ACR Meeting Abstracts

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  • Abstract Number: 2197 • 2017 ACR/ARHP Annual Meeting

    Systemic Inflammation and Physical Function in Knee Osteoarthritis

    Devyani Misra1, Carrie Brown2, Roger A. Fielding3, Tuhina Neogi4, Michael C. Nevitt5, Cora E. Lewis6, James Torner7 and David T. Felson4, 1Medicine, Section of, Boston University School of Medicine, Boston, MA, 2Boston University School of Public Health, Boston, MA, 3Nutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, 4Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, 5Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, 6University of Alabama Birmingham, Birmingham, AL, 7University of Iowa, Iowa City, IA

    Background/Purpose: Knee osteoarthritis (OA) is a leading cause of functional limitation and disability in older adults. But why some knee OA patients develop functional limitation…
  • Abstract Number: 2198 • 2017 ACR/ARHP Annual Meeting

    Combinatorial Peripheral Blood Inflammatory and MRI-Based Biomarkers Predict Radiographic Joint Space Narrowing in Knee OA

    Svetlana Krasnokutsky Samuels1, Hua Zhou2, Mukundan Attur1, Jonathan Samuels1, Gregory Chang3, Jenny Bencardino4, Sisi Ma2, Leon Rybak3 and Steven B. Abramson5, 1Rheumatology, NYU Langone Medical Center, New York, NY, 2Bioinformatics, New York University, New York, NY, 3Department of Radiology, NYU Langone Medical Center, New York, NY, 4Radiology, NYU Langone Medical Center, New York, NY, 5Dept of Medicine, NYU Langone Medical Center, New York, NY

    Background/Purpose: Inflammation contributes to OA disease pathogenesis. Subsets of knee OA patients with peripheral blood leukocyte (PBL) detected inflammatory gene expression profiles exhibit more rapid…
  • Abstract Number: 2199 • 2017 ACR/ARHP Annual Meeting

    Feasibility of a Novel Approach to Studying Early Knee Osteoarthritis: An Offspring Study

    Grace H. Lo1, Jane A. Cauley2, Michael T. Strayhorn3, Mary Jansen4, Michael J Hannon5, Donna White6, Stephanie Green7 and C. Kent Kwoh8,9, 1Immunology, Allergy, Rheumatology, Baylor College of Medicine, Houston, TX, 2Department of Epidemiology, Univ of Pittsburgh, Pittsburgh, PA, 3VA HSR&D Center for Innovations in Quality, Effectiveness and Safety; Department of Medicine, Michael E. DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX, 4University of Pittsburgh, Pittsburgh, PA, 5Medicine, University of Pittsburgh, Pittsburgh, PA, 6Baylor College of Medicine, Houston, TX, 7Univeristy of Pittsburgh, Houston, PA, 8University of Arizona, Tucson, AZ, 91501 N. Campbell Avenue, Room 8303, The University of Arizona Arthritis Center, Tucson, AZ

    Background/Purpose: Much of osteoarthritis (OA) research has focused on identifying treatments for late stage disease. However, interventions in early disease may be most effective. Capitalizing…
  • Abstract Number: 2200 • 2017 ACR/ARHP Annual Meeting

    History of Walking for Exercise Is Not Associated with More Symptomatic Knee Osteoarthritis: Data from the Osteoarthritis Initiative

    Grace H. Lo1, Jeffrey B. Driban2, Andrea Kriska3, Timothy E. McAlindon4, Richard Souza5, Nancy J. Petersen6, Bonny Jane Rockette-Wagner7, Charles Eaton8, Marc Hochberg9, Rebecca D. Jackson10, C. Kent Kwoh11, Michael C. Nevitt12 and Maria Suarez-Almazor13, 1Immunology, Allergy, Rheumatology, Baylor College of Medicine, Houston, TX, 2Rheumatology, Tufts Medical Center, Boston, MA, 3University of Pittsburgh, Pittsburgh, PA, 4Division of Rheumatology, Tufts Medical Center, Boston, MA, 5University of California, San Francisco, San Francisco, CA, 6Medicine, Baylor College of Medicine, Houston, TX, 7University of Pittsburgh Medical Center, Pittsburgh, PA, 8Family Medicine and Epidemiology, Warren Alpert Medical School, School of Public Health, Brown University, Providence, RI, 9Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, 10Ohio State University, Columbus, OH, 11University of Arizona, Tucson, AZ, 12Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, 13Section of Rheumatology and Clinical Immunology, Department of General Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA, Houston, TX

    Background/Purpose: Walking is recommended for those with knee OA (KOA). However, few studies have explored the association between walking and symptomatic OA, and conflicting data…
  • Abstract Number: 2201 • 2017 ACR/ARHP Annual Meeting

    Baseline Periarticular Tibial Knee Bone Mineral Density Is Associated with Change in Static Alignment

    Grace H. Lo1, Jeffrey B. Driban2, Michael T. Strayhorn3, Lori Lyn Price4, Charles Eaton5 and Timothy E. McAlindon6, 1Immunology, Allergy, Rheumatology, Baylor College of Medicine, Houston, TX, 2Rheumatology, Tufts Medical Center, Boston, MA, 3VA HSR&D Center for Innovations in Quality, Effectiveness and Safety; Department of Medicine, Michael E. DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX, 4Tufts Clinical and Translational Science Institute, Tufts University, Boston, MA, 5Family Medicine and Epidemiology, Warren Alpert Medical School, School of Public Health, Brown University, Providence, RI, 6Division of Rheumatology, Tufts Medical Center, Boston, MA

    Background/Purpose: Relative local knee periarticular bone mineral density (paBMD) as measured by dual x-ray absorptiometry (DXA) has been associated with static alignment cross-sectionally, but not…
  • Abstract Number: 2202 • 2017 ACR/ARHP Annual Meeting

    Association between Oxidative Balance Score and Osteoarthritis in Korean Adults: The Korea National Health and Nutrition Examination Survey (2014–2015)

    Young Bin Joo1, Joo-Hyun Lee2, Minkyung Han3, Seong-Ryul Kwon4, Won Park5, Kyung-Su Park6, Bo Young Yoon7 and Kyong-Hee Jung4, 1Internal Medicine, Department of Rheumatology, St. Vincent's Hospital, The Catholic University of Korea, Suwon, Gyeonggido, Korea, Republic of (South), 2Rheumatology, Inje University Ilsan Paik Hospital, Goyang, Korea, Republic of (South), 3Public health, Yonsei University graduate school, Seoul, Korea, Republic of (South), 4Rheumatology, Inha University, Incheon, Korea, Republic of (South), 5Medicine/Rheumatology, Inha University Hospital, Incheon, Korea, Republic of (South), 6Internal Medicine, St. Vincent's Hospital, The Catholic University of Korea, Suwon, Korea, Republic of (South), 7Rheumatology/Internal medicine, Inje Iniversity Ilsan Paik Hospital, Goyang, Korea, Republic of (South)

    Background/Purpose: Osteoarthritis (OA) is the most common form of arthritis, caused by a combination of systemic and local factors. Its multi-factorial etiology includes oxidative stress…
  • Abstract Number: 2203 • 2017 ACR/ARHP Annual Meeting

    Association of Hip Bone Geometry and Volumetric Density with Hip Osteoarthritis

    Johann Grapinet1, Jean-Baptiste Pialat1, mathilde Proriol1, Pawel Szulc2, Eric Lespessailles3 and Roland Chapurlat4, 1INSERM UMR 1033, LYON, France, 2Epidemiology of Osteoporosis, INSERM UMR 1033, Lyon, France, 3University Orleans, Orleans, France, 4INSERM 1033, University of Lyon, E. Herriot Hospital, Hospices Civils de Lyon, Lyon, France

    Background/Purpose: Hip osteoarthritis (OA) is a major public health concern. It is associated with hip pain, functional decline and possibly increased cardiovascular mortality. The determinants…
  • Abstract Number: 2204 • 2017 ACR/ARHP Annual Meeting

    Neuropathic Pain in Patients with Knee Osteoarthritis and Related Factors: A Multicenter Longitudinal Study-Preliminary Report

    Ece Kaptanoglu1, Ozlem Şahin2, Tiraje Tuncer3, Sami Hizmetli1, Lale Altan4, Figen Ayhan5, Ajda Bal6, Meral Bilgilisoy7, Gulnur Bozbas8, Lale Cerrahoglu9, Remzi Cevik10, Tuncay Duruoz11, Deniz Dulgeroglu6, Gulcan Gurer12, Savas Gursoy13, Simin Hepguler14, Cahit Kacar15, Taciser Kaya16, Meltem Melikoglu17, Kemal Nas18, Suheda Ozcakir19, Senay Ozdolap20, merih Saridogan21, Selda Sarikaya20, Dilsad Sindel22, Omer F Şendur8, Canan Tikiz23 and Hatice Ugurlu24, 1Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Cumhuriyet University School of Medicine, Sivas, Turkey, 2Department of Physical Medicine and Rehabilitation, Cumhuriyet University School of Medicine, Sivas, Turkey, 3Department of Physical Medicine and Rehabilitation, Akdeniz University School of Medicine, Antalya, Turkey, 4Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Uludag University School of Medicine, Bursa, Turkey, 5Department of Physical Medicine and Rehabilitation, University of Health Ankara Training and Research Hospital, Ankara, Turkey, 6Department of Physical Medicine and Rehabilitation, University of Health Sciences Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey, 7Department of Physical Medicine and Rehabilitation, University of Health Sciences Antalya Training and Research Hospital, Antalya, Turkey, 8Department of Physical Medicine and Rehabilitation, Adnan Menderes University School of Medicine, Aydin, Turkey, 9Department of Physical Medicine and Rehabilitation, Celal Bayar University School of Medicine, Manisa, Turkey, 10Department of Physical Medicine and Rehabilitation, Dicle University School of Medicine, Diyarbakir, Turkey, 11Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Marmara University School of Medicine, Istanbul, Turkey, 12Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Adnan Menderes University School of Medicine, Aydin, Turkey, 13Department of Physical Medicine and Rehabilitation, Gaziantep University School of Medicine, Gaziantep, Turkey, 14Department of Physical Medicine and Rehabilitation, Ege University School of Medicine, Izmir, Turkey, 15Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Akdeniz University School of Medicine, Antalya, Turkey, 16Department of Physical Medicine and Rehabilitation, University of Health Sciences İzmir Bozyaka Training and Research Hospital, Izmir, Turkey, 17Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Ataturk University School of Medicine, Erzurum, Turkey, 18Department of Physical Medicine and Rehabilitation, Sakarya University School of Medicine, Sakarya, Turkey, 19Department of Physical Medicine and Rehabilitation, Uludag University School of Medicine, Bursa, Turkey, 20Department of Physical Medicine and Rehabilitation, Bulent Ecevit University School of Medicine, Zonguldak, Turkey, 21Department of Physical Medicine and Rehabilitation, Istanbul University Cerrahpasa School of Medicine, Istanbul, Turkey, 22Department of Physical Medicine and Rehabilitation, Istanbul University Istanbul Faculty of Medicine, Istanbul, Turkey, 23Celal Bayar University School of Medicine, Manisa, Turkey, 24Department of Physical Medicine and Rehabilitation, Necmettin Erbakan University Meram School of Medicine, Konya, Turkey

    Background/Purpose: Neuropathic pain (NP) was accused for increased pain and reduced functional capacity in knee osteoarthritis (KO). Here we aimed to find out the prevalence…
  • Abstract Number: 2205 • 2017 ACR/ARHP Annual Meeting

    Trajectories of Knee Bone Shape Change Are Associated with Sex and Osteoarthritis

    Barton L Wise1, Jingbo Niu2, Yuqing Zhang3, Felix Liu4, Joyce Pang5, John A. Lynch6 and Nancy E. Lane7, 1Orthopaedics, Internal Medicine, University of California, Davis School of Medicine, Sacramento, CA, 2Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, 3School Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 4Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, 5University of Nevada, Reno, Reno, NV, 6Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, 7Center for Musculoskeletal Health, University of California, Davis School of Medicine, Sacramento, CA

    Background/Purpose: Knee osteoarthritis (OA) is more common in women than men; however, the biological mechanisms for sex difference in knee OA are not well understood.…
  • Abstract Number: 2206 • 2017 ACR/ARHP Annual Meeting

    Healthy Weight Loss Is Associated with Improved Pain and Function over 8 Years in Overweight Subjects with Knee Osteoarthritis: Data from the Osteoarthritis Initiative

    Naoko Onizuka1 and Anna K. Shmagel2, 1Medicine, University of Minnesota, Minneapolis, MN, 2Rheumatic & Autoimmune Diseases, University of Minnesota, Minneapolis, MN

    Background/Purpose: In clinical trials, weight loss was associated with improvement in knee osteoarthritis (OA) pain and function up to 18 months of follow up. However,…
  • Abstract Number: 2207 • 2017 ACR/ARHP Annual Meeting

    Urine CTX-II, CTX-I, Osteocalcin, and Radiographic Severity of Multiple OA Knee Joints: Does CTX-II Originate from Bone or Cartilage?

    Asger R. Bihlet1, Inger Byrjalsen2, Anne C. Bay-Jensen3, Jeppe Andersen4, Claus Christiansen1, Bente J. Riis1 and Morten Asser Karsdal3, 1Nordic Bioscience, Clinical Development, Herlev, Denmark, 2Nordic Bioscience, Herlev, Denmark, 3Rheumatology, Nordic Bioscience, Herlev, Denmark, 4Clinical Development, Nordic Bioscience, Herlev, Denmark

    Background/Purpose: Excessive cartilage degradation is a known characteristic of osteoarthritis (OA), and several methods of quantification of cartilage degradation exist. Biomarkers such as urinary C-telopeptide…
  • Abstract Number: 2208 • 2017 ACR/ARHP Annual Meeting

    A Novel Omeract MRI Scoring System Providing Insights in the Association of MRI Synovitis and Bone Marrow Lesions with Pain in Thumb Base Osteoarthritis

    F.P.B. Kroon1, S. van Beest1, W. Damman1, R. Liu1, J.L. Bloem2, M. Reijnierse2 and M. Kloppenburg1,3, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Radiology, Leiden University Medical Center, Leiden, Netherlands, 3Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: Osteoarthritis (OA) in the thumb base joints (first carpometacarpal [CMC1] and scaphotrapeziotrapezoid [STT]) is highly prevalent and disabling, however much is still unknown about…
  • Abstract Number: 2209 • 2017 ACR/ARHP Annual Meeting

    Leptin and Adiponectin Mediate the Association between Body Mass Index and Hand and Knee Osteoarthritis

    F.P.B. Kroon1, A. Veenbrink1, R. de Mutsert2, A.W. Visser1, Saskia le Cessie3, F.R. Rosendaal2 and M. Kloppenburg1,2, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands, 3Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: Associations between obesity and osteoarthritis (OA) in non-weight bearing joints suggest that systemic influences also contribute to OA. Systemically active substances secreted by adipose…
  • Abstract Number: 2210 • 2017 ACR/ARHP Annual Meeting

    Thumb Base Osteoarthritis: Associations between Pain and Synovitis on Ultrasound

    F.P.B. Kroon1, S. Ermurat2, M. Kortekaas1, M. Reijnierse3 and M. Kloppenburg1,4, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Rheumatology, Uludag University Medical Faculty, Bursa, Turkey, 3Radiology, Leiden University Medical Center, Leiden, Netherlands, 4Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: Osteoarthritis (OA) in the first carpometacarpal (CMC1) joint in the thumb base is frequent and has a large contribution in hand pain and disability.…
  • Abstract Number: 2211 • 2017 ACR/ARHP Annual Meeting

    Investigation of Self-Reported Painful Joint Count As an Outcome Measure in Hand Osteoarthritis

    F.P.B. Kroon1, J.L. van der Plas1, S. van Beest1, W. Damman1 and M. Kloppenburg1,2, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: Hand osteoarthritis (OA) research is in need of disease-specific validated instruments to measure patient-reported outcomes. Self-reported painful joint count (PJC) could be useful to…
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