ACR Meeting Abstracts

ACR Meeting Abstracts

  • Home
  • Meetings Archive
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP PRSYM
    • 2016-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • Meeting Resource Center

Abstract Number: 353

A Longitudinal Cohort Study of Weekly Teriparatide, Denosmab, and Bisphosphonates for Prevention of Vertebral Fractures in Glucocorticoid-Induced Osteoporosis

Hisaji Oshima1, Mari Ushikubo1, Kumiko Akiya1, Ikuko Tanaka2, Shigenori Tamaki2 and Keisuke Izumi3, 1Department of Connective Tissue Diseases, National Tokyo Medical Center, Tokyo, Japan, 2NAGOYA Rheumatology Clinic, Nagoya, Japan, 3National Tokyo Medical Center, Tokyo, Japan

Meeting: 2015 ACR/ARHP Annual Meeting

Date of first publication: September 29, 2015

Keywords: denosumab, Fracture risk, glucocorticoids, osteoporosis and teriparatide

  • Tweet
  • Email
  • Print
Session Information

Date: Sunday, November 8, 2015

Session Title: Osteoporosis and Metabolic Bone Disease - Clinical Aspects and Pathogenesis Poster

Session Type: ACR Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose: Although weekly teriparatide (56.5ug, wTPTD) and denosmab (DMAB) have been developed as potent anti-osteoporotic agents, effects of these agents on prevention of osteoporotic fractures in glucocorticoid-induced osteoporosis (GIO) have not yet well demonstrated.  We conducted a cohort study to clarify effects of wTPTD and DMAB when compared with bisphosphonates (BIS) on osteoporotic vertebral fractures in GIO.

Methods: A one-year cohort study recruiting 223 patients (196 women) with connective tissue diseases was conducted in Tokyo, Japan.  Means of age, disease duration, total prednisolone (PSL) dosages, and daily PSL dosages (dPSL) of subjects were 65+/-15 (yo, +/-SD), 11+/-11 (y), 25+/-29 (g) and 6.4+/-5.7 (mg/day), respectively.  Vertebral fractures were defined from X-ray films with the semi-quantitated method (SQ; Genant, 1993).  Lumbar bone mineral densities (BMD) were measured with Lunar 3030 (GE).  Prevalent vertebral fractures were seen in 103 (46%) patients.  Bisphosphonates, wTPTD, and DMAB were used in 149, 53, and 21 patients, respectively.

Results: 1) The BMD at the base line was 0.916 +/- 0.181, and showed no difference between treatment groups.  The daily PSL was significantly increased (p<0.03) in the group of wTPTD than in BIS and DMAB (10.5, 6.0, and 6.0, respectively).  2) Incident vertebral fractures were observed in 24 (16%), 2 (4%), and 2 (10%) in BIS, DMAB, and wTPTD, respectively.  3) A multivariate logistic regression analysis revealed that statistically significant factors for incident fractures were BMD (per 0.1 decrease, OR; 1.40, 95%CI; 1.02–1.91), dPSL (per 5mg increase, 1.95, 1.29–2.95), prevalent fractures (5.16, 1.85–14.4), DMAB (vs BIS, 0.01, 0.001-0.05), wTPTD (vs BIS, 0.12, 0.03-0.88). 4) There were no significant differences in severe adverse effects between the treatment groups.

Conclusion: These results suggested that wTPTD and DMAB might be more effective than bisphosphonates for prevention of osteoporotic vertebral fractures in patients treated with glucocorticoids.


Disclosure: H. Oshima, None; M. Ushikubo, None; K. Akiya, None; I. Tanaka, None; S. Tamaki, None; K. Izumi, None.

To cite this abstract in AMA style:

Oshima H, Ushikubo M, Akiya K, Tanaka I, Tamaki S, Izumi K. A Longitudinal Cohort Study of Weekly Teriparatide, Denosmab, and Bisphosphonates for Prevention of Vertebral Fractures in Glucocorticoid-Induced Osteoporosis [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/a-longitudinal-cohort-study-of-weekly-teriparatide-denosmab-and-bisphosphonates-for-prevention-of-vertebral-fractures-in-glucocorticoid-induced-osteoporosis/. Accessed May 17, 2022.
  • Tweet
  • Email
  • Print

« Back to 2015 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/a-longitudinal-cohort-study-of-weekly-teriparatide-denosmab-and-bisphosphonates-for-prevention-of-vertebral-fractures-in-glucocorticoid-induced-osteoporosis/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

ACR Pediatric Rheumatology Symposium 2020

© COPYRIGHT 2022 AMERICAN COLLEGE OF RHEUMATOLOGY

Wiley

  • Home
  • Meetings Archive
  • Advanced Search
  • Meeting Resource Center
  • Online Journal
  • Privacy Policy
  • Permissions Policies
loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.