Abstracts Archive - Page 1896 of 2425 - ACR Meeting Abstracts

Abstract Number: 2335 • 2014 ACR/ARHP Annual Meeting
Reliability and Validity of the Arthritis Helplessness Index in Systemic Sclerosis
Shadi Gholizadeh¹, Sarah D. Mills², Rina S. Fox², Philip J. Clements³, Suzanne Kafaja⁴, Vanessa L. Malcarne⁵, Daniel E. Furst⁶ and Dinesh Khanna⁷, ¹Psychology, SDSU/UCSD Joint Doctoral Program in Clinical Psychology, San Diego, CA, ²SDSU/UCSD Joint Doctoral Program in Clinical Psychology, San Diego, CA, ³University of California, Los Angeles, Department of Medicine, Los Angeles, CA, ⁴Medicine, University of California, Los Angeles, Department of Medicine, Los Angeles, CA, ⁵Psychology, SDSU/UCSD Joint Doctoral Program in Clinical Psychology; Department of Psychology, San Diego State University, San Diego, CA, ⁶Medicine/ Rheumatology, University of California, Los Angeles, Department of Medicine, Los Angeles, CA, ⁷University of Michigan Health System, Ann Arbor, MI
Background/Purpose: The unpredictable and uncontrollable course of rheumatic diseases has made them an interesting area of study in the learned helplessness and health outcomes literature.…
Abstract Number: 2336 • 2014 ACR/ARHP Annual Meeting
Evaluating the Use of Video-Stimulated Recall to Research the Osteoarthritis Consultation in Primary Care: Reaching Parts Other Methods don’t Reach
Zoe Paskins¹, Tom Sanders¹, Peter Croft¹ and Andrew Hassell², ¹Research Institute for Primary Care and Health Sciences, Keele University, Keele, United Kingdom, ²School of Medicine, Keele University, Keele, United Kingdom
Background/Purpose Video-stimulated recall (VSR) is a method of enhancing participants’ accounts of a consultation using a video recording of the event to encourage and prompt…
Abstract Number: 2337 • 2014 ACR/ARHP Annual Meeting
The Cost and Effectiveness of Various Recruitment Strategies in a Mind Body Clinical Trial Among Older Adults with Knee Osteoarthritis
Jade V. Goldsmith¹, Lori Lyn Price², Jeffrey B. Driban³, William F. Harvey³ and Chenchen Wang³, ¹Center for Integrative Medicine and Division of Rheumatology, Tufts Medical Center, Boston, MA, ²Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, ³Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose : Recruitment and adherence are important and challenging factors that can determine the success of a clinical trial. Mind body therapies are an emerging and…
Abstract Number: 2338 • 2014 ACR/ARHP Annual Meeting
Cost-Effectiveness and Yield of Different Recruitment Strategies Utilized in an Exercise Trial of Fibromyalgia Patients
Anna Schmid¹, William F. Harvey¹, Lori Lyn Price² and Chenchen Wang¹, ¹Rheumatology, Tufts Medical Center, Boston, MA, ²Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA
Background/Purpose In a large-scale clinical trial with a long-term outcome, it is essential to use recruitment strategies that are both cost-effective and likely to yield…
Abstract Number: 2339 • 2014 ACR/ARHP Annual Meeting
Detecting Inflammation in Vivo Using Activatable Fluorescence Contrast Agents in Inflammatory Arthritis
Monica Guma¹, Beatrix Bartok², Viet Anh Nguyen Huu³, Mathieu L. Viger³, Jacques Lux³, Shivanjali Joshi-Barr³, Adah Almutairi³ and Gary S. Firestein⁴, ¹Division of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA, ²Division of Rheumatology, allergy and immunology, University of California, San Diego, La Jolla, CA, ³UC San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences., University of California, San Diego, La Jolla, CA, ⁴Division of Rheumatology, Allergy and Immunology, University of California at San Diego School of Medicine, La Jolla, CA
Background/Purpose: Current medical imaging technology detects structural rather than functional manifestations of disease. Imaging agents designed to enhance signal based on molecular mechanisms might permit…
Abstract Number: 2340 • 2014 ACR/ARHP Annual Meeting
Human Osteoclasts Are Mobilized in Erosive Arthritis of Epstein-Barr Virus-Infected Humanized NOD/Shi-Scid/IL-2Rγ^null Mice
Yosuke Nagasawa¹, Natsumi Ikumi², Takamasa Nozaki¹, Hirotake Inomata¹, Kenichi Imadome³, Noboru Kitamura¹, Mitsuhiro Iwata¹, Shigeyoshi Fujiwara⁴ and Masami Takei¹, ¹Division of Hematology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan, ²Division of Heamatology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan, ³Department of Infectious Diseases, National Research Institute for Child Health and Development, Tokyo, Japan, ⁴Department of Iinfectious Diseases, National Research Institute for Child Health and Development, Tokyo, Japan
Background/Purpose Various studies of the relationship between Epstein-Barr virus (EBV) and rheumatoid arthritis (RA) have not produced convincing evidence. Many human viruses do not infect…
Abstract Number: 2341 • 2014 ACR/ARHP Annual Meeting
The Combination Therapy of Cell Cycle Regulation Therapy Combined and TNF Blockade Ameliorated the Established Arthritis
Tadashi Hosoya^1,2, Kimito Kawahata¹, Hideyuki Iwai¹ and Hitoshi Kohsaka^2,3, ¹Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan, ²Japan Science and Technology Agency–CREST Program, Tokyo, Japan, ³Department of Rheumatology, Graduate School of Medical and Dental Sciences,, Tokyo Medical and Dental University (TMDU), Tokyo, Japan
Background/Purpose The pathogenesis of rheumatoid arthritis (RA) is characterized by infiltration of inflammatory cells to the synovial tissues and their hyperplasia. Activated synovial fibroblasts become…
Abstract Number: 2342 • 2014 ACR/ARHP Annual Meeting
Redox Regulation of a New Autoimmune Mouse Model, Glucose-6-Phosphate Isomerase Peptide Induced Arthritis in Mice
Min Yang¹ and Rikard Holmdahl², ¹Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden, ²Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
Background/Purpose Rheumatoid arthritis (RA) is a perpetuating disease, which affects approximately 1% of the population. Until now, the pathogenic mechanisms of RA remain elusive and…
Abstract Number: 2343 • 2014 ACR/ARHP Annual Meeting
Therapeutic Effects of Mesenchymal Stem Cells, Anti-Tumor Necrosis Factor and Anti-CD20 Treatment on Collagen Induced Arthritis
Yue Sun¹, Xuebing Feng² and Lingyun Sun², ¹The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China, ²Department of Rheumatology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
Background/Purpose Tremendous progress has been made in the development of non-conventional therapies for rheumatoid arthritis (RA). In this study, the effects of mesenchymal stem cells…
Abstract Number: 2344 • 2014 ACR/ARHP Annual Meeting
Amelioration of Collagen-Induced Arthritis By Water-Soluble Fullerene C60(OH)₃₆ Nanoparticles through the Inhibition of Angiogenesis
Chia-Tse Weng^1,2, Shih-Yao Chen³, Yu-Hung Chen⁴, Chao-Liang Wu³, Ming-Fei Liu^1,2, Ai-Li Shiau⁵ and Chrong-Reen Wang^1,2, ¹Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan, ²Internal Medicine, National Cheng Kung University Medical College, Tainan, Taiwan, ³Biochemistry and Molecular Biology, National Cheng Kung University Medical College, Tainan, Taiwan, ⁴Medicine, National Cheng Kung University Medical College, Tainan, Taiwan, ⁵Microbiology and Immunology, National Cheng Kung University Medical College, Tainan, Taiwan
Background/Purpose Our previous study has shown that injection of 13-nm gold nanoparticles ameliorates collagen-induced arthritis (CIA) through the inhibition of angiogenesis by binding to VEGF.…
Abstract Number: 2345 • 2014 ACR/ARHP Annual Meeting
Anti-IL-6 Receptor Antibody Prevents Deterioration in Bone Structure in a Mouse Model of Collagen-Induced Arthritis
Hiroto Yoshida, Mika Yagoto, Miho Suzuki, Keisuke Tanaka, Misato Hashizume and Yoshihiro Matsumoto, Product Research Department, Chugai Pharmaceutical Co., Ltd., Gotemba, Japan
Background/Purpose: Rheumatoid arthritis (RA) is a disease that typically induces secondary osteoporosis, which increases the risk of bone fractures and, consequently, mortality. Bone fracture is…
Abstract Number: 2346 • 2014 ACR/ARHP Annual Meeting
Specific Overexpression of FPR2(FPRL-1) on Th1 Cells in GPI-Induced Arthritis and Patients with Rheumatoid Arthritis
Yuki Tanaka¹, Isao Matsumoto², Asuka Inoue³, Naoto Umeda⁴, Chinatsu Takai⁵, Yuko Kurashima⁶, Hoshimi Kawaguchi⁶ and Takayuki Sumida⁷, ¹Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba city, Ibaraki, Japan, ²Department of Interenal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ³Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, University of Tsukuba, Tsukuba city, Ibaraki, Japan, ⁴Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba City, Japan, ⁵University of Tsukuba, Ibaraki, Japan, ⁶University of Tsukuba, Tsukuba, Japan, ⁷Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
【Background/Purpose 】 CD4+T cell are critical to the pathogenesis of rheumatoid arthritis (RA). In glucose-6-phosphate isomerase (GPI) induced-arthritis (GIA), Th1 and Th17 cells are indispensable…
Abstract Number: 2347 • 2014 ACR/ARHP Annual Meeting
Therapeutic Effect of a Novel Histone Deacetylase 6 Inhibitor, CKD-L, on Collagen Induced Arthritis and Peripheral Blood Mononuclear Cells from Patients with Rheumatoid Arthritis
Bo Ram Oh¹, Hyojin Lim², Daekwon Bae², Nina Ha², Young il Choi², Hyun Jung Yoo^3,4, Jin Kyun Park³, Eun Young Lee⁵, Eun Bong Lee³ and Yeong Wook Song^3,4, ¹Division of Rheumatology, Department of Molecular Medicine and Biophamaceutical Sciences, BK 21 plus Graduate School of Convergence Science Technology, Colleage of Medicine, Seoul National University, Seoul, South Korea, ²Department of Pharmacology and Toxicology, CKD Research Institute, CKD Pharmaceutical Company, Seoul, South Korea, ³Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea, ⁴Department of Molecular Medicine and Biophamaceutical Sciences, BK 21 plus Graduate School of Convergence Science Technology, Colleage of Medicine, Seoul National University, Seoul, South Korea, ⁵Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea
Background/Purpose Epigenetic regulation plays an important role in inflammatory arthritis, including rheumatoid arthritis (RA). Histone deacetylase inhibitor (HDACi) has been recently reported to have therapeutic…
Abstract Number: 2348 • 2014 ACR/ARHP Annual Meeting
Activatory Fc Gamma Receptor IV Plays a Crucial Role in Pathogenesis of Experimental Immune Complex Mediated Chronic Arthritis
Irene Di Ceglie¹, Arjen Blom¹, Sjef Verbeek², Peter van der Kraan³, Wim van den Berg¹ and Peter L. van Lent¹, ¹Experimental Rheumatology, Experimental Rheumatology, Radboud University, Nijmegen, Netherlands, ²Human Genetic, Human Genetic, Leiden University Medical Center, Leiden, Netherlands, ³Experimental Rheumatology, Radboud University, Nijmegen, Netherlands
Background/Purpose Rheumatoid arthritis is characterized by Immune complex dependent chronic joint inflammation and severe cartilage and bone destruction. Earlier we found that in the absence…
Abstract Number: 2349 • 2014 ACR/ARHP Annual Meeting
Early Sympathectomy Inhibits Egress of Lymphocytes in Control and Arthritic Animals and Ameliorates Arthritic Disease
Susanne Klatt¹ and Rainer Straub², ¹Internal Medicine I, University Hospital Regensburg, Regensburg, Germany, ²Internal Medicine, University Hospital Regensburg, Regensburg, Germany

Background/Purpose: The sympathetic nervous system (SNS) plays an important role in course and development of autoimmune diseases like arthritis. In type II collagen- induced arthritis…

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