ACR Meeting Abstracts

ACR Meeting Abstracts

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Abstracts tagged "cytokines and psoriatic arthritis"

  • Abstract Number: 989 • 2018 ACR/ARHP Annual Meeting

    Reduction of Serum IL17F and IL22 By IL23p19 Blockade with Guselkumab Is Associated with Improvement in Joint Symptoms in Psoriatic Arthritis

    Qingxuan Song, Matthew Loza, Karen Leander, Brittney Scott, Patrick Branigan and Kristen Sweet, Janssen Research & Development, LLC, Spring House, PA

    Background/Purpose: Guselkumab (GUS) is a fully human monoclonal antibody that binds to the p19 subunit of IL23. In a recent Phase 2 study, GUS demonstrated…
  • Abstract Number: 1792 • 2017 ACR/ARHP Annual Meeting

    Distinct and Overlapping Activities of IL-17A and TNF on the Expression of Proinflammatory Cytokines and MMPs in Psoriatic Arthritis: Rationale for Anti-IL-17A/Anti-Tnfalpha Combination Therapy?

    Xiaofei Xu1, Nadine Davelaar2, Anne-Marie Otten-Mus3, Patrick Asmawidjaja2, J.M.W. Hazes4, Dominique Baeten5, Marijn Vis6, Radjesh Bisoendial1 and Erik Lubberts2, 1Rheumatology, Erasmus MC, Rotterdam, Netherlands, 2Rheumatology and Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, 3Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, 4Department of Rheumatology, Erasmus University Medical Centre, Rotterdam, Netherlands, 5Clinical Immunology and Rheumatology/Experimental immunology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 6Rheumatology, Erasmus Medical Centre, Rotterdam, Netherlands

    Background/Purpose: TNF and IL-17A are proinflammatory cytokines critically involved in the pathogenesis of psoriatic arthritis (PsA). Currently, targeting TNF is the first choice of a…
  • Abstract Number: 1670 • 2016 ACR/ARHP Annual Meeting

    Cytokine Expression in Groups of Psoriatic Arthritis Patients Characterised By Specific HLA Genotypes and Clinical Features

    Musaab Elmamoun1, Wilco de Jager2, Sytze de Roock3, Muhammad Haroon4, Robert Winchester5, Stephen R. Pennington6 and Oliver FitzGerald7, 1Rheumatology, St. Vincent's University Hospital, Department of Rheumatology, Dublin 4, Ireland, 2Dept Immunology, UMC Utrecht, Utrecht, Netherlands, 3Immunology, University Medical Center, Utrecht, Netherlands, 4St. Vincent's University Hospital, Department of Rheumatology, Dublin, Ireland, 5Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, 6Proteome Research Centre, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland, 7St. Vincent's University Hospital, Department of Rheumatology. UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland

    Background/Purpose: Psoriatic arthritis (PsA) is a heterogeneous disease with diverse clinical and radiographic manifestations. A number of human leukocyte antigen (HLA) alleles have been found…
  • Abstract Number: 1598 • 2014 ACR/ARHP Annual Meeting

    Serum Fetuin-a, Intercellular Adhesion Molecule -1 and Interleukin -18 Levels in Ankylosing Spondylitis and Psoriatic Arthritis

    Hanna Przepiera-Bedzak1, Katarzyna Fischer2 and Marek Brzosko1, 1Department of Rheumatology and Internal Diseases, Department of Rheumatology and Internal Diseases Pomeranian Medical University in Szczecin, Szczecin, Poland, 2Independent Laboratory of Rheumatic Diagnostics, Pomeranian Medical University in Szczecin, Szczecin, Poland

    Background/Purpose In recent years, increased incidences of metabolic disorders have been observed in patients with systemic inflammatory rheumatic diseases. Fetuin-A, Intercellular Adhesion Molecule -1(ICAM-1) and…
  • Abstract Number: 633 • 2014 ACR/ARHP Annual Meeting

    Immunological and Clinical Relationships of Synovial IL-17+ T Cells in Psoriatic Arthritis

    Bruce Kirkham1, Bina Menon2 and Leonie S. Taams3, 1Rheumatology, Guy's & St Thomas NHS Foundation Trust, London, United Kingdom, 2Rheumatology, Guy's and St. Thomas' Foundation Hospital NHS Trust, London, United Kingdom, 3Centre for Molecular and Cellular Biology of Inflammation, King's College London, London, United Kingdom

    Background/Purpose We recently reported elevated numbers of synovial fluid IL-17+CD4- T cells (mainly CD8+ (Tc17) cells) in Psoriatic Arthritis (PsA), correlating with clinical, serological and…
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ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

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