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Abstract Number: 2199

Feasibility of a Novel Approach to Studying Early Knee Osteoarthritis: An Offspring Study

Grace H. Lo1, Jane A. Cauley2, Michael T. Strayhorn3, Mary Jansen4, Michael J Hannon5, Donna White6, Stephanie Green7 and C. Kent Kwoh8,9, 1Immunology, Allergy, Rheumatology, Baylor College of Medicine, Houston, TX, 2Department of Epidemiology, Univ of Pittsburgh, Pittsburgh, PA, 3VA HSR&D Center for Innovations in Quality, Effectiveness and Safety; Department of Medicine, Michael E. DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX, 4University of Pittsburgh, Pittsburgh, PA, 5Medicine, University of Pittsburgh, Pittsburgh, PA, 6Baylor College of Medicine, Houston, TX, 7Univeristy of Pittsburgh, Houston, PA, 8University of Arizona, Tucson, AZ, 91501 N. Campbell Avenue, Room 8303, The University of Arizona Arthritis Center, Tucson, AZ

Meeting: 2017 ACR/ARHP Annual Meeting

Date of first publication: September 18, 2017

Keywords: Osteoarthritis

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Session Information

Date: Tuesday, November 7, 2017

Session Title: Osteoarthritis – Clinical Aspects Poster II: Observational and Epidemiological Studies

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose: Much of osteoarthritis (OA) research has focused on identifying treatments for late stage disease. However, interventions in early disease may be most effective. Capitalizing on the heritability of knee OA, we assessed the feasibility of using the phenotype of a proband to study risk factors in their offspring. The objectives of this study were: 1) to establish feasibility of deploying such an offspring study within the Osteoarthritis Initiative (OAI) where the proband phenotype is well-characterized, 2) to assess whether this offspring design can detect known risk factors of medial compartment knee OA, and 3) to evaluate exploratory risk factors.

Methods: We selected two groups of proband OAI participants from the University of Pittsburgh site: medial tibiofemoral OA group and no OA group. To preferentially include those more likely to have a heritable etiology of their phenotype, we recruited probands with the same OA phenotype in both knees.  The case probands had bilateral medial tibiofemoral OA; control probands had no radiographic evidence of OA in either knee.  We only included biological offspring who were ≥18 years old.  We approached current OAI participants from the Pittsburgh site who met our eligibility criteria.  We developed a privacy-sensitive method of contacting the proband’s offspring to invite them to participate. Willing offspring completed an online survey that assessed OA symptoms and diagnoses as well as known and exploratory risk factors.  We calculated the percentage of probands with OA in each strata of the risk factors.  To see if OA risk factors in offspring are associated with proband OA status, we used logistic regression models conducted with generalized estimating equations to account for the correlation among offspring related to a given proband. 

Results: We established contact with 269/413 (65.1%) potential probands. Most (227/269,84.4%) had ≥1 eligible biological offspring, with 213/227 (93.8%) willing to share information about the study with their offspring.  Our online survey was completed by 185 offspring from 109 probands. Offspring age ranged from 21 – 67 years old (mean=42.9), with 64.9% female, 84.3% White/Caucasian, and mean BMI=23.7 kg/m2. Median time to complete survey =14.1 minutes.

Table. Associations of risk factors between offspring and proband OA status.

Known OA Risk Factors in the Offspring

% of Probands with bilateral medial TF knee OA

p-values

Heberden’s Nodes Present

13/15 (87%)

0.03

Heberden’s Nodes Absent

92/170 (54%)

Overweight

19/61 (69%)

0.07

Not Overweight

63/124 (51%)

Obese

20/28 (72%)

0.1

Not Obese

85/157 (54%)

Knee Injury

31/51 (61%)

0.5

No Knee Injury

74/134 (55%)

Exploratory OA Risk Factors in the Offspring

Regular Cigarette Smoker

24/37 (65%)

0.6

Never Regular Cigarette Smoker

77/141 (55%)

Diabetes Present

4/7 (57%)

1.0

Diabetes Absent

99/176 (56%)

Hypertension Present

20/25 (80%)

0.03

Hypertension Absent

84/158 (53%)

Hyperlipidemia Present

16/27 (59%)

0.8

Hyperlipidemia Absent

88/157 (56%)

Conclusion: Our pilot study establishes feasibility of deploying an offspring study within the OAI using an online survey.  Using this design, we detected significant associations between offspring presence of Heberden’s nodes and hypertension, and presence of parental OA.  Our findings show good proof of concept for performing an offspring study based out of the OAI. 


Disclosure: G. H. Lo, None; J. A. Cauley, None; M. T. Strayhorn, None; M. Jansen, None; M. J. Hannon, None; D. White, None; S. Green, None; C. K. Kwoh, None.

To cite this abstract in AMA style:

Lo GH, Cauley JA, Strayhorn MT, Jansen M, Hannon MJ, White D, Green S, Kwoh CK. Feasibility of a Novel Approach to Studying Early Knee Osteoarthritis: An Offspring Study [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/feasibility-of-a-novel-approach-to-studying-early-knee-osteoarthritis-an-offspring-study/. Accessed January 27, 2023.
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