Session Information
Session Type: Poster Session A
Session Time: 10:30AM-12:30PM
Background/Purpose: Rheumatoid arthritis (RA) causes systemic inflammation that leads to specific changes in the patients’ blood cells; this offers the opportunity to measure inflammatory activity in these patients. Three indices that can be used to this end are: 1. the neutrophil-to-lymphocyte ratio (NLR), 2. the platelet-to-lymphocyte ratio (PLR) and the systemic immune inflammatory index (SIII). These ratios are easy to measure, reproducible, and cost-effective markers of inflammation. They can provide guidance for making treatment decisions on these patients
Methods: One-hundred and ninety RA patients who met the 2010 ACR/EULAR criteria were examined and had their medical histories reviewed. Disease activity was assessed with the DAS28 CRP score. The patients’ characteristics are reported as percentages or as means and standard deviations. The NLR, PLR, SIII, CRP and DAS28 CRP scores were examined using Spearman’s bivariate and multivariate correlations. A significance level of p < 0.05 was set, and SPSS v. 15.0 was used for the analysis
Results: The study included 99.0% Mestizo RA patients, 88.4% (168) of them being women. The patients’ average age was 59.8 years (12.2), and their average disease duration was 18.38 years (10.32). Corticosteroids were used by 77.9% of the patients, while 95.3% (181) used synthetic DMARDs, and 19.5% (37) used biological DMARDs. Significant associations were observed between NLR and CRP (coefficient of 0.69), NLR and DAS28 CRP (0.66), PLR and CRP (0.43), and PLR and DAS28 CRP (0.46); correlations between SIII and DAS28 CRP (0.57) and SIII and CRP(0.61), were also significant ( all with p< 0.001).
Conclusion: The correlations between NLR, PLR and SIII with CRP and DAS28 CRP were found to be significant. These findings highlight the importance of these biomarkers to assess disease activity in regions of the world like Latin America where resources are limited.
To cite this abstract in AMA style:
Velarde Mejia Y, Mejia V, velarde g, Alarcon G. Usefulness of the Neutrophil-to-Lymphocyte Ratio, the Platelet-to-Lymphocyte Ratio and the Systemic Immune Inflammatory Index in Assessing Disease Activity in Rheumatoid Arthritis Patients [abstract]. Arthritis Rheumatol. 2024; 76 (suppl 9). https://acrabstracts.org/abstract/usefulness-of-the-neutrophil-to-lymphocyte-ratio-the-platelet-to-lymphocyte-ratio-and-the-systemic-immune-inflammatory-index-in-assessing-disease-activity-in-rheumatoid-arthritis-patients/. Accessed .« Back to ACR Convergence 2024
ACR Meeting Abstracts - https://acrabstracts.org/abstract/usefulness-of-the-neutrophil-to-lymphocyte-ratio-the-platelet-to-lymphocyte-ratio-and-the-systemic-immune-inflammatory-index-in-assessing-disease-activity-in-rheumatoid-arthritis-patients/