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Abstract Number: 1278 • 2018 ACR/ARHP Annual Meeting
Evaluating a Causal Role of Mitochondrial Variation in the Development of Gout
Amara Shaukat¹, Anna Gosling¹, Matthew Bixley¹, Amanda Phipps-Green¹, Tanya J. Major¹, Murray Cadzow¹, Nicola Dalbeth², Lisa K. Stamp³, Elizabeth Matisoo-Smith¹, Jennie Harre Hindmarsh⁴, Leo .A.B. Joosten⁵, Tim Jansen⁶, Matthijs Janssen⁶, Anne-Kathrin Tausche⁷, Philip Riches⁸, Alexander So⁹, Mariano Andres¹⁰, Geraldine M. McCarthy¹¹, Fernando Perez-Ruiz¹², Michael Doherty¹³, Rosa Torres¹⁴, Tom W.J. Huizinga¹⁵, Rachel Knevel¹⁶, Fina Kurreeman¹⁷ and Tony R. Merriman¹, ¹University of Otago, Dunedin, New Zealand, ²University of Auckland, Auckland, New Zealand, ³University of Otago, Christchurch, New Zealand, ⁴Ngati Porou Hauora Charitable Trust, Te Puia Springs, New Zealand, ⁵Radboud University Medical Center, Nijmegen, Netherlands, ⁶VieCuri Medical Center, Venlo, Netherlands, ⁷Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Dresden, Germany, ⁸University of Edinburgh, Edinburgh, United Kingdom, ⁹University of Lausanne, Lausanne, Switzerland, ¹⁰Hospital General Universitario de Alicante-ISABIAL, Alicante, Spain, ¹¹Mater Misericordiae University Hospital, Dublin, Ireland, ¹²BioCruces Health Research Institute, Barakaldo, Spain, ¹³The University of Nottingham, Nottingham, United Kingdom, ¹⁴La Paz University Hospital, Madrid, Spain, ¹⁵Department of Rheumatology, LUMC, Leiden, Netherlands, ¹⁶Brigham and Women's Hospital, Boston, MA, ¹⁷Leiden University Medical Centre, Leiden, Netherlands
Background/Purpose: Mitochondria execute roles in diverse cellular pathways. As a danger signal, damaged mitochondria can induce inflammation in response to stress through NLRP3 inflammasome activation,…
Abstract Number: 1279 • 2018 ACR/ARHP Annual Meeting
Relative Insufficiency of Renal Uric Acid Excretion in Gout Patients with Obesity Leads to High Serum and Glomerular Filtration Load of Uric Acid
Jin-Jian Liang, Qian-Hua Li, Ying-Qian Mo, Xiu-Ning Wei, Dong-Hui Zheng and Lie Dai, Department of Rheumatology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China
Background/Purpose: Gout is usually accompanied by metabolic diseases including obesity, hypertension, diabetes, and dyslipidemia. Obesity has been confirmed as a risk factor for gout. This study aims to explore…
Abstract Number: 1280 • 2018 ACR/ARHP Annual Meeting
Higher Body Fat Percentage in Non-Obese Late-Onset Gout Patients
Qian-Hua Li, Kui-Min Yang, Yan-Hui Xu, Xin-Yun Du, Jin-Jian Liang, Jian-Zi Lin, Ying-Qian Mo and Lie Dai, Department of Rheumatology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China
Background/Purpose: There is a trend of younger gout onset related to higher obesity prevalence. BMI is limited to discriminate between fat and lean mass. Body…
Abstract Number: 1282 • 2018 ACR/ARHP Annual Meeting
Influence of Renal Function on the Velocity of Tophus Resolution and Achievement of Disease Remission in Patients with Chronic Refractory Gout Treated with Pegloticase
Brian F. Mandell¹, Naomi Schlesinger², N. Lawrence Edwards³, Anthony Yeo⁴ and Peter E. Lipsky⁵, ¹Rheumatology, Cleveland Clinic, Cleveland, OH, ²Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, ³Rheumatology, University of Florida Health Science Center, Gainesville, FL, ⁴Horizon Pharma, Lake Forest, IL, ⁵AMPEL BioSolutions, Charlottesville, VA
INFLUENCE OF RENAL FUNCTION ON THE VELOCITY OF TOPHUS RESOLUTION AND ACHEIVEMENT OF DISEASE REMISSION IN PATIENTS WITH CHRONIC REFRACTORY GOUT TREATED WITH PEGLOTICASEBackground/Purpose: Impaired…
Abstract Number: 1284 • 2018 ACR/ARHP Annual Meeting
Initial Pegloticase Serum Levels Predict Persistent Responsiveness in Patients with Chronic Refractory Gout
Kenneth Saag¹, Mitchell Feinman², Herbert S. B. Baraf³, Roy Fleischmann⁴, Arthur Kavanaugh⁵ and Peter E. Lipsky⁶, ¹Division Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ²ACME Research, LLC, Orangeburg, SC, ³Arthritis and Rheumatism Associates, Wheaton, MD, ⁴Metroplex Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, TX, ⁵University of California, San Diego, School of Medicine, La Jolla, CA, ⁶AMPEL BioSolutions, Charlottesville, VA
Background/Purpose: Pegloticase is a pegylated recombinant mammalian uricase approved for treatment of persons with chronic gout refractory to standard urate lowering therapy1. Despite an initial…
Abstract Number: 1285 • 2018 ACR/ARHP Annual Meeting
Comparision of Urate Burden in Well and Poorly Controlled Gout Patients: A Dual-Energy CT Study
Min Kyung Chung¹, Hyeran Hyun², Ji Young Hwang² and Jisoo Lee¹, ¹Division of Rheumatology, Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea, Republic of (South), ²Department of Radiology, Ewha Womans University School of Medicine, Seoul, Korea, Republic of (South)
Background/Purpose: Dual-energy computed tomography (DECT) allows sensitive and quantative detection of monosodium urate (MSU) crystals in patients with gout. Although its usefulness in diagnosing gout…
Abstract Number: 1287 • 2018 ACR/ARHP Annual Meeting
Strong Impact of Dysfunctional Variants of ABCG2 on Hyperuricemia and Gout in Children and Adolescents
Blanka Stiburkova^1,2, Katerina Pavelcova^1,3, Marketa Pavlikova¹ and Karel Pavelka⁴, ¹Institute of Rheumatology, Prague, Czech Republic, ²Department of Pediatrics and Adolescent Medicine, Charles University and General University Hospital in Prague, First Faculty of Medicine, Prague, Czech Republic, ³Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, ⁴Na Slupi 4, Institute of Rheumatology, Prague, Czech Republic
Background/Purpose: Common dysfunctional variants of ABCG2, a high-capacity urate transporter gene, that result in decreased urate excretion, are major causes of hyperuricemia and gout. However,…
Abstract Number: 1288 • 2018 ACR/ARHP Annual Meeting
Association between Musculoskeletal Ultrasonography and Bone Remodeling Markers and the Role of Ultrasonography on Monitoring Treatment Responsiveness in Patients with Gout and Hyperuricemia
Ya-dan Zou^1,2, Ya-nan Fei¹, Hui Gao³, Lin-feng Xie¹, Yu-chao Zhong¹ and Xuewu Zhang³, ¹Peking University People's Hospital, Beijing, China, ²Peking University International Hospital, Beijing, China, ³Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China
Background/Purpose: Musculoskeletal ultrasonography (US) is an invasive method to identify gout related bone damage, while Dickkopf-1 (DKK-1) and receptor activator of nuclear factor-κB ligand（RANKL）are bone…
Abstract Number: 1289 • 2018 ACR/ARHP Annual Meeting
Immunosuppressant Use and Gout in the Prevalent Solid Organ Transplant Population
Andrew Milgroom¹, Mara Onita Lenco¹, Kevin Francis¹, Jeffrey D. Kent², Brian LaMoreaux³ and Brian F. Mandell⁴, ¹Trinity Partners, Waltham, MA, ²Medical Affairs, Horizon Pharma USA, Inc, Lake Forest, IL, ³Horizon Pharma USA, Inc, Lake Forest, IL, ⁴Rheumatology, Cleveland Clinic, Cleveland, OH
Background/Purpose: Gout is a frequent co-morbidity of solid organ transplant (SOT). Cyclosporine (CsA) is often cited as the main cause of gout in SOT, as…
Abstract Number: 1290 • 2018 ACR/ARHP Annual Meeting
Systemic Inflammation and Atherosclerosis in Patients with Gout. Results from the NOR-Gout Study
Silvia Rollefstad¹, Till Uhlig^2,3, Lars Fridtjof Karoliussen³, Hilde B. Hammer⁴ and Anne Grete Semb⁵, ¹Preventive Cardio-Rheuma clinic, Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ²University of Oslo, Oslo, Norway, ³Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ⁴Dept. of Rheumtology, Diakonhjemmet Hospital, Oslo, Norway, ⁵Preventive Cardio-Rheuma clinic, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway
Systemic inflammation and atherosclerosis in patients with gout. Results from the NOR-Gout studyBackground/Purpose: The association between gout and cardiovascular disease (CVD) is well known, whereas…
Abstract Number: 1291 • 2018 ACR/ARHP Annual Meeting
Efficacy and Safety of Anakinra in Congestive Heart Failure Patients, Including Lvad, with Acute Gouty Arthritis: A Retrospective Study of 36 Patients at an Academic Medical Center
Arash Hassantoufighi¹, Paloma Alejandro², Christopher E. Collins², Florina Constantinescu² and Juhi Bhargava³, ¹Rheumatology, MedStar Washington Hospital Center/Georgetown University Medical Center, washington, DC, ²Rheumatology, MedStar Washington Hospital Center/Georgetown University Medical Center, Washington, DC, ³Internal Medicine, MedStar Washington Hospital Center/Georgetown University Medical Center, washington, DC
Background/Purpose: Gout is the most common inflammatory arthritis worldwide and many patients with gout are ‘complicated’ by multiple comorbidities including metabolic syndrome, renal disease and…
Abstract Number: 1293 • 2018 ACR/ARHP Annual Meeting
Identification of New and Rare Variants in ABCG2, SLC22A1 and ALDH16A1 Genes in Crystal-Proven Early-Onset Gout
Corinne Collet¹, Hélène Morel¹, Manon Ricquebourg¹, Martine Cohen-Solal², Jean-Louis Laplanche¹, Tristan Pascart³, Thomas Bardin⁴, Frederic Liote⁵, Pascal Richette⁶ and Hang-Korng Ea⁷, ¹biochemistry, Laribosiere hospital, Paris, France, ²INSERM UMR1132, Paris Diderot University, Paris, France, ³Rheumatology, Groupe Hospitalier de l'Institut Catholique de Lille, Lomme, France, ⁴Rheumatology, Hôpital Lariboisière, Paris, France, ⁵University Paris Diderot, Paris, France, ⁶Lariboisière Hospital, Lariboisière, University of Paris 7, Paris, France, ⁷INSERM UMR1132, Bioscar, University Paris Diderot, PARIS, France
Background/Purpose: Early-onset or juvenile gout (EOG) without hypoxanthine-guanine phosphoribosyltransferase enzyme deficiency (HPRT, OMIM 300323) and not related to familial juvenile hyperuricemic nephropathy (UMOD, OMIM 300323)…
Abstract Number: 1294 • 2018 ACR/ARHP Annual Meeting
Initial Phase 2 Clinical Data of SEL-212 in Symptomatic Gout Patients: Monthly Dosing of a Pegylated Uricase (Pegadricase) with Svp-Rapamycin Enables Sustained Reduction of Acute Gout Flares
Rehan Azeem¹, Alan J. Kivitz², Earl Sands¹, Wesley DeHaan Ph.D.³, Lloyd Johnston³ and Takashi Kei Kishimoto³, ¹Selecta Biosciences, Inc, Watertown, MA, ²Altoona Center for Clinical Research, Duncansville, PA, ³Selecta Biosciences, Watertown, MA
Background/Purpose: Pegylated uricases are therapies for treatment of severe chronic gout, particularly for rapid tophi resolution. However, uricases are limited by induction of anti-drug antibodies…
Abstract Number: 1297 • 2018 ACR/ARHP Annual Meeting
Risk of Dementia in Patients with Gout and the Impact of Urate-Lowering Therapies: A Large Population-Based Cohort Study
Louise Crowley, Alyshah Abdul Sultan, Edward Roddy, Christian Mallen, Joanne Protheroe and Lorna Clarson, Research Institute for Primary Care and Health Sciences, Keele University, Keele, United Kingdom
Background/Purpose: Evidence is conflicting concerning dementia risk in gout patients, with hyperuricaemia proposed to exert a neuroprotective effect. Serum urate (sUA) targets guiding urate-lowering therapies…
Abstract Number: 1298 • 2018 ACR/ARHP Annual Meeting
Gout and the Risk of Parkinson’s Disease in Older Adults: A Study of U.S. Medicare Data
Jasvinder A. Singh and John Cleveland, Rheumatology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: In the presence of limited available data, our objective was to assess the association of gout with the risk of incident Parkinson’s disease (PD)…

Evaluating a Causal Role of Mitochondrial Variation in the Development of Gout

Relative Insufficiency of Renal Uric Acid Excretion in Gout Patients with Obesity Leads to High Serum and Glomerular Filtration Load of Uric Acid

Higher Body Fat Percentage in Non-Obese Late-Onset Gout Patients

Influence of Renal Function on the Velocity of Tophus Resolution and Achievement of Disease Remission in Patients with Chronic Refractory Gout Treated with Pegloticase

Initial Pegloticase Serum Levels Predict Persistent Responsiveness in Patients with Chronic Refractory Gout

Comparision of Urate Burden in Well and Poorly Controlled Gout Patients: A Dual-Energy CT Study

Strong Impact of Dysfunctional Variants of ABCG2 on Hyperuricemia and Gout in Children and Adolescents

Association between Musculoskeletal Ultrasonography and Bone Remodeling Markers and the Role of Ultrasonography on Monitoring Treatment Responsiveness in Patients with Gout and Hyperuricemia

Immunosuppressant Use and Gout in the Prevalent Solid Organ Transplant Population

Systemic Inflammation and Atherosclerosis in Patients with Gout. Results from the NOR-Gout Study

Efficacy and Safety of Anakinra in Congestive Heart Failure Patients, Including Lvad, with Acute Gouty Arthritis: A Retrospective Study of 36 Patients at an Academic Medical Center

Identification of New and Rare Variants in ABCG2, SLC22A1 and ALDH16A1 Genes in Crystal-Proven Early-Onset Gout

Initial Phase 2 Clinical Data of SEL-212 in Symptomatic Gout Patients: Monthly Dosing of a Pegylated Uricase (Pegadricase) with Svp-Rapamycin Enables Sustained Reduction of Acute Gout Flares

Risk of Dementia in Patients with Gout and the Impact of Urate-Lowering Therapies: A Large Population-Based Cohort Study

Gout and the Risk of Parkinson’s Disease in Older Adults: A Study of U.S. Medicare Data

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