Abstracts Archive - Page 1549 of 2425 - ACR Meeting Abstracts

Abstract Number: 1975 • 2016 ACR/ARHP Annual Meeting
Severity and Improvement of Morning Stiffness Independently Associate with Tenosynovitis in Patients with Rheumatoid Arthritis
Yoshihisa Kobayashi^1,2,3, Kei Ikeda¹, Takayuki Nakamura^1,4, Mieko Yamagata^1,5, Takuya Nakazawa^1,6, Shigeru Tanaka¹, Shunsuke Furuta¹, Takeshi Umibe³ and Hiroshi Nakajima¹, ¹Chiba University Hospital, Chiba, Japan, ²Chiba Aoba Municipal Hospital, Chiba, Japan, ³Matudo City Hospital, Matudo, Japan, ⁴Asahi General Hospital, Asahi, Japan, ⁵National Hospital Organization Shimoshizu National Hospital, Yotsukaido, Japan, ⁶National Hospital Organization Chiba-East Hospital, Chiba, Japan
Background/Purpose: Morning stiffness has long been recognized by both patients and rheumatologists as a characteristic feature of rheumatoid arthritis (RA). However, morning stiffness is no…
Abstract Number: 1976 • 2016 ACR/ARHP Annual Meeting
Ultrasound Inflammation in Patients Presenting with Arthralgia Is Associated with Developing Arthritis
Myrthe van der Ven¹, Marjolein Van der Veer-Meerkerk¹, David F. Ten Cate², Nigara Rasappu³, Marc R. Kok⁴, Dora Csakvari⁵, Johanna M.W. Hazes², Andreas H. Gerards⁶ and Jolanda J. Luime³, ¹Rheumatology, Erasmus University Medical Centre, Rotterdam, Netherlands, ²Department of Rheumatology, Erasmus University Medical Centre, Rotterdam, Netherlands, ³Rheumatology, Erasmus Medical Centre, Rotterdam, Netherlands, ⁴Rheumatology, Maasstad Hospital, Rotterdam, Netherlands, ⁵Rheumatology, Erasmus University Medical Centre, ROTTERDAM, Netherlands, ⁶Rheumatology, Vlietland Hospital, Schiedam, Netherlands
Background/Purpose: To further decrease the burden of RA we need to identify patients early, preferably in absence of clinical apparent synovitis. Recent studies in US…
Abstract Number: 1977 • 2016 ACR/ARHP Annual Meeting
Impact of Ultrasound in Treatment Decision of Rheumatoid Arthritis Assessed in Routine Clinical Practice
César Sifuentes-Cantú¹, Lina Saldarriaga-Rivera², Ana Cecilia Lozada², Irazu Contreras-Yañez³, Marwin Gutierrez⁴ and Virginia Pascual-Ramos⁵, ¹Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ²Division of musculoskeletal and rheumatic diseases, Instituto Nacional de Rehabilitación, Mexico City, Mexico, ³Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico, Mexico, ⁴Instituto Nacional de Rehabilitación, Mexico, Mexico, ⁵Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Background/Purpose: Remission or low disease activity is the therapeutic target for rheumatoid arthritis (RA). There is a consistent body of evidence supporting the value of…
Abstract Number: 1978 • 2016 ACR/ARHP Annual Meeting
Differential Pattern of Doppler Signals at Lower Extremity Entheses of Healthy Children
Johannes Roth¹, Sara Stinson² and Luca Di Geso³, ¹Pediatric Rheumatology, Children's Hospital Eastern On, Ottawa, ON, Canada, ²Pediatric Rheumatology, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada, ³Department of Internal Medicine Ospedale Madonna del Soccorso, San Benedetto del Tronto, Italy
Background/Purpose: Musculoskeletal ultrasound (MSUS) can enhance the clinical assessment of the pediatric enthesis. Doppler signals in particular are considered a sign of pathology but may…
Abstract Number: 1979 • 2016 ACR/ARHP Annual Meeting
Post-Arthroplasty Pain Trajectories after Total Knee Arthroplasty and Their Association with 6- and 12-Month Pain
Jasvinder A. Singh¹, Lisa Nobel², Norman Weissman², Kenneth G. Saag³, Phillip J. Foster⁴, Jeroan J. Allison⁵, Celeste Lemay⁶ and Patricia D. Franklin⁷, ¹Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ²University of Massachusetts, Boston, MA, ³Division Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁴Department of Medicine, Division of Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁵University of Massachusetts Medical School, Worcester, MA, ⁶Orthopedics, University of Massachusetts Medical School, Worcester, MA, ⁷Orthopedics & Physical Rehab, University of Massachusetts Medical School, Worcester, MA
Background/Purpose: Total knee arthroplasty (TKA) is a common elective surgery to treat pain and functional limitation due to refractory arthritis. Post-operative pain is commonly underestimated…
Abstract Number: 1980 • 2016 ACR/ARHP Annual Meeting
Relation of Pain Sensitization to the Evolution from Intermittent to Chronic, Persistent Pain in Knee Osteoarthritis: The Multicenter Osteoarthritis Study
Jia Liu¹, Laura Frey-Law², Gillian Hawker³, Carrie Brown⁴, Cora E. Lewis⁵, Michael C. Nevitt⁶ and Tuhina Neogi⁷, ¹Boston Medical Center, Boston, MA, ²UIowa, Iowa City, IA, ³University of Toronto, Toronto, ON, Canada, ⁴Boston University School of Public Health, Boston, MA, ⁵University of Alabama Birmingham, Birmingham, AL, ⁶Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, ⁷Clinical Epidemiology, Boston University School of Medicine, Boston, MA
Background/Purpose: Patients with knee osteoarthritis (OA) often start with acute intermittent, activity-related pain, which evolves to additionally experiencing chronic, persistent pain; why this transition happens…
Abstract Number: 1981 • 2016 ACR/ARHP Annual Meeting
A Pilot Pulsed Arterial Spin Labeling Study of Regional Cerebral Blood Flow in Response to Pain in RA, before and after DMARD Treatment
Yvonne C. Lee¹, Alexander Fine², Ekaterina Protsenko³, Elena Massarotti⁴, Robert R. Edwards⁵, Vitaly Napadow⁶ and Marco Loggia³, ¹Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ²Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ³Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, ⁴Rheumatology Immunology & Allergy, Brigham & Women's Hospital, Boston, MA, ⁵Anesthesiology, Brigham & Womens Hospital, Chestnut Hill, MA, ⁶Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA
Background/Purpose: Although significant advances have been made in treating inflammation in RA, little is known about central nervous system (CNS) pain pathways in inflammatory arthritis.…
Abstract Number: 1982 • 2016 ACR/ARHP Annual Meeting
Comparative Safety of Long-Acting Opioids for Non-Cancer Pain
Cecilia P. Chung¹, William Dupont², Katherine Murray¹, Kathi Hall³, C. Michael Stein¹ and Wayne Ray³, ¹Medicine, Vanderbilt University Medical Center, Nashville, TN, ²Biostatistics, Vanderbilt University Medical Center, Nashville, TN, ³Health Policy, Vanderbilt University Medical Center, Nashville, TN
Background/Purpose: Methods: Results: Conclusion:
Abstract Number: 1983 • 2016 ACR/ARHP Annual Meeting
Pain and Sensitization in Women with Aromatase Inhibitor-Associated Arthralgias
Monica Crespo-Bosque¹, Carrie Brown², Brenda Cartmel³, Maura Harrigan⁴, Melinda Irwin³ and Tuhina Neogi⁵, ¹Internal Medicine, Boston Medical Center, Boston, MA, ²Boston University School of Public Health, Boston, MA, ³Yale School of Public Health, New Haven, CT, ⁴Cancer Center, Yale School of Public Health, New Haven, CT, ⁵Clinical Epidemiology, Boston University School of Medicine, Boston, MA
Background/Purpose: Aromatase inhibitors (AIs) are the preferred treatment for estrogen receptor positive breast cancer in postmenopausal women, but are frequently associated with arthralgias, which can…
Abstract Number: 1984 • 2016 ACR/ARHP Annual Meeting
Which Factors Associate with Localized Knee Pain and Generalized Pain: A 10-Year Longitudinal Study?
Feng Pan¹, Dawn Aitken², Jing Tian³, Flavia M Cicuttini⁴, Changhai Ding² and Graeme Jones², ¹Musculoskeletal Unit, Menzies Institute for Medical Research, University of Tasmania, Hobart,7000, Australia, ²Musculoskeletal Unit, Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, ³Public health unit, Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, ⁴Monash University, Department of Epidemiology and Preventive Medicine, Melbourne, Australia
Background/Purpose: The correlates of localized knee pain (KP) and multi-site pain (MSP) have been clearly demonstrated; however, whether these factors also contribute to intermittent or…
Abstract Number: 1985 • 2016 ACR/ARHP Annual Meeting
IL-18 Elevation in Macrophage Activation Syndrome: Human Evidence for a Chronic Set-Point and Murine Evidence for a Non-Hematopoietic Source
Zeshan Tariq¹, Eric Weiss², Wendy Goodspeed³, Raphaela Goldbach-Mansky⁴ and Scott Canna², ¹Autoinflammatory Pathogenesis Unit, NIAMS/NIH, Bethesd, MD, ²Autoinflammatory Pathogenesis Unit, NIAMS/NIH, Bethesda, MD, ³Office of the Clinical Director, NIAMS/NIH, Bethesda, MD, ⁴Translational Autoinflammatory Disease Studies, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD
Background/Purpose: Macrophage Activation Syndrome (MAS) is a life-threatening sepsis-like condition complicating many systemic JIA (sJIA) and Adult-Onset Stills Disease (AOSD) patients. We recently identified that…
Abstract Number: 1986 • 2016 ACR/ARHP Annual Meeting
Murine Model of Arthritis Flare Identifies Tissue Resident Memory T Cells in Recurrent Synovitis
Margaret H Chang¹, Anais Levescot², Allyn Morris², Robert Fuhlbrigge^1,3 and Peter Nigrovic^1,2, ¹Immunology, Boston Children's Hospital, Boston, MA, ²Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Boston, MA, ³Dermatology, Brigham and Women’s Hospital, Boston, MA
Background/Purpose: There are 75,000 children affected by JIA in the United States. Despite recent therapeutic advances, treatment often requires chronic therapy and is associated with…
Abstract Number: 1987 • 2016 ACR/ARHP Annual Meeting
Recessive Coding and Regulatory Mutations in FBLIM1 Underlie the Pathogenesis of Sterile Osteomyelitis
Allison Cox¹, Benjamin W Darbro², Ronald Laxer³, Xinyu Bing⁴, Alexis Finer⁵, Albert Erives⁶, Vinit Mahajan⁷, Alexander G Bassuk¹ and Polly Ferguson⁸, ¹Pediatrics and Interdisciplinary Graduate Program in Genetics, University of Iowa Carver College of Medicine, Iowa City, IA, ²Department of Pediatrics and Interdisciplinary Graduate Program in Genetics, University of Iowa Carver College of Medicine, Iowa City, IA, ³Div of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ⁴Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA, ⁵Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA, ⁶Biology and Interdisciplinary Graduate Program in Genetics, University of Iowa Carver College of Medicine, Iowa City, IA, ⁷Department of Ophthalmology and Visual Sciences,, University of Iowa Carver College of Medicine, Iowa City, IA, ⁸Department of Pediatrics--Rheumatology, University of Iowa Carver College of Medicine, Iowa City, IA
Background/Purpose: Chronic recurrent multifocal osteomyelitis (CRMO) is a rare, pediatric, autoinflammatory disease characterized by bone pain due to sterile osteomyelitis, and is often accompanied by…
Abstract Number: 1988 • 2016 ACR/ARHP Annual Meeting
Oral Health and Anti-Citrullinated Peptide Antibodies in Juvenile Idiopathic Arthritis
Sriharsha Grevich^1,2, Peggy Lee³, Sarah Ringold^1,4,5, Brian Leroux³, Hannah Leahey⁵, Megan Yuasa⁵, Jessica Foster⁵, Jeremy Sokolove⁶, Lauren Lahey⁷, William Robinson⁷, Joshua Newson⁸ and Anne Stevens^2,5,8, ¹Pediatrics, University of Washington, Seattle, WA, ²Seattle Children's Hospital, Seattle, WA, ³School of Dentistry, University of Washington, Seattle, WA, ⁴Seattle Children's Hospital, seattle, WA, ⁵Seattle Children’s Research Institute, Seattle, WA, ⁶Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ⁷Stanford University, Stanford, CA, ⁸University of Washington, Seattle, WA
Background/Purpose: Oral pathogens that cause periodontitis have been implicated as triggers for rheumatoid arthritis (RA), via antibodies to citrullinated proteins. Gingivitis is common in children…
Abstract Number: 1989 • 2016 ACR/ARHP Annual Meeting
Mechanism of STAT3 Gain-of-Function in a Patient with JIA
Tiphanie P. Vogel^1,2, Nermina Saucier³, Molly P. Keppel³ and Megan A. Cooper^3,4, ¹Pediatrics/Rheumatology, Washington University in St. Louis, St. Louis, MO, ²Internal Medicine/Rheumatology, Washington University in St. Louis, Saint Louis, MO, ³Pediatrics/Rheumatology, Washington University in St. Louis, Saint Louis, MO, ⁴Pathology and Immunology, Washington University in St. Louis, Saint Louis, MO
Background/Purpose: The transcription factor signal transducer and activator of transcription 3 (STAT3) mediates cytokine-induced changes in gene expression. STAT3 is classically activated by phosphorylation followed…

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