Abstracts tagged "ACPA"

Abstract Number: 449 • 2014 ACR/ARHP Annual Meeting
Citrullinated-Vimentin-Specific Regulatory T-Cell Responses Associate with ACPA Positive Individuals with Non-Specific Musculoskeletal Symptoms
Aamir Aslam¹, Jackie L. Nam¹, Laura Hunt¹, Chadi Rakieh¹, Ann W. Morgan² and Paul Emery¹, ¹NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²NIHR-Leeds Musculoskeletal Biomedical Research Unit, University of Leeds, Leeds, United Kingdom
Background/Purpose: The pathogenesis of RA can be conceptualised by sequential phases that precede the development of synovitis. Autoimmune antibody responses, including ACPA, can precede clinical…
Abstract Number: 2019 • 2014 ACR/ARHP Annual Meeting
Antibodies to Citrullinated Clusterin, Filaggrin, Vimentin, and Fibrinogen Are Associated with Blood Pressure in First-Degree Relatives of Rheumatoid Arthritis Patients: The Studies of the Etiology of Rheumatoid Arthritis
Jan M. Hughes-Austin¹, Ryan W. Gan², Kevin D. Deane³, Peter K. Gregersen⁴, Michael H. Weisman⁵, Joachim H. Ix⁶, Jeremy Sokolove⁷, William H. Robinson⁸, V. Michael Holers⁹ and Jill M. Norris², ¹Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA, ²Epidemiology, Colorado School of Public Health, Aurora, CO, ³Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ⁴The Feinstein Institute for Medical Research, Manhasset, NY, ⁵Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁶University of California, San Diego, La Jolla, CA, ⁷VA Palo Alto Healthcare System and Stanford University, Palo Alto, CA, ⁸VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, ⁹Rheumatology Division, University of Colorado School of Medicine, Aurora, CO
Background/Purpose Hypertension is common in rheumatoid arthritis (RA), but it is unclear whether this prevalence is due to RA-related medications or to the disease process…
Abstract Number: 448 • 2014 ACR/ARHP Annual Meeting
Citrulline-Specific Autoimmunity Resides in Quiescent Circulating Memory B Cells in Rheumatoid Arthritis
Adam Pelzek, Caroline Grönwall, Jeffrey D. Greenberg and Gregg J. Silverman, Medicine, New York University School of Medicine, New York, NY
Background/Purpose . The detection of anti-citrullinated protein antibodies (ACPA) aids RA diagnosis, while B cell depletion by anti-CD20 can provide clinical benefits. We therefore undertook…
Abstract Number: 1740 • 2014 ACR/ARHP Annual Meeting
Predicting the Evolution of Inflammatory Arthritis in ACPA-Positive Individuals: Can T-Cell Subsets Model Help?
Laura Hunt¹, Agata Burska², Elizabeth M.A. Hensor¹, Jackie L. Nam¹, Frederique Ponchel¹ and Paul Emery¹, ¹NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds., Leeds, United Kingdom
Background/Purpose: ACPA+ individuals with non-specific musculoskeletal symptoms are at high risk of developing rheumatoid arthritis (RA). We previously demonstrated dys-regulation of T-cell subsets with loss…
Abstract Number: 447 • 2014 ACR/ARHP Annual Meeting
Rheumatoid Factor Isotypes in Relation to Antibodies Against Citrullinated Peptides in Individuals before Onset of Rheumatoid Arthritis
Mikael Brink¹, Monika Hansson², Linda Mathsson-Alm³, Johan Rönnelid³, Lars Klareskog² and Solbritt Rantapää-Dahlqvist⁴, ¹Public Health & Clinical Medicine/Rheumatology, Umeå University, Umeå, Sweden, ²Department of Medicine, Rheumatology Unit, Karolinska Institute, Stockholm, Sweden, ³Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden, ⁴Public Health & Clinical Medicine/Rheumatology, Institution of Public health and clinical medicine/ Rheumatology, University of Umeå, Rheumatology, Sweden, Umeå, Sweden
Background/Purpose The presence of rheumatoid factor (RF) and antibodies against citrullinated peptides (ACPA) has been shown to precede the development of rheumatoid arthritis (RA) by…
Abstract Number: 1786 • 2013 ACR/ARHP Annual Meeting
91% Of Early RA Patients Are Positive For Serum 14-3-3η Or Its Auto-Antibodies
Walter P. Maksymowych¹, Dirkjan van Schaardenburg², Désirée van der Heijde³, Robert Landewé⁴, Gilles Boire⁵, Maarten Boers⁶, Vivian P. Bykerk⁷, Edward C. Keystone⁸, Katherine A. Siminovitch⁹, Mairead Murphy¹⁰ and Anthony Marotta¹¹, ¹Medicine, University of Alberta, Edmonton, AB, Canada, ²Jan van Breemen Research Institute | Reade, Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands, ³Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁴Int Med/Rheumatology, Academic Medical Center, Amsterdam, Netherlands, ⁵Rheumatology Division, Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁶Epidemiology & Biostatistics, VU University Medical Center, Amsterdam, Netherlands, ⁷Rheumatology, Hospital for Special Surgery, Weill Cornell Medical College, New York, NY, ⁸Department of Medicine, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ⁹Mount Sinai Hospital, Toronto, ON, Canada, ¹⁰Augurex Life Sciences Corp., North Vancouver, BC, Canada, ¹¹Augurex Life Sciences Corp, North Vancouver, BC, Canada
Background/Purpose: Current serological markers such as RF and ACPA are useful for early diagnosis and perhaps for screening people at risk, but there remains a…
Abstract Number: 177 • 2013 ACR/ARHP Annual Meeting
Differences and Overlap Of Immunological Pathways Implicated In The Aetiology Of Anti-Citrullinated Peptide Antibody Positive and Negative Rheumatoid Arthritis
Sebastien Viatte¹, Paul Martin², Andrew Brass³, Mark Lunt⁴, Anne Barton⁵ and Stephen Eyre⁵, ¹Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom, ²Arthritis Research UK Epidemiology Unit, Manchester Academic Health Sciences Centre, Institute of Inflammation and Repair, The University of Manchester, Manchester, United Kingdom, ³School of Computer Science, University of Manchester, Manchester, United Kingdom, Manchester, United Kingdom, ⁴Arthritis Research UK Centre for Epidemiology, University of Manchester, Manchester, United Kingdom, ⁵Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, United Kingdom
Background/Purpose: Genome-wide association studies have been successful in identifying single nucleotide polymorphisms (SNPs) associated with disease. However, previous studies have been under-powered to detect differences…
Abstract Number: 1421 • 2013 ACR/ARHP Annual Meeting
Treatment Responses and Their Predictors Of Abatacept In Biologic naïve Patients With Rheumatoid Arthritis; Data Form Abroad Study
Yutaka Kawahito¹, Takao Fujii², Akira Yokota³, Hideo Hashimoto⁴, Kiyoshi Matsui⁵, Kenji Miki⁶, Masayasu Kitano⁵, Naoki Shinmyo⁷, Aihiro Yamamoto¹, Koichiro Ohmura⁸, Takanori Kuroiwa⁹, Toshihiko Hidaka¹⁰, Ichiro Yoshii¹¹, Hideko Nakahara¹², Takashi Fujimoto¹³, Kosaku Murakami¹⁴, Satoshi Morita¹⁵, Masahiro Sekiguchi⁵, Norihiro Nishimoto^16,17, Tsuneyo Mimori⁸ and Hajime Sano⁵, ¹Department of Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan, ²Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ³Yokota Clinic for Rheumatology, Osaka, Japan, ⁴Dept of Orthopedic Surgery, Rinku Hashimoto Rheumatology Orthopaedics, Osaka, Japan, ⁵Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya-city, Japan, ⁶Department of Orthopaedic Surgery, Amagasaki Central Hospital, Amagasaki, Japan, ⁷Kashiba Asahigaoka Hospital, Kashiba, Japan, ⁸Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ⁹Department of Rheumatology, Yukioka Hospital, Osaka, Japan, ¹⁰Zenjinkai Shimin-No-Mori Hospital, Miyazaki, Japan, ¹¹Department of Orthopaedic Surgery, Yoshii Hospital, Shimanto, Japan, ¹²Division of Allergy, Rheumatology and Connective Tissue Diseases, Department of Internal Medicine, NTT West Osaka Hospital, Osaka, Japan, ¹³Nara Medical University, Kashihara, Japan, ¹⁴Rheumatology and Clinical Immunology, Osaka Red Cross Hospital, Osaka, Japan, ¹⁵Graduate School of Medicine & Medical Center, Department of Biostatistics and Epidemiology, Yokohama City University, Kanagawa, Japan, ¹⁶Tokyo Medical University, Tokyo, Japan, ¹⁷Osaka Rheumatology Clinic, Osaka, Japan
Background/Purpose: The identification of predictors of good response to biologic therapy is needed in the perspective of personalized medicine.　To determine the predicting factors of efficacy…
Abstract Number: 2819 • 2013 ACR/ARHP Annual Meeting
Administration Of a Multi-Epitope Citrullinated Peptide Attuneuates adjuvant Induced Arthritis In Rats Via Induction Of Immune Tolerance
Howard Amital¹, Smadar Gertel² and Yehuda Shoenfeld³, ¹The Zabludowicz Center For Autoimmune Diseases, and Department of Medicine 'B',, Sheba Medical Center,Tel-Hashomer, Tel-Aviv University, Tel-hashomer, Israel, ²The Zabludowicz Center For Autoimmune Diseases, and Department of Medicine 'B', Sheba Medical Center, Tel-Hashomer, Israel, ³Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Affiliated to Sackler Faculty of Medicine, Tel-Aviv University,Tel-Aviv, Tel-Aviv, Israel
Background/Purpose: Antigen-induced peripheral tolerance is a potentially efficient and specific therapeutic approach to attenuate autoimmunity. Citrullinated peptides are major targets of disease-specific autoantibodies in Rheumatoid…
Abstract Number: 1389 • 2013 ACR/ARHP Annual Meeting
Serum 14-3-3η Precedes and Independently Predicts The Development Of RA
Dirkjan van Schaardenburg¹, Reetinder Dhaliwal¹, Walter P. Maksymowych² and Anthony Marotta³, ¹Jan van Breemen Research Institute | Reade, Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands, ²Medicine, University of Alberta, Edmonton, AB, Canada, ³Augurex Life Sciences Corp, North Vancouver, BC, Canada
Background/Purpose: We have previously reported on a risk prediction rule for the development of rheumatoid arthritis (RA) in 374 seropositive (RF and/or ACPA) arthralgia patients,…
Abstract Number: 2659 • 2013 ACR/ARHP Annual Meeting
Antibodies To Citrullinated Enolase, Fibrinogen, and Vimentin Are Associated With Markers Of Endothelial Dysfunction In First-Degree Relatives Of Patients With Rheumatoid Arthritis: The Studies Of The Etiology Of Rheumatoid Arthritis
Jan M. Hughes-Austin¹, Kendra A. Young², Kevin D. Deane³, Michael H. Weisman⁴, Jane H. Buckner⁵, Ted R. Mikuls⁶, James R. O'Dell⁷, Richard M. Keating⁸, Peter K. Gregersen⁹, Jeremy Sokolove¹⁰, William H. Robinson¹¹, V. Michael Holers¹² and Jill M. Norris², ¹Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA, ²Epidemiology, Colorado School of Public Health, Aurora, CO, ³Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ⁴Rheumatology, Cedars-Sinai Med Ctr, Los Angeles, CA, ⁵Benaroya Research Institute at Virginia Mason, Seattle, WA, ⁶Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ⁷Dept of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, ⁸Rheumatology Section, The University of Chicago, Chicago, IL, ⁹Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, ¹⁰VA Palo Alto Healthcare System and Stanford University, Palo Alto, CA, ¹¹Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ¹²Rheumatology Division, University of Colorado School of Medicine, Aurora, CO
Background/Purpose: Among rheumatoid arthritis (RA) patients, antibodies to citrullinated protein antigens (ACPA) have been detected in atherosclerotic plaques. In particular, antibodies to citrullinated fibrinogen (cit-fib)…
Abstract Number: 1396 • 2013 ACR/ARHP Annual Meeting
Survivin–positivity Increases Risk For RA and Has a Strong Additive Effect On The Shared Epitope Alleles and Antibodies To Citrullinated Peptides In Patients Of The Malaysian Epidemiological Investigation Of Rheumatoid Arthritis (MyEIRA) Study Group
Chun Lai Too¹, Shahnaz Murad², Malin Erlandsson³, Heselynn Hussein⁴, Wahinuddin Sulaiman⁵, Jasbir Singh Dhaliwal¹ and Maria Bokarewa³, ¹Institute for Medical Research, Allergy and Immunology Research Center, Jalan Pahang, Kuala Lumpur, Malaysia, ²Institute for Medical Research, Jalan Pahang, Kuala Lumpur, Malaysia, ³Rheumatology and Inflammation Research, University of Gothenburg, Gothenburg, Sweden, ⁴Department of Medicine, Putrajaya Hospital, Putrajaya, Malaysia, ⁵Department of Medicine, Tengku Bainun Hospital, Ipoh, Perak, Malaysia
Background/Purpose: The human leukocyte antigen (HLA)-DRB1 with alleles that contain common amino acid motif QKRAA termed shared epitope (SE) confer the major locus of genetic…
Abstract Number: 2432 • 2013 ACR/ARHP Annual Meeting
Characterization Of Lung Inflammation and Identification Of Shared Citrullinated Targets In The Lungs and Joints Of Early RA
Vijay Joshua¹, Gudrun Reynisdottir², Jimmy Ytterberg¹, Marianne Engström², Anders Eklund³, Magnus Skold³, Per-Johan Jakobsson⁴, Johan Rönnelid⁵, Vivianne Malmström⁶, Lars Klareskog⁴, Johan Grunewald³ and Anca I Catrina⁴, ¹Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ²Department of Medicine, Rheumatology unit, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, ³Department of Medicine, Division of Respiratory Medicine, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, ⁴Medicine, Rheumatology unit, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, ⁵Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden, ⁶Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: To investigate if lung changes are present in rheumatoid arthritis (RA) patients early in the disease process and to address the contribution of these…
Abstract Number: 1319 • 2013 ACR/ARHP Annual Meeting
Diagnostic Value Of Anti-Citrullinated Proteins Antibodies In Rheumatoid Arthritis
Claudia L. Giraldo¹, Rafael Chaparro del Moral², Mercedes Ciancio^3,4, Oscar L. Rillo⁵, Emilia Saint Martin⁶, Emilce Schneeberger⁷, Gustavo Citera⁷, Federico Zazzetti⁸, Amalia Schiel⁹ and Juan C. Barreira¹⁰, ¹Rheumatology, Hospital Gral. de Agudos Dr. E. Tornú, Buenos Aires, Argentina, ²Rheumatology Section, Hospital General de Agudos Dr. E. Tornú, Buenos Aires, Argentina, ³Hospital General de Agudos "Dr. E. Tornú", Buenos Aires, Argentina, ⁴Biochemestry, Buenos Aires, Argentina, ⁵Rheumatology, Hospital General de Agudos "Dr. E. Tornú", Buenos Aires, Argentina, ⁶Rheumatology, Instituto de Rehabilitacion Psicofisica, Buenos Aires, Argentina, ⁷Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, ⁸Rheumatology, Buenos Aires Hospital Britanico, Buenos Aires, Argentina, ⁹Central Laboratory, British Hospital, Buenos Aires, Argentina, ¹⁰Rheumatology, Buenos Aires British Hospital, Buenos Aires, Argentina
Background/Purpose: Citrulline and vimentin are some of the proteins used as antigens for anti-citrullinated proteins antibodies (ACPAs) detection for the diagnosis of rheumatoid arthritis (RA).…
Abstract Number: 2430 • 2013 ACR/ARHP Annual Meeting
Antibodies To Porphyromonas Gingivalis as An Etiological Clue To The Development Of Anti-Citrullinated Protein Antibody Positive Rheumatoid Arthritis
Nastya Kharlamova¹, Natalia Sherina¹, Anne-Marie Quirke², Kaja Eriksson³, Lena Israelsson⁴, Jan Potempa⁵, Patrick Venables⁶, Tulay Yucel-Lindberg³ and Karin Lundberg⁷, ¹Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, ²University of Oxford, Kennedy Institute of Rheumatology, Oxford, United Kingdom, ³Department of Dentistry, Karolinska Institutet, Stockholm, Sweden, ⁴Medicine, Rheumatology unit, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, ⁵Microbiology Department, Jagiellonian University, Krakow, Poland, ⁶Kennedy Institute of Rheumatology, Oxford, United Kingdom, ⁷Rheumatology unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Rheumatoid arthritis (RA) is characterized by the production of autoantibodies to citrullinated proteins (ACPA). Citrullinated proteins are generated by the actions of peptidyl arginine…

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