Abstract Number: 2869 • 2016 ACR/ARHP Annual Meeting
Critical Roles of IRAK4 Kinase Activity in Inflammation but Not B Cell Response in SLE
Background/Purpose: Interleukin-1 receptor (IL-1R)-associated kinase 4 (IRAK4) is a key component of the Myddosome complex, which is essential for signalling downstream of IL-1R and most…Abstract Number: 2870 • 2016 ACR/ARHP Annual Meeting
Overexpression of EZH2 at the microRNA-142 Regulatory Region Contributes to Down-Regulation of microRNA-142-3p/5p in Systemic Lupus Erythematosus
Background/Purpose: Recently, our group has demonstrated that decreased microRNA-142-3p/5p (miR-142-3p/5p) which contributes to T cell overactivation and B cell hyperstimulation plays an essential role in…Abstract Number: 2871 • 2016 ACR/ARHP Annual Meeting
Unaffected Lupus Relatives Are Distinguished from SLE Patients and Unaffected Individuals Not Related to SLE Patients By Lupus-Specific Connective Tissue Disease Questionnaire Scores, Autoantibodies, and Distinct Soluble Mediators
Background/Purpose: Identifying populations at risk of SLE is essential to curtail inflammatory damage and select individuals for prevention trials. Blood relatives (Rel) of lupus patients…Abstract Number: 2872 • 2016 ACR/ARHP Annual Meeting
SLE Subjects Express High Levels of Intracellular Interferon-β That Acts in an Autocrine Fashion to Promote Survival of Transitional Stage B Cells
Background/Purpose: Upregulation of interferon-β (IFNβ) is an important step in promoting maturation and survival of B cells. Secretion and autocrine action of IFNβ requires assembly…Abstract Number: 2873 • 2016 ACR/ARHP Annual Meeting
B-Cell activating Factor Genetic Variants in Systemic Lupus Erythematosus and Lupus Related Atherosclerosis
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease with an increased atherosclerotic risk compared to healthy population, partially explained by traditional cardiovascular…Abstract Number: 2874 • 2016 ACR/ARHP Annual Meeting
CD16+monocytes Are Enriched and Functionally Exacerbated in Driving B Cell Activation Under Systemic Lupus Erythematosus Condition
Background/Purpose: Systemic lupus erythematosus(SLE) was an autoimmune disease characterized by extensive B cell activation and autoantibody production. Human peripheral monocytes could be categorized into three subsets…Abstract Number: 2875 • 2016 ACR/ARHP Annual Meeting
Depressed Serum IgM Levels in SLE Are Restricted to Defined Subgroups
Background/Purpose: Natural IgM autoantibodies have been proposed to have protective properties, and decreased levels of IgM to phosphorylcholine (PC) in SLE are associated with higher…Abstract Number: 2876 • 2016 ACR/ARHP Annual Meeting
SLE Serum Impairs NO Production in Huvecs through Induction of eNOS Uncoupling
Background/Purpose: Systemic lupus erythematosus (SLE) induces endothelial cell dysfunction (ECD) that can manifest as glomerulonephritis or atherosclerosis. Lupus-prone mice lacking endothelial nitric oxide synthase (eNOS,…Abstract Number: 2877 • 2016 ACR/ARHP Annual Meeting
Notch Ligand Delta-like Ligand 4 (DLL4) Expression on Dendritic Cells Is Increased in Systemic Lupus Erythematosus
Background/Purpose: Dendritic cells (DCs) activate the immune system with a variety of cytokines and co-stimulatory molecules. Our group recently described the Notch ligand Delta-like Ligand…Abstract Number: 2878 • 2016 ACR/ARHP Annual Meeting
Major Lymphocyte Populations Share a Common Interferon Signature but Express Cell Type-Specific Interferon Pathway Genes in SLE
Background/Purpose: All lymphocyte populations contribute to SLE pathogenesis, but little is known of the specific gene transcripts particularly involved in each cell type. Activation of…Abstract Number: 2879 • 2016 ACR/ARHP Annual Meeting
Genome-Wide Pathway Analysis Reveals That VEGF Genetic Pathway Is Associated with Oral Ulcers in Systemic Lupus Erythematosus
Background/Purpose: Systemic lupus erythematosus (SLE) is a genetically complex rheumatic disease with heterogeneous clinical manifestations. Recent studies have suggested the existence of a genetic basis…Abstract Number: 2880 • 2016 ACR/ARHP Annual Meeting
Distinct Metabolic Pathways Regulate Lipid Antigen Presentation By Monocytes and B Cells: Implications for SLE Patients with Pre-Clinical Atherosclerotic Plaque
Background/Purpose: Systemic lupus erythematosus (SLE) patients have an increased risk of developing clinically apparent cardiovascular disease (CVD) and subclinical atherosclerotic plaque, detectable by vascular ultrasound…Abstract Number: 2881 • 2016 ACR/ARHP Annual Meeting
Reduced Hippocampal-Thalamic Fiber Tracts in Systemic Lupus Erythematosus
Background/Purpose: SLE patients experience deterioration in cognitive function over time but attribution to disease-related mechanisms is confounded by medication effects, psychiatric disease, hormonal influences and…Abstract Number: 2882 • 2016 ACR/ARHP Annual Meeting
CD4+ T Helper Cells and Regulatory T Cells in Active Lupus Nephritis – an Imbalance Towards a Predominant Th1 Response?
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic inflammatory disease characterized by the involvement of multiple organs and systems with aberrations in T cell response,…Abstract Number: 2883 • 2016 ACR/ARHP Annual Meeting
The CD4+CD52low T Cell Contributes to the Development of Systemic Lupus Erythematosus through the CCR8/TARC Pathway
Background/Purpose: CD52 is a cell-surface glycoprotein that is widely expressed in lymphocytes, monocytes and eosinophils. CD4+CD52high T cells inhibit the activation of CD4+CD52low T cells…
ACR Meeting Abstracts