Abstracts Archive - Page 824 of 2425 - ACR Meeting Abstracts

Abstract Number: 984 • 2019 ACR/ARP Annual Meeting
Important Role of CD11c+ Cells in Inflammatory Arthritis
Antonia Puchner¹, Elisabeth Simader ¹, Victoria Saferding ², Gerhard Kroenke ³, Rene Pfeifle ⁴, Daniel Aletaha ¹, Josef Smolen ¹ and Stephan Blueml ¹, ¹Medical University of Vienna, Vienna, Austria, ²Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria, ³Department of Internal Medicine 3, Friedrich-Alexander-University Erlangen-Nuremberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Austria, ⁴University Hospital Erlangen, Erlangen, Germany
Background/Purpose: Dendritic cells (DCs) are important antigen presenting cells (APCs) and therefore they play an important role in bridging the innate and the adaptive immune…
Abstract Number: 985 • 2019 ACR/ARP Annual Meeting
Inhibition of Calcium/calmodulin-dependent Protein Kinase IV in Rheumatoid Arthritis: Dual Effect on Th17 Cell Activation and Osteoclastogenesis
Tomohiro Koga¹, Tomohito Sato ², Yushiro Endo ¹, Sosuke Tsuji ¹, Ayuko Takatani ¹, Toshimasa Shimizu ¹, Remi Sumiyoshi ¹, Takashi Igawa ¹, Shin-ya Kawashiri ¹, Naoki Iwamoto ¹, Kunihiro Ichinose ¹, Mami Tamai ¹, Hideki Nakamura ¹, Tomoki Origuchi ³, Nobuya Yoshida ⁴, Masataka Umeda ⁵, George Tsokos ⁴ and Atsushi Kawakami ⁶, ¹Nagasaki University Graduate School of Biomedical Sciences, Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki, Japan, ²Nagasaki University, Nagasaki, Japan, ³Nagasaki University School of health sciences, Division of physical therapy, Nagasaki, Japan, ⁴Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ⁵Beth Israel Deaconess Medical Center, Boston, MA, ⁶Nagasaki University Graduate School of Biomedical Sciences, Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki
Background/Purpose: Background: CD4 + T cells are important in the pathogenesis of rheumatoid arthritis (RA), and therapies targeting the differentiation of osteoclasts are attracting attention. Calcium/calmodulin-dependent…
Abstract Number: 986 • 2019 ACR/ARP Annual Meeting
Tofacitinib Enhanced Cerebral Brain-derived Neurotrophic Factor Levelsin a Rat Model of Rheumatoid Arthritis
Aurore Quirié ¹, Clément PRATI ², Daniel WENDLING³, Perle Totoson ⁴, Céline Demougeot ⁴ and Christine Marie ¹, ¹Inserm U1093, Action, cognition et plasticité sensorimotrice, F-21000 Dijon, France, Dijon, France, ²University Teaching Hospital (CHRU), Besançon, France, ³Rheumatology, University Teaching Hospital (CHRU), Besançon, France, ⁴PEPITE EA4267, Univ. Bourgogne Franche-Comté, F-25000 Besançon, France, BESANCON, France
Background/Purpose: Cognitive dysfunction including depression-like symptoms is a frequent comorbidity of rheumatoid arthritis (RA). Recently, rats with adjuvant-induced arthritis (AIA) were found to exhibit reduced…
Abstract Number: 987 • 2019 ACR/ARP Annual Meeting
Anti-citrullinated Protein Antibodies Induce Subclinical Inflammation, Bone Loss and Pain in Mice
Akilan Krishnamurthy¹, Yogan Kisten ², Alexandra Circiumaru ³, Katalin Sandor ⁴, Koji Sakurabas ⁵, Gustaf Wigerblad ⁶, Peter Damberg ⁷, Heidi Wähämaa ³, Patrik Jarvolli ⁷, Vivianne Malmström ⁸, Lars Klareskog ⁹, Camilla I Svensson ¹⁰, Juan Jimenez Jimenez Andrade ¹¹, Bence Rethi ³ and Anca Catrina ⁹, ¹Rheumatology unit, Department of Medicine, Karolinska University Hospital and Karolinska Institutet, Solna, Stockholm, ²Rheumatology unit Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden, Stockholm, Stockholms Lan, Sweden, ³Rheumatology unit Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden, Stockholm, ⁴Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden, stockholm, Sweden, ⁵Rheumatology unit, Department of Medicine, Karolinska University Hospital and Karolinska Institutet, Solna, stockholm, Sweden, ⁶karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, ⁷Karolinska Institutet, Karolinska Experimental Research and Imaging Centre (KERIC), stockholm, Sweden, stockholm, Sweden, ⁸Rheumatology Unit, Department of Medicine, Karolinska University Hospital and Institutet, Stockholm, Sweden., Stockholm, Sweden, ⁹Rheumatology unit Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden, Stockholm, Sweden, ¹⁰Karolinska Institutet, Physiology and Pharmacology, stockholm, Sweden, Stockholm, Sweden, ¹¹Universidad Autónoma de Tamaulipas, Reynosa, Tamaulipas, Mexico, Tamaulipas, Mexico
Background/Purpose: Autoantibodies against citrullinated proteins (ACPAs) could be associated with bone loss, pain and tenosynovitis prior to disease onset in human rheumatoid arthritis (RA) and…
Abstract Number: 988 • 2019 ACR/ARP Annual Meeting
Translational Imaging of Treatment Effects for a Novel Anti-TNF-Steroid Antibody Drug Conjugate in a Rat Model of Rheumatoid Arthritis
Bradley Hooker¹, Xiaomeng Zhang ², Todd Cole ², Ann Tovcimak ², Shaughn Bryant ³, Lucy Phillips ³, David Blanchard ², Dustin Wooten ², Qi Guo ², Melanie Ruzek ³, Adrian Hobson ³, Michael McPherson ³, Robert Stoffel ³, Wendy Waegell ³ and Yanping Luo ², ¹AbbVie, North Chicago, IL, ²AbbVie, North Chicago, ³AbbVie, Worcester
Background/Purpose: Rheumatoid arthritis (RA) is an inflammatory joint disease of autoimmune etiology. If insufficiently treated, RA leads to joint damage and irreversible disability. Although there…
Abstract Number: 989 • 2019 ACR/ARP Annual Meeting
Lineage Tracing of Murine Lymphatic Smooth Muscle Cells to Determine the Role of the Lymphatic System in Inflammatory Arthritis
H. Mark Kenney¹, Richard Bell ² and Edward Schwarz ¹, ¹University of Rochester, Rochester, NY, ²University of Rochester Medical Center, Rochester, NY
Background/Purpose: Dysfunction of lymphatic vessel contraction has been implicated in inflammatory arthritis progression and arthritic flare in murine models. Previous studies have demonstrated that tumor…
Abstract Number: 990 • 2019 ACR/ARP Annual Meeting
Development of a Novel Anti TNF-Steroid Antibody Drug Conjugate That Shows Promising Efficacy at Doses That Avoid Steroid Side Effects in a Mouse Model of Rheumatoid Arthritis
Wendy Waegell¹, Christian Goess ², Robert Stoffel ¹, Michael McPherson ¹, Adrian Hobson ¹, Suzanne Mathieu ², Lucy Phillips ¹ and Shaughn Bryant ¹, ¹AbbVie, Worcester, ²Abbvie bioresearch Center, Worcester, MA
Background/Purpose: TNF-inhibitors are a well established therapy for autoimmune diseases including rheumatoid arthritis, Crohn’s disease, psoriasis and ankylosing spondylitis but they have limited efficacy in…
Abstract Number: 991 • 2019 ACR/ARP Annual Meeting
Identification of Citrullinated Peptide Specific T-cells in Humanized Mice Immunized with Citrullinated Peptides
Matthew McElwee¹, Thamotharampillai Dileepan ¹ and Marc Jenkins ¹, ¹University of Minnesota, Minneapolis, MN
Background/Purpose: Seropositive rheumatoid arthritis (RA) is a T-cell mediated disease that is characterized by the presence of antibodies to proteins that have undergone the post-translational…
Abstract Number: 992 • 2019 ACR/ARP Annual Meeting
Identification of CJ-15314, a Novel Highly Selective JAK1 Inhibitor, for the Treatment of Rheumatoid Arthritis
So Young Ki¹, Dongkyu Kim ¹, Juhyun Lee ¹, Byoung Seok Moon ¹ and Shin-Young Ryu ¹, ¹CJ Healthcare, Icheon-si, Republic of Korea
Background/Purpose: Janus kinases (JAKs) play critical roles in mediating various cytokine signaling. First-generation non-selective JAK inhibitors such as tofacitinib and baricitinib are widely used for…
Abstract Number: 993 • 2019 ACR/ARP Annual Meeting
pH-Sensitive Nanoformulated Triptolide as a Targeted Therapeutic Strategy for Rheumatoid Arthritis
Liu Yang¹, Jin JianQiu ¹, Xu Hao ¹, Han HaiHui ¹, Hou Tong ¹, Zhang WeiAn ² and Liang QianQian ¹, ¹Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China (People's Republic), ²Shanghai Key Laboratory of Advanced Polymeric Materials, East China University of Science and Technology, Shanghai, China (People's Republic)
Background/Purpose: The best packaging of holistic therapy for Rheumatoid arthritis (RA) will involve two components: a potent anti-inflammatory therapeutic and a rationally designed drug delivery…
Abstract Number: 994 • 2019 ACR/ARP Annual Meeting
Increased Antibody and T-cell Responses Following Treatment of Collagen-Induced Arthritis in C57Bl/6 Mice with Organic Dust Inhalants
Michael Duryee¹, Jill Poole ¹, Amy Nelson ¹, Katherine Janike ¹, Kathryn Rentfro ¹, Lynell Klassen ¹, James O'Dell ², Bryant England ³, Geoffrey Thiele ² and Ted Mikuls ², ¹University of Nebraska Medical Center, Omaha, NE, ²VA Nebraska-Western IA Health Care System & University of Nebraska Medical Center, Omaha, NE, ³VA Nebraska-Western IA Health Care System & University of Nebraska Medical Center, Omaha
Background/Purpose: Increasing evidence suggests that inhalant exposures, such as tobacco smoke or silica, are implicated in the initiation of autoimmunity leading to rheumatoid arthritis (RA).…
Abstract Number: 995 • 2019 ACR/ARP Annual Meeting
Inhibition of Endoplasmic Reticulum Stress Using 4-phenylbutyric Acid Ameliorates the Severity of Collagen-induced Arthritis in Mice via Attenuation of Proliferation and Inflammatory Responses of Synovial Fibroblasts
Wan-Hee Yoo¹, Yunjung Choi ², Eun-gyeong Lee ², Chang-hoon Lee ³ and Myeung-Su Lee ³, ¹Department of Internal Medicine, Chonbuk National University Medical School, Research Institute of Clinical Medicine of Chonbuk National University-Biomedical, Research Institute of Chonbuk National University Hospital, Jeonju, Korea, JeonJu, Republic of Korea, ²Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, JeonJu, Republic of Korea, ³Wonkwang University College of Medicine, Iksan, Republic of Korea
Background/Purpose: Several studies have recently revealed the pathological role of endoplasmic reticulum (ER) stress in the pathogenesis of inflammatory diseases. In addition, 4-phenylbutyric acid (4-PBA) was…
Abstract Number: 996 • 2019 ACR/ARP Annual Meeting
The Role of Flip in Differentiation and Survival of Synovial Tissue Resident Macrophages
Qi Huang¹, Renee Doyle ¹, Shang-Yang Chen ², Alexander Misharin ³, Deborah Winter ⁴ and Richard Pope ⁵, ¹Northwestern University Feinberg School of Medicine, Chicago, IL, ²Northwestern University, Chicago, ³Northwestern University Feinberg School of Medicine, chicago, ⁴Northwestern University Feinberg School of Medicine, Division of Rheumatology, Chicago, ⁵Northwestern University Feinberg School of Medicine, Division of Rheumatology, chicago, IL
Background/Purpose: We previously identified that under homeostatic conditions Flip was necessary for macrophage (MΦ) survival. The mechanisms responsible for the differentiation of monocyte-derived MΦs into…
Abstract Number: 997 • 2019 ACR/ARP Annual Meeting
Stromal Cell-derived DCSTAMP Coordinates Cell Migration and Osteoclast Activation in TNF-driven Murine Arthritis
Maria de la luz Garcia-Hernandez¹, Javier Rangel-Moreno ², Benjamin Korman ², Ananta Paine ¹, Nelson Huertas ³ and Christopher T. Ritchlin ³, ¹Division of Allergy, Immunology and Rheumatology, Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA, Rochester, NY, ²University of Rochester Medical center, Rochester, NY, ³University of Rochester, Rochester, NY
Background/Purpose: DC-STAMP is a transmembrane protein involved in the fusion of mononuclear osteoclasts and essential for the formation of fully functional multinucleated osteoclasts (OCs). Recently…
Abstract Number: 998 • 2019 ACR/ARP Annual Meeting
Stimulation of Splenic Neurovascular Bundle Protect Mice from Developing Collagen-induced Arthritis
Thomas Simon¹, Clara Panzolini ², Julien Lavergne ², Arun Srihar ³, Margriet Vervoordeldonk ³, nicolas Glaichenhaus ² and Philippe Blancou ², ¹CNRS/IPMC, Valbonne, France, ²IPMC/CNRS, VALBONNE, France, ³Galvani Bioelectronics, Stevenage, United Kingdom
Background/Purpose: Vagus nerve (VN) stimulation has shown the potential to improve the disease development in animal models of arthritis and in patients with RA. However,…

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