Session Type: ACR Poster Session C
Session Time: 9:00AM-11:00AM
Osteoarthritis (OA) is the most common form of arthritis, caused by a combination of systemic and local factors. Its multi-factorial etiology includes oxidative stress and the overproduction of reactive oxygen species (ROS). Previous researchers tried to investigate the role of ROS pathway to reveal the pathogenesis of OA. Oxidative balance score (OBS), which is based on the summed intake of various pro-oxidants and anti-oxidants, is well known to reflect oxidative stress in an individual. Recent studies have investigated the associations between OBS and several chronic diseases, including prostate cancer, colorectal cancer, and the risk of cardiovascular disease and end-stage renal diseases. However, the association between OBS and OA has not been studied. This study aimed to investigate the association between OBS and OA and between OBS and quality of life in patients with OA.
Using the Korea National Health and Nutrition Examination Survey (KNHANES) VI (2014–2015) program, OBS was calculated by combining 10 pro- (polyunsaturated fatty acid, omega-6, smoking, alcohol, BMI) and anti-oxidant (carotene, retinol, vitamin C, omega-3, physical activity) factors through baseline nutritional and lifestyle assessment. OBS was divided into quartiles (Q1–Q4), considering the lowest quartile, Q1 (predominance of pro-oxidants), as a reference. Multivariable logistic regression was used to estimate adjusted odds ratios (ORs) for OA and EuroQol five dimensions questionnaire (EQ-5D) in patients with OA after adjusting for demographic factors and comorbidities.
Among the 14,930 participants, 296 patients with OA and 1,309 controls were included in the analysis. Patients with OA had lower OBS than that of controls (17.04 ± 0.22 and 17.08 ± 0.12, respectively), although there was no statistically significant difference between the groups. Especially, patients with OA had significantly lower anti-oxidant OBS than that of controls (p<0.01). The OR of dietary anti-oxidant OBS was 0.92 (95% confidence interval 0.87–0.97) and that of non-dietary lifestyle anti-oxidant (physical activity) OBS was 0.82 (0.71–0.94). In a logistic regression model to assess the association of OBS with OA, the adjusted OR for OA was 0.95 (0.91–1.00). Moreover, the adjusted OR for higher EQ5D was 1.17 (1.06–1.30) in patients with OA.
Higher OBS was associated with a lower risk of OA. Among the OBS items, lower physical activity had the greatest contribution to the risk of OA. In addition, higher OBS was associated with better quality of life in patients with OA.
To cite this abstract in AMA style:Joo YB, Lee JH, Han M, Kwon SR, Park W, Park KS, Yoon BY, Jung KH. Association between Oxidative Balance Score and Osteoarthritis in Korean Adults: The Korea National Health and Nutrition Examination Survey (2014–2015) [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/association-between-oxidative-balance-score-and-osteoarthritis-in-korean-adults-the-korea-national-health-and-nutrition-examination-survey-2014-2015/. Accessed March 25, 2019.
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