Abstracts Archive - Page 955 of 2425 - ACR Meeting Abstracts

Abstract Number: 10 • 2019 ACR/ARP Annual Meeting
Roles of Histone Acetyltransferases CBP/p300 and Transcriptional Factor RORα/REV-ERBα Against TNFα-induced CCL2 Expression in RA-FLSs
Ikumi Okumura¹, Kohsuke Yoshida ¹, Kenta Kaneshiro ², Koto Uchida ³, Arisa Yaekura ⁴, Yuto Oketani ⁵, Kanta Morii ¹, Koji Tateishi ⁶, Yasuhiro Terashima ⁶, Yoshiko Kawasaki ⁷, Nao Shibanuma ⁷, Yoshitada Sakai ⁸ and Akira Hashiramoto ¹, ¹Kobe University Graduate School of Health Sciences, Kobe, Hyogo, Japan, ²Kobe University Graduate School of Health Sciences, Osaka, Osaka, Japan, ³Kobe University Graduate School of Health Sciences, Okayama, Okayama, Japan, ⁴Kobe University Graduate School of Health Sciences, Kawanishi, Hyogo, Japan, ⁵Kobe University Graduate School of Health Sciences, Himeji, Hyogo, Japan, ⁶Kohnan Kakogawa Hospital, Kakogawa, Hyogo, Japan, ⁷Kobe Kaisei Hospital, Kobe, Hyogo, Japan, ⁸Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan
Background/Purpose: We have reported that TNFα induced expressions of clock gene Bmal1 by up-regulating transcriptional activator RORα and down-regulating repressor REV-ERBα in RA fibroblast-like synoviocytes…
Abstract Number: 11 • 2019 ACR/ARP Annual Meeting
Biomarker Changes for Patients with Rheumatoid Arthritis Receiving Tofacitinib with Methotrexate or Glucocorticoids vs Tofacitinib Monotherapy
Julie Lee¹, Xing Chen ¹, Weidong Zhang ¹, David Martin ¹, Craig Hyde ¹, Tomohiro Hirose ², Shweta Shah ³ and Lori Fitz ¹, ¹Pfizer Inc, Cambridge, MA, ²Pfizer Japan Inc, Toyko, Japan, ³Pfizer Inc, Collegeville, PA
Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor for the treatment of RA. Herpes zoster (HZ) is more common in patients (pts) with RA vs…
Abstract Number: 12 • 2019 ACR/ARP Annual Meeting
Intraarticular and Circulatory Cytokine Responses to Chlamydia Trachomatis: A Clinical Study in Reactive Arthritis/ Undifferentiated Spondyloarthropathy Patients
Sangita Rastogi¹, Praveen Kumar ², Darshan Bhakuni ³ and Geetika Khanna ⁴, ¹ICMR- National Institute of Pathology, Safdarjung hospital campus, New Delhi- 110 029, India, New Delhi, Delhi, India, ²ICMR- National Institute of Pathology, Safdarjung hospital campus, New Delhi- 110 029, India, Kota, Rajasthan, India, ³Department of Rheumatology and Clinical Immunology, Army Hospital (Research & Referral), Dhaula Kuan, New Delhi- 110 010, India, New Delhi, Delhi, India, ⁴Central Institute of Orthopedics (CIO), Vardhaman Mahavir Medical College (VMMC) & Safdarjung hospital, New Delhi-110029, India, New Delhi, Delhi, India
Background/Purpose: Chlamydia trachomatis-induced reactive arthritis (ReA)/ undifferentiated spondyloarthropathy (uSpA) is an immune-mediated situation where development of disease and maintenance of this pathogen remains elusive. The…
Abstract Number: 13 • 2019 ACR/ARP Annual Meeting
The Effect of Estrogen and Interferon γ on the Immunobiology of Minor Salivary Gland Mesenchymal Stromal Cells
Sara McCoy¹, Jayeeta Giri ² and Jacques Galipeau ³, ¹University of Wisconsin School of Medicine and Public Health, Madison, ²University of Wisconsin, Madison, ³University of Wisconsin School of Medicine and Public Health, Madison, WI
Background/Purpose: Primary Sjӧgren’s syndrome (pSS) is a female-predominant autoimmune disease with peak onset in perimenopause. pSS is characterized by severe ocular and oral sicca, leading…
Abstract Number: 14 • 2019 ACR/ARP Annual Meeting
Sec16A Abnormalities Affect the Intracellular Trafficking of HLA-B27 in the Pathogenesis of Axial Spondyloarthritis
Ayantika Talukdar¹, Fanxing Zeng ², Zhenbo Zhang ¹ and Nigil Haroon ³, ¹University Health Network, Toronto, ON, Canada, ²University Health Network, Toronto, Canada, ³Toronto Western Hospital, Krembil Research Institute, University of Toronto, Toronto, ON, Canada
Background/Purpose: Axial Spondyloarthritis (AxSpA) is a chronic inflammatory arthritis, mainly affecting the axial skeleton. HLA-B27 confers the greatest genetic association in AxSpA. Exome sequencing in…
Abstract Number: 15 • 2019 ACR/ARP Annual Meeting
CYR61/TGF-β Axis Promotes Adventitial Fibrosis of Takayasu Arteritis in the IL-17 Mediated Inflammatory Microenvironment
Lili Ma¹, Xiufang Kong ², Xiaomeng Cui ¹, Sifan Wu ¹, Yujiao Wang ¹ and Lindi Jiang ¹, ¹Zhongshan hospital, Fudan University, Shanghai, China (People's Republic), ²University of Michigan & Fudan University, Ann Arbor, MI
Background/Purpose: As a novel proinflammatory and potential profibrotic factor, the role of CYR61 on the vascular fibrosis of Takayasu arteritis (TA) has not been investigated.Methods:…
Abstract Number: 16 • 2019 ACR/ARP Annual Meeting
Monoclonal ACPA Promote Synovial Fibroblasts Migration Through a Peptidylarginine Deiminases (PAD) Dependent Pathway
Meng Sun¹, Bence Rethi ¹, Akilan Krishnamurthy ², Vijay Joshua ³, Alexandra Circiumaru ¹, Aase Hensvold ¹, Marianne Engström ⁴, Sergiu-Bogdan Catrina ⁵, Johanna Steen ⁶, Vivianne Malmström ³, Caroline Grönwall ³, Lars Klareskog ⁷, Heidi Wähämaa ¹ and Anca Catrina ⁷, ¹Rheumatology unit Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden, Stockholm, ²Rheumatology unit, Department of Medicine, Karolinska University Hospital and Karolinska Institutet, Solna, Stockholm, ³Rheumatology Unit, Department of Medicine, Karolinska University Hospital and Institutet, Stockholm, Sweden., Stockholm, Sweden, ⁴Karolinska Institutet and Karolinska University Hospital, Stockholm, ⁵Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden, ⁶Stockholm University, Stockholm, ⁷Rheumatology unit Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden, Stockholm, Sweden
Background/Purpose: Anti-citrullinated protein antibodies (ACPAs) play an important role in rheumatoid arthritis (RA) pathogenesis. ACPAs have different amino acid motif recognition patterns and show cross-reactivity…
Abstract Number: 17 • 2019 ACR/ARP Annual Meeting
Transcription Factor Fli-1 Impacts Lupus Nephritis by Orchestrating CXCL10/CXCR3 Axis
Xuan Wang¹, Mara Lennard Richard ¹, Tomika Caldwell ², Brittany Henry ², Tammy Nowling ², Jim Oates ³, Gary Gilkeson ⁴ and Xian Zhang ¹, ¹Medical University of South Carolina, Charleston, SC, ²Medical University of South Carolina, Charleston, ³Division of Rheumatology & Immunology/Medical University of South Carolina, Charleston, SC, ⁴Division of Rheumatology & Immunology/Ralph H. Johnson VA Medical Center/Medical University of South Carolina, Charleston, SC
Background/Purpose: Lupus nephritis is a major cause of death in both animal models and human patients. Expression of Fli-1, a member of the Ets family…
Abstract Number: 18 • 2019 ACR/ARP Annual Meeting
Undifferentiated Connective Tissue Disease at Risk for SSc: Potential Role of Circulating CXCL-10, CXCL-11 and IL-33 in Predicting Disease Evolution
Antonella Riccardi¹, Alessia Borgia ², Serena Fasano ¹, Valentina Messiniti ³, Rosaria Irace ³ and Gabriele Valentini ⁴, ¹Rheumatology Unit, Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, Naples, Italy, Naples, Italy, ²University of Campania L. Vanvitelli, Naples, Italy, ³Rheumatology Unit, Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, Naples, Italy, Naples, ⁴Dipartimento di Medicina di Precisione, II Policlinico U.O. Reumatologia, Napoli, Italy, Napoli, Italy
Background/Purpose: Higher levels of CXCL10 and CXCL11 in patients with a very early diagnosis of systemic sclerosis (SSc) subsequently shifted to SSc were pointed out…
Abstract Number: 19 • 2019 ACR/ARP Annual Meeting
Inhibition of IkB Kinase-IKK Complex of Canonical NF-κB Pathway in Antiphospholipid Antibody-Mediated Endothelial Cell Activation
Rohan Willis¹, Elizabeth Papalardo ¹, Mohammad Jamaluddin ¹, Zurina Romay-Penabad ¹, Alvaro Schleh ¹, Allan Brasier ¹ and Emilio B Gonzalez ², ¹University of Texas Medical Branch, Galveston, TX, ²University of Texas Medical Branch, Galveston
Background/Purpose: Antiphospholipid antibodies (aPL) activate several target cell types leading to inflammatory damage and thrombosis in the antiphospholipid syndrome (APS). NF-κB activation is essential for…
Abstract Number: 20 • 2019 ACR/ARP Annual Meeting
Comparative Efficacy of Beta-2-Glycoprotein I Domain V Structural Analogue Variants in Preventing Antiphospholipid Antibody-Mediated Endothelial Cell Activation
Rohan Willis¹, Elizabeth Papalardo ¹, Mohammad Jamaluddin ¹, Zurina Romay-Penabad ¹, Alvaro Schleh ¹, Allan Brasier ¹ and Emilio B Gonzalez ², ¹University of Texas Medical Branch, Galveston, TX, ²University of Texas Medical Branch, Galveston
Background/Purpose: In previous studies, our group has demonstrated that a synthetic 20 amino acid peptide (“TIFI”) with structural similarity to Beta-2-Glycoprotein I Domain V (β2GPI…
Abstract Number: 21 • 2019 ACR/ARP Annual Meeting
Immuno-Phenotypic Analysis of Peripheral Blood Mononuclear Cells in Rheumatoid Arthritis Patients Treated with E6011, a Humanized Anti-Fractalkine Monoclonal Antibody
Tomohiro Yamada¹, Jungo Kakuta ¹, Eri Fusaoka-Nishioka ¹, Jun-ichi Ito ², Nobuyuki Yasuda ³, Tetsu Kawano ³ and Toshio Imai ³, ¹KAN Research Institute Inc., Kobe, Japan, ²EISAI Co. Ltd., Tsukuba, Japan, ³KAN Research Institute, Inc., Kobe, Japan
Background/Purpose: Fractalkine (FKN) and its solo receptor CX3CR1 are deeply involved in the pathogenesis of rheumatoid arthritis (RA). FKN is expressed on vascular endothelium, while…
Abstract Number: 22 • 2019 ACR/ARP Annual Meeting
Beta-2 Glycoprotein I as a DNA- and NET-binding Protein
Kelsey Gockman¹, Srilakshmi Yalavarthi ¹, Gautam Sule ¹, Alexandra Morris ¹, Yu Zuo ² and Jason Knight ³, ¹University of Michigan, Ann Arbor, MI, ²University of Texas Southwestern, Dallas, TX, ³Division of Rheumatology, Department of Internal Medicine, Michigan Medicine, Ann Arbor, MI
Background/Purpose: Beta-2 glycoprotein I (β2GPI) is a prominent autoantigen in antiphospholipid syndrome (APS). As an abundant plasma protein, β2GPI has variably been suggested to have…
Abstract Number: 23 • 2019 ACR/ARP Annual Meeting
Covalent High Molecular Weight HMGB1 Complexes in Muscle Regeneration: Implications in Inflammatory Myopathy
William Willis¹, Jennifer Petrosino ², Giancarlo Valiente ¹, Lai-Chu Wu ³ and Wael Jarjour ⁴, ¹The Ohio State University, Columbus, ²The Ohio State University Wexner Medical Center, Columbus, OH, ³Ohio State College of Medicine, Columbus, ⁴Ohio State College of Medicine, Columbus, OH
Background/Purpose: Increased levels of the alarmin high mobility group box one (HMGB1) have been implicated as a possible pathogenic mediator and biomarker for myositis. We…
Abstract Number: 24 • 2019 ACR/ARP Annual Meeting
Role of Trained Immunity in the Pathogenesis of Erdheim-Chester Disease
Giulio Cavalli¹, Riccardo Biavasco ¹, Marina Ferrarini ², Elisabetta Ferrero ², Eugenio Montini ², Simone Cenci ², Cardaci Simone ² and Lorenzo Dagna ¹, ¹Vita-Salute San Raffaele University, Milan, Italy, ²IRCCS San Raffaele Hospital, Milan, Italy
Background/Purpose: Erdheim-Chester disease (ECD) is a chronic inflammatory disease characterized by infiltration of bone and other tissues by foamy macrophages. These cells exhibit activating mutations…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].