHP Annual Meeting

    Identification of Endogenous Autoantigens Bound to Anti-Citrullinated Peptide Antibodies in Rheumatoid Arthritis: A Key Role for Citrulline Residues in Histone 4

    Xiaobo Meng1, Peyman Ezzati1, Irene Smolik2, Carol Hitchon3 and Hani El-Gabalawy4, 1UNIVERSITY OF MANITOBA, WINNIPEG, MB, Canada, 2Arthritis Center, University of Manitoba, Winnipeg, MB, Canada, 3University of Manitoba, Winnipeg, MB, Canada, 4University of Manitoba Arthritis Center, Winnipeg, MB, Canada

    Background/Purpose: Anti-Citrullinated Peptides Antibodies (ACPA) aid in rheumatoid arthritis (RA) diagnosis. The nature of autoantigens specifically bound to ACPA immune complex in vivoremains unclear. We…
  • Abstract Number: 571 • 2016 ACR/ARHP Annual Meeting

    High Titer Rheumatoid Arthritis Antibodies Distinguish Between PAD2 and PAD4 Citrullinated Fibrinogen

    Nathalie Blachere1,2, Salina Parveen1, Mayu Frank1, Brian D. Dill1, Henrik Molina1 and Dana E. Orange1,3,4, 1The Rockefeller University, New York, NY, 2Howard Hughes Medical Institute, Chevy Chase, MD, 3Rheumatology, Hospital for Special Surgery, New York, NY, 4The New York Genome Center, New York, NY

    Background/Purpose: Most patients with rheumatoid arthritis (RA) harbor antibodies to citrullinated autoantigens, such as citrullinated fibrinogen. Two isoforms of peptidylarginine deiminase (PAD), PAD2 and PAD4,…
  • Abstract Number: 2035 • 2016 ACR/ARHP Annual Meeting

    Dosage Contribution of a Non-Classical HLA Gene, HLA-Doa, to the Risk of Rheumatoid Arthritis

    Yukinori Okada1, Akari Suzuki2, Katsunori Ikari3, Chikashi Terao4, Yuta Kochi2, Koichiro Ohmura5, Koichiro Higasa5, Masato Akiyama2, Kyoto Ashikawa2, Masahiro Kanai2, Jun Hirata1, Naomasa Suita1, Yik-Ying Teo6, Huji Xu7, Sang-Cheol Bae8, Yukihide Momozawa2, koichi Matsuda9, Shigeki Momohara10, Atsuo Taniguchi10, Ryo Yamada5, Tsuneyo Mimori5, Michiaki Kubo2, Matthew A. Brown11, Soumya Raychaudhuri12, Fumihiko Matsuda5, Hisashi Yamanaka10, Yoichiro Kamatani2 and Kazuhiko Yamamoto9, 1Osaka University, Osaka, Japan, 2Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan, 3Inst of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, 4Departments of Genetics and Rheumatology, Brigham and Women'’s Hospital, Harvard Medical School, Boston, MA, 5Kyoto University Graduate School of Medicine, Kyoto, Japan, 6Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore, 7The Second Military Medical University, Shanghai, Japan, 8Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea, The Republic of, 9The University of Tokyo, Tokyo, Japan, 10Tokyo Women's Medical University, Tokyo, Japan, 11The University of Queensland Diamantina Institute, Brisbane, Australia, 12Brigham and Women's Hospital, Boston, MA

    Background/Purpose: Despite the progress in human leukocyte antigen (HLA) causal variant mapping, independent localization of major histocompatibility complex (MHC) risk from classical HLA genes is…
  • Abstract Number: 572 • 2016 ACR/ARHP Annual Meeting

    Anti-Periodontal Bacteria Antibody Titers Are Inversely Correlated with ACPA in RA-Free Individuals with Periodontal Disease Compared to Community Controls

    Emma Weeding1, Londyn Robinson2, Jeremy Sokolove3, Julie Marchesan4, Steven Offenbacher4, William H. Robinson3, Ryan Demmer5, Bryan Michalowicz6 and Jerry A. Molitor7, 1Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 2University of Minnesota, Minneapolis, MN, 3Stanford University School of Medicine, Stanford, CA, 4Department of Periodontology, Dental School, University of North Carolina at Chapel Hill, Chapel Hill, NC, 5Epidemiology, Columbia University Mailman School of Public Health, New York, NY, 6Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN, 7Rheumatic/Autoimmune Diseases, University of Minnesota, Minneapolis, MN

    Background/Purpose: Rheumatoid arthritis (RA) and periodontal disease (PD) are comorbid conditions that share multiple underlying risk factors and pathophysiological features. A dysbiotic periodontal microbiome might…
  • Abstract Number: 2107 • 2016 ACR/ARHP Annual Meeting

    Targeting Mir-155 in Rheumatoid Arthritis B Cells Reduces Antibody Production

    Mariola Kurowska-Stolarska1, Iain B McInnes2, Stefano Alivernini3, Aziza Elmesmari4, Gianfranco Ferraccioli5, James Reilly2 and David W. McCarey6,7, 1Institute of Infection,Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom, 2Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow, United Kingdom, 3Division of Rheumatology, Institute of Rheumatology and Affine Sciences, Catholic University of the Sacred Heart, Rome, Italy, 4Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom, 5Division of Rheumatology - Institute of Rheumatology and Affine Sciences, Catholic University of the Sacred Heart, Rome, Italy, 6Glasgow Royal Infirmary, Glasgow, United Kingdom, 7Centre for Rheumatic Diseases, Centre for Rheumatic Diseases, Glasgow, United Kingdom

    Background/Purpose: Better understanding of epigenetic regulatory mechanisms in RA pathogenesis will facilitate the development of new biomarkers or therapeutic strategies.  MicroRNAs are post-transcriptional regulators that…
  • Abstract Number: 575 • 2016 ACR/ARHP Annual Meeting

    Differences in Histological Scores and Histoclinical Correlations in ACPA- Versus ACPA+ Rheumatoid Arthritis Patients

    Fadil Pirbuccus1, Christine Galant1, Adrien Nzeusseu Toukap2, Frédéric A. Houssiau1, Patrick Durez2 and Bernard R. Lauwerys1, 1Pôle de pathologies rhumatismales inflammatoires et systémiques, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium, 2Pôle de Maladies Rhumatismales, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium

    Background/Purpose:  Differences in the pathogenesis of ACPA- versus ACPA+ rheumatoid arthritis are still poorly understood. In this study, we compared patterns of synovial changes in…
  • Abstract Number: 2111 • 2016 ACR/ARHP Annual Meeting

    Generation and Characterization of Anti-Citrullinated Protein Antibody-Producing B-Cell Clones

    Kristine Germar1,2, Mark Kwakkenbos3, Sabrina Pollastro1,2, Nathalie van Uden1,2,4, Priscilla Kerkman5, Ellen I.H. van der Voort6, Evan Reed7, Karin Lundberg7, Niek de Vries1,8, Lars Klareskog7, Hans U. Scherer5, René E.M. Toes5, Arjen Bakker3, Hergen Spits3,9,10 and Dominique Baeten1,2,10, 1Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 2Amsterdam Rheumatology and immunology Center, Amsterdam, Netherlands, 3AIMM Therapeutics, Amsterdam, Netherlands, 4Experimental Immunology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 5Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 6Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 7Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, 8Clinical Immunology and Rheumatology F4-105, Amsterdam Rheumatology and immunology Center, location AMC, Amsterdam, Netherlands, 9Department of Cell Biology and Histology, Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands, 10These authors contributed equally to this work, Amsterdam, Netherlands

    Background/Purpose:  Rheumatoid arthritis (RA) is the most frequent form of autoimmune arthritis with a prevalence of almost 1% worldwide. Anti-citrullinated protein antibodies (ACPA) are the…
  • Abstract Number: 582 • 2016 ACR/ARHP Annual Meeting

    ACPA Induce Pathogenic Cytokines Expression in PBMC of ACPA+-RA Patients and Inhibition of Its Effect By Cit-ME a Synthetic Citrullinated Peptide

    Smadar Gertel1, Gidi Karmon2, Eszter Szarka3, , Esther Houri-Levi4, Edna mozes5, Yehuda Shoenfeld4 and Howard Amital6,7, 1Sheba Medical Center, Zabludowicz Center for Autoimmune Diseases, affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Ramat Gan, Israel, 2Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Israel, 3Department of Immunology,, Eötvös Loránd University, Budapest,, Budapest, Hungary, 4Zabludowicz Center For Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel, Ramat-Gan, Israel, 5Department of Immunology,, The Weizmann Institute of Science, Rehovot, Israel., Rehovot, Israel, 6Department of Medicine B, Center for Autoimmune Diseases, Sheba Medical Center, Tel-hashomer, Israel, 7Department of Internal Medicine 'D', Sackler Faculty of Medicine, Tel-Aviv University, Kfar-Saba, Israel

     ACPA induce pathogenic cytokines expression in PBMC of ACPA+-RA patients and inhibition of its effect by Cit-ME a synthetic citrullinated peptide.Smadar Gertel1, Gidi Karmon1, Eszter…
  • Abstract Number: 2496 • 2016 ACR/ARHP Annual Meeting

    DMARD, Biologic and Small Molecule Drug Use Among ACPA Positive and ACPA Negative RA Patients in a Tertiary Referral Center

    Richard Meehan1, Eric Hoffman2, David Muram3, Barbara Goldstein4, Jim Crooks5 and Pearlanne Zelarney6, 1MEDICINE, National Jewish Health, Denver, CO, 2Medicine/Rheumjatology, National Jewish Health, denver, CO, 3Eli Lilly and Company, Indianapolis, IN, 4Rheumatology, National Jewish Health, Denver, CO, 5Biostatistics, National Jewish Health, Denver, CO, 6Bioinformatics, National Jewish Health, Denver, CO

    Background/Purpose:  Rheumatoid arthritis (RA) can be divided into two major subsets based on the presence or absence of antibodies to citrullinated peptide antigens (ACPA). Some…
  • Abstract Number: 583 • 2016 ACR/ARHP Annual Meeting

    Associations of Serum Anti-Citrullinated Proteins and Cytokines with Radiographic Scores in African-American Rheumatoid Arthritis Patients

    Dongmei Sun1, William H Robinson2, Xiangqin Cui3, Vincent A. Laufer4, Maria I. Danila5, Richard J. Reynolds6, Chander Raman7, Stephanie Ledbetter8, Alexander Szalai9 and S. Louis Bridges Jr.9, 1Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 2Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, 3Biostatistics, University of Alabama at Birmingham, Birmingham, AL, 4Division of Clinical Rheumatology and Immunology, University of Alabama at Birmingham, Birmingham, AL, 5University of Alabama at Birmingham, Birmingham, AL, 6Medicine, University of Alabama at Birmingham, Birmingham, AL, 7Medicine/Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 81825 University Blvd., University of Alabama at Birmingham, Birmingham, AL, 9Rheumatology, University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: Serum anti-citrullinated proteins (ACPA, including anti-CCP antibodies) and rheumatoid factor (RF) are critical diagnostic markers for RA, and are associated with more severe radiographic…
  • Abstract Number: 2612 • 2016 ACR/ARHP Annual Meeting

    Sero-Positivity for Rheumatoid Factor Is an Independent Predictor for Achievement of Good EULAR Response at 24 Weeks in ACPA Positive Rheumatoid Arthritis Patients Treated with Abatacept: Results from Japanese Multicenter Registry

    Nobunori Takahashi1, Toshihisa Kojima1, Shuji Asai1 and Naoki Ishiguro2, 1Department of Orthopedic Surgery, Nagoya University Hospital, Nagoya, Japan, 2Nagoya University, Nagoya, Japan

    Background/Purpose: Abatacept is a new class of biologic agent for the treatment of rheumatoid arthritis (RA) that inhibits T cell activation by binding to CD80/86.…
  • Abstract Number: 584 • 2016 ACR/ARHP Annual Meeting

    Glycoprotein VI: A Potential Target for ACPA-Mediated Platelet Activation?

    John Stack1, Anne Madigan2, Laura Helbert1, Niamh Redmond1, Eimear Dunne3, Dermot Kenny3 and Geraldine M. McCarthy2, 1Rheumatology, Mater Misericordiae University Hospital, Dublin, Ireland, 2Rheumatology, Mater Misericordiae University Hospital, Dublin 7, Ireland, 3Molecular and Cellular Therapeutics, RCSI, Dublin 2, Ireland

    Background/Purpose: Arterial thrombosis is a major cause of mortality in  rheumatoid arthritis (RA),especially in anti-citrullinated protein antibody (ACPA)-positive patients Recent studies suggest that platelet activation…
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