ACR Meeting Abstracts

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Abstracts tagged "ACPA"

  • Abstract Number: 327 • 2017 ACR/ARHP Annual Meeting

    Association of Anti-Cyclic Citrullinated Peptide Seropositivity and Lean Mass Index with Low Bone Mineral Density in Patients with Rheumatoid Arthritis

    Katherine D. Wysham1, Dolores M. Shoback2, Kashif Jafri1, Sarah L. Patterson3, Gabriela Schmajuk4, John B. Imboden Jr.5 and Patricia P. Katz5, 1University of California, San Francisco, San Francisco, CA, 2Medicine, San Francisco VA Medical Center, University of California, San Francisco, San Francisco, CA, 3Division of Rheumatology, University of California, San Francisco, San Francisco, CA, 4San Francisco VA Medical Center, University of California San Francisco, San Francisco, CA, 5Medicine, University of California, San Francisco, San Francisco, CA

    Background/Purpose:   Osteoporotic fractures are associated with high morbidity and mortality. Persons with rheumatoid arthritis (RA) have twice the risk of osteoporosis-related fracture than age-matched…
  • Abstract Number: 1383 • 2017 ACR/ARHP Annual Meeting

    IMPACT of Smoking in the Expression of Periodontitis and Anticitrullinated Protein Antibodies in Rheumatoid Arthritis

    Jerián González Febles1, Jorge Luis Garnier Rodríguez2, Fernando Sánchez-Alonso3, Sagrario Bustabad4, Federico Díaz-González5, Mariano Sanz Alonso1 and Beatriz Rodriguez Lozano6, 1Periodontology, Universidad Complutense de Madrid, Madrid, Spain, 2Odontology, Dental Clinic Garnier, S/C Tenerife, Spain, 3Unidad de Investigación, Spanish Society of Rheumatology, Madrid, Spain, 4Rheumatology, Servicio de Reumatología. Hospital Universitario de Canarias, La Laguna, Tenerife, Spain, 5Servicio de Reumatología. Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain, 6Rheumatology, Hospital de Canarias, S/C Tenerife, Spain

    Background/Purpose: Environmental, genetic and epigenetic factors can induce citrullination of structural peptides by the enzyme PAD, which induce anti-citrullinated protein antibodies (ACPA) preceding RA. Among…
  • Abstract Number: 410 • 2017 ACR/ARHP Annual Meeting

    Association between Anti-Citrullinated Protein Antibody Status and the Incidence of Erosive Disease in Patients with RA

    Leslie R Harrold1, Heather J. Litman2, SE Connolly3, E Alemao3, Sabrina Rebello4, W Hua2 and Joel Kremer5, 1University of Massachusetts Medical School, Worcester, MA, 2Corrona, Southborough, MA, 3Bristol-Myers Squibb, Princeton, NJ, 4Corrona, LLC, Southborough, MA, 5Albany Medical College and The Center for Rheumatology, Albany, NY

    Background/Purpose: RA is characterized by the production of autoantibodies including anti-citrullinated protein antibodies (ACPAs).1 ACPAs are considered a prognostic indicator for more severe RA and…
  • Abstract Number: 1432 • 2017 ACR/ARHP Annual Meeting

    The Prognostic Value of IgA Subtypes of Rheumatoid Factor and Anti-Citrullinated Protein Antibodies (ACPA)  for Prediction of Therapeutic Responses to TNF Inhibitory Therapy in Patients with Rheumatoid Arthritis

    Daniela Sieghart1, Farideh Alasti2, Paul Studenic1 and Günter Steiner2, 1Medical University Vienna, Division of Rheumatology, Department of Internal Medicine III, Vienna, Austria, 2Rheumatology, Medical University of Vienna, Vienna, Austria

    Background/Purpose: Rheumatoid factor (RF) and Anti-Citrullinated Protein antibodies (ACPA) are the most specific diagnostic markers of rheumatoid arthritis (RA). These antibodies are predominantly of the…
  • Abstract Number: 413 • 2017 ACR/ARHP Annual Meeting

    Economic Burden Associated with Anti-Cyclic Citrullinated Peptide Antibody Positivity in Patients Newly Diagnosed with RA

    J An1, Z Bider2, J Kang1, E Alemao3, SE Connolly3 and TC Cheetham1, 1Western University of Health Sciences, Pomona, CA, 2Southern California Permanente Medical Group, Pasadena, CA, 3Bristol-Myers Squibb, Princeton, NJ

    Background/Purpose: Anti-cyclic citrullinated peptide (anti-CCP) antibody positivity has been suggested as a strong predictor of joint erosion as well as a potential biomarker for guiding…
  • Abstract Number: 1454 • 2017 ACR/ARHP Annual Meeting

    Association of Poor Prognostic Factors with Medication Persistence Among Adult RA Patients within a Community of Rheumatology Clinics

    Damemarie Paul1, Laura McDonald2, Aarti Rao3, Ruthwik Anupindi4 and Keith Knapp5,6, 1HEOR, Bristol Myers Squibb, Lawrence Township, NJ, 2CORDS, Bristol Myers Squibb, Uxbridge, United Kingdom, 3Analytics, Mu-Sigma, Bengaluru, India, 4Analytics, Mu-Sigma, Lawrence Township, NJ, 5Arthritis Northwest PLLC., Spokane, WA, 6Discus Analytics LLC., Spokane, WA

    Background/Purpose: A fixed treatment paradigm often exists for Rheumatoid Arthritis(RA) patient(pts)1. However, RA is a heterogeneous disease and differences in pts’ serostatus affect disease progression.…
  • Abstract Number: 432 • 2017 ACR/ARHP Annual Meeting

    ACPA and RF As Predictors of Sustained Clinical Remission in Rheumatoid Arthritis Patients: Data from a Rheumatoid Arthritis Cohort

    Janet E. Pope1, Emmanouil Rampakakis2, Mohammad Movahedi3, Angela Cesta3, John S. Sampalis4 and Claire Bombardier3, 1Department of Medicine, Division of Rheumatology, University of Western Ontario, St Joseph's Health Care, London, ON, Canada, 2JSS Medical Research, Montreal, QC, Canada, 3Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada, 4McGill University, Montreal, QC, Canada

    ACPA and RF as Predictors of Sustained Clinical Remission in Rheumatoid Arthritis Patients: Data From a Rheumatoid Arthritis CohortBackground/Purpose: Positive serology for anti-citrullinated protein antibody…
  • Abstract Number: 2012 • 2017 ACR/ARHP Annual Meeting

    First Description of Tenosynovitis Prevalence in a Large Cohort of ACPA-Positive Patients

    Gisela Eugénio1,2,3, Kulveer Mankia3,4, Peta Pentony2,3, Jackie L. Nam2,3, Laura Hunt2,3, Hanna Gul2,3, Richard J. Wakefield2,3 and Paul Emery3,5, 1Rheumatology, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal, 2Leeds Teaching Hospitals NHS Trust, NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds, United Kingdom, 3University of Leeds, Leeds Institute of Rheumatic and Musculoskeletal Medicine, Leeds, United Kingdom, 4Rheumatology, Leeds Teaching Hospitals NHS Trust, NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds, United Kingdom, 5NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom

    Background/Purpose: Tenosynovitis has been regarded as a feature of RA, although its true prevalence in early stages has not been firmly established. The aim of…
  • Abstract Number: 459 • 2017 ACR/ARHP Annual Meeting

    Disease Course in Seronegative RA Patients Classified According to the 2010 ACR/EULAR Criteria

    Lena Bugge Nordberg1, Siri Lillegraven2, Anna-Birgitte Aga2, Inge C Olsen3, Elisabeth Lie4, Hilde B Hammer2, Till Uhlig2, Désirée van der Heijde5, Tore Kvien6 and Espen A. Haavardsholm2, 1Departement of Rheumatology, Diakonhjemmet hospital, oslo, Norway, 2Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 3Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 4Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 5Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 6Diakonhjemmet Hospital, Oslo, Norway

    Background/Purpose: The development of the 2010 classification criteria for rheumatoid arthritis (RA) has led to a redefinition of the patient population, including classification of seropositive…
  • Abstract Number: 2016 • 2017 ACR/ARHP Annual Meeting

    Favourable Changes in Power Doppler Scores in the Feet over 1-Year in an Early Rheumatoid Arthritis Cohort: The Role of Rheumatoid Factor and Anti–Citrullinated Protein Antibody

    Karen A. Beattie1, Hanyan Zou2, George Ioannidis3 and Maggie Larche1, 1Medicine, McMaster University, Hamilton, ON, Canada, 2McMaster University, Hamilton, ON, Canada, 3St Joseph's Healthcare Hamilton, Hamilton, ON, Canada

    Background/Purpose : MTP joints are seldom examined in routine clinical visits. As such, it is important to understand how the standard treatment of patients with…
  • Abstract Number: 478 • 2017 ACR/ARHP Annual Meeting

    Ectopic Lymphoid Tissue in the Lung Is Uniquely Associated with the ACPA IgA Isotype Even in Absence of Classifiable RA

    Lindsay B. Kelmenson1, M. Kristen Demoruelle1, Carlyne D. Cool2 and Kevin D. Deane1, 1Rheumatology Division, University of Colorado Denver, Aurora, CO, 2Pathology, University of Colorado Denver, Aurora, CO

    Background/Purpose: Antibodies to citrullinated protein antigens (ACPA) precede the development of rheumatoid arthritis (RA) and may be generated in the lung of established and preclinical…
  • Abstract Number: 2375 • 2017 ACR/ARHP Annual Meeting

    Does the Body Mass Index Have Any Influence in the Characteristics of Early Arthritis Patients?

    Pablo Moreno Fresneda1, Lola Martínez-Quintanilla Jiménez1, Ana M. Ortiz Garcia2, Eva Tomero3, Rosario García-Vicuña4 and Isidoro Gonzalez-Alvaro2, 1Rheumatology, Rheumatology Division, Hospital Universitario La Princesa, IIS-IP, Madrid, Spain, 2Rheumatology, Rheumatology Service, Hospital Universitario de La Princesa, IIS-IP, Madrid, Spain, 3Hospital La Princesa. Madrid., Madrid, Spain, 4Rheumatology, Hospital Universitario de La Princesa. IIS La Princesa, Madrid, Spain

    Background/Purpose: Obesity has been proposed as a risk factor to develop rheumatoid arthritis (RA) and it has been associated with a worse response to several…
  • Abstract Number: 482 • 2017 ACR/ARHP Annual Meeting

    The Link between ACPA and Erosion Development: Is ACPA Sufficient? an Association Study in Clinically Suspect Arthralgia

    Robin M ten Brinck1, REM Toes2 and Annette H.M. van der Helm-van Mil1, 1Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Rheumatology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: Anti-citrullinated protein antibodies (ACPA) associate with more severe joint erosions in rheumatoid arthritis (RA), but the underlying mechanism is unclear. Recent in vitro and…
  • Abstract Number: 2406 • 2017 ACR/ARHP Annual Meeting

    Increased Cartilage Damage in Metacarpophalangeal Joints of ACPA Positive Rheumatoid Arthritis (RA) Patients Using T2 Mapping in 3 Tesla Magnetresonance Imaging (MRI)

    Nina Renner1, Arnd Kleyer2, David Simon2, Gerhard Krönke3, Juergen Rech2, Georg Schett2, Goetz Welsch4 and Milena L. Pachowsky1, 1Department of Trauma and Orthopedic Surgery, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany, Erlangen, Germany, 2Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Erlangen, Germany., Erlangen, Germany, 3Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Erlangen, Germany., Erlangen, Austria, 4UKE Athleticum, University Hospital Hamburg-Eppendorf, Hamburg, Germany

    Background/Purpose: T2 mapping is a non-invasive MRI approach to measure cartilage quality, reflecting cartilage hydration and collagen integrity without using contrast enhancement. It has been…
  • Abstract Number: 484 • 2017 ACR/ARHP Annual Meeting

    Sputum Neutrophils Demonstrate Increased Neutrophil Extracellular Trap Formation in RA-Free Subjects at-Risk of Future RA

    Yuko Okamoto1, Michael P. Mohning2, Stacey M. Thomas2, Ashley Visser1, Lindsay B. Kelmenson3, Jill M. Norris4, Mariana J. Kaplan5, William J. Janssen2, V. Michael Holers1, Kevin D. Deane1 and M. Kristen Demoruelle1, 1Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, 2Division of Pulmonary Disease and Critical Care Medicine, National Jewish Health, Denver, CO, 3Division of Rheumatoloty, University of Colorado School of Medicine, Aurora, CO, 4Department of Epidemiology, Colorado School of Public Health, Aurora, CO, 5Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, MD

    Background/Purpose: Data support that ACPAs are generated in the lung in RA-free subjects At-Risk of future RA. Our group previously demonstrated a significant positive correlation…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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