Abstracts Archive - Page 1324 of 2425 - ACR Meeting Abstracts

Abstract Number: 1777 • 2017 ACR/ARHP Annual Meeting
Incidence and Prevalence of Granulomatosis with Polyangiitis and Microscopic Polyangiitis in a Health Management Organization: A 15-Year Study
Florencia Pierini¹, Marina Scolnik¹, Valeria Scaglioni², Florencia Beatriz Mollerach³ and Enrique R. Soriano¹, ¹Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, CABA, Argentina, ²Rheumatology Unit, Internal Medicine Service. Hospital Italiano de Buenos Aires, CABA, Argentina, ³Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina
Background/Purpose: ANCA-associated vasculitides are rare diseases and epidemiological data on them is scarce. Our objective was to estimate incidence and prevalence rates of Granulomatosis with…
Abstract Number: 1778 • 2017 ACR/ARHP Annual Meeting
Prophylactic Treatment and Incidence of Pneumocystis Jirovecci Pneumonia in Japanese Patients with Antineutrophil Cytoplasmic Antibody-Associated Vasculitis
Izaya Nakaya¹, Ken-ei Sada², Jun Soma¹, Yoshihiro Arimura³, Masayoshi Harigai⁴, Kunihiro Yamagata⁵, Hirofumi Makino⁶ and Seiichi Matsuo⁷, ¹Department of Nephrology and Rheumatology, Iwate Prefectural Central Hospital, Morioka, Japan, ²Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, ³First Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan, ⁴Division of Epidemiology and Pharmacoepidemiology of Rheumatic Diseases, Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ⁵Department of Nephrology, University of Tsukuba, Faculty of Medicine, Tsukuba, Japan, ⁶Okayama University Hospital, Okayama, Japan, ⁷Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan
Background/Purpose: Pneumocystis jiroveciipneumonia (PCP) is a fatal complication in antineutrophil cytoplasmic antibody-associated vasculitis (AAV). However, the current situation of prophylactic treatment of PCP and its…
Abstract Number: 1779 • 2017 ACR/ARHP Annual Meeting
Off-Label Use of Biological Therapies in Relapsing and/or Refractory Eosinophilic Granulomatosis with Polyangiitis (Churg–Strauss)
Laure Denis¹, Maxime Samson², Francois Maurier³, Chahéra Khouatra⁴, Vincent Germain⁵, Xavier Delbrel⁶, Philippe Bonniaud⁷, Alban Deroux⁸, Nicolas Girszyn⁹, Claire de Moreuil¹⁰, Dominique Chauveau¹¹, Anne Gondouin¹², Stephane Dominique¹³, Guillaume Le Guenno¹⁴, Laurence Bouillet¹⁵, Bernard Bonnotte², Jean-Emmanuel Kahn¹⁶, Boris Bienvenu¹⁷, Bertrand Godeau¹⁸, Claire Le Jeunne¹⁹, Xavier Puéchal²⁰, Loïc Guillevin for the French Vasculitis Study Group²⁰ and Benjamin Terrier¹⁹, ¹Internal Medicine, CHU Estaing, Clermont-Ferrand, Clermont-Ferrand, France, ²Department of Internal Medicine and Clinical Immunology, Hôpital François Mitterrand, CHU de Dijon, Dijon, France, ³Internal Medicine, Sainte-Blandine de Metz Hospital, Metz, France, ⁴Lyon, Lyon, France, ⁵Rheumatology, CHU Pellegrin, Bordeaux, France, BORDEAUX, France, ⁶Internal Medicine, CH de Pau, PAU, France, ⁷Pulmonology, CHU de Dijon, Dijon, France, ⁸Internal Medicine, CHU de Grenoble, Grenoble, France, ⁹CHU de Rouen, Rouen, France, ¹⁰CHU de Brest, Brest, France, ¹¹Nephrology, CHU de Toulouse, Toulouse, France, ¹²CH de Lons le Saunier, Lons le Saunier, France, ¹³Pulmonology, CHU de Rouen, Rouen, France, ¹⁴Internal Medicine department, Clermont-Ferrand, France, ¹⁵CHU, Grenoble, France, ¹⁶foch hospital, foch, France, ¹⁷Internal Medicine, Hôpital Saint Joseph, Marseille, France, ¹⁸Internal medicine, Hôpital Henri-Mondor, Créteil, France, ¹⁹Service de Médecine Interne, Hôpital Cochin, Centre de référence national pour les maladies systémiques autoimmunes rares d’Ile de France, DHU Authors, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France, Paris, France, ²⁰Service de Médecine Interne, Centre de Référence Maladies Auto-Immunes et Auto-Inflammatoires Systémiques Rares, Hôpital Cochin, Paris, France
Background/Purpose: Eosinophilic granulomatosis with polyangiitis (EGPA) (Churg–Strauss) is characterized by pulmonary and systemic small-vessel necrotizing vasculitis, vascular and/or extravascular granulomas, eosinophilia and tissue infiltration by…
Abstract Number: 1780 • 2017 ACR/ARHP Annual Meeting
Prognostic Factors in Patients with Granulomatosis with Polyangiitis Requiring Hospitalization- a 10 Year Nationwide Analysis
Yumeng Wen¹, Yiming Luo¹ and Changchuan Jiang², ¹Department of Medicine, Mount Sinai St Luke's and Mount Sinai West Hospitals, Icahn School of Medicine at Mount Sinai, New York, NY, ²Department of Medicine, Mount Sinai St. Luke's West Hospitals. Icahn School of Medicine at Mount Sinai., New York, NY
Background/Purpose: Granulomatosis with Polyangiitis (GPA) is a form of systemic vasculitis with necrotizing granulomatous inflammation commonly involving upper and lower respiratory tracts, necrotizing glomerulonephritis and…
Abstract Number: 1781 • 2017 ACR/ARHP Annual Meeting
Pituitary Disease and Granulomatosis with Polyangiitis: A Collaborative Canadian Case Series and Review of the Literature
Martha Decker¹, Christian Pagnoux², Constance Chik³, Nader A. Khalidi⁴, Derek Emery⁵ and Elaine Yacyshyn⁶, ¹Division of Rheumatology, University of Alberta, Edmonton, AB, Canada, ²Division of Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ³Division of Endocrinology, University of Alberta, Edmonton, AB, Canada, ⁴Rheumatology, McMaster University, Hamilton, ON, Canada, ⁵Division of Radiology, University of Alberta, Edmonton, AB, Canada, ⁶Medicine, University of Alberta, Edmonton, AB, Canada
Background/Purpose: Pituitary involvement in granulomatosis with polyangiitis (GPA) is rare with an incidence of approximately 1%. Objectives were: (1) Describe ten new cases of pituitary…
Abstract Number: 1782 • 2017 ACR/ARHP Annual Meeting
Mycophenolic Acid Decreases IL-10 and IL-6 Production By B Cells of Granulomatosis with Polyangiitis Patients and Healthy Controls in Vitro
Anouk von Borstel¹, Wayel H. Abdulahad², Abraham Rutgers², Judith Land², Coen A. Stegeman¹, Peter Heeringa³ and Jan-Stephan F. Sanders¹, ¹Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ²Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ³Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands
Background/Purpose: Granulomatosis with polyangiitis (GPA) is a relapsing autoimmune disease affecting small- to medium-sized blood vessels. B cells are thought to play an important antibody-independent…
Abstract Number: 1783 • 2017 ACR/ARHP Annual Meeting
The Value of a Combination of Serum Proteins to Identify Response to Induction Therapy Among Patients with ANCA-Associated Vasculitis
Sadao Jinno^1,2, S. Reza Jafarzadeh³, Roscoe Warner⁴, Ulrich Specks⁵, John H. Stone⁶, Gary S. Hoffman⁷, Cees G.M. Kallenberg⁸, Carol A. Langford⁹, Philip Seo¹⁰, Robert F. Spiera¹¹, E. William St Clair¹², Kent Johnson¹³, Peter A. Merkel¹⁴ and Paul A. Monach², ¹Rheumatology, Boston University School of Medicine, Boston, MA, ²Boston University School of Medicine, Boston, MA, ³Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ⁴University of Michigan Medical School, Ann Arbor,, MI, ⁵Mayo Clinic College of Medicine, Rochester, MN, ⁶Massachusetts General Hospital Rheumatology Unit, Harvard Medical School, Boston, MA, ⁷Rheumatology, Cleveland Clinic, Cleveland, OH, ⁸Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ⁹Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, ¹⁰Medicine, Johns Hopkins University, Baltimore, MD, ¹¹Rheumatology, Hospital for Special Surgery, New York, NY, ¹²Rheumatology, Duke University Medical Center, Durham, NC, ¹³University of Michigan Medical School, Ann Arbor, MI, ¹⁴Division of Rheumatology, University of Pennsylvania; Perelman School of Medicine, Philadelphia, PA
Background/Purpose: Most patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) achieve clinical remission after induction therapy. However, even among patients who achieve remission, induction therapy…
Abstract Number: 1784 • 2017 ACR/ARHP Annual Meeting
The Novel Anti-CD40 Monoclonal Antibody CFZ533 Shows Beneficial Effects in Patients with Primary Sjögren’s Syndrome: A Phase IIa Double-Blind, Placebo-Controlled Randomized Trial
Benjamin Fisher¹, Margit Zeher², Wan-Fai Ng³, Michele Bombardieri⁴, Maximilian Posch⁵, Athena S Papas⁶, Arwa M Farag⁶, Thomas Daikeler⁷, Bettina Bannert⁸, Alan J. Kivitz⁹, Steven E. Carsons¹⁰, David A. Isenberg¹¹, Francesca Barone¹², Simon Bowman¹³, Pascal Espie¹⁴, Grazyna Wieczorek¹⁴, Pierre Moulin¹⁴, David Floch¹⁴, Cyrielle Dupuy¹⁴, Xiaohui Ren¹⁴, Petra Faerber¹⁴, Andrew M Wright¹⁵, Hans Ulrich Hockey¹⁵, Michael Rotte¹⁴, James S. Rush¹⁵ and Peter Gergely¹⁴, ¹Rheumatology Research Group, University of Birmingham, Birmingham, United Kingdom, ²Division of Clinical Immunology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary., Debrecen, Hungary, ³Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom, ⁴Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, UK, London, United Kingdom, ⁵Charité Research Organisation GmbH, Berlin, Germany, ⁶Tufts University, Boston, MA, ⁷Rheumatology, University Hospital Basel, Basel, Switzerland, ⁸University Hospital Basel, Basel, Switzerland, ⁹Department of Rheumatology, Altoona Center for Clinical Research, Duncansville, PA, ¹⁰NYU Winthrop University Hospital, Department of Medicine, Mineola, NY, ¹¹Centre for Rheumatology, Division of Medicine, University College London, London, United Kingdom, ¹²Institute of Inflammation and Ageing (IIA), University of Birmingham, Birmingham, United Kingdom, ¹³Department of Rheumatology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK, Birmingham, United Kingdom, ¹⁴Novartis Institutes for Biomedical Research, Basel, Switzerland, ¹⁵Novartis Pharmaceuticals Corporation, Basel, Switzerland
Background/Purpose: Primary Sjogren’s syndrome (pSS) is a systemic, progressive autoimmune disease characterized by formation of ectopic germinal centers in exocrine glands and secretory gland dysfunction.…
Abstract Number: 1785 • 2017 ACR/ARHP Annual Meeting
Serious or Opportunistic Infections in Infants Born to Pregnant Women with Rheumatoid Arthritis and Treated with a Biologic Medication
Christina D Chambers¹, Diana L Johnson², Yunjun Luo³, Ronghui Xu⁴ and Kenneth L Jones³, ¹Pediatrics and Family Medicine and Public Health, University of California San Diego, La Jolla, CA, ²Department of Pediatrics, University of California, San Diego, La Jolla, CA, ³Pediatrics, University of California San Diego, La Jolla, CA, ⁴Department of Family Medicine and Public Health, University of California, San Diego, La Jolla, CA
Background/Purpose: Use of biologic therapies for rheumatoid arthritis (RA) in pregnancy is common. There is theoretical concern that these medications could interfere with postnatal…
Abstract Number: 1786 • 2017 ACR/ARHP Annual Meeting
Lupus Nephritis Is Linked to Immunity to an Intestinal Commensal Lachnospiracaea Species
Gregg J. Silverman¹, Doua F. Azzouz², Hanane El Bannoudi², Aidana Omarbekova³, Brad H. Rovin⁴, Roberto Caricchio⁵, Alexander Alekseyenko⁶ and Jill P. Buyon², ¹Department of Medicine, New York University School of Medicine, New York, NY, ²Medicine, New York University School of Medicine, New York, NY, ³New York University School of Medicine, New York, NY, ⁴Ohio State University Medical Center, Columbus, OH, ⁵Medicine/Rheumatology, Temple University, Philadelphia, PA, ⁶Medical University of South Carolina, Charleston, SC
Background/Purpose: A transmissible agent has long been suspected in the pathogenesis of SLE, yet the potential contribution of members of the intestinal microbiome to the…
Abstract Number: 1787 • 2017 ACR/ARHP Annual Meeting
Efficacy and Safety of Continuing Versus Withdrawing Adalimumab in Maintaining Remission in Patients with Non-Radiographic Axial Spondyloarthritis
Robert B.M. Landewé¹, Joachim Sieper², Philip J Mease³, Robert D Inman⁴, Xin Wang⁵, Mei Li⁵, Aileen L. Pangan⁵ and Jaclyn K. Anderson⁵, ¹University of Amsterdam, Amsterdam, Netherlands, ²Charité Universitätsmedizin Berlin, Berlin, Germany, ³Swedish Medical Center and University of Washington, Seattle, WA, ⁴Department of Immunology, University of Toronto, Toronto, ON, Canada, ⁵AbbVie Inc., North Chicago, IL
Background/Purpose: It is not known whether TNF blockers can be stopped in non-radiographic (nr-axSpA) patients who are in remission. In ABILITY-1, adalimumab (ADA) significantly improved…
Abstract Number: 1788 • 2017 ACR/ARHP Annual Meeting
Dose Intra-Articular Injection of Corticosteroids Increase the Risk of Knee Osteoarthritis Progression? Data from the Osteoarthritis Initiative
Guang-hua Lei¹, Chao Zeng¹, Jie Wei^2,3, Yi-lun Wang¹ and Dong-xing Xie¹, ¹Department of orthopaedics, Xiangya Hospital, Central South University, Changsha, China, ²Health Management Center, Xiangya Hospital, Central South University, Changsha, China, ³Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China
Background/Purpose: Although intra-articular injection of corticosteroids (IAIC) has been one of the modalities of treatment for symptomatic knee OA, the recommendations for its use are…
Abstract Number: 1789 • 2017 ACR/ARHP Annual Meeting
Improved Survival with Transplantation in Granulomatosis with Polyangiitis in the United States: Data from the US Renal Data System
Zachary S. Wallace¹, Rachel Wallwork², Leo Lu³, John H. Stone⁴, Yuqing Zhang⁵ and Hyon K. Choi⁶, ¹Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²Department of Medicine, Massachusetts General Hospital, Boston, MA, ³Allergy, Immunology, and Rheumatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁴Massachusetts General Hospital Rheumatology Unit, Harvard Medical School, Boston, MA, ⁵Department of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁶Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
Improved Survival with Transplantation in Granulomatosis with Polyangiitis in the United States: Data from the US Renal Data SystemBackground/Purpose: Granulomatosis with polyangiitis (GPA) is a…
Abstract Number: 1790 • 2017 ACR/ARHP Annual Meeting
Sphingosine -1 Phosphate Receptor-1-Mediated Endothelial Cell Barrier Function Protects Against Immune Complex-Induced Vascular Injury: A Potential Novel Therapeutic Target for SLE
Nathalie Burg¹, Steven Swendeman², Stefan Worgall³, Timothy Hla² and Jane E. Salmon¹, ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Boston Children's Hospital, Boston, MA, ³Pediatrics/ Pulmonary, Weill Cornell Medical Center, New York, NY
Background/Purpose: Sphingosine 1-phosphate (S1P), a bioactive lysophospholipid, is important for vascular homeostasis via signaling through S1P receptors. HDL-bound apolipoprotein M (ApoM) is a physiological S1P…
Abstract Number: 1791 • 2017 ACR/ARHP Annual Meeting
TET1 Is an Important Transcriptional Activator of the Tnfa Locus in Macrophages
Emmanuel Karouzakis¹, Fangfang Sun², Agnieszka Pajak¹, Shuang Ye², Steffen Gay¹, Oliver Distler³ and Michel Neidhart¹, ¹Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Department of Rheumatology, Renji Hospital South Campus, School of Medicine, Shanghai Jiao Tong University, Shanghai, China, ³Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland
Background/Purpose: Activated macrophages are found in the inflamed and hyperplastic synovial RA tissue. Macrophages are the main producers of high levels of pro-inflammatory cytokines such…

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