Abstracts Archive - Page 2075 of 2425 - ACR Meeting Abstracts

Abstract Number: 2674 • 2013 ACR/ARHP Annual Meeting
Vitamin D Deficiency Is Common and Associated With Increased C-Reactive Protein In Children With Lupus: An Atherosclerosis Prevention In Pediatric Lupus Erythematosus Substudy
Angela B. Robinson¹, Vin Tangpricha², Eric Yow³, Reut Gurion⁴, Grace McComsey⁴ and Laura E. Schanberg⁵, ¹Pediatric Infectious Disease, Rheumatology and Geographic Medicine, Rainbow Babies and Children's Hospital / Case Medical Center, Cleveland, OH, ²Medicine, Emory University School of Medicine, Atlanta, GA, ³Biostatistics, Duke Clinical Research Institute, Durham, NC, ⁴Pediatric Infectious Diseases, Rheumatology, and Geographic Medicine, Rainbow Babies and Children's Hospital / Case Medical Center, Cleveland, OH, ⁵Pediatrics, Duke University Medical Center, Durham, NC
Background/Purpose: Epidemiologic associations suggest vitamin D may play a role in inflammation and progression of atherosclerosis. Using frozen serum, carotid intima medial thickness (CIMT) measurements,…
Abstract Number: 2635 • 2013 ACR/ARHP Annual Meeting
IgA Vasculitis In Adults – a Rare and Benign Disease?
Alojzija Hocevar¹, Jaka Ostrovrsnik¹, Vesna Jurcic² and Matija Tomsic^3,4, ¹Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, ²Institute of Pathology, University of Ljubljana, Faculty of Medicine, Ljubljana, Slovenia, ³Department of Rheumatology, University Medical Centre Ljubjana, Ljubljana, Slovenia, ⁴Faculty of Medicine, Unversity Ljubljana, Ljubljana, Slovenia
Background/Purpose: IgA vasculitis (IgAV) is the most common vasculitis in children, with a defined epidemiology (14 cases/ 105children), clinical picture and generally favourable prognosis. In…
Abstract Number: 2636 • 2013 ACR/ARHP Annual Meeting
IgA Vasculitis – The Second Most Common Systemic Vasculitis In Adults In Slovenia
Alojzija Hocevar¹, ŽIga Rotar¹, Jaka Ostrovrsnik¹, Vesna Jurcic², Jelka Lindic³ and Matija Tomsic^4,5, ¹Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, ²Institute of Pathology, University of Ljubljana, Faculty of Medicine, Ljubljana, Slovenia, ³Department of Nephrology, University Medical Centre Ljubljana, Ljubljana, Slovenia, ⁴Department of Rheumatology, University Medical Centre Ljubjana, Ljubljana, Slovenia, ⁵Faculty of Medicine, Unversity Ljubljana, Ljubljana, Slovenia
Background/Purpose: IgA vasculitis (IgAV) is assumed to be rare in adults. Reported annual incidence rates vary between 0.8 and 1.8 cases per 100,000 adults.1 Our…
Abstract Number: 2637 • 2013 ACR/ARHP Annual Meeting
Validation Study Of The International Classification Criteria For The Cryoglobulinemic Vasculitis
Luca Quartuccio¹, Miriam Isola², Laura Corazza³, Soledad Retamozo⁴, Manal Abdel-Moneim El-Menyawi⁵, Elisa Gremese⁶, Marco Sebastiani⁷, Nicolo Pipitone⁸, Teresa Urraro⁹, Vincenza Conteduca¹⁰, Christos Koutsianas¹¹, Benjamin Terrier¹², Mostafa Naguib Zoheir¹³, Alessandra Ghinoi¹⁴, Davide Filippini¹⁵, Francesco Saccardo¹⁶, Mohamed Nabil Salem¹⁷, Salvatore Scarpato¹⁸, Paolo Fraticelli¹⁹, Antonio Tavoni²⁰, Eleonora Catarsi²¹, Cesare Mazzaro²², Pietro Pioltelli²³, Mervat Matar⁵, Patrizia Scaini²⁴, Matija Tomsic²⁵, Norihiro Nishimoto^26,27, Dimitrios Vassilopoulos²⁸, Michael Voulgarelis²⁹, Gaafar M. Ragab³⁰, Carlo Salvarani³¹, Armando Gabrielli³², Patrice Cacoub³³, Loic Guillevin³⁴, Domenico Sansonno³⁵, Anna Linda Zignego³⁶, Gianfranco Ferraccioli⁶, Athanasios G. Tzioufas³⁷, Manuel Ramos-Casals³⁸, Clodoveo Ferri³⁹, Maurizio Pietrogrande⁴⁰, Giuseppe Monti¹⁶, Massimo Galli⁴¹, Stefano Bombardieri⁴² and Salvatore De Vita⁴³, ¹Rheumatology Clinic, DSMB, University of Udine, Udine, Italy, ²Institute of Statistics, DSMB, University of Udine, Udine, Italy, ³Rheumatology Clinic, University of Udine, Udine, Italy, ⁴Laboratorio de Enfermedades Autoinmunes Josep Font, IDIBAPS, Hospital Clínic, Barcelona, Spain, ⁵Faculty of Medicine, Cairo, Egypt, ⁶Division of Rheumatology, Institute of Rheumatology and Affine Sciences, Catholic University of the Sacred Heart, Rome, Italy, ⁷Internal Medicine, University of Modena and Reggio Emilia, Modena, Italy, ⁸Rheumatology Service, Arcispedale S Maria Nuova, IRCCS, Reggio Emilia, Italy, ⁹Center for Systemic Manifestations of Hepatitis Viruses (MASVE), Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy, ¹⁰Department of Internal Medicine and Clinical Oncology, University of Bari, Bari, Italy, ¹¹Department of Pathophysiology, Medical School of Athens, Athens, Greece, ¹²Internal Medicine, Cochin University Hospital, Paris, France, ¹³Faculty of Medicine, Cairo University, Cairo, Egypt, ¹⁴Rheumatology, Arcispedale S Maria Nuova, Reggio Emilia, Italy, ¹⁵Rheumatology Unit, Ospedale Niguarda,, Milan, Italy, ¹⁶Internal Medicine Unit, Saronno Hospital, Azienda Ospedaliera di Busto Arsizio, Saronno (VA), Italy, ¹⁷Faculty of Medicine, Beni Swafe University, Beni Swafe, Egypt, ¹⁸Rheumatology Unit, M. Scarlato Hospital, Scafati, Salerno, Italy, ¹⁹Istituto di Clinica Medica, Università Politecnica delle Marche, Ancona, Italy, ²⁰University of Pisa, Immunoallergology Unit, Pisa, Italy, ²¹Department of Internal Medicine, Section of Immunoallergology, University of Pisa, Pisa, Italy, ²²Department of Internal Medicine, Pordenone General Hospital, Pordenone, Italy, ²³Hematology, S.Gerardo Hospital, Monza, Italy, ²⁴Nephrology, Spedali Civili di Brescia, Brescia, Italy, ²⁵Department of Rheumatology, University Medical Centre Ljubjana, Ljubljana, Slovenia, ²⁶Laboratory of Immune Regulation, Wakayama Medical University, Ibaraki, Japan, ²⁷Osaka Rheumatology Clinic, Osaka, Japan, ²⁸2nd Department of Medicine, Athens University School of Medicine, Athens, Greece, ²⁹School of Medicine, University, Department of Pathophysiology, Athens, Greece, ³⁰Int Medicine Hosp/Rheum&Immun, Faculty of Medicine, Cairo University, Giza, Egypt, ³¹Rheumatology, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy, ³²Scienze Cliniche e Molecolari, Università Politecnica delle Marche, Ancona, Italy, ³³Médecine Interne 2, Hopital Pitié-Salpétrière, Paris, France, ³⁴Internal Medicine, Division of Internal Medicine, Hôpital Cochin, University Paris Descartes, Paris, France, ³⁵Section of Internal Medicine and Clinical Oncology, Department of Biomedical Sciences and Human Oncology, University of Bari, Medical School, Bari, Italy, ³⁶University of Florence, Center for Systemic Manifestations of Hepatitis Viruses (MASVE), Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy, ³⁷Pathophysiology, School of Medicine, National University of Athens, Athens, Greece, ³⁸Laboratorio de Enfermedades Autoinmunes Josep Font, Hospital Clínic, Barcelona, Spain, ³⁹Department of Internal Medicine, University of Modena and Reggio Emilia, Modena, Italy, ⁴⁰Internal Medicine Unit, Policlinico San Marco, Bergamo, Italy, ⁴¹Istituto di Malattie Infettive e Tropicali, Università di Milano c/o Ospedale L. Sacco, Milano, Italy, ⁴²Department of Clinical and Experimental Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy, ⁴³Rheumatology, DSMB, University Hospital Santa Maria della Misericordia, Udine, Italy
Background/Purpose: preliminary Classification Criteria for cryoglobulinemic vasculitis (CV) have been developed in 2011 by an European cooperative study, with an adequate methodology in a large…
Abstract Number: 2638 • 2013 ACR/ARHP Annual Meeting
Cryoglobulinemia Vasculitis With Or Without Associated Cryofibrinogenemia: A Different Phenotype?
Martin Michaud¹, Guillaume Moulis², Jacques Pourrat¹, Benedicte Puissant¹, Antoine Blancher¹ and Laurent Sailler³, ¹Toulouse University Hospital, University of Toulouse, Toulouse, France, ²Toulouse University Hospital, Clinical Pharmacology Department, University of Toulouse, UMR INSERM-UPS 1027, Toulouse, France, ³Department of Internal Medicine, Toulouse University Hospital, Toulouse, France
Background/Purpose: Cryoglobulin (CryoGl) and cryofibrinogen (CryoFg) are cryoproteins, both responsible for well-described systemic vasculitis. Nevertheless, cryoglobulinemia may be associated with cryofibrinogenemia. Such mixed cryoprotein vasculitis…
Abstract Number: 2639 • 2013 ACR/ARHP Annual Meeting
Long-Term Outcome of Monoclonal (type 1) Cryoglobulinemia
Antoine Néel¹, François Perrin¹, Olivier Decaux², Thomas Dejoie³, Maxime Halliez³, Béatrice Mahé⁴, Thierry Lamy⁵, Fadi Fakhouri⁶, Patrick Jego², Christian Agard¹, Cécile Vigneau⁷, Lucienne Guenet⁸, Bernard Grosbois⁹, Philippe Moreau⁴ and Mohamed Hamidou¹, ¹Internal Medicine Department, Nantes University Hospital, Nantes, France, ²Department of Internal Medicine, Rennes University Hospital, Rennes, France, ³Biochemistry Laboratory, Nantes University Hospital, Nantes, France, ⁴Hematology, Nantes University Hospital, Nantes, France, ⁵Hematology, Rennes University Hospital, Rennes, France, ⁶Nephrology, Nantes University Hospital, Nantes, France, ⁷Nephrology, Rennes University Hospital, Rennes, France, ⁸Biochemistry Laboratory, Rennes University Hospital, Rennes, France, ⁹Internal Medicine Department, Rennes University Hospital, Rennes, France
Background/Purpose: To investigate long-term outcome of symptomatic type 1 cryoglobulinemia and its determinants. Methods: Retrospective analysis of a prospective cohort from 2 French university hospitals.…
Abstract Number: 2640 • 2013 ACR/ARHP Annual Meeting
VERY LONG-TERM Effects Of The “4 PLUS2 Infusion PROTOCOL” Of Rituximabalone In Patients With HCV-Associatedmixed Cryoglobulinemia With Diffusemembranoproliferative Glomerulonephritis,Severe Polyneuropathy and Necrotic Ulcersof Skin
Dario Roccatello¹, Savino Sciascia¹, Simone Baldovino² and Daniela Rossi¹, ¹Department of Rare, Immunologic, Hematologic and Immunohematologic Diseases, Centro di Immunopatologia e Documentazione su Malattie rare, Torino, Italy, ²Centro di Ricerche di Immunologia Clinica ed Immunopatologia e Documentazione su Malattie Rare (CMID), Università di Torino, Torino, Italy
Background/Purpose: Mixed cryoglobulinemia syndrome (MCs) is a systemic vasculitischaracterized by multiple organ involvement due to the vascular deposition ofIgMk/IgG cryoglobulins. B cells expansion usually triggered…
Abstract Number: 2641 • 2013 ACR/ARHP Annual Meeting
Earlier Admission To Specialized Care, Intensified Treatment and Improved Outcome In Patients With Autoimmune Connective Tissue Disorders and Vasculitides In Germany 2011 Compared To 1995
Dörte Huscher¹, Katinka Albrecht², Katja Thiele², Sascha Bischoff², Jutta G. Richter³, Ina Kötter⁴, Wolfgang Ochs⁵ and Angela Zink¹, ¹German Rheumatism Research Centre and Charité University Medicine, Berlin, Germany, ²German Rheumatism Research Centre, Berlin, Germany, ³Department of Rheumatology, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany, ⁴ZIRS, Centre for Interdisciplinary Rheumatology Stuttgart, Stuttgart, Germany, ⁵Rheumatologist in private practice, Bayreuth, Germany
Background/Purpose: Compared to rheumatoid arthritis and other arthritis-associated rheumatic diseases, autoimmune connective tissue disorders and vasculitides are still in the early stages of biological therapies.…
Abstract Number: 2642 • 2013 ACR/ARHP Annual Meeting
A Novel Genetic Basis For Systemic Vasculitis: Polyarteritis Nodosa Caused By Recessive Mutations In An Immune-Related Gene
Reeval Segel^1,2, Pnina Elkan-Navon³, Sarah B. Pierce⁴, Tom Walsh⁴, Judith Barash⁵, Shay Padeh⁶, Avraham Zlotogorski⁷, Yackov Berkun⁸, Isabel Voth⁹, Philip Hashkes¹⁰, Liora Harel¹¹, Eduard Ling¹², Fatos Yalcinkaya¹³, Ozgur Kasapcopur¹⁴, Paul F. Renbaum¹⁵, Ariella Weinberg-Shukron¹⁵, Barbara Schormair¹⁶, Mordechai Shohat¹⁷, Alan A. Rubinow¹⁸, Elon Pras¹⁹, Juliane Winkelmann²⁰, Mustafa Tekin²¹, Yair Anikster²², Mary-Claire King⁴ and Ephrat Levy-Lahad¹⁵, ¹Medical Genetics and Pediatrics, Shaare Zedek Medical Center, Jerusalem, Israel, ²Hebrew University Medical School, Jerusalem, Israel, ³Pediatrics, Shaare Zedek Medical Center, Jerusalem, Israel, ⁴Medical Genetics, University of Washington, Seattle, WA, ⁵Pediatric Day Care, Kaplan Medical Center, Rehovot, Israel, ⁶Pediatrics, Sheba Medical Center, Ramat Gan, Israel, ⁷Department of Dermatology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel, ⁸Pediatrics, Hadassah Medical Center, Mount Scopus, Jerusalem, Israel, ⁹Department of Neurology, Technische Universitat Munchen Klinikum rechts der Isar, Munich, Germany, ¹⁰Pediatric Rheumatology, Shaare Zedek Medical Center, Jerusalem, Israel, ¹¹Pediatric Rheumatology unit, Schneider Children's Medical Center, Tel Aviv University, Petach Tikvah, Israel, ¹²Rheumatology Unit, Soroka University Medical Center and Ben-Gurion University, Beer-Sheva, Beer Sheva, Israel, ¹³Pediatric Nephrology and Rheumatology, Ankara University, Ankara, Turkey, ¹⁴Ankara University, Ankara, Turkey, ¹⁵Medical Genetics, Shaare Zedek Medical Center, Jerusalem, Israel, ¹⁶Helmholtz Zentrum Munchen, Munich, Germany, ¹⁷Rafael Recanati medical genetics Institute, Rabin Medical Center, Beilinson Hospital, Petach Tikvah, Israel, ¹⁸Hadassah Medical Center, Jerusalem, Israel, ¹⁹Institute of Human Genetics, Sheba Medical Center, Ramat Gan, Israel, ²⁰Genetics, Stanford University, San Francisco, CA, ²¹Dr. John T. Macdonald Foundation Department of Human Genetics and John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, ²²Metabolic Disease Unit, Sheba Medical Center, Ramat Gan, Israel
Background/Purpose: Polyarteritis nodosa (PAN) is a systemic necrotizing vasculitis. Disease pathogenesis and possible genetic factors are poorly understood. We identified familial, mostly pediatric PAN, in…
Abstract Number: 2643 • 2013 ACR/ARHP Annual Meeting
Midkine Is a Novel Prognostic Factor In Patients With Vasculitis Syndrome
Yoshie Kusunoki¹, Yutaka Okano¹, Natsuko Kusunoki², Natsuki Fujio², Mai Kawazoe², Emiko Shindo², Kotaro Shikano², Makoto Kaburaki², Sei Muraoka², Kanako Kitahara², Kaichi Kaneko², Nahoko Tanaka², Tatsuhiro Yamamoto², Kenji Takagi², Tomoko Hasunuma², Hirahito Endo² and Shinichi Kawai², ¹Center for Arthritis and Rheumatic Diseases, Kawasaki Municipal Kawasaki Hospital, Kanagawa, Japan, ²Division of Rheumatology, Department of Internal Medicine, School of Medicine, Faculty of Medicine, Toho University, Tokyo, Japan
Background/Purpose: Midkine (MK) is a heparin-binding growth factor, promotes growth, survival, and migration of various cells. Recently several reports show that MK may also play…
Abstract Number: 2644 • 2013 ACR/ARHP Annual Meeting
Phase IB/Iia Study On Intravenous Administration Of Expanded Allogeneic Adipose-Derived Mesenchymal Stem Cells In Refractory Rheumatoid Arthritis Patients
JM Alvaro-Gracia¹, Juan A. Jover², Rosario Garcia-Vicuña³, Luis Carreño⁴, Alberto Alonso⁵, Sara Marsal⁶, Francisco J. Blanco⁷, Víctor M. Martínez-Taboada⁸, Peter C. Taylor⁹, Federico Díaz-González¹⁰ and Lydia Dorrego¹¹, ¹Unidad de Terapias Biológicas. Servicio de Reumatología, Hospital Universitario de La Princesa, Madrid, Spain, ²Rheumatology, Hospital Clínico San Carlos, Madrid, Spain, ³Rheumatology, Hospital Universitario de La Princesa. IIS La Princesa, Madrid, Spain, ⁴Rheumatology, Gregorio Marañón Hospital, Madrid, Spain, ⁵Hospital de Cruces, Bilbao, Spain, ⁶Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain, ⁷INIBIC-Hospital Universitario A Coruña. Rheumatology Division. Genomic Group, A Coruña, Spain, ⁸Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV., Santander, Spain, ⁹NDORMS, Botnar Research Centre, University of Oxford, Oxford, United Kingdom, ¹⁰Hospital Universitario de Canarias, La Laguna. Tenerife, Spain, ¹¹TiGenix, Tres Cantos, Spain
Background/Purpose: Expanded adipose-derived stem cells (eASCs) are shown to have immune-modulatory effects both in vitro and in animal models of arthritis. eASCs are currently under…
Abstract Number: 2645 • 2013 ACR/ARHP Annual Meeting
Pathological Roles Of The Anti-Oxidative Enzyme Peroxiredoxin 2 In Patients With Kawasaki Disease
Rie Karasawa¹, Toshiko Sato¹, Mayumi Tamaki¹, Mikiya Fujieda², Kazuhide Ohta³ and Kazuo Yudoh¹, ¹Institute of Medical Science, St. Marianna University School of Medicine, Kawasaki, Japan, ²Department of Pediatrics, Kochi Medical School, Nankoku, Japan, ³Department of Pediatrics, Kanazawa Medical Center, Kanazawa, Japan
Background/Purpose: Anti-endothelial cell antibodies (AECA) are autoantibodies that are detected frequently in vasculitis caused by, for example, Kawasaki disease (KD). However, AECA target molecules have…
Abstract Number: 2646 • 2013 ACR/ARHP Annual Meeting
Cost-Effectiveness Analysis Of Triple Therapy Versus Etanercept Plus Methotrexate In Early Aggressive Rheumatoid Arthritis: Analysis Based On The TEAR Trial
Hawre Jalal¹, Jeffrey R. Curtis², Stacey Cofield³, Larry W. Moreland⁴, James R. O'Dell⁵ and Kaleb Michaud⁶, ¹Health Polisy and Management, University of Minnesota, Minneapolis, MN, ²Immunology/Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ³University of Alabama at Birmingham, Birmingham, AL, ⁴University of Pittsburgh, Pittsburgh, PA, ⁵Veteran Affairs Nebraska Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE, ⁶Rheumatology, National Data Bank for Rheumatic Diseases & University of Nebraska Medical Center, Omaha, NE
Background/Purpose: The long-term cost-effectiveness of triple therapy (methotrexate [MTX], sulfasalazine [SSZ], hydroxychloroquine [HCQ]) disease modifying anti-rheumatic drugs (DMARDs) compared to a combination of MTX and…
Abstract Number: 2647 • 2013 ACR/ARHP Annual Meeting
Recombinant Monoclonal Antibodies Derived From Single CD19+ Synovial B Cells Of RA Patients With Tertiary Lymphoid Structures Display a Strong Immunoreactivity Towards Citrullinated Histones
Elisa Corsiero¹, Michele Bombardieri², Emanuela Carlotti¹, Hedda Wardemann³, William H. Robinson⁴ and Costantino Pitzalis¹, ¹Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, QMUL, London, United Kingdom, ²Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom, ³Max Planck Research Group Molecular Immunology, Max Planck Institute for Infection Biology, Berlin, Germany, ⁴Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA
Background/Purpose: Rheumatoid arthritis (RA) is characterised by breach of self-tolerance towards citrullinated proteins. Around 40% of patients display synovial tertiary lymphoid structures (TLS) with functional…
Abstract Number: 2648 • 2013 ACR/ARHP Annual Meeting
Characterization Of Histidyl-tRNA Synthetase Specific Th Cell Response In Blood and Broncheoalveolar Lavage (BAL) Of Myositis Patients
Inka Albrecht¹, Eddie James², Maryam Fathi³, Maryam Dastmalchi⁴, Jessica Herrath¹, Vivianne Malmström⁵ and Ingrid E. Lundberg⁶, ¹Department of Medicine, Solna, Unit of Rheumatology, Karolinska University Hospital, Department of Medicine, Solna, Unit of Rheumatology, Stockholm, Sweden, ²Benaroya Research Institute, Seattle, WA, ³Karolinska Institutet, Department of Medicine , Respiratory Medicine Unit, Stockholm, Sweden, ⁴Department of Medicine, Karolinska University Hospital, Department of Medicine, Solna, Unit of Rheumatology, Stockholm, Sweden, ⁵Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, ⁶Rheumatology Unit, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Idiopathic inflammatory myopathy is a rare chronic inflammatory disease that is associated with the presence of autoantibodies pointing to a contribution of adaptive immune…

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