Abstracts tagged "ACPA"

Abstract Number: 453 • 2014 ACR/ARHP Annual Meeting
In a Periodontal Disease Cohort without RA, Indeterminate or Low-Positive Anti-CCP-2 Antibodies Are Associated with Multiple Distinct ACPA
Jerry A. Molitor¹, Bryan S. Michalowicz², Ryan T. Demmer³, Jane H. Buckner⁴, Mark H. Wener⁵ and William H. Robinson⁶, ¹Rheumatology, University of Minnesota, Minneapolis, MN, ²Department of Developmental and Surgical Sciences, University of Minnesota School of Dentistry, Minneapolis, MN, ³Epidemiology, Columbia Univ. Mailman School of Public Health, New York, NY, ⁴Benaroya Research Institute at Virginia Mason, Seattle, WA, ⁵Rheumatology & Lab Med, University of Washington, Seattle, WA, ⁶Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA
Background/Purpose: Periodontal disease (PD) and RA share the risk factors HLA DR B1 shared epitope (SE) and tobacco exposure (TE). PD may represent a risk…
Abstract Number: 1465 • 2014 ACR/ARHP Annual Meeting
Follicular Helper T Cells Control Autoimmunity through IL-21/IL-21 Receptor Interaction in RA Patients
Shikha Singla¹, Minzi Chen², Jerry Pounds Jr.², Omar Khan², Jerald M. Zakem², Kismet Collins², Tamika Webb-Detiege², William E. Davis², Robert Quinet² and Xin Zhang³, ¹Rheumatology, Ochner Medical Center, New Orleans, LA, ²Rheumatology, Ochsner Medical Center, New Orleans, LA, ³Institute of Translational Research, Ochsner Medical Center, New Orleans, LA
Background/Purpose Rheumatoid Arthritis (RA) is an autoimmune disease characterized by chronic inflammation of the synovium, causing progressive joint destruction and reduction in quality of life…
Abstract Number: 423 • 2014 ACR/ARHP Annual Meeting
Circulating Anti-Citrullinated Peptide Antibodies and Cytokines As Biomarkers of Response to Disease-Modifying Antirheumatic Drugs Therapy in Early Rheumatoid Arthritis
Mahmood MTM Ally¹, Pieter Meyer², Bridget Hodkinson³, Eustasius Musenge⁴, Gregory Tintinger², Mohammed Tikly⁵ and Ronald Anderson¹, ¹University of Pretoria, Pretoria, South Africa, ²university of pretoria, pretoria, South Africa, ³Rheumatology, University of the Witwatersrand, Johannesburg, South Africa, ⁴University of Witwatersrand, Johannesburg, South Africa, ⁵Rheumatology Wits University, C H Baragwanath Hospital, Johannesburg, South Africa
Background/Purpose Serial measurement of circulating anti-citrullinated peptide antibodies (ACPA) and cytokines is of potential importance in the management of patients with rheumatoid arthritis (RA). However,…
Abstract Number: 1476 • 2014 ACR/ARHP Annual Meeting
A Dose Response Relationship Between Shared Epitope and ACPA Level: But Not All SE Alleles Are Created Equal
Jeremy Sokolove¹, Lauren J. Lahey¹, Catriona Wagner², Irene Smolik³, David B. Robinson⁴, Elizabeth D. Ferucci⁵, Marianna Newkirk⁶, Marvin Fritzler⁷, William H. Robinson⁸ and Hani El-Gabalawy⁹, ¹VA Palo Alto Healthcare System and Stanford University, Palo Alto, CA, ²VA Palo Alto Heatlh Care System and Stanford University, Palo Alto, CA, ³Arthritis Center, University of Manitoba, Winnipeg, MB, Canada, ⁴Arthritis Centre, University of Manitoba, Winnipeg, MB, Canada, ⁵Division of Community Health Services, Alaska Native Tribal Health Consortium, Anchorage, AK, ⁶McGill University, Montreal, QC, Canada, ⁷Medicine, University of Calgary, Calgary, AB, Canada, ⁸VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, ⁹University of Manitoba, Winnipeg, MB, Canada
Background/Purpose: Indigenous North American populations have high prevalence of seropositive RA. The Cree/Ojibway population in Central Canada and the Alaska Native population have a high prevalence…
Abstract Number: 434 • 2014 ACR/ARHP Annual Meeting
Characterization of Lung Inflammation in the Lungs of Early Rheumatoid Arthritis
Gudrun Reynisdottir¹, Vijay Joshua², Aase Haj Hensvold², Lars Klareskog³ and Anca I Catrina², ¹Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet,, Stockholm, Sweden, ²Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ³Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska institutet, Stockholm, Sweden
Background/Purpose We have previously demonstrated that lung abnormalities are present already at disease onset in ACPA positive RA patients. We aimed to further investigate lung…
Abstract Number: 2659 • 2013 ACR/ARHP Annual Meeting
Antibodies To Citrullinated Enolase, Fibrinogen, and Vimentin Are Associated With Markers Of Endothelial Dysfunction In First-Degree Relatives Of Patients With Rheumatoid Arthritis: The Studies Of The Etiology Of Rheumatoid Arthritis
Jan M. Hughes-Austin¹, Kendra A. Young², Kevin D. Deane³, Michael H. Weisman⁴, Jane H. Buckner⁵, Ted R. Mikuls⁶, James R. O'Dell⁷, Richard M. Keating⁸, Peter K. Gregersen⁹, Jeremy Sokolove¹⁰, William H. Robinson¹¹, V. Michael Holers¹² and Jill M. Norris², ¹Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA, ²Epidemiology, Colorado School of Public Health, Aurora, CO, ³Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ⁴Rheumatology, Cedars-Sinai Med Ctr, Los Angeles, CA, ⁵Benaroya Research Institute at Virginia Mason, Seattle, WA, ⁶Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ⁷Dept of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, ⁸Rheumatology Section, The University of Chicago, Chicago, IL, ⁹Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, ¹⁰VA Palo Alto Healthcare System and Stanford University, Palo Alto, CA, ¹¹Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ¹²Rheumatology Division, University of Colorado School of Medicine, Aurora, CO
Background/Purpose: Among rheumatoid arthritis (RA) patients, antibodies to citrullinated protein antigens (ACPA) have been detected in atherosclerotic plaques. In particular, antibodies to citrullinated fibrinogen (cit-fib)…
Abstract Number: 1396 • 2013 ACR/ARHP Annual Meeting
Survivin–positivity Increases Risk For RA and Has a Strong Additive Effect On The Shared Epitope Alleles and Antibodies To Citrullinated Peptides In Patients Of The Malaysian Epidemiological Investigation Of Rheumatoid Arthritis (MyEIRA) Study Group
Chun Lai Too¹, Shahnaz Murad², Malin Erlandsson³, Heselynn Hussein⁴, Wahinuddin Sulaiman⁵, Jasbir Singh Dhaliwal¹ and Maria Bokarewa³, ¹Institute for Medical Research, Allergy and Immunology Research Center, Jalan Pahang, Kuala Lumpur, Malaysia, ²Institute for Medical Research, Jalan Pahang, Kuala Lumpur, Malaysia, ³Rheumatology and Inflammation Research, University of Gothenburg, Gothenburg, Sweden, ⁴Department of Medicine, Putrajaya Hospital, Putrajaya, Malaysia, ⁵Department of Medicine, Tengku Bainun Hospital, Ipoh, Perak, Malaysia
Background/Purpose: The human leukocyte antigen (HLA)-DRB1 with alleles that contain common amino acid motif QKRAA termed shared epitope (SE) confer the major locus of genetic…
Abstract Number: 2432 • 2013 ACR/ARHP Annual Meeting
Characterization Of Lung Inflammation and Identification Of Shared Citrullinated Targets In The Lungs and Joints Of Early RA
Vijay Joshua¹, Gudrun Reynisdottir², Jimmy Ytterberg¹, Marianne Engström², Anders Eklund³, Magnus Skold³, Per-Johan Jakobsson⁴, Johan Rönnelid⁵, Vivianne Malmström⁶, Lars Klareskog⁴, Johan Grunewald³ and Anca I Catrina⁴, ¹Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ²Department of Medicine, Rheumatology unit, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, ³Department of Medicine, Division of Respiratory Medicine, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, ⁴Medicine, Rheumatology unit, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, ⁵Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden, ⁶Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: To investigate if lung changes are present in rheumatoid arthritis (RA) patients early in the disease process and to address the contribution of these…
Abstract Number: 1319 • 2013 ACR/ARHP Annual Meeting
Diagnostic Value Of Anti-Citrullinated Proteins Antibodies In Rheumatoid Arthritis
Claudia L. Giraldo¹, Rafael Chaparro del Moral², Mercedes Ciancio^3,4, Oscar L. Rillo⁵, Emilia Saint Martin⁶, Emilce Schneeberger⁷, Gustavo Citera⁷, Federico Zazzetti⁸, Amalia Schiel⁹ and Juan C. Barreira¹⁰, ¹Rheumatology, Hospital Gral. de Agudos Dr. E. Tornú, Buenos Aires, Argentina, ²Rheumatology Section, Hospital General de Agudos Dr. E. Tornú, Buenos Aires, Argentina, ³Hospital General de Agudos "Dr. E. Tornú", Buenos Aires, Argentina, ⁴Biochemestry, Buenos Aires, Argentina, ⁵Rheumatology, Hospital General de Agudos "Dr. E. Tornú", Buenos Aires, Argentina, ⁶Rheumatology, Instituto de Rehabilitacion Psicofisica, Buenos Aires, Argentina, ⁷Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, ⁸Rheumatology, Buenos Aires Hospital Britanico, Buenos Aires, Argentina, ⁹Central Laboratory, British Hospital, Buenos Aires, Argentina, ¹⁰Rheumatology, Buenos Aires British Hospital, Buenos Aires, Argentina
Background/Purpose: Citrulline and vimentin are some of the proteins used as antigens for anti-citrullinated proteins antibodies (ACPAs) detection for the diagnosis of rheumatoid arthritis (RA).…
Abstract Number: 2430 • 2013 ACR/ARHP Annual Meeting
Antibodies To Porphyromonas Gingivalis as An Etiological Clue To The Development Of Anti-Citrullinated Protein Antibody Positive Rheumatoid Arthritis
Nastya Kharlamova¹, Natalia Sherina¹, Anne-Marie Quirke², Kaja Eriksson³, Lena Israelsson⁴, Jan Potempa⁵, Patrick Venables⁶, Tulay Yucel-Lindberg³ and Karin Lundberg⁷, ¹Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, ²University of Oxford, Kennedy Institute of Rheumatology, Oxford, United Kingdom, ³Department of Dentistry, Karolinska Institutet, Stockholm, Sweden, ⁴Medicine, Rheumatology unit, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, ⁵Microbiology Department, Jagiellonian University, Krakow, Poland, ⁶Kennedy Institute of Rheumatology, Oxford, United Kingdom, ⁷Rheumatology unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Rheumatoid arthritis (RA) is characterized by the production of autoantibodies to citrullinated proteins (ACPA). Citrullinated proteins are generated by the actions of peptidyl arginine…
Abstract Number: 1072 • 2013 ACR/ARHP Annual Meeting
Gene-Environment Interaction Between HLA-DRB1 Shared Epitope and Occupational Textile Dust Exposure In The Risk Of ACPA-Positive Rheumatoid Arthritis In Female Patients: Evidence From The Malaysian Epidemiological Investigation Of Rheumatoid Arthritis Case-Control Study
Chun Lai Too^1,2, Nor Asiah Muhamad¹, Leonid Padyukov³, Lars Alfredsson⁴, Camilla Bengtsson⁵, Lars Klareskog⁶ and Shahnaz Murad⁷, ¹Institute for Medical Research, Jalan Pahang.Kuala Lumpur, Malaysia, Kuala Lumpur, Malaysia, ²Karolinska Institutet. Department of Medicine. Stockholm, Sweden, Stockholm, Sweden, ³Rheumatology Unit, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden, ⁴Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden, ⁵Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, ⁶Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ⁷Institute for Medical Research, Jalan Pahang, Kuala Lumpur, Malaysia
Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease with interacting genetic and environmental factors contributing to its etiology. In this study, we investigated…
Abstract Number: 2395 • 2013 ACR/ARHP Annual Meeting
Plasma Short-Talin Is a New Rheumatoid Arthritis Monitoring Biomarker Independent Of The Inflammatory Markers
Kensei Tsuzaka, Masako Takao and Jiro Nishida, Dept of Internal Medicine, Ichikawa General Hospital,TDC, Ichikawa, Chiba, Japan
Methods: ). Sixteen (31.4 %) of these 51 patients were untreated, and 18 patients (35.3%) were treated with biologics DMARD at the time of collecting…
Abstract Number: 911 • 2013 ACR/ARHP Annual Meeting
Neutralization Of Anti-Citrullinated Protein Antibodies – a Way To Go?
Catia Cerqueira¹, Elena Ossipova², Monika Hansson³, Linda Mathsson⁴, Lars Klareskog³, Johan Rönnelid⁴ and Per Johan Jakobsson⁵, ¹Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ²Rheumatology unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ³Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ⁴Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden, ⁵Rheumatology unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: In a previous study, we have identified endogeneously citrullinated sites in fibrinogen from RA synovial tissue (Hermansson M. et al. Proteomics Clin Appl, 2010).…
Abstract Number: 2363 • 2013 ACR/ARHP Annual Meeting
Positivity Of Rheumatoid Factor and Anti-Cyclic Citrullinated Peptide Is Associated With The Response Rate Of Infliximab, But Not Tocilizumab, In Treatment Of Rheumatoid Arthritis
Masao Sato¹, Masao Takemura², Ryuki Shinohe¹, Yasuko Yamamoto³ and Kuniaki Saito³, ¹Orthopaedic Surgery, Gifu University, Gifu, Japan, ²Informative Clinical Medicine, Gifu University, Gifu, Japan, ³Human Health Science, Kyoto University, Kyoto, Japan
Background/Purpose: Recent reports have shown that positivity for rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPA) can influence the efficacy of rheumatoid arthritis (RA) treatment.…
Abstract Number: 870 • 2013 ACR/ARHP Annual Meeting
How To Predict That Early Arthritis Without Rheumatoid Factor and ACPA Becomes Rheumatoid Arthritis According To ACR/EULAR 2010 After a 3-Years Follow-Up? Results From The Espoir Cohort
Gaël Mouterde¹, Cédric Lukas², Nathalie Rincheval³, Alain Saraux⁴, Philippe Dieude⁵ and Bernard Combe⁶, ¹Rheumatology, Montpellier 1 University, Lapeyronie Hospital, Montpellier, France, ²Immuno-Rhumatologie, Hopital Lapeyronie, Montpellier, France, ³Institut Universitaire de Recherche Clinique, Montpellier, France, ⁴Department of rheumatology and unit of immunology (EA 2216), CHU Brest et Université Bretagne Occidentale, Brest, France, ⁵Rheumatology, Rheumatology departement & INSERM U699, Paris Diderot university, APHP, Bichat hospital, Paris, France, ⁶Rheumatology, Lapeyronie Hospital, Montpellier I university, Montpellier, France
Background/Purpose: To describe disease course of patients without rheumatoid factor (RF) and anti-citrullinated protein auto-antibodies (ACPA) in an inception cohort of early arthritis patients. To determine…

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