ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstract Number: 218

Surface Area and Fatty Infiltration of Vastus Medialis Measured By Magnetic Resonance Imaging Are Risk Factors for the Progression of Knee Osteoarthritis and Discriminate Two Osteoarthritis Phenotypes

Johanne Martel-Pelletier1, Jean-Pierre Raynauld1, François Abram2, Marc Dorais3, Yuanyuan Wang4, Jessica Fairley4, Flavia Cicuttini4 and Jean-Pierre Pelletier1, 1Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, 2Medical Imaging Research & Development, ArthroLab Inc., Montreal, QC, Canada, 3StatSciences Inc., Notre-Dame de l’Île Perrot, QC, Canada, 4Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia

Meeting: 2014 ACR/ARHP Annual Meeting

Keywords: cartilage, Knee, magnetic resonance imaging (MRI) and osteoarthritis

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print
Session Information

Title: Osteoarthritis - Clinical Aspects: Imaging and Biomechanics

Session Type: Abstract Submissions (ACR)

Background/Purpose: Osteoarthritis (OA) is the most common arthritic condition but its treatment still remains symptomatic. Understanding factors affecting the progression of this disease may enable the development of disease-modifying therapies. Vastus medialis (VM) muscle surface has been proposed in recent OA studies to be associated with cartilage volume loss over time. However, the VM may include a significant proportion of fatty infiltration, which could also influence knee metabolism and mechanics. These two parameters can be visualized and quantified by MRI. Using data from a recent randomized clinical trial in knee OA1, this study contrasted the VM surface area and fatty infiltration (% Fat) with cartilage volume loss and changes in bone marrow lesions as assessed by MRI.

Methods: OA patients, diagnosed according to American College of Rheumatology clinical and radiological criteria, were from the according-to-protocol population (n=143) of a 2-year randomized clinical trial, and had MRI acquisitions at baseline and 2 years. MR images of the VM (mm2) were assessed semi-automatically and VM % Fat by a fully automated software. Univariate and multivariate analyses were performed to assess the relationship between VM area and its % Fat, cartilage volume loss, and bone marrow lesion changes over 2 years.

Results: The median baseline of the VM area and % Fat were chosen to stratify patients. Female (p≤0.001), higher BMI (p≤0.008), and disability (p≤0.040) were associated with both a higher baseline VM surface area and % Fat. Higher baseline VM area was associated with greater cartilage volume loss in the medial compartment, medial femur, and lower cartilage volume loss in the lateral plateau (all p≤0.048). Change in % Fat, but not in surface area, was associated with an increase in the bone marrow lesion score in the global knee and cartilage volume loss in the global knee, lateral compartment, lateral femur, and medial plateau (all p≤0.035). Multivariate analyses revealed correlations between % Fat, but not surface area, and cartilage volume loss in the global knee (p=0.011) and most subregions studied. Importantly, % Fat change was independently associated with bone marrow lesion change at 2 years (p=0.001). All of the above changes were found irrespective of the treatment the patients had during the clinical trial.

Conclusion: This study is the first to demonstrate that the % Fat in the VM is strongly associated with cartilage volume loss and the presence and progression of bone marrow lesions. Importantly, two different OA phenotypes were evidenced: i) low VM area phenotype comprising female patients with lower BMI, being more symptomatic at baseline, having more cartilage volume damage at baseline, and at 2 years less cartilage volume loss in the medial femur and more cartilage volume loss in the lateral plateau; ii) higher VM % Fat phenotype comprises female patients with higher BMI, having more disability at baseline, more cartilage volume damage at baseline, and at 2 years more cartilage volume loss in the medial plateau and lateral femur.

Reference: 1) Raynauld JP, et al. Ann Rheum Dis 2009;68:938-47.


Disclosure:

J. Martel-Pelletier,

ArthroLab ,

9;

J. P. Raynauld,

ArthroLab,

5;

F. Abram,

ArthroLab,

3;

M. Dorais,

ArthroLab,

5;

Y. Wang,
None;

J. Fairley,
None;

F. Cicuttini,
None;

J. P. Pelletier,

ArthrioLab,

9.

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print

« Back to 2014 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/surface-area-and-fatty-infiltration-of-vastus-medialis-measured-by-magnetic-resonance-imaging-are-risk-factors-for-the-progression-of-knee-osteoarthritis-and-discriminate-two-osteoarthritis-phenotypes/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2025 American College of Rheumatology