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Abstract Number: 1355 • 2018 ACR/ARHP Annual Meeting
Asymptomatic Hyperuricemia Is Associated with Increased Prevalence of Symptomatic Knee Osteoarthritis: Data from Third National Health and Nutrition Examination Survey
Shudan Wang^1,2, Michael Pillinger³, Svetlana Krasnokutsky Samuels⁴ and Kamil E. Barbour⁵, ¹Department of Medicine, Division of Rheumatology, NYU School Medicine, New York City, NY, ²Medicine/Rheumatology, VA Medical Center- Manhattan, New York, NY, ³Medicine/Rheumatology, NYU School of Medicine, New York, NY, ⁴NYU School of Medicine, New York, NY, ⁵Arthritis Program, Centers for Disease Control and Prevention, Atlanta, GA
Background/Purpose: Inflammation plays a pathogenetic role in OA, and catabolic cytokines including IL-1β potentiate joint space narrowing. Elevated serum urate (sUA) levels promote crystal-induced stimulation…
Abstract Number: 1744 • 2018 ACR/ARHP Annual Meeting
Prognostic Value of Right Heart Involvement in Systemic Sclerosis:Not Only Pulmonary Arterial Hypertension
Luna Gargani¹, Cosimo Bruni², Antonella Moreo³, Laura Belloli³, Silvia Bellando-Randone², Oscar Massimiliano Epis³, Francesco Ferrara⁴, Olga Vriz⁵, Eduardo Bossone⁶, Petar M. Seferovic⁷, Daniel E. Furst⁸ and Marco Matucci-Cerinic⁹, ¹Institute of Clinical Physiology, Consiglio Nazionale delle Ricerche (CNR), Pisa, Italy, ²Department of Experimental and Clinical Medicine, Division of Rheumatology, University of Florence, Firenze, Italy, ³Niguarda Ca’ Granda Hospital, Milan, Italy, ⁴"Cava de' Tirreni and Amalfi Coast", University Hospital, Salerno, Italy, ⁵King Faisal Hospital, Riyadh, Saudi Arabia, ⁶Cardarelli Hospital, Naples, Italy, ⁷Department of Cardiology, , Clinical Center of Serbia and Belgrade University School of Medicine, Belgrade, Serbia, ⁸University of California Los Angeles, Los Angeles, CA, ⁹Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy
Background/Purpose: In SSc, cardiac dysfunction is associated with poor prognosis. Right ventricular involvement is frequently secondary to PAH. Echocardiography is the routine imaging tool to…
Abstract Number: 1908 • 2018 ACR/ARHP Annual Meeting
Bariatric Surgery Does Not Affect the Incidence of Rheumatoid Arthritis in Obese Subjects
Yuan Zhang¹, Cristina Maglio², Anna Rudin³ and Lena Carlsson⁴, ¹Dep. of Rheumatology and Inflammation Research, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, ²Dep. of Rheumatology and Inflammation Research and Wallenberg Centre for Molecular and Translational Medicine, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, ³Dept of Rheumatology and Inflammation Research, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, ⁴Department of Molecular and Clinical Medicine, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
Background/Purpose: Obesity is among the risk factors for rheumatoid arthritis (RA). Bariatric surgery is an effective treatment to achieve weight loss and to prevent obesity-related…
Abstract Number: 1950 • 2018 ACR/ARHP Annual Meeting
Self-Reported Depression and Anxiety Among US Adults Aged 18-44 Years with Arthritis, National Health Interview Survey 2014-2016
Dana Guglielmo¹, Jennifer M. Hootman², Louise Murphy², Michael Boring³, Kristina Theis², Charles G. Helmick², Kamil E. Barbour² and Patricia Katz⁴, ¹Oak Ridge Institute for Science and Education, Oak Ridge, TN, ²Arthritis Program, Centers for Disease Control and Prevention, Atlanta, GA, ³Cutting Edge Technology and Solutions, Mesa, AZ, ⁴University of California San Francisco, San Francisco, CA
Background/Purpose: Depression and anxiety are frequent comorbid conditions among adults with arthritis, and are associated with poorer quality of life, reduced adherence and efficacy of…
Abstract Number: 2082 • 2018 ACR/ARHP Annual Meeting
ERAP1 Deficiency Partially Relieves HLA-B27-Induced ER Stress and IL-23 Expression, but Does Not Restore Dendritic Cell Function in Experimental Spondyloarthritis
Tri Tran¹, Vance Holt², Tejpal Gill¹, Joshua R. Bennett², Joel Taurog³ and Robert Colbert⁴, ¹National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ²National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ³Dept Int Med-Rheum Dis Div, University of Texas Southwestern Medical Center, Dallas, TX, ⁴National Institute of Arthritis and Musculuskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD
Background/Purpose: Preliminary results suggest that endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1) deficiency partially protects HLA-B27/human b2m transgenic (B27-Tg) rats from spondyloarthritis (SpA) as evidenced by…
Abstract Number: 2131 • 2018 ACR/ARHP Annual Meeting
Prevalence of Systemic Lupus Erythematosus (SLE) and Associated Comorbidities in the 2011-2015 Medicare Population
Suying Li, Tingting Gong, Yi Peng, Kimberly M. Nieman and David T. Gilbertson, Minneapolis Medical Research Foundation, Chronic Disease Research Group, Minneapolis, MN
Background/Purpose: Prevalence of systemic lupus erythematosus (SLE) has been estimated in different US regions. An estimate based on the 2005 US population showed SLE affecting…
Abstract Number: 2204 • 2018 ACR/ARHP Annual Meeting
Clinical Utility of a Multi-Energy Spectral CT in Crystal Arthritis
Lisa K. Stamp¹, Nigel Anderson², Fabio Becce³, Maya Rajeswari², Matthew Polson⁴, Olivier Guyen³, Anais Viry³, Chloe Choi², Tracy Kirkbride⁵ and Aamir Raja², ¹University of Otago, Christchurch, New Zealand, ²University of Otago, Christchurch, Christchurch, New Zealand, ³Lausanne University Hospital, Lausanne, Switzerland, ⁴University of Canterbury, Christchurch, New Zealand, ⁵Ara Institute of Canterbury, Christchurch, New Zealand
Background/Purpose: The gold standard for the diagnosis of crystal-related arthritis requires aspiration and visualization of crystals from synovial fluid or tophus material. However, crystal identification…
Abstract Number: 2218 • 2018 ACR/ARHP Annual Meeting
Use of Anakinra in Hospitalized Patients with Acute Crystalline Arthritis
Jean Liew and Gregory Gardner, Rheumatology, University of Washington, Seattle, WA
Background/Purpose: Medically complex individuals may have contraindications to standard therapies for acute arthritis secondary to gout or calcium pyrophosphate disease (CPPD). Observational studies have demonstrated…
Abstract Number: 2219 • 2018 ACR/ARHP Annual Meeting
Safety, Pharmacokinetics and Pharmacodynamics of NC-2500, a Novel Xanthine Oxidoreductase Inhibitor, in Healthy Volunteers
Masuharu Hirano¹, Shiro Kobayashi², Eri Miyayama², Takashi Ohta¹, Masao Yamamoto² and Tomio Yamakawa³, ¹Discovery Research Laboratories, Nippon Chemiphar Co., Ltd., Misato, Saitama Prefecture, Japan, ²Development Planning Department, Nippon Chemiphar Co., Ltd., Chiyoda-ku, Tokyo, Japan, ³Discovery Research Laboratories, Nippon Chemiphar Co., Ltd., Misato, Saitama prefecture, Japan
Background/Purpose: Gout flare due to rapid urate reduction after initiating urate-lowering therapy (ULT) is one of the major issues in the therapy. International guidelines recommend…
Abstract Number: 2223 • 2018 ACR/ARHP Annual Meeting
Proton Pump Inhibitors and Risk of Calcium Pyrophosphate Deposition (CPPD) in a Population-Based Study
Tuhina Neogi¹, Christine Peloquin¹, Yuqing Zhang^1,2, Hyon K. Choi³, Robert Terkeltaub⁴ and David T. Felson¹, ¹Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ²Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ³Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Boston, MA, ⁴VA San Diego Healthcare System, San Diego, CA
Background/Purpose: There are no therapies available that specifically target CPPD, with treatment limited to symptomatic management. Hypomagnesemia is a recognized risk factor for CPPD, and…
Abstract Number: 2229 • 2018 ACR/ARHP Annual Meeting
Can We Predict Inadequate Response to Allopurinol Dose Escalation? Analysis of a Randomized Controlled Trial
Lisa K. Stamp¹, Peter T. Chapman², Murray Barclay³, Anne Horne⁴, Christopher Frampton¹, Paul Tan⁵, Jill Drake⁶ and Nicola Dalbeth⁵, ¹University of Otago, Christchurch, New Zealand, ²Christchurch Hospital, Christchurch, New Zealand, ³Medicine, University of Otago, Christchurch, New Zealand, ⁴Department of Medicine, University of Auckland, Auckland, New Zealand, ⁵University of Auckland, Auckland, New Zealand, ⁶University of Otago, Christchurch, Christchurch, New Zealand
Background/Purpose: The two most common causes of inadequate serum urate (SU) lowering with allopurinol are low adherence and under-dosing. Those who are adherent, but do…
Abstract Number: 2238 • 2018 ACR/ARHP Annual Meeting
Non-Coding Urate-Associated Variants Function in a Conserved Lincrna Regulatory Domain That Alters MAF transcription
Megan Leask¹, Tony R. Merriman¹, Amy Dowdle¹, Hamish Salvesen¹, Ruth Topless¹, Tayaza Fadason², Wenhua Wei¹, William Schierding², Justin O'Sullivan² and Julia Horsfield¹, ¹University of Otago, Dunedin, New Zealand, ²University of Auckland, Auckland, New Zealand
Background/Purpose: Genome-wide association studies (GWAS) have revealed that the large majority of disease-associated single nucleotide polymorphisms (SNPs) are located in the non-coding regions of the…
Abstract Number: 2245 • 2018 ACR/ARHP Annual Meeting
Lubricin/Proteoglycan 4 (PRG4) Inhibits NLRP3 Inflammasome Assembly in Monosodium Urate (MSU)-Crystal Induced Arthritis.
Anthony M. Reginato¹, Changqi Sun², Elsaid A. Khaled³, Tannin A. Schmidt⁴, Olin D. Liang⁵ and Gregory D Jay⁶, ¹Division of Rheumatology, Rhode Island Hospital, Providence, RI, ²Division of Rheumatology, Rhode Island Hospital, Providence, MA, ³Department of Biomedical and Phramaceutical Science, Chapman University School of Pharmacy, Irvine, CA, ⁴Biomedical Engineering, University of Connecticut Health Center, Framington, CT, ⁵Division of Hematology/Oncology, Rhode Island Hospital, Providence, RI, ⁶Department of Emergency Medicine, Rhode Island Hospital, Providence, RI
Background/Purpose: Lubricin/proteoglycan-4 (PRG4) is a mucinous glycoprotein secreted by synovial fibroblast and superficial zone chondrocytes. PRG4 has a multifaceted homeostatic role in the joint including…
Abstract Number: 2250 • 2018 ACR/ARHP Annual Meeting
Mitigation of Inflammation Induced By Monosodium Urate Crystals in Mice By Treatment with Svp-Rapamycin
Pallavi Kolte, Robert LaMothe, Joseph Ferrari, Sheldon Leung, Wesley DeHaan Ph.D., Earl Sands and Takashi Kei Kishimoto, Selecta Biosciences, Watertown, MA
Background/Purpose: Initiation of urate-lowering therapies is typically associated with an increase in gout flares due to mobilization of pro-inflammatory urate crystals. SEL-212 is a novel…
Abstract Number: 2252 • 2018 ACR/ARHP Annual Meeting
Serum Urate Ant Its Clearance in Patients with Chronic Kidney Disease Under Peritoneal Dialysis
Claudia Diez¹, Javier Pérez-Contreras^1,2 and Mariano Andrés^1,3, ¹Departamento de Medicina Clínica, Universidad Miguel Hernández, Alicante, Spain, ²Servicio de Nefrología, Hospital General Universitario de Alicante-ISABIAL, Alicante, Spain, ³Hospital General Universitario de Alicante-ISABIAL, Alicante, Spain
Background/Purpose: Hyperuricemia and gout are common in patients with chronic kidney disease (CKD), some ultimately requiring replacement therapy. Serum urate (SU) levels appear to achieve…

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