Abstracts Archive - Page 985 of 2425 - ACR Meeting Abstracts

Abstract Number: 460 • 2019 ACR/ARP Annual Meeting
Fertility of Women with Rheumatoid Arthritis: Disease Activity Negatively Correlates with Serum AMH Levels
Camille Valdeyron¹, Martin SOUBRIER ², Bruno Pereira ¹, Arnaud Constantin ³, Jacques Morel ⁴, Philippe Gaudin ⁵, Bernard Combe ⁶ and Florence Brugnon ¹, ¹CHU CLERMONT-FERRAND, Clermont-Ferrand, France, ²CHU Gabriel Montpied, Clermont Ferrand, Auvergne, France, ³CHU TOUOUSE, TOULOUSE, France, ⁴CHU MONTPELLIER, MONTPELLIER, France, ⁵Rheumatology Department, CHU Grenoble Alpes Hôpital Sud and GREPI - Université Grenoble Alpes, EA7408, Grenoble - Echirolles, France, ⁶CHU Montpellier, Montpellier University, Montpellier, France
Background/Purpose: Patients with rheumatoid arthritis (RA) display a higher infertility prevalence compared with the general population. Disease-related inflammation and RA treatments are likely to be…
Abstract Number: 461 • 2019 ACR/ARP Annual Meeting
Maximal Improvement in Fatigue Lags Behind Achievement of Sustained Remission in Early Rheumatoid Arthritis
Melissa Holdren¹, Orit Schieir ², Susan J. Bartlett ³, Louis Bessette ⁴, Gilles Boire ⁵, Glen Hazlewood ⁶, Carol Hitchon ⁷, Edward Keystone ⁸, Diane Tin ⁹, Carter Thorne ¹⁰, Vivian Bykerk ¹¹, Janet Pope ¹² and Canadian Early Arthritis Cohort (CATCH) Investigators ¹³, ¹The University of Western Ontario, London, ON, Canada, ²University of Toronto Dalla Lana School of Public Health, Toronto, ON, Canada, ³McGill University, Montreal, QC, Canada, ⁴Laval University, Quebec City, QC, Canada, ⁵Sherbrooke University, Sherbrooke, QC, Canada, ⁶University of Calgary, Calgary, AB, Canada, ⁷University of Manitoba, Winnipeg, Canada, ⁸Mount Sinai Hospital and University of Toronto, Toronto, ON, Canada, ⁹Southlake Regional Health Centre, Newmarket, Canada, ¹⁰Southlake Regional Health Centre, Newmarket, ON, Canada, ¹¹Hospital for Special Surgery, New York City, NY, ¹²Western University, London, ON, Canada, ¹³Canadian Early Arthritis Cohort (CATCH) Study, Toronto, Canada
Background/Purpose: Up to 80% of rheumatoid arthritis patients report clinically relevant fatigue. Fatigue is a complex multi-factorial process that can result in adverse affects on patients'…
Abstract Number: 462 • 2019 ACR/ARP Annual Meeting
The Endogenous Plasma Small RNAome of Rheumatoid Arthritis
Michelle Ormseth¹, Joseph Solus ², Quanhu Sheng ², Fei Ye ², Haocan Song ², Qiong Wu ², Yan Guo ³, Annette Oeser ², Ryan Allen ², Kasey Vickers ² and C. Michael Stein ², ¹Vanderbilt University Medical Center and Veterans Administration: TN Valley Healthcare System, Nashville, ²Vanderbilt University Medical Center, Nashville, ³University of New Mexico, Albuquerque
Background/Purpose: Small RNA (sRNA) sequencing has revealed new classes of sRNAs beyond microRNAs. These sRNAs can regulate genes and are also useful biomarkers of disease.…
Abstract Number: 463 • 2019 ACR/ARP Annual Meeting
High-titer Rheumatoid Factor Impacts Real-life Management Outcomes of Rheumatoid Arthtitis
Cleandro Albuquerque¹, Ana Reis ², Ana Santos ³, Claiton Brenol ⁴, Ivanio Pereira ⁵, Karina Bonfiglioli ⁶, Manoel Bertolo ⁷, Maria Guimarães ⁸, Maria Sauma ⁹, Paulo Filho ¹⁰, Rina Giorgi ¹¹, Sebastião Radominski ¹², Licia Mota ¹ and Geraldo Castelar ³, ¹UnB, Brasília, Brazil, ²UniCeub, Brasília, Brazil, ³UERJ, Rio de Janeiro, Brazil, ⁴Universidade Federal do Rio Grande do Sul, Porto Alegre, ⁵UFSC, Florianópolis, Brazil, ⁶Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Sao Paulo, Brazil, ⁷University of Campinas, Campinas, Brazil, ⁸UFMG, Belo Horizonte, Brazil, ⁹UFPA, Belém, Brazil, ¹⁰USP, São Paulo, Brazil, ¹¹Hospital do Servidor Público Estadual de São Paulo, São Paulo, Brazil, ¹²Universidade Federal do Paraná, Curitiba, Brazil
Background/Purpose: The rheumatoid factors (RF) have established roles in rheumatoid arthritis (RA) diagnosis, prediction of disease onset and drug response, and in classifying patients as…
Abstract Number: 464 • 2019 ACR/ARP Annual Meeting
Continuous Decrease in Serum RF Titer During Anti-TNF Therapy Was Associated with Suppression in Progression of RA Joint Damage
Takayoshi Owada¹, Kazuhiro Kurasawa ¹, Yuta Takamura ¹, Toshiyuki Miyao ¹, Ayae Tanaka ¹, Ryutaro Yamazaki ¹, Satoko Arai ¹, Reika Maezawa ¹ and Masafumi Arima ¹, ¹Dokkyo Medical University, Mibu-machi, Shimotsuga-gun, Tochigi, Japan
Background/Purpose: A number of studies have investigated the association between serum RF and joint damage in early and established RA patients, and positive and high-titer…
Abstract Number: 465 • 2019 ACR/ARP Annual Meeting
Prognostic Factors and Clinical Outcome Modifiers in Patients with Rheumatoid Arthritis: A Review
Leticia Ferri¹, Grace Crocket ², Xue Han ¹, Boris Breznen ³ and Mir Sohail Fazeli ³, ¹Bristol-Myers Squibb Company, Princeton, NJ, ²Bristol-Myers Squibb; Rutgers University, New York City, NY, ³Doctor Evidence, Santa Monica, CA
Background/Purpose: The current goal in treatment of RA is to deliver therapies tailored to individual patients’ characteristics. Establishing disease prognosis is a crucial first step…
Abstract Number: 466 • 2019 ACR/ARP Annual Meeting
Predicting Risk of Radiographic Progression for Patients with Rheumatoid Arthritis
Thomas Huizinga ¹, Michael Weinblatt ², Nancy Shadick ², Cecilie Heegaard Brahe ³, Mikkel Østergaard ⁴, Merete Lund Hetland ⁵, Karen Hambardzumyan ⁶, Saedis Saevarsdottir ⁶, Megan Horton ⁷, Brent Mabey ⁸, Darl Flake ⁸, Alexander Gutin ⁸, Rotem Ben-Shachar ⁷, Eric Sasso ⁹ and Jeffrey Curtis¹⁰, ¹Leiden University Medical Center, Leiden, Netherlands, ²Brigham and Women's Hospital, Boston, MA, ³EuroSpA Coordinating Center, Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet, Glostrup, Glostrup, Denmark, ⁴Copenhagen Center for Arthritis Research, University of Copenhagen, Copenhagen, Denmark, ⁵DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopaedics, Rigshospitalet, Copenhagen, Denmark, ⁶Karolinska Institutet, Stockholm, Sweden, ⁷Myriad Genetics, Inc., Salt Lake City, UT, ⁸Myriad Genetics, Inc, South San Francisco, CA, ⁹Crescendo Bioscience, South San Francisco, CA, ¹⁰University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: The multi-biomarker disease activity (MBDA) blood test has been shown to be a predictor of risk for radiographic progression in patients with rheumatoid arthritis…
Abstract Number: 467 • 2019 ACR/ARP Annual Meeting
Serum Long-chain n-3 and -6 Fatty Acids Are Associated with Disease Feature at Onset and with 6-month Disease Activity in Early RA: Results from the ESPOIR Cohort
Johanna Sigaux ¹, Camille Buscail ², Chantal Julia ³, René-Marc Flipo ⁴, Alain Cantagrel ⁵, Bernard Bannwarth ⁶, Francois Laporte ⁷, Salima Challal ⁸, Marie-Christophe Boissier ⁹ and Luca Semerano¹⁰, ¹INSERM UMR 1125, Université Paris 13, Bobigny, France, ²Equipe de Recherche en Epidémiologie Nutritionnelle (EREN) UMR U1153 Inserm/U1125 Inra/Cnam/Univ Paris 13 Centre de Recherche en Epidémiologie et Biostatistiques UFR SMBH, Bobigny, France, ³uipe de Recherche en Epidémiologie Nutritionnelle (EREN) UMR U1153 Inserm/U1125 Inra/Cnam/Univ Paris 13 Centre de Recherche en Epidémiologie et Biostatistiques UFR SMBH, Bobigny, France, ⁴Roger Salengro University-Hospital, Lille , France, Lille, France, ⁵Centre de Rhumatologie, CHU de Toulouse, 31059, Toulouse, France, Toulouse, France, ⁶Service de rhumatologie, hôpital Pellegrin, centre hospitalier universitaire de Bordeaux, Bordeaux, France, ⁷Département de Biochimie- Pharmacologie-Toxicologie CHU de Grenoble, Grenoble, France, ⁸Assistance Publique-Hôpitaux de Paris, Hôpital Avicenne Service de Rhumatologie, Bobigny, France, ⁹Assistance Publique-Hôpitaux de Paris (AP-HP), Rheumatology Department, Avicenne Hospital, Bobigny, France, ¹⁰INSERM UMR 1125 , Université Paris 13, Bobigny, France
Background/Purpose: Long-chain polyunsaturated fatty acids (PUFAs) of the n3 and n6 families can contribute to modulate inflammatory processes. Dietary intake of n3PUFA is inversely associated…
Abstract Number: 468 • 2019 ACR/ARP Annual Meeting
Effect of Body Mass Index on the Disease Activity of Patients with Rheumatoid Arthritis in a Gender Specific Manner and Association of Respective Serum C – Reactive Protein Levels with the Body’s Inflammatory Status
Shumaila Iqbal¹, Linda Burns ², Joseph Grisanti ² and Cassandra Zhi ³, ¹University at Buffalo, Sisters of Charity Hospital, Buffalo, ²Buffalo Rheumatology and Medicine, Buffalo, ³Dexel University College of Medicine, Philadelphia, PA
Background/Purpose: Current literature evaluating the effect of high Body Mass Index (BMI) on the disease activity of patients with rheumatoid arthritis (RA) is mixed as…
Abstract Number: 469 • 2019 ACR/ARP Annual Meeting
Location and Size of Affected Joints Are Useful to Predict Prognosis of Patients with Rheumatoid Arthritis
Susumu Nishiyama¹, Tetsuji Sawada ² and Shigeto Tohma ³, ¹Rheumatic Disease Center, Kurashiki Medical Center, Kurashiki, Japan, ²Department of Rheumatology, Tokyo Medical University Hospital, Tokyo, Japan, ³National Hospital Organization Tokyo National Hospital, Tokyo, Japan
Background/Purpose: To predict prognosis of patients with rheumatoid arthritis (RA) from the location and the size of affected joints.Methods: Data of 7,776 patients with RA,…
Abstract Number: 470 • 2019 ACR/ARP Annual Meeting
Obesity Is a Robust Predictor of Persistent High Fatigue at 1 Year in Women and Men with Early Rheumatoid Arthritis
Susan J. Bartlett¹, Orit Schieir ², Marie-France Valois ³, Janet Pope ⁴, Louis Bessette ⁵, Carol Hitchon ⁶, Carter Thorne ⁷, Diane Tin ⁸, Glen Hazlewood ⁹, Gilles Boire ¹⁰, Edward Keystone ¹¹, Vivian Bykerk ¹² and Canadian Early Arthritis Cohort (CATCH) Investigators ¹³, ¹McGill University, Montreal, QC, Canada, ²University of Toronto, Montreal, Canada, ³McGill University, Montreal, Canada, ⁴Western University, London, ON, Canada, ⁵Laval University, Quebec City, QC, Canada, ⁶University of Manitoba, Winnipeg, Canada, ⁷Southlake Regional Health Centre, Newmarket, ON, Canada, ⁸Southlake Regional Health Centre, Newmarket, Canada, ⁹University of Calgary, Calgary, Canada, ¹⁰Sherbrooke University, Sherbrooke, QC, Canada, ¹¹Mount Sinai Hospital and University of Toronto, Toronto, ON, Canada, ¹²Hospital for Special Surgery, New York City, NY, ¹³Canadian Early Arthritis Cohort (CATCH) Study, Toronto, Canada
Background/Purpose: While treat-to-target strategies can dramatically reduce inflammation in RA, persistently high levels of fatigue are present in many patients and represent an important unmet need.…
Abstract Number: 471 • 2019 ACR/ARP Annual Meeting
When Will I Get past This Exhaustion? Predictors of Improved Fatigue in the First Year of RA
Susan J. Bartlett¹, Orit Schieir ², Marie-France Valois ³, Carol Hitchon ⁴, Louis Bessette ⁵, Glen Hazlewood ⁶, Carter Thorne ⁷, Janet Pope ⁸, Gilles Boire ⁹, Diane Tin ¹⁰, Edward Keystone ¹¹, Vivian Bykerk ¹² and Canadian Early Arthritis Cohort (CATCH) Investigators ¹³, ¹McGill University, Montreal, QC, Canada, ²University of Toronto, Montreal, Canada, ³McGill University, Montreal, Canada, ⁴University of Manitoba, Winnipeg, Canada, ⁵Laval University, Quebec City, QC, Canada, ⁶University of Calgary, Calgary, Canada, ⁷Southlake Regional Health Centre, Newmarket, ON, Canada, ⁸Western University, London, ON, Canada, ⁹Sherbrooke University, Sherbrooke, QC, Canada, ¹⁰Southlake Regional Health Centre, Newmarket, Canada, ¹¹Mount Sinai Hospital and University of Toronto, Toronto, ON, Canada, ¹²Hospital for Special Surgery, New York City, NY, ¹³Canadian Early Arthritis Cohort (CATCH) Study, Toronto, Canada
Background/Purpose: Although overwhelming fatigue is common at the onset of RA, some patients continue to experience debilitating high levels of fatigue that impact mood, interfere with work…
Abstract Number: 472 • 2019 ACR/ARP Annual Meeting
Sleep Quality in Women with Rheumatoid Arthritis Is Associated with Disease Activity and Depressive Symptoms
Deborah Da Costa¹, Teresa Szlachetka ² and Diane Lacaille ³, ¹McGill University, Montreal, QC, Canada, ²University of British Columbia, Vancouver, BC, Canada, ³Arthritis Research Canada and University of British Columbia, Vancouver, BC, Canada
Background/Purpose: Sleep disturbances, including difficulty initiating sleep, maintaining sleep, and/or early morningawakenings are prevalent in persons with rheumatoid arthritis (RA) and can significantly impact quality…
Abstract Number: 473 • 2019 ACR/ARP Annual Meeting
RA Presents in Disease Patterns Impacting Treatment Response
Kathryne Marks¹, Dana Symons ², Cynthia Crowson ³, Pamela Sinicrope ⁴ and Kelly O'Neill ⁵, ¹Rosalind Franklin University of Medicine and Science, Gurnee, IL, ²Rheumatoid Patient Foundation, Inc., Rockford, MI, ³Mayo Clinic Rochester, Rochester, ⁴Mayo Clinic, Rochester, MN, ⁵Rheumatoid Patient Foundation, Inc., Winter Springs, FL
Background/Purpose: Despite significant research on rheumatoid arthritis (RA), disease courses have not been clearly described. Like systemic lupus erythematosus and multiple sclerosis, RA displays a…
Abstract Number: 474 • 2019 ACR/ARP Annual Meeting
Associations of Plasma Extravesicular (EV) MicroRNA Levels in Seropositive and Seronegative Rheumatoid Arthritis (RA)
Lissette Delgado-Cruzata ¹, Milena Rodriguez Alvarez ², Nickolas Almodovar³, Toni-Ann Bravo ³ and Shante Hinson ⁴, ¹John Jay College of Criminal Justice, City University of New York, New York, ²SUNY Downstate Medical Center, New York, NY, ³John Jay College of Criminal Justice, City University of New York, New York, NY, ⁴Lincoln Medical & Mental Mental Health Center, New York
Background/Purpose: Rheumatoid factor (RF) and anti-citrullinated peptide antibodies (ACPA) are biomarkers that allow early diagnosis of RA in seropositive (ACPA+ or RF+) patients. However, some…

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