Abstracts tagged "ACPA"

Abstract Number: 348 • 2014 ACR/ARHP Annual Meeting
Smoking Status Is Associated with Inflammatory Cytokine Profile and Disease Activity: Decreased Inflammation and Disease Improvement with Smoking Cessation?
Jeremy Sokolove¹, Harlan Sayles², Catriona Wagner³, Lauren J. Lahey¹, Geoffrey M. Thiele⁴, William H. Robinson¹, Andreas Reimold⁵, Gail S. Kerr⁶, Grant W. Cannon⁷ and Ted R. Mikuls², ¹VA Palo Alto Healthcare System and Stanford University, Palo Alto, CA, ²Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ³VA Palo Alto Heatlh Care System and Stanford University, Palo Alto, CA, ⁴Internal Medicine, Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ⁵Rheumatology, Dallas VA and Univ of TX Southwestern Med Ct, Dallas, TX, ⁶Rheumatology, Washington DC VAMC, Georgetown and Howard University, Washington, DC, ⁷Division of Rheumatology, Salt Lake City VA and University of Utah, Salt Lake City, UT
Background/Purpose: Cigarette smoking is a risk factor for RA and has been associated with increased disease severity and lower rates of disease remission. We examined…
Abstract Number: 815 • 2014 ACR/ARHP Annual Meeting
Netosis Induced Histone Citrullination Facilitates Onset and Propagation of Rheumatoid Arthritis
Dong Hyun Sohn¹, Kazuhiro Onuma¹, Chris Rhodes¹, Xioayan Zhao¹, Tal Gazitt², Rani Shiao¹, Justyna Fert Bober³, Danye Cheng¹, Lauren J. Lahey¹, Heidi Wong⁴, Jennifer van Eyk³, William H. Robinson^1,5 and Jeremy Sokolove¹, ¹VA Palo Alto Healthcare System and Stanford University, Palo Alto, CA, ²Rheumatology, University of Washington, Seattle, WA, ³Johns Hopkins University and Cedars Sinai Medical Center, Los Angeles, CA, ⁴Stanford University School of Medicine, Stanford, CA, ⁵Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA
Background/Purpose: Anti-citrullinated protein antibodies (ACPAs) are characteristic of rheumatoid arthritis however, their presence years before onset of clinical RA is perplexing. Although multiple putative…
Abstract Number: 123 • 2014 ACR/ARHP Annual Meeting
Combination with Joint Power Doppler Signals with Anti-Citrullinated Peptide Antibody Predicts Joint Destruction in Rheumatoid Arthritis
Yohei Kirino¹, Maasa Hama¹, Kaoru Minegishi-Takase¹, Yosuke Kunishita¹, Daiga Kishimoto¹, Ryusuke Yoshimi¹, Yukiko Asami¹, Atsushi Ihata², Shigeru Ohno³, Atsuhisa Ueda¹, Mitsuhiro Takeno⁴ and Ishigatsubo Yoshiaki¹, ¹Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan, ²Department of Rheumatology, Yokohama Minami Kyosai Hospital, Yokohama, Japan, ³Center for Rheumatic Diseases, Yokohama City University Medical Center, Yokohama, Japan, ⁴Clinical Laboratory Department, Yokohama City University Hospital, Yokohama, Japan
Background/Purpose , Categorizing RA patients who require intensive treatments is highly warranted to optimize the therapy and to avoid overtreatments. We here evaluated the use…
Abstract Number: 2918 • 2014 ACR/ARHP Annual Meeting
Fine-Mapping Major Histocompatibility Complex Associations in ACPA-Positive Rheumatoid Arthritis Identified Shared HLA Amino Acid Polymorphisms in Asian and European Populations
Yukinori Okada¹, Kwangwoo Kim², Buhm Han³, Nisha E. Pillai⁴, Rick T-H. Ong⁴, Woei-Yuh Saw⁴, Ma Luo⁵, Lei Jiang⁶, Jian Yin⁶, So-Young Bang⁷, Hye-Soon Lee⁷, Matthew A. Brown⁸, Sang-Cheol Bae², Huji Xu⁹, Yik-Ying Teo⁴, Paul IW. de Bakker¹⁰ and Soumya Raychaudhuri³, ¹Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan, ²Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ³Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, ⁴National University of Singapore, Singapore, Singapore, ⁵University of Manitoba, Winnipeg, MB, Canada, ⁶The Second Military Medical University, Shanghai, China, ⁷Department of Rheumatology, Hanyang University Guri Hospital, Guri, South Korea, ⁸University of Queensland Diamantina Institute, Brisbane, Australia, ⁹Shanghai Changzheng Hospital, Shanghai, China, ¹⁰Department of Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: Rheumatoid arthritis (RA) risk is strongly associated with variations within the major histocompatibility complex (MHC) region, and in particular to HLA-DRB1 alleles. We aimed…
Abstract Number: 441 • 2014 ACR/ARHP Annual Meeting
Arthritis Associated Autoantibodies in Non-Rheumatoid Arthritis Patients with Mucosal Inflammation
Koen M. J. Janssen¹, Menke J. de Smit², Elisabeth Brouwer³, Berber Doornbos-van der Meer³, Arie Jan van Winkelhoff^2,4, Arjan Vissink⁵, Josje Altenburg⁶, Nivine Levarht⁷, Marije K. Verheul⁷, Leendert A. Trouw⁷ and Johanna Westra³, ¹Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ²Center for Dentistry and Oral Hygiene, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ³Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ⁴Department of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ⁵Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ⁶Department of Pulmonary Diseases, Medical Center Alkmaar, Alkmaar, Netherlands, ⁷Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Rheumatoid arthritis (RA) associated autoantibodies, such as anti-citrullinated protein antibodies (ACPA), rheumatoid factor (RF) and anti-carbamylated protein antibodies (anti-CarP), can be present in serum…
Abstract Number: 2224 • 2013 ACR/ARHP Annual Meeting
Tumor Necrosis Factor Alpha Induces Anti-Citrullinated Protein Antibodies and Arthritis In Part Through Peptidyl Arginine Deiminase 4
Miriam A. Shelef¹, Jeremy Sokolove², Catriona Wagner³, Eric Sackmann⁴, Thomas Warner⁵, David Beebe⁴, William H. Robinson⁶ and Anna Huttenlocher⁷, ¹Medicine, Univ of Wisconsin Schl of Med, Madison, WI, ²VA Palo Alto Healthcare System and Stanford University, Palo Alto, CA, ³VA Palo Alto Heatlh Care System and Stanford University, Palo Alto, CA, ⁴Materials Science Program and Department of Biomedical Engineering, University of Wisconsin, Madison, WI, ⁵Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, WI, ⁶VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, ⁷Dept of Pediatrics and MMI, Univ of Wisconsin Schl of Med, Madison, WI
Background/Purpose: Rheumatoid arthritis is an autoimmune, destructive arthritis characterized by anti-citrullinated protein antibodies (ACPAs) and high levels of inflammatory cytokines like tumor necrosis factor alpha…
Abstract Number: 1869 • 2013 ACR/ARHP Annual Meeting
Serum Cytokine/Chemokine Profiles Are Useful For Evaluating Pathological Conditions Of Rheumatoid Arthritis and Diagnosing Anti-CCP Antibody-Negative Patients
Hitoshi Uga¹, Takahiro Okazawa¹, Yoshiaki Miyamoto¹, Takehiro Hasegawa¹, Jun Saegusa², Goh Tsuji³, Sho Sendo⁴, Akio Morinobu⁵, Shunichi Kumagai^6,7 and Hirokazu Kurata¹, ¹Sysmex Corporation, Kobe, Japan, ²Department of Evidence-based Laboratory Medicine, Kobe University Graduate School of Medicine, Kobe, Japan, ³Center for Rheumatic Diseases, Shinko Hospital, Kobe, Japan, ⁴Center of rheumatic diseases, Shinko Hospital, Kobe, Japan, ⁵Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, ⁶Center of rheumatic diseases, Shinko hospital, Kobe, Japan, ⁷Department of Evidence-Based Laboratory Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
Background/Purpose: The diagnosis of anti-CCP antibody (ACPA) negative rheumatoid arthritis (RA) are known to be difficult and delayed as compared with ACPA-positive RA. This study…
Abstract Number: 1875 • 2013 ACR/ARHP Annual Meeting
A Dense Mapping Of Human Leukocyte Antigen Region For Study Of Interaction With Smoking In The Development Of Rheumatoid Arthritis
Xia Jiang¹, Henrik Källberg¹, Lisbeth Ärlestig², Solbritt M. Rantapää-Dahlqvist³, Lars Klareskog⁴, Leonid Padyukov⁵ and Lars Alfredsson⁶, ¹Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, ²Department of Public Health and Clinical Medicine/Rheumatology, Umeå University, Umeå, Sweden, ³Department for Public Health and Clinical Medicine/ Rheumatology, Umeå University, Umeå, Sweden, ⁴Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ⁵Rheumatology Unit, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden, ⁶Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden
Background/Purpose: Rheumatoid arthritis (RA) is believed to have a multifactorial etiology, involving both genetic and environmental components, and can be divided into two major subsets…
Abstract Number: 1839 • 2013 ACR/ARHP Annual Meeting
Osteoclastogenesis Is Enhanced By Synovial Fluid Derived Anti-Citrullinated Proteins Antibodies In Rheumatoid Arthritis
Akilan Krishnamurthy¹, Heidi Wähämaa¹, Vijay Joshua¹, Catia Cerqueira¹, Elena Ossipova², Nancy Vivar Pomiano³, Karin Lundberg², Vivianne Malmström⁴, Per-Johan Jakobsson⁵, Lars Klareskog⁵, Georg Schett⁶, Jimmy Ytterberg¹ and Anca I Catrina⁵, ¹Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ²Rheumatology unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ³Rheumatology unit, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, ⁴Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden, ⁵Medicine, Rheumatology unit, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, ⁶Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: Anti citrullinated modified vimentin antibodies isolated from peripheral blood (PB) of RA patients induce osteoclasts (OC) formation from PB derived monocytes of healthy individuals.…
Abstract Number: 1786 • 2013 ACR/ARHP Annual Meeting
91% Of Early RA Patients Are Positive For Serum 14-3-3η Or Its Auto-Antibodies
Walter P. Maksymowych¹, Dirkjan van Schaardenburg², Désirée van der Heijde³, Robert Landewé⁴, Gilles Boire⁵, Maarten Boers⁶, Vivian P. Bykerk⁷, Edward C. Keystone⁸, Katherine A. Siminovitch⁹, Mairead Murphy¹⁰ and Anthony Marotta¹¹, ¹Medicine, University of Alberta, Edmonton, AB, Canada, ²Jan van Breemen Research Institute | Reade, Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands, ³Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁴Int Med/Rheumatology, Academic Medical Center, Amsterdam, Netherlands, ⁵Rheumatology Division, Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁶Epidemiology & Biostatistics, VU University Medical Center, Amsterdam, Netherlands, ⁷Rheumatology, Hospital for Special Surgery, Weill Cornell Medical College, New York, NY, ⁸Department of Medicine, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ⁹Mount Sinai Hospital, Toronto, ON, Canada, ¹⁰Augurex Life Sciences Corp., North Vancouver, BC, Canada, ¹¹Augurex Life Sciences Corp, North Vancouver, BC, Canada
Background/Purpose: Current serological markers such as RF and ACPA are useful for early diagnosis and perhaps for screening people at risk, but there remains a…
Abstract Number: 177 • 2013 ACR/ARHP Annual Meeting
Differences and Overlap Of Immunological Pathways Implicated In The Aetiology Of Anti-Citrullinated Peptide Antibody Positive and Negative Rheumatoid Arthritis
Sebastien Viatte¹, Paul Martin², Andrew Brass³, Mark Lunt⁴, Anne Barton⁵ and Stephen Eyre⁵, ¹Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom, ²Arthritis Research UK Epidemiology Unit, Manchester Academic Health Sciences Centre, Institute of Inflammation and Repair, The University of Manchester, Manchester, United Kingdom, ³School of Computer Science, University of Manchester, Manchester, United Kingdom, Manchester, United Kingdom, ⁴Arthritis Research UK Centre for Epidemiology, University of Manchester, Manchester, United Kingdom, ⁵Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, United Kingdom
Background/Purpose: Genome-wide association studies have been successful in identifying single nucleotide polymorphisms (SNPs) associated with disease. However, previous studies have been under-powered to detect differences…
Abstract Number: 1421 • 2013 ACR/ARHP Annual Meeting
Treatment Responses and Their Predictors Of Abatacept In Biologic naïve Patients With Rheumatoid Arthritis; Data Form Abroad Study
Yutaka Kawahito¹, Takao Fujii², Akira Yokota³, Hideo Hashimoto⁴, Kiyoshi Matsui⁵, Kenji Miki⁶, Masayasu Kitano⁵, Naoki Shinmyo⁷, Aihiro Yamamoto¹, Koichiro Ohmura⁸, Takanori Kuroiwa⁹, Toshihiko Hidaka¹⁰, Ichiro Yoshii¹¹, Hideko Nakahara¹², Takashi Fujimoto¹³, Kosaku Murakami¹⁴, Satoshi Morita¹⁵, Masahiro Sekiguchi⁵, Norihiro Nishimoto^16,17, Tsuneyo Mimori⁸ and Hajime Sano⁵, ¹Department of Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan, ²Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ³Yokota Clinic for Rheumatology, Osaka, Japan, ⁴Dept of Orthopedic Surgery, Rinku Hashimoto Rheumatology Orthopaedics, Osaka, Japan, ⁵Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya-city, Japan, ⁶Department of Orthopaedic Surgery, Amagasaki Central Hospital, Amagasaki, Japan, ⁷Kashiba Asahigaoka Hospital, Kashiba, Japan, ⁸Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ⁹Department of Rheumatology, Yukioka Hospital, Osaka, Japan, ¹⁰Zenjinkai Shimin-No-Mori Hospital, Miyazaki, Japan, ¹¹Department of Orthopaedic Surgery, Yoshii Hospital, Shimanto, Japan, ¹²Division of Allergy, Rheumatology and Connective Tissue Diseases, Department of Internal Medicine, NTT West Osaka Hospital, Osaka, Japan, ¹³Nara Medical University, Kashihara, Japan, ¹⁴Rheumatology and Clinical Immunology, Osaka Red Cross Hospital, Osaka, Japan, ¹⁵Graduate School of Medicine & Medical Center, Department of Biostatistics and Epidemiology, Yokohama City University, Kanagawa, Japan, ¹⁶Tokyo Medical University, Tokyo, Japan, ¹⁷Osaka Rheumatology Clinic, Osaka, Japan
Background/Purpose: The identification of predictors of good response to biologic therapy is needed in the perspective of personalized medicine.　To determine the predicting factors of efficacy…
Abstract Number: 2819 • 2013 ACR/ARHP Annual Meeting
Administration Of a Multi-Epitope Citrullinated Peptide Attuneuates adjuvant Induced Arthritis In Rats Via Induction Of Immune Tolerance
Howard Amital¹, Smadar Gertel² and Yehuda Shoenfeld³, ¹The Zabludowicz Center For Autoimmune Diseases, and Department of Medicine 'B',, Sheba Medical Center,Tel-Hashomer, Tel-Aviv University, Tel-hashomer, Israel, ²The Zabludowicz Center For Autoimmune Diseases, and Department of Medicine 'B', Sheba Medical Center, Tel-Hashomer, Israel, ³Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Affiliated to Sackler Faculty of Medicine, Tel-Aviv University,Tel-Aviv, Tel-Aviv, Israel
Background/Purpose: Antigen-induced peripheral tolerance is a potentially efficient and specific therapeutic approach to attenuate autoimmunity. Citrullinated peptides are major targets of disease-specific autoantibodies in Rheumatoid…
Abstract Number: 1389 • 2013 ACR/ARHP Annual Meeting
Serum 14-3-3η Precedes and Independently Predicts The Development Of RA
Dirkjan van Schaardenburg¹, Reetinder Dhaliwal¹, Walter P. Maksymowych² and Anthony Marotta³, ¹Jan van Breemen Research Institute | Reade, Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands, ²Medicine, University of Alberta, Edmonton, AB, Canada, ³Augurex Life Sciences Corp, North Vancouver, BC, Canada
Background/Purpose: We have previously reported on a risk prediction rule for the development of rheumatoid arthritis (RA) in 374 seropositive (RF and/or ACPA) arthralgia patients,…
Abstract Number: 2659 • 2013 ACR/ARHP Annual Meeting
Antibodies To Citrullinated Enolase, Fibrinogen, and Vimentin Are Associated With Markers Of Endothelial Dysfunction In First-Degree Relatives Of Patients With Rheumatoid Arthritis: The Studies Of The Etiology Of Rheumatoid Arthritis
Jan M. Hughes-Austin¹, Kendra A. Young², Kevin D. Deane³, Michael H. Weisman⁴, Jane H. Buckner⁵, Ted R. Mikuls⁶, James R. O'Dell⁷, Richard M. Keating⁸, Peter K. Gregersen⁹, Jeremy Sokolove¹⁰, William H. Robinson¹¹, V. Michael Holers¹² and Jill M. Norris², ¹Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA, ²Epidemiology, Colorado School of Public Health, Aurora, CO, ³Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ⁴Rheumatology, Cedars-Sinai Med Ctr, Los Angeles, CA, ⁵Benaroya Research Institute at Virginia Mason, Seattle, WA, ⁶Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ⁷Dept of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, ⁸Rheumatology Section, The University of Chicago, Chicago, IL, ⁹Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, ¹⁰VA Palo Alto Healthcare System and Stanford University, Palo Alto, CA, ¹¹Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ¹²Rheumatology Division, University of Colorado School of Medicine, Aurora, CO
Background/Purpose: Among rheumatoid arthritis (RA) patients, antibodies to citrullinated protein antigens (ACPA) have been detected in atherosclerotic plaques. In particular, antibodies to citrullinated fibrinogen (cit-fib)…

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