ACR Meeting Abstracts

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  • Abstract Number: 1464 • 2019 ACR/ARP Annual Meeting

    The Oral Microbiome as a Risk Factor for Benign or Pathologic Autoimmunity Associated with Anti-SSA/Ro Positivity and Mimicry for Von Willebrand Factor Type a Domain Protein (vWFA) of L. Mirabilis

    Robert Clancy1, Miranda Marion 2, Peter Izmirly 1, Hannah Ainsworth 3, Timothy Howard 3, Mala Masson 1, Jill Buyon 1 and Carl Langefeld 3, 1NYU School of Medicine, New York, 2Wake Forest School of Medicine, Winston-Salem, NC, 3Wake Forest School of Medicine, Winston-Salem

    Background/Purpose: Autoantibody production precedes SLE or SS by years, including anti-Ro. Anti-Ro+ mothers of children with congenital heart block (CHB) are a unique population at…
  • Abstract Number: 1465 • 2019 ACR/ARP Annual Meeting

    Diversity Analysis of Intestinal Flora in Patients with Sjogren’s Syndrome

    Xiao-juan Mao 1, Sheng-xiao Zhang2, Xu-fang Yin 2, Ming-xing Zhang 1, Jia Wang 1, Min-jing Chang 2, Meng-ting Qiu 1, Jia-qian Zhang 1, Chong Gao 3 and Xiao-feng Li 1, 1The Second Hospital of Shanxi Medical University, Taiyuan, China (People's Republic), 2The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China (People's Republic), 3Brigham and Women’s Hospital, Harvard Medical School, Boston

    Background/Purpose: Sjogren's syndrome (SS) is characterized by lymphocyte infiltration of exocrine gland, resulting in decreased exocrine function and dry symptoms, affecting the quality of life…
  • Abstract Number: 1466 • 2019 ACR/ARP Annual Meeting

    Evaluation of Changes in Oral Health-Related Quality of Life over Time in Patients with Sjögren’s Syndrome

    Naoto Azuma1, Yoshinori Katada 2, Aki Nishioka 3, Masahiro Sekiguchi 4, Masayasu Kitano 5, Sachie Kitano 1, Hajime Sano 6 and Kiyoshi Matsui 1, 1Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan, 2Department of Rheumatology, Sakai City Medical Center, Sakai, Japan, 3Department of Rheumatology, Nishinomiya Watanabe Hospital, Nishinomiya, Japan, 4Departement of Rheumatology, Hyogo Prefectural Nishinomiya Hospital, Nishinomiya, Japan, 5Department of Rheumatology, Kyoto Okamoto Memorial Hospital, Kumiyama, Japan, 6Kyoto Okamoto Memorial Hospital, Kumiyama, Japan

    Background/Purpose: In addition to xerostomia symptoms, patients with Sjögren’s syndrome (SS) experience pain and discomfort in the oral cavity, and difficulties in speaking and eating,…
  • Abstract Number: 1467 • 2019 ACR/ARP Annual Meeting

    Clinical Characteristics of Primary Sjögren’s Syndrome in Adult Patients Diagnosed at Age Less Than or Equal to 35 Years versus Those over 35 Years of Age

    Noel Agustin Callahuara Goiburu1, Patricia Sasaki 1, Anastasia Secco 2, Catalan Pellet 3, Nadia Riscanevo 4, Janet Flores 5, Francisco Caeiro 5, cristina Amitrano 6, Cecilia Asnal 7, Alejandro Nitsche 8, Carolina Segura Escobar 9, Julia Demarchi 10, Damian Duartes 10, Lida santiago 11, Laura Raiti 12, Vanesa Cruzat 13, Carla Gobbi 14, Paula Alba 15, Silvia Papasidero 16, Sofia Velez 17, Vicente Juarez 18 and Gabriela Salvatierra 19, 1Rivadavia, CABA, Ciudad Autonoma de Buenos Aires, Argentina, 2Hospital Rivadavia, Caba, Buenos Aires, Argentina, 3Rivadavia, CABA, Argentina, 4Hospital Privado de Córdoba, Cordoba, Cordoba, Argentina, 5Hospital Privado de Córdoba, Cordoba, Argentina, 6Hospital Aleman, CABA, Argentina, 7Instituto Centenario, Buenos Aires, Buenos Aires, Argentina, 8Hospital Aleman, Ciudad Autonoma de Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina, 9Hospital Británico, Buenos Aires, Buenos Aires, Argentina, 10Hospital Británico, Ciudad Autonoma de Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina, 11OMI, Ciudad Autonoma de Buenos Aires, Argentina, 12Clinica Bessone, Buenos Aires, Buenos Aires, Argentina, 13Clinica Bessone, Buenos Aires, Argentina, 14CÁTEDRA DE CLÍNICA MÉDICA I, HOSPITAL CÓRDOBA, FACULTAD DE CIENCIAS MÉDICAS, UNIVERSIDAD NACIONAL DE CÓRDOBA, ARGENTINA, Cordoba, Cordoba, Argentina, 15UNIDAD DE REUMATOLOGÍA, CÁTEDRA DE SEMIOLOGÍA, HOSPITAL CÓRDOBA, FACULTAD DE CIENCIAS MÉDICAS, UNIVERSIDAD NACIONAL DE CÓRDOBA, ARGENTINA, Cordoba, Cordoba, Argentina, 16Hospital General de Agudos Dr. E. Tornú, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, 17Consultorio Privado S.V, Buenos Aires, Buenos Aires, Argentina, 18Hospital Milagros de Salta, Salta, Salta, Argentina, 19IPRI, Santiago del estero, Santiago del Estero, Argentina

    Background/Purpose: Although there is little information, the debut of primary Sjögren's syndrome in adult patients aged less than or equal to 35 years, would be…
  • Abstract Number: 1468 • 2019 ACR/ARP Annual Meeting

    Effects of Resistive Exercise on Fatigue and Disease Activity in Women with Primary Sjogren’s Syndrome

    Luciana Paula Dardin 1, Fernanda Gazoni 1, Ana Beatriz Garcia 1, Paulo Alexandre Minali 2 and Virginia Fernandes Moça Trevisani3, 1Sao Paulo Federal University - Brazil, Sao Paulo, Sao Paulo, Brazil, 2Sao Paulo Federal University - Brazil, Sao Paulo, Brazil, 3Department of Evidence-Based Medicine, Brazilian Cochrane Centre, Federal University of São Paulo, Sao Paulo, Brazil, Sao Paulo, Brazil

    Background/Purpose: Fatigue is a frequent symptom of pSS, considered debilitating and the most important cause of dysfunction in these patients. The present study aimed to…
  • Abstract Number: 1469 • 2019 ACR/ARP Annual Meeting

    New 2019 SLE EULAR/ACR Classification Criteria for SLE Are Valuable for Distinguishing Patients with SLE from Patients with pSS in Daily Practice

    Florence Assan1, Raphaele Seror 2, Gaetane Nocturne 3 and Xavier Mariette 4, 1Université Paris Sud, Hôpitaux Universitaires Paris-Sud, AP-HP, INSERM UMR 1184, Le Kremlin-Bicêtre, France, 2Hopitaux universitaires Paris Sud, Kremlin-Bicetre, France, 3Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique – Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM, Paris, France., Paris, France, 4Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique – Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM, Paris, France

    Background/Purpose: The new 2019 SLE EULAR/ACR Classification Criteria for Systemic lupus erythematosus (SLE) have been developed to find a better equilibrium between specificity and sensitivity…
  • Abstract Number: 1470 • 2019 ACR/ARP Annual Meeting

    Health-Related Quality of Life in Primary Sjogren’s Syndrome: Insights from Using PROMIS and Comparison to ESSPRI

    Dana DiRenzo1, Susan Robinson 2, Clifton Bingham 1 and Thomas Grader-Beck 2, 1Johns Hopkins University, Baltimore, MD, 2Johns Hopkins University, Baltimore

    Background/Purpose: Background. Sjogren’s Syndrome (SS) is a chronic, autoimmune disease affecting the exocrine glands that may negatively affect health-related quality of life (HRQL). The importance…
  • Abstract Number: 1471 • 2019 ACR/ARP Annual Meeting

    Polyautoimmunity and Major Organ Involvement Prevalence in Sjögren´s Syndrome: Thyroid, Liver, Lung and Kidney as Targets. a Single Center Cross Sectional Study

    Larissa Valor1, Hannah Schenker 2, Johannes Knitza 3, Melanie Hagen 3, Jürgen Rech 4 and Georg Schett 5, 1Friedrich-Alexander-University Erlangen-Nürnberg. Department of Internal Medicine 3 - Rheumatology and Immunology. Erlangen., Erlangen, Germany, 2Friedrich-Alexander-University Erlangen-Nürnberg. Department of Internal Medicine 3 - Rheumatology and Immunology. Erlangen. Germany., Erlangen, Germany, 3Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg, University Hospital Erlangen, Erlangen, Germany, Erlangen, Germany, 4Department of Internal Medicine 3, Friedrich-Alexander-University Erlangen-Nuremberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany, 5Department of Internal Medicine 3, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany

    Background/Purpose: Polyautoimmunity has been described to be associated with primary Sjögren´s syndrome (SjS) and the most frequent observed associated autoimmune diseases (AID) are autoimmune thyroid…
  • Abstract Number: 1472 • 2019 ACR/ARP Annual Meeting

    Primary Sjögren’s Syndrome and Development of Another Connective Tissue Disease During Follow-up

    MARIA FLORENCIA Rodriguez1, Anastasia Secco 2, Catalan Pellet 3, natalia herscovich 1, cristina Amitrano 4, Cecilia Asnal 5, Alejandro Nitsche 6, Julia Demarchi 7, damian duartes 8, Francisco Caeiro 9, Veronica Saurit 10, Nadia Riscanevo 11, Silvia Papasidero 12, Carla Gobbi 13, laura raiti 14, vanesa cruzat 14, Lida santiago 15, Sofia Velez 16, Gabriela Salvatierra 17 and Vicente Juarez 18, 1hospital rivadavia, buenos aires, Argentina, 2Hospital Rivadavia, Caba, Buenos Aires, Argentina, 3Rivadavia, CABA, Argentina, 4Hospital Aleman, CABA, Argentina, 5Instituto Centenario, Buenos Aires, Buenos Aires, Argentina, 6Hospital Aleman, Ciudad Autonoma de Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina, 7Hospital Británico, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, 8hospital britanico, buenos aires, Argentina, 9Hospital Privado de Córdoba, Cordoba, Argentina, 10Hospital Privado, Centro Médico de Córdoba, Córdoba, Argentina, Cordoba, Argentina, 11Hospital Privado de Córdoba, Cordoba, Cordoba, Argentina, 12Hospital General de Agudos Dr. E. Tornú, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, 13CÁTEDRA DE CLÍNICA MÉDICA I, HOSPITAL CÓRDOBA, FACULTAD DE CIENCIAS MÉDICAS, UNIVERSIDAD NACIONAL DE CÓRDOBA, ARGENTINA, Cordoba, Cordoba, Argentina, 14clinica bessone, buenos aires, Argentina, 15OMI, Ciudad Autonoma de Buenos Aires, Argentina, 16Consultorio Privado S.V, Buenos Aires, Buenos Aires, Argentina, 17IPRI, Santiago del estero, Santiago del Estero, Argentina, 18Hospital Milagros de Salta, Salta, Salta, Argentina

    Background/Purpose: Primary Sjögren's Syndrome (pSS) is a chronic autoimmune disease characterized by lymphocytic infiltration of the exocrine glands. Is the connective tissue disease that is…
  • Abstract Number: 1473 • 2019 ACR/ARP Annual Meeting

    Syndecan-1 Is a Potential Biomarker for Salivary Glandular Function and Disease Activity in Patients with Sjögren’s Syndrome

    Gunwoo Kim1, Min-Su Han 2, Ju Hye Jeong 3, Man-Hoon Han 4, Sang Jin Lee 5 and Eon Jeong Nam 6, 1Division of Rheumatology, Department of Internal medicine, Daegu Fatima Hospital, Daegu, Taegu-jikhalsi, Republic of Korea, 2Laboratory for arthritis and bone biology, Fatima Research Institute, Daegu Fatima Hospital, Daegu, Taegu-jikhalsi, Republic of Korea, 3Department of Nuclear medicine, Kyungpook National University Chilgok Hospital, 807, Hoguk-ro, Buk-gu, Daegu 41404, Taegu-jikhalsi, Republic of Korea, 4Department of Pathology, Kyungpook National University Hospital, 130 Dongdeok-ro, Jung-gu, Daegu 41944, Taegu-jikhalsi, Republic of Korea, 5Division of Rheumatology, Kyungpook National University Hospital, Daegu, Republic of Korea, 6Division of Rheumatology, Department of Internal Medicine, Kyungpook National University Chilgok Hospitalospital, 807, Hoguk-ro, Buk-gu, Daegu 41404, Taegu-jikhalsi, Republic of Korea

    Background/Purpose: Sjögren’s syndrome (SS) is known as autoimmune epithelitis, because epithelial cells in the glands are the primary target of disease and play a major…
  • Abstract Number: 1474 • 2019 ACR/ARP Annual Meeting

    Factors Influencing the ESSPRI Index in Primary Sjögren’s Syndrome

    Maria Graciela Sandoval-Flores1, Isela Chan-Campos 2 and Gabriela Hernandez-Molina 2, 1Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, Distrito Federal, Mexico, 2Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico

    Background/Purpose: The ESSPRI is a validated index for measuring symptoms (pain, fatigue and dryness) in primary Sjögren’s syndrome (pSS). Herein we evaluated its association with…
  • Abstract Number: 1475 • 2019 ACR/ARP Annual Meeting

    Comparison of Different Remission Indices in Patients with Psoriatic Arthritis: A Post Hoc Analysis of Data from Phase 3 Tofacitinib Studies

    Gustavo Citera1, Emilce Schneeberger 2, Peter Nash 3, Josef Smolen 4, Philip Mease 5, Enrique Soriano 6, Vesna Matulic 7, Claudia Helling 8, Annette Szumski 9, Rajiv Mundayat 10, Daniela Graham 11 and Dario Ponce de Leon 12, 1Instituto de Rehabilitación Psicofísica, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, 2Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, 3University of Queensland, Brisbane, Queensland, Australia, 4Medical University of Vienna, Vienna, Austria, 5Swedish Medical Center/Providence St Joseph Health, and University of Washington, Seattle, WA, 6Rheumatology Section, Internal Medicine Service, Hospital Italiano de Buenos Aires, Argentina., Buenos Aires, Buenos Aires, Argentina, 7Pfizer Chile S.A., Santiago, Chile, 8Pfizer Inc, Buenos Aires, Argentina, 9Syneos Health, Princeton, NJ, 10Pfizer Inc, New York, NY, 11Pfizer Inc, Groton, CT, 12Pfizer Inc, Lima, Peru

    Background/Purpose: An international task force has agreed that remission or low disease activity (LDA) are key treatment targets for patients (pts) with PsA, and recommends…
  • Abstract Number: 1476 • 2019 ACR/ARP Annual Meeting

    Impact of Alternate Mechanism of Action Biologics and Tofacitinib on TNF-α Inhibitor Prescribing in Psoriatic Arthritis: Results from Annual National Patient Chart Audits

    Lynn Price1, Phil Pouliot 1 and Lauren Schmitt 1, 1Spherix Global Insights, Exton, PA

    Background/Purpose: TNF-α inhibitor therapy has long been the standard of care for adult patients diagnosed with moderate to severe psoriatic arthritis (PsA), though several new…
  • Abstract Number: 1477 • 2019 ACR/ARP Annual Meeting

    Golimumab Improves Direct Costs of Healthcare Utilization and Indirect Costs Within Patients with RA, PsA, and as – Analysis of a Non-Interventional Study in Germany

    Klaus Krüger 1, Gerd Burmester 2, Siegfried Wassenberg 3, Astrid Thiele 4 and Matthias Thomas5, 1Medical Centre of Rheumatology, Munich, Germany, 2Charité—University Medicine Berlin, Berlin, Germany, 3Centre of Rheumatology, Ratingen, Germany, 4Krankenhaus St. Josef Wuppertal, Wuppertal, Germany, 5MSD Sharp & Dohme GmbH, Haar, Germany

    Background/Purpose: Rheumatic diseases are associated with pain, loss of functionality, fatigue, hospitalization, sick leave, and work disability. This results in high economic burden for patients…
  • Abstract Number: 1478 • 2019 ACR/ARP Annual Meeting

    Systematic Literature Review and Network Meta-Analysis Comparing Incidence of Uveitis and IBD in Axial Spondyloarthritis Patients Treated with Anti-TNF versus Anti-IL17A in Placebo Controlled Randomized Trials

    Damien Roche1, Martin Badard 1, Laurent Boyer 2, Pierre Lafforgue 1 and Thao Pham 1, 1Aix-Marseille University, CHU Marseille, department of Rheumatology, 13,000 Marseille, France, Marseille, France, 2Aix-Marseille University, EA 3279 Research Unit, 13,000 Marseille, France, Marseille, France

    Background/Purpose: Inflammatory bowel diseases (IBD) and anterior uveitis (AU) are frequent extra-articular features of axial spondyloarthritis (axSpA). Although effect of anti-TNF on IBD and AU…
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