ACR Meeting Abstracts

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  • Abstract Number: 1265 • 2016 ACR/ARHP Annual Meeting

    Ultra-High Field MRI and Biomechanical Investigation of Vertebral Bone Microarchitecture

    Daphné Guenoun1, Alexandre Foure2, Martine Pithioux3, Sandrine Guis4,5, Thomas Lecorroller6, Patrick Chabrand3, Jean Pierre Mattei7, Monique Bernard8, Pierre Champsaur6 and David Bendahan9, 1Radiology, APHM, Hôpital Sainte Marguerite, Aix-Marseille Université, Marseille, France, 2CRMBM-CEMEREM UMR 7339, Aix-Marseille Université, CNRS, Marseille, France, 3ISM UMR 7287, Aix-Marseille Université, CNRS, Marseille, France, 4Rheumatology 1, CRMBM-CEMEREM 7339, Aix-Marseille Université, AP-HM, CNRS, Marseilles, France, 5Rheumatology1, CRMBM UMR CNRS 7339, Aix Marseille Univ; AP-HM, Marseille, France, 6Radiology, APHM, Hôpital Sainte Marguerite, Aix-Marseille University, Marseille, France, 7Rheumatology 1, Aix-Marseille Université, AP-HM, CNRS, Marseilles Cedex 9, France, 8CRMBM CNRS 7339, CNRS, Aix-Marseille Université, Marseille, France, 9CRMBM-CEMEREM 7339, Aix-Marseille Université, CNRS, Marseille, France

    Background/Purpose:  The purpose of this study was to investigate bone microarchitecture variables of cadaveric vertebrae using ultra-high field MRI (7 Tesla). Methods:  Twenty four vertebrae…
  • Abstract Number: 1266 • 2016 ACR/ARHP Annual Meeting

    Predictors of Radiographic Progression in Early Rheumatoid Arthritis Patients Treated By an Aggressive Treat-to-Target Regimen

    Nina P. Sundlisater1, Siri Lillegraven1, Inge C Olsen1, Anna-Birgitte Aga1, Till Uhlig1, Hilde B. Hammer2, D van der Heijde1,3, Tore K. Kvien1, Espen Haavardsholm1 and ARCTIC study group, 1Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 2Dept. of Rheumtology, Diakonhjemmet Hospital, Oslo, Norway, 3Dept of Rheumatology, Leiden University Medical Ctr, Leiden, Netherlands

    Background/Purpose: With implementation of tight control strategies and defined treatment targets in rheumatoid arthritis (RA) care, a majority of early RA patients may reach remission…
  • Abstract Number: 1267 • 2016 ACR/ARHP Annual Meeting

    Application of the Spondyloarthritis Research Consortium of Canada Magnetic Resonance Imaging Sacroiliac Joint Structural Score in Chinese Patients with Axial Spondyloarthritis

    Zaiying Hu1, Jun Qi2, Shanglin Zhu3, Baiyu Zhang3 and Zetao Liao4, 1Department of Rheumatology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, 2The Third Affiliated Hospital of Sun Yat-sen University, guangzhou, China, 3Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, 4Rheumatology, 3rd Affiliated Hoapital of Sun Yat-Sen Uni, Guangzhou, China

    Background/Purpose:  Three readers (two radiologists and one rheumatologist) investigated fat metaplasia, erosion, backfill and ankylosis seen on MR images from 423 patients. All these patients…
  • Abstract Number: 1268 • 2016 ACR/ARHP Annual Meeting

    Hand Bone Loss in Early Rheumatoid Arthritis Is Independent of Adalimumab Treatment – Results from a Randomized Controlled Clinical Trial. 

    Lykke Midtbøll Ørnbjerg1, Mikkel Østergaard2, Trine David Jensen3, Kim Hørslev-Petersen4, Kristian Stengaard-Pedersen5, Peter Junker6, Torkell Ellingsen7, Palle Ahlquist8, Hanne Lindegaard9, Asta Linauskas10, Annette Schlemmer11, Mette Yde Dam7, Ib Hansen12, Tine Lottenburger8, Christian G. Ammitzbøll5, Anette Jørgensen5, Sophine B. Krintel1, Johnny Lillelund Raun13 and Merete Lund Hetland2, 1Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark, 2Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Denmark, Copenhagen, Denmark, 3Department of Endocrinology, Hvidovre Hospital, Copenhagen, Denmark, 4King Christian X Hospital for Rheumatic Diseases, Graasten, Denmark, 5Department of Rheumatology, Institute of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark, 6Department of Rheumatology C, Odense University Hospital, Odense, Denmark, 7Diagnostic Centre, Silkeborg Regional Hospital, Silkeborg, Denmark, 8Department of Medicine, Vejle Regional Hospital, Vejle, Denmark, 9The DANBIO registry and the Danish Departments of Rheumatology, Odense, Denmark, 10Department of Rheumatology, Vendsyssel Hospital, Hjørring, Denmark, 119Department of Rheumatology, Aalborg University Hospital, Aalborg, Denmark, 12Department of Rheumatology, Viborg Regional Hospital, Viborg, Denmark, 13King Christian X Hospital for Rheumatic Diseases, South Jutland Hospital, Graasten, Denmark

    Background/Purpose:  Rheumatoid arthritis (RA) is characterised by progressive destruction of joint bone and loss of periarticularbone mineral. Hand bone loss (HBL) measured by Digital X-ray…
  • Abstract Number: 1269 • 2016 ACR/ARHP Annual Meeting

    Description of Radiographic Hip Measurements By OA Status in a Large Community-Based Study of African American and White Men and Women

    Amanda E. Nelson1, Reshmi Raveendran1, Jamie L. Stiller1, Carolina Alvarez2, Jordan B. Renner3, Todd A. Schwartz4, Nigel K Arden5 and Joanne M. Jordan1, 1Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 2Thurston Arthritis Research Center, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, 3Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 4Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, 5Oxford NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, United Kingdom

    Background/Purpose: There has been increasing interest in hip morphology as a risk factor for OA. There is a need for frequency estimates in the general…
  • Abstract Number: 1271 • 2016 ACR/ARHP Annual Meeting

    Plasma Concentration of S100A8/A9 Proteins Is an Independent Biomarker for Radiological Progression in in Early Rheumatoid Arthritis

    Maxime Chevreau1, Marie Helène Paclet2, Jean-Louis Quesada3, Marine Clay4, Philippe Dieudé5,6, Olivier Vittecoq7, Philippe Gaudin8 and Athan Baillet9, 1Rheumatology, CHU Sud Hospital, Grenoble, France, 2IPB _ Grenoble teaching hospital, Grenoble, France, 3Grenoble University Hospital, France, Grenoble, France, Grenoble, France, 4Rheumatology Grenoble, Grenoble, France, 5Rheumatology, Bichat hospital APHP, Paris, France, 6Rheumatology, Hôpital Bichat, Paris, France, 7Rheumatology, Rouen University Hospital &INSERM U905, Rouen, France, 8Grenoble University Hospital, France, Grenoble, France, 9Rheumatology, Grenoble University Hospital, France, Echirolles, France

    Background/Purpose: Increasing body of evidence suggest that alarmins such as S100A8/A9 proteins play a critical role in Rheumatoid Arthritis pathogenesis (RA). We aimed to analyze…
  • Abstract Number: 1272 • 2016 ACR/ARHP Annual Meeting

    Can Histologically Defined Peri-Articular Vascular Channels be Identified on High-Resolution Computed Tomography? – a Study in Cadaveric Finger Joints

    A. Scharmga1, K. K. Keller2, M. Peters1, A. van Tubergen1, J. van den Bergh3, B. van Rietbergen4, R. Weijers5, D. Loeffen5, E-M. Hauge2 and P. Geusens6, 1Department of Internal Medicine, Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, 2Rheumatology, Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, 3Internal Medicine, Viecuri Medical Center, Venlo, Netherlands, 4Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, 5Department of Radiology, Maastricht University Medical Center, Maastricht, Netherlands, 6Internal Medicine/Rheumatology, Maastricht University Medical Center and Hasselt University, Biomedical Research Institute, Diepenbeek, Belgium

    Background/Purpose: Several studies have indicated that High Resolution peripheral CT (HR-pQCT) scanning is more sensitive than radiography in detecting cortical interruptions in destructive joint diseases…
  • Abstract Number: 1273 • 2016 ACR/ARHP Annual Meeting

    Effect of Anti-Cyclic Citrullinated Protein Antibodies and Rheumatoid Factor on Bone Erosions in Early Rheumatoid Arthritis Patients Using HR-pQCT: A Cross-Sectional Study

    JIANG YUE1, James F Griffith2, Lin Shi3, Defeng Wang2, Jiayun Shen4, Priscilla Wong5, Edmund LI5, Martin Li6, Tena K. Li6, Tracy Y. Zhu7, Ling qin8 and Lai-Shan TAM9, 1The Prince of Wales Hospital, The Chinese University of Hong Kong, Department of Medicine and Therapeutics, HONG KONG, Hong Kong, 2The Prince of Wales Hospital, The Chinese University of Hong Kong, Department of Imaging and Interventional Radiology, HONGKONG, Hong Kong, 3Department of Medicine & Therapeutics, Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong, 4Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, China, 5Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong, 6Department Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China, 7Department of Orthopaedics & Traumatology, The Chinese University of Hong Kong, Hong Kong, China, 8Department of Orthopedics & Traumatology, hongkong, Hong Kong, 9Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong

    Background/Purpose: Concomitant presence of anti-cyclic citrullinated peptide antibodies (ACPA) and rheumatoid factor (RF) is associated with higher erosive disease burden in patients with established rheumatoid…
  • Abstract Number: 1274 • 2016 ACR/ARHP Annual Meeting

    The Reproducibility of a Semi-Automatic Algorithm in the Detection of Cortical Breaks and Adjacent Trabecular Bone Loss in Scan-Rescan Data from Patients with Early Arthritis

    M. Peters1, J. de Jong2, A. Scharmga1, A. van Tubergen1, D. Loeffen3, R. Weijers3, B. van Rietbergen4, Steven K. Boyd5, Cheryl Barnabe6, Kathryn S. Stok7, Piet Geusens8 and J. van den Bergh9, 1Department of Internal Medicine, Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, 2Maastricht University, Maastricht, Netherlands, 3Department of Radiology, Maastricht University Medical Center, Maastricht, Netherlands, 4Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, 5Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, 6Division of Rheumatology, University of Calgary, Calgary, AB, Canada, 7Institute for Biomechanics, ETH Zurich, Zurich, Switzerland, 8Maastricht University Hospital, Maastricht, Netherlands, 9Internal Medicine, Viecuri Medical Center, Venlo, Netherlands

    Background/Purpose: In RA bone erosions are defined as cortical breaks with adjacent trabecular bone loss. High resolution peripheral quantitative CT (HR-pQCT) is more sensitive than…
  • Abstract Number: 1275 • 2016 ACR/ARHP Annual Meeting

    Evaluation of Spine and Tibia Bone Microarchitecture Using Trabecular Bone Score (TBS) and HR-pQCT in Patients with Ankylosing Spondylitis

    Valeria F Caparbo1, Carla G.S. Saad1, Jackeline Couto Alvarenga2 and Rosa M R Pereira3, 1Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, 2Division of Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, 3Rheumatology Division, Faculdade de Medicina da USP, São Paulo, Brazil

    Background/Purpose: Ankylosing Spondylitis (AS) is a chronic inflammatory disease characterized by new bone growth that leads to syndesmophytes formation. However, AS patients present low bone…
  • Abstract Number: 1276 • 2016 ACR/ARHP Annual Meeting

    Sensitive SPECT/CT Imaging of Fibroblast Activation Protein Expression after Anti-IL-22 Treatment in Experimental Arthritis

    Debbie M. Roeleveld1, Tessa van der Geest2, Birgitte Walgreen1, Monique M. Helsen1, Tapan K. Nayak3, Christian Klein4, Martin Hegen5, Peter Laverman2, Otto C. Boerman2 and Marije I. Koenders1, 1Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, 2Radiology & Nuclear Medicine, Radboud university medical center, Nijmegen, Netherlands, 3Research & Early development, Roche Pharmaceutical, Basel, Switzerland, 4Research & Early Development, Roche Pharmaceutical, Schlieren, Switzerland, 5Immunoscience Research Unit, Pfizer, Cambridge, MA

    Background/Purpose: Rheumatoid arthritis (RA) synovial tissue has been demonstrated to express high levels of fibroblast activation protein (FAP) using anti-FAP-antibody 28H1. In addition, RA patients…
  • Abstract Number: 1278 • 2016 ACR/ARHP Annual Meeting

    Combined Positron Emission Tomography and Magnetic Resonance Imaging in Assessing Gastrointestinal Involvement in Systemic Sclerosis: A Pilot Study

    Sue-Ann Ng1, Stephanie Marchesseau2, Yu Tien Wang3, Josh Schaefferkoetter2, Wanying Xie4, David Ng4, John Totman2 and Andrea HL Low1, 1Department of Rheumatology and Immunology, Singapore General Hospital, Singapore; Duke-National University of Singapore, Singapore, Singapore, 2Clinical Imaging Research Center, A*STAR & National University of Singapore, Singapore, Singapore, Singapore, 3Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore, Singapore, Singapore, 4Department of Nuclear Medicine and PET, Singapore General Hospital, Singapore, Singapore, Singapore

    Background/Purpose: Systemic sclerosis (SSc), a multi-organ fibrotic disease, affects the gastrointestinal tract (GIT) in 90% of patients. An urgent unmet need in the management of…
  • Abstract Number: 1279 • 2016 ACR/ARHP Annual Meeting

    Imaging of Ankylosing Spondylitis By [18f]Fluoride PET-CT to Assess Bone Formation Activity and to Monitor Anti-TNF Therapy

    Stefan Bruijnen1, Nicki Verweij2, Leonie van Duivenvoorde3, Dominique Baeten4, Christiaan van Denderen5, Joost Bot6, Otto Hoekstra7, Pieter Raijmakers6, Irene van der Horst - Bruinsma8 and Conny van der Laken2, 1Dept. of Rheumtaology, Amsterdam Rheumatology and immunology Center - location VU University Medical Center, Amsterdam, The Netherlands, Amsterdam, Netherlands, 2Dept. of Rheumatology, Amsterdam Rheumatology and immunology Center - location VU University Medical Center, Amsterdam, The Netherlands, Amsterdam, Netherlands, 3Amsterdam Rheumatology and immunology Center, Academic Medical Center, Amsterdam, Netherlands, 4Amsterdam Rheumatology and immunology Center, Amsterdam, Netherlands, 5READE, Amsterdam Rheumatology and immunology Center, Reade, Amsterdam, Netherlands, 6Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, Netherlands, 7Nuclear medicine and PET research, VU University Medical Center, Amsterdam, Netherlands, 8Rheumatology, Amsterdam Rheumatology and immunology Center, VU University medical center, Amsterdam, Netherlands

    Background/Purpose: Bone formation is an important hallmark of ankylosing spondylitis (AS). Recently, we demonstrated that axial bone formation activity in AS patients can be visualized…
  • Abstract Number: 1280 • 2016 ACR/ARHP Annual Meeting

    Positron Emission Tomography Images with an Amyloid-Specific Tracer 11C-BF-227 in Systemic Amyloidosis Patients

    Yuko Shirota1, Katsutoshi Furukawa2, Manabu Tashiro3, Tsuyoshi Shirrai1, Hiroshi Fujii1, Tomonori Ishii1 and Hideo Harigae1, 1Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan, 2Department of Geriatrics and Gerontology, Division of Brain Sciences, Institute of Development, Aging and Cancer,, Tohoku University, Sendai, Japan, 3Department of Cyclotron Nuclear Medicine, Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan

    Background/Purpose: In order to visualize amyloid deposition in the specific organs, the patients with systemic amyloidosis underwent positron-emission tomography (PET) study with 11C-BF-227 that specifically…
  • Abstract Number: 1281 • 2016 ACR/ARHP Annual Meeting

    Feasibility and Reliability of the Spondyloarthritis Research Consortium of Canada Sacroiliac Joint Inflammation Score for Children with Spondyloarthritis

    Nancy A. Chauvin1, Walter P. Maksymowych2,3, Robert G. Lambert4, Jacob Jaremko5, David M. Biko1, Timothy G. Brandon6, Joel Paschke2 and Pamela F. Weiss7,8, 1Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, 2CaRE Arthritis, Edmonton, AB, Canada, 3Medicine, University of Alberta, Edmonton, AB, Canada, 4Radiology, University of Alberta, Edmonton, AB, Canada, 5Radiology, Radiology, University of Alberta, Edmonton, AB, Canada, 6Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, 7Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 8Division of Rheumatology, Center for Pediatric Clincial Effectiveness, Children's Hospital of Philadelphia, Philadelphia, PA

    Background/Purpose: We lack a method to quantify severity of inflammation in the pediatric sacroiliac joint. We evaluated the reliability and construct validity of the Spondyloarthritis…
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