ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 1598

Serum Fetuin-a, Intercellular Adhesion Molecule -1 and Interleukin -18 Levels in Ankylosing Spondylitis and Psoriatic Arthritis

Hanna Przepiera-Bedzak1, Katarzyna Fischer2 and Marek Brzosko1, 1Department of Rheumatology and Internal Diseases, Department of Rheumatology and Internal Diseases Pomeranian Medical University in Szczecin, Szczecin, Poland, 2Independent Laboratory of Rheumatic Diagnostics, Pomeranian Medical University in Szczecin, Szczecin, Poland

Meeting: 2014 ACR/ARHP Annual Meeting

Keywords: ,

Session Information

Session Title: Spondyloarthropathies and Psoriatic Arthritis - Clinical Aspects and Treatment II

Session Type: Abstract Submissions (ACR)

Background/Purpose In recent years, increased incidences of metabolic disorders have been observed in patients with systemic inflammatory rheumatic diseases. Fetuin-A, Intercellular Adhesion Molecule -1(ICAM-1) and interleukin 18 (IL-18) have been implicated in the endothelial function and atherosclerosis. The aim of the study was to investigate serum levels of fetuin-A, ICAM-1and IL-18 in ankylosing spondylitis (AS) and psoriatic arthritis (PsA).

Methods

We studied 123 patients and 20 controls. We recorded: age, sex, disease duration, treatment type, history of metabolic disorders, VAS, BASDAI, PASI, BMI, waist-hip ratio. Blood was collected for analysis of fetuin-A, ICAM-1, IL-18, IL-6, IL-23, VEGF and EGF by ELISA method. We assessed lipid profile, CRP and ESR. This work was supported by a grant from the National Science Centre in Poland (UMO-2011/03/B/NZ5/04192).

Results

A total of 59 AS (43,5 ± 12,5; 12F/47M) and 64 PsA (49,7 ± 12,9 years; 36 F/28 M) patients were studied. Serum fetuin-A, ICAM-1and IL-18, levels were significantly higher in patients compared to controls (p<0,05).

No differences were found in serum fetuin-A, ICAM-1 and IL-18 levels in AS and PsA patients

Serum fetuin-A positively correlated with triglycerides (r=0,3; p=0,02) and VEGF  (r=0,3; p=0,02) in AS and with IL-23 (r=0,2; p=0,05) and VEGF  (r=0,3; p=0,04) in PsA patients.

Serum ICAM-1 positively correlated with IL-6 (r=0,3; p=0,007) and ESR  (r=0,3; p=0,007) in AS and with IL-6 (r=0,2; p=0,05) in PsA patients.

Serum Il-18 positively correlated with CRP (r=0,25; p=0,05), cholesterol (r=0,4; p=0,01), triglycerides (r=0,4; p=0,04) and BASFI  (r=0,3; p=0,02) in AS and with IL-6 (r=0,3; p=0,03) and VEGF (r=0,3; p=0,04) in PsA patients.

No differences were found in comparison of subjects to treatment type regarding to serum fetuin-A, ICAM-1 and IL-18 levels in AS and PsA patients.

Conclusion

Serum fetuin-A, ICAM-1,  IL-18, levels were increased and correlated with disease activity in AS and PsA patients. Serum fetuin-A and IL-18 correlated with triglycerides in AS patients.

Disclosure:

H. Przepiera-Bedzak,
None;

K. Fischer,
None;

M. Brzosko,
None.

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