Date: Sunday, November 8, 2015
Session Type: ACR Poster Session A
Session Time: 9:00AM-11:00AM
The aim of the present study was to identify the FRAX®Port (FRAX® validated for Portugal) ten-year major and hip osteoporotic fracture probabilities, above which pharmacologic interventions become cost effective in the Portuguese context.
A previously developed and validated state transition Markov cohort model was populated with epidemiologic, economic and quality-of-life fracture data from Portugal. Cost-effective FRAX-based intervention thresholds for generic alendronate, zoledronic acid, denosumab and teriparatide when compared to “no intervention” were calculated assuming a willingness to pay of €32,000 (2 times national Gross Domestic Product per capita) per QALY (Quality-Adjusted Life Years).
In the Portuguese epidemiological and economic context, treatment with generic alendronate is cost-effective for people aged 50+, presenting 10-year probabilities (FRAX®Port) at or above 8.8% for major osteoporotic fractures and 2.5% for hip fractures. These values increase to 20.4% and 10.1% for zoledronic acid, 34.9% and 10.1% for denosumab and to 77.8% and 62.6% to teriparatide for major osteoporotic and hip fractures respectively. A tool is provided to perform the calculation of cost-effective intervention thresholds for different medications, according to age group and diverse levels of willingness to pay (WTP).
Cost-effective intervention thresholds, for different medications, age-groups and WTP, based on 10-year probabilities of major and hip fracture probabilities calculated with FRAX®Port are provided.
To cite this abstract in AMA style:Marques A, Lourenço O, Gustaf O, Borgström F, Da Silva J. Cost-Effective Osteoporosis Treatment Intervention Thresholds Based on FRAX in Portugal [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/cost-effective-osteoporosis-treatment-intervention-thresholds-based-on-frax-in-portugal/. Accessed November 27, 2022.
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