Session Type: Abstract Submissions (ACR)
Background/Purpose In recent years, increased incidences of metabolic disorders have been observed in patients with systemic inflammatory rheumatic diseases. Fetuin-A, Intercellular Adhesion Molecule -1(ICAM-1) and interleukin 18 (IL-18) have been implicated in the endothelial function and atherosclerosis. The aim of the study was to investigate serum levels of fetuin-A, ICAM-1and IL-18 in ankylosing spondylitis (AS) and psoriatic arthritis (PsA).
We studied 123 patients and 20 controls. We recorded: age, sex, disease duration, treatment type, history of metabolic disorders, VAS, BASDAI, PASI, BMI, waist-hip ratio. Blood was collected for analysis of fetuin-A, ICAM-1, IL-18, IL-6, IL-23, VEGF and EGF by ELISA method. We assessed lipid profile, CRP and ESR. This work was supported by a grant from the National Science Centre in Poland (UMO-2011/03/B/NZ5/04192).
A total of 59 AS (43,5 ± 12,5; 12F/47M) and 64 PsA (49,7 ± 12,9 years; 36 F/28 M) patients were studied. Serum fetuin-A, ICAM-1and IL-18, levels were significantly higher in patients compared to controls (p<0,05).
No differences were found in serum fetuin-A, ICAM-1 and IL-18 levels in AS and PsA patients
Serum fetuin-A positively correlated with triglycerides (r=0,3; p=0,02) and VEGF (r=0,3; p=0,02) in AS and with IL-23 (r=0,2; p=0,05) and VEGF (r=0,3; p=0,04) in PsA patients.
Serum ICAM-1 positively correlated with IL-6 (r=0,3; p=0,007) and ESR (r=0,3; p=0,007) in AS and with IL-6 (r=0,2; p=0,05) in PsA patients.
Serum Il-18 positively correlated with CRP (r=0,25; p=0,05), cholesterol (r=0,4; p=0,01), triglycerides (r=0,4; p=0,04) and BASFI (r=0,3; p=0,02) in AS and with IL-6 (r=0,3; p=0,03) and VEGF (r=0,3; p=0,04) in PsA patients.
No differences were found in comparison of subjects to treatment type regarding to serum fetuin-A, ICAM-1 and IL-18 levels in AS and PsA patients.
Serum fetuin-A, ICAM-1, IL-18, levels were increased and correlated with disease activity in AS and PsA patients. Serum fetuin-A and IL-18 correlated with triglycerides in AS patients.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/serum-fetuin-a-intercellular-adhesion-molecule-1-and-interleukin-18-levels-in-ankylosing-spondylitis-and-psoriatic-arthritis/