Session Type: ACR Poster Session A
Session Time: 9:00AM-11:00AM
Anti- melanoma differentiation-associated gene 5 (MDA5) antibody positive dermatomyositis (DM) and clinically amyopathic DM (CADM) often develop rapidly progressive interstitial lung disesase (RP-ILD), but the pathogenesis is still unclear. We noticed that the sera from many anti-MDA5 antibody positive patients immunoprecipitated the common 110kDa polypeptide. Thus we intended to identify the autoantigen and investigated the clinical significance.
Autoantibodies were screened in 340 patients with various connective tissue diseases (CTDs) and 15 healthy controls (HCs) by immunoprecipitation with [
Results: Anti-110 kDa antibody was detected in 25 DM/CADM patients but not in patients with other CTDs or HCs. All patients with anti-110 kDa antibody were also positive for anti-MDA5 antibody, and had interstitial lung disease. The corresponding polypeptide was identified as splicing factor proline/glutamine-rich protein (SPFQ). Anti-SFPQ antibody was detected at diagnosis and newly appeared in some patients during the disease course. The onsets of DM/CADM had seasonal patterns and showed two peaks according to the temporal appearance of anti-SFPQ antibody. 67% (8/12) of disease onset of patients who had anti-SFPQ antibody at diagnosis were between August and October, whereas 69% (9/13) of those who had newly appearing anti-SFPQ antibody during the disease course were between January and March.
To cite this abstract in AMA style:Hosono Y, Nakashima R, Murakami K, Imura Y, Serada S, Fujimoto M, Yoshifuji H, Ohmura K, Naka T, Mimori T. Splicing Factor Proline/Glutamine-Rich Is a Novel Autoantigen of Dermatomyositis and Associated with Anti-Melanoma Differentiation-Associated Gene 5 Antibody. [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/splicing-factor-prolineglutamine-rich-is-a-novel-autoantigen-of-dermatomyositis-and-associated-with-anti-melanoma-differentiation-associated-gene-5-antibody/. Accessed December 2, 2020.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/splicing-factor-prolineglutamine-rich-is-a-novel-autoantigen-of-dermatomyositis-and-associated-with-anti-melanoma-differentiation-associated-gene-5-antibody/