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Abstract Number: 1109

Pain in Women with Knee and/or Hip Osteoarthritis Is Related to Systemic Inflammation and to Adipose Tissue Dysfunction and Distribution: A Cross-sectional Metabolic Biomarkers Cohort Study

Jeremie Sellam1, Anne-Christine Rat2, Soraya Fellahi3, Jean-Philippe Bastard4, Willy NGUEYON SIME5, Hang Korng EA6, Pascal Richette7, Jacqueline Capeau8, Francis Guillemin9 and Francis Berenbaum1, 1AP-HP, Hôpital Saint-Antoine, Service de Rhumatologie, Centre de Recherche Saint-Antoine, INSERM UMR_S 938,Sorbonne Université, Paris, 75012, France, Paris, France, 2Universite de Caen Normandie and Université de Lorraine, EA 4360, Caen, France, 3AP-HP INSERM, Paris, France, 4INSERM AP-HP UPEC, Paris, France, 5Universite de Lorraine, INSERM, CIC, Nancy, France, 6Universite de Paris, AP-HP, INSERM, paris, France, 7Department of Rheumatology, Lariboisière Hospital, Paris, France, 8INSERM Sorbonne Universite, Paris, France, 9Universite de Lorraine CIC INSERM, Nancy, France

Meeting: ACR Convergence 2020

Keywords: Biomarkers, Cohort Study, Osteoarthritis, pain

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Session Information

Date: Sunday, November 8, 2020

Title: Osteoarthritis – Clinical Poster I

Session Type: Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose: Beyond the link between metabolic diseases and osteoarthritis (OA) risk, some studies have suggested an association between metabolic syndrome or visceral obesity and OA-related pain (1,2). Here, we investigated whether biomarkers of adipose tissue dysfunction and distribution could be associated with OA-related pain.

Methods: We cross-sectionally analyzed patients with knee and/or hip OA at inclusion in the 863 patients included in the national multicentric KHOALA cohort (NCT00481338). We used visual analogic scale (VAS) for pain, the Western Ontario and McMaster Universities Arthritis Index (WOMAC) and Osteoarthritis Knee and Hip Quality of Life (OAKHQOL) pain subscores. For WOMAC and VAS pain, higher scores reflects more symptoms, while it is the opposite for OAKHQOL.

At inclusion, we measured in the serum ultra-sensitive C reactive protein (usCRP), leptin and total adiponectin for calculation of leptin:adiponectin ratio (LAR), a marker of adipose tissue dysfunction associated with truncal obesity, high-molecular-weight adiponectin, visfatin and apolipoproteins (apoA1, apoB100). Univariate and multivariate analyses using stepwise linear regression models were performed to search for correlation between pain assessments and these biomarkers, with adjustment on age and Kellgren-Lawrence score and with stratification by sex since gender interacts with pain intensityand with adipokines level.

Results: In 596 women with hip and/or knee OA, multivariate analyses indicated that higher pain intensity was associated with higher LAR (VAS pain: b=0.48; p=0.0001, OAKHQOL pain: b=-0.45; p=0.0002, WOMAC pain: b=0.29; p=0.002) in the whole group. Analyzing knee and hip OA populations separately, these correlations were found for both joints in multivariate analyses (knee OA: VAS pain b = 0.52 p = 0.0001; OAKHQOL pain: b = -0.48 p = 0.0002; WOMAC pain b = 0.28 p = 0.006; hip OA: VAS pain b = 0.64 p = 0.03; OAKHQOL pain: b = -0.55 p = 0.04). Pain intensity correlated also with usCRP level (VAS pain: b= 0.27; p=0.02, OAKHQOL pain: b =-0.31; p=0.01) and Kellgren-Lawrence score. Serum visfatin, high-molecular-weight adiponectin, Apo A1 and Apo B100 levels were not related to pain level, whatever the score used. In 267 men, no correlation between biomarkers and pain was found.

Conclusion: Serum LAR and usCRP level are associated with pain level, independently of radiographic structural severity in women with hip and/or knee OA, emphasizing the role of adipose tissue dysfunction, truncal fat repartition and meta-inflammation in pain experience in this population.

  1. Pan F et al Osteoarthr Cartilage 2020;28:45–52. 2. Li S, et al. Arthritis & Rheumatology (Hoboken, NJ) 2020.

Disclosure: J. Sellam, None; A. Rat, Sanofi Genzyme, 5; S. Fellahi, None; J. Bastard, None; W. NGUEYON SIME, None; H. EA, None; P. Richette, AbbVie Inc., 1, Biogen, 1, Janssen, 1, BMS, 1, Roche, 1, Pfizer, 1, Amgen, 1, Sanofi-Aventis, 1, UCB, 1, Lilly, 1, Novartis, 1, Celgene, 1; J. Capeau, None; F. Guillemin, Expanscience, 2; F. Berenbaum, Pfizer, 1, Eli Lilly, 1.

To cite this abstract in AMA style:

Sellam J, Rat A, Fellahi S, Bastard J, NGUEYON SIME W, EA H, Richette P, Capeau J, Guillemin F, Berenbaum F. Pain in Women with Knee and/or Hip Osteoarthritis Is Related to Systemic Inflammation and to Adipose Tissue Dysfunction and Distribution: A Cross-sectional Metabolic Biomarkers Cohort Study [abstract]. Arthritis Rheumatol. 2020; 72 (suppl 10). https://acrabstracts.org/abstract/pain-in-women-with-knee-and-or-hip-osteoarthritis-is-related-to-systemic-inflammation-and-to-adipose-tissue-dysfunction-and-distribution-a-cross-sectional-metabolic-biomarkers-cohort-study/. Accessed .
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