Abstracts Archive - Page 1324 of 2607 - ACR Meeting Abstracts

Abstract Number: 2066 • 2018 ACR/ARHP Annual Meeting
Serum IL-37 Is an Efficient Biomarker of Disease Activity and Treatment Response in Patients with Ankylosing Spondylitis
Ga Young Ahn¹, Su Man Kang², Juyeon Kang¹, Bora Nam¹, Hyuk-Hee Kwon¹, Tae-Hwan Kim³ and Dae-Hyun Yoo¹, ¹Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea, Republic of (South), ²Institute of Rheumatology, Hanyang University, Seoul, Korea, Republic of (South), ³Rheumatology, The Hospital for Rheumatic Diseases, Hanyang University, Seoul, Korea, Seoul, Korea, Republic of (South)
Background/Purpose: The measurement of disease activity is mainly dependent on the patient-reported outcome measures in ankylosing spondylitis (AS) patients. Current inflammatory biomarkers have insufficient sensitivity…
Abstract Number: 2067 • 2018 ACR/ARHP Annual Meeting
Dysbiosis-Dependent Inflammasomes Activation Drives Innate Immune Responses in Ankylosing Spondylitis Patients
Francesco Ciccia¹, Giuliana Guggino¹, Aroldo Rizzo², Stefania Raimondo³, Simon Milling⁴ and Riccardo Alessandro³, ¹Rheumatology Unit, University of Palermo, Palermo, Italy, ²Azienda Ospedaliera Ospedali Riuniti Villa Sofia Cervello, Palermo, Italy, ³University of Palermo, Palermo, Italy, ⁴University of Glasgow, Glasgow, United Kingdom
Background/Purpose: A growing body of evidences indicate that the aberrant activation of innate immune systems, occurring in genetically predisposed patients, drives inflammatory processes in Ankylosing…
Abstract Number: 2068 • 2018 ACR/ARHP Annual Meeting
The Role of Extracellular Matrix Metalloproteinase Inducer Emmprin in the Pathogenesis of Psoriatic Arthritis
Devy Zisman^1,2, Mirna Saphieh², Joy Feld³, Amir Haddad³, Muna Elias³, Alina Kaganovitch³, Idit Lavi⁴ and Michal Amit Rahat^2,5, ¹Technion, Rheumatology Unit Carmel Medical Center, Haifa, Israel, ²The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel, ³Rheumatology Unit Carmel Medical Center, Haifa, Israel, ⁴Epidemiology Unit Carmel Medical Center, Haifa, Israel, ⁵Immunotherapy Laboratory Carmel Medical Center, Haifa, Israel
Background/Purpose: Angiogenesis is an essential component in the pathogenesis of psoriatic arthritis (PsA). Extracellular matrix metalloproteinase inducer (EMMPRIN) is a multifunctional protein that can enhance…
Abstract Number: 2069 • 2018 ACR/ARHP Annual Meeting
The Epigenetic Regulator Sirtuin-1 Modulates T-Helper 17 Cell Differentiation in Axial Spondyloarthritis
Sarah Unterberger¹, Patrizia Fasching², Elisabeth Fliesser¹, Angelika Lackner³, Christian Dejaco², Winfried Graninger³, Martin Stradner² and Johannes Fessler^4,5, ¹Div. of Rheumatology and Immunology, Medical University of Graz, Graz, Austria, ²Department of Rheumatology and Immunology, Medical University of Graz, Graz, Austria, ³Rheumatology and Immunology, Medical University of Graz, Graz, Austria, ⁴Dep. of Rheumatology and Immunology, Medical University of Graz, Graz, Austria, ⁵Department of Neurology, Harvard Medical School, Boston, MA
Background/Purpose: The NAD+ -dependent protein/histone deacetylase Sirtuin 1 (SIRT1) acts as an epigenetic regulator and has recently been reported to be involved in the development…
Abstract Number: 2070 • 2018 ACR/ARHP Annual Meeting
Activated Tendon Stromal Cells Drive a Type 17 Immune Response Via CCL20: A Potential Role in the Pathogenesis of Enthesitis in Psoriatic Arthritis
Emma Garcia-Melchor¹, Giacomo Cafaro^2,3, Moeed Akbar¹, Derek Gilchrist¹, Susan M Kitson¹, Stefan Siebert⁴, Iain B. McInnes⁵ and Neal L Millar¹, ¹Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom, ²Institute of Infection, Immunity and Inflammation, University of Glasgow, Glagow, United Kingdom, ³Rheumatology Unit, Department of Medicine, University of Perugia, Perugia, Italy, ⁴Institute of Infection, Immunity and Inflammation, University of Glasgow, Cardiff, United Kingdom, ⁵Immunology, Infection and Inflammation, University of Glasgow, Glasgow, United Kingdom
Background/Purpose: While the exact pathogenesis of psoriatic arthritis (PsA) remains unclear, it is recognised that several environmental factors operate in individuals with genetic susceptibility leading…
Abstract Number: 2071 • 2018 ACR/ARHP Annual Meeting
Inflammation at Distant Immunocompetent Sites Combined with a Protocol of Forced Exercise Induces Mild Joint Inflammation
Giulia Rossana Gulino¹, Margot Van Mechelen^1,2 and Rik Lories^1,2, ¹Skeletal Biology and Engineering Research Center, KU Leuven, Leuven, Belgium, ²Rheumatology, UZ Leuven, Leuven, Belgium
Background/Purpose: Psoriatic arthritis is a chronic joint disease clinically associated with psoriasis. Some patients also have signs of inflammatory bowel disease. Enthesitis, inflammation at the…
Abstract Number: 2072 • 2018 ACR/ARHP Annual Meeting
Beneficial Effect of Combination Therapy of Etanercept with Non-Steroidal Anti-Inflammatory Drugs Compared to Etanercept Monotherapy in a Spondyloarthritis Animal Model
Seung-Cheol Shim¹, Ji-Young Kim², Seung Taek Song³, Jin-Sun Choi², Chan Keol Park⁴ and In-Seol Yoo¹, ¹Division of Rheumatology, Department of Internal Medicine, Daejeon Rheumatoid & Degenerative Arthritis Center, Chungnam National University Hospital, Daejeon, Korea, Republic of (South), ²Division of Rheumatology, Daejeon Rheumatoid & Degenerative Arthritis Center, Chungnam National University Hospital, Daejeon, Korea, Republic of (South), ³Department of Rheumatology, Cheongju St. Mary's Hospital, Cheongju, Korea, Republic of (South), ⁴Internal medicine, Daejeon Rheumatoid & Degenerative Arthritis Center, Chungnam National University Hospital, Daejeon, Korea, Republic of (South)
Background/Purpose: Non-steroidal anti-inflammatory drugs (NSAIDs) are recommended as first-line drug treatment of spondyloarthritis (SpA) which is frequently associated with inflammatory bowel disease. Biologic disease modifying…
Abstract Number: 2073 • 2018 ACR/ARHP Annual Meeting
Role of miRNA-21-5p As a Potential Biomarker for the Inflammation Pathway in Psoriatic Disease and Response to Methotrexate Treatment
Rohan Machhar¹, Justine Y. Ye², Vinod Chandran² and Dafna D Gladman³, ¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³Toronto Psoriatic Arthritis Research Program, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: Psoriatic arthritis (PsA) is an inflammatory arthritis occurring in patients with psoriasis. miRNAs are small non coding RNAs whose main function, at a post…
Abstract Number: 2074 • 2018 ACR/ARHP Annual Meeting
Micrornas Deregulation in Monocytes and T CD4 Lymphocytes from Patients with Axial Spondyloarthritis
Olivier Fogel¹, Andreas Bugge Tinggaard², Maud Fagny¹, Nelly Sigrist³, Elodie Roché³, Laurence Leclère³, Jean-François Deleuze⁴, Maxime Dougados⁵, Corinne Miceli-Richard^6,7 and Jorg Tost¹, ¹Centre National de Recherche en Génomique Humaine, Institut François Jacob, CEA, Laboratory for Epigenetics and Environment, Evry, France, ²Aarhus University, Department of Biomedicine, Aarhus, Denmark, ³Laboratory for Epigenetics and Environment, Evry, France, ⁴Centre National de Recherche en Génomique Humaine, Evry, France, ⁵Paris Descartes University, Hôpital Cochin, Paris, France, ⁶Department of Immunology, Pasteur Institute, Immunoregulation Unit, Paris, France, ⁷Department of Rheumatology, Paris Descartes University, Hôpital Cochin, Paris, France
Background/Purpose: MicroRNAs have been shown to play a crucial role during innate or adaptive immune response. Deregulation of miRNAs has been described in several autoimmune…
Abstract Number: 2075 • 2018 ACR/ARHP Annual Meeting
Vascular Endothelial and Inflammatory Differences in Psoriasis and Psoriatic Arthritis Patients
Michael Gashick¹, Todd Wechter², Tessa Barrett¹, Sarah Azarchi², Stuart Katz³, Andrea L. Neimann⁴, James Krueger⁵, Sanja Jelic⁶, Edward Fisher¹, Jose U. Scher⁷ and Jeffrey S. Berger⁸, ¹Medicine/Cardiology, New York University School of Medicine, New York City, NY, ²Dermatology, New York University School of Medicine, New York City, NY, ³Medicine/Cardiology, New York University School of Medicine, New York, NY, ⁴Department of Dermatology, New York University School of Medicine, New York, NY, ⁵The Rockefeller University, New York, NY, ⁶Medicine/Pulmonary, Columbia University Medical Center, New York City, NY, ⁷New York University School of Medicine, New York, NY, ⁸Medicine, Division of Cardiology, New York University School of Medicine, New York, NY
Background/Purpose: Psoriatic arthritis (PsA) and Psoriasis (PsO) are chronic inflammatory diseases associated with vascular inflammation and increased CVD risk. Few studies have examined vascular inflammatory…
Abstract Number: 2076 • 2018 ACR/ARHP Annual Meeting
Transmembrane TNF (tmTNF) Transgenic Mice Exhibit Enlarged Lymph Nodes and Elevated Numbers of High Endothelial Cells Associated with Increased Lymphocyte Recruitment
Kim Jeucken¹, Jan Piet van Hamburg², Merlijn Kaaij³, Leonie van Duivenvoorde³, Dominique Baeten³ and Sander W. Tas², ¹2Department of Clinical Immunology & Rheumatology and Laboratory for Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ²Amsterdam Rheumatology & immunology Center | Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ³Department of Clinical Immunology & Rheumatology and Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: The NF-κB family of transcription factors plays a crucial role in chronic inflammatory diseases and can be activated via two distinct pathways. Non-canonical NF-κB…
Abstract Number: 2077 • 2018 ACR/ARHP Annual Meeting
Pathological Osteogenesis and Inflammation in Experimental Spondyloarthritis Are Associated with Aberrant Type H Blood Vessels and Development of High Endothelial Venules Accompanied By Ectopic Lymphoid Structures in Bone Marrow
Merlijn Kaaij¹, Jan Piet van Hamburg², George Kollias³, Dominique Baeten¹, Leonie van Duivenvoorde¹ and Sander W. Tas², ¹Department of Clinical Immunology & Rheumatology and Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ²Amsterdam Rheumatology & immunology Center | Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ³Department of Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece
Background/Purpose: Spondyloarthritis (SpA) is characterized by pathological osteogenesis, inflammation and extensive angiogenesis in inflamed tissues. TNF plays a central role in SpA pathology and transgenic…
Abstract Number: 2078 • 2018 ACR/ARHP Annual Meeting
Induction of Netosis in Ankylosing Spondylitis: Association to Disease Pathogenesis and Modulation By Anti-Tnfα Therapy
Patricia Ruiz-Limon¹, M. Carmen Castro-Villegas², Chary Lopez-Pedrera³, Rafaela Ortega-Castro⁴, Maria Carmen Abalos-Aguilera¹, Nuria Barbarroja⁴, Carlos Perez-Sanchez⁴, Ivan Arias de la Rosa¹, Alejandro Ibáñez-Costa³, Alejandra Maria Patiño-Trives³, Daniel Espejo-Peralbo¹, Pilar Font-Ugalde⁴, Jose Antonio Gonzalez-Reyes⁵, Jose Manuel Villalba⁵, Clementina López-Medina⁴, Alejandro Escudero-Contreras¹, Eduardo Collantes-Estévez⁴ and Yolanda Jiménez-Gómez⁴, ¹Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ²Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Córdoba, Spain, ³IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ⁴Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ⁵Departamento de Biologia Celular, Fisiologia e Inmunología, University of Córdoba, Cordoba, Spain
Background/Purpose: NETosis has been suggested to play a central role in several rheumatology diseases. Nevertheless, this process, and its modulation in therapeutic response has not…
Abstract Number: 2079 • 2018 ACR/ARHP Annual Meeting
Dysbiosis of Gut Microbiomes in Ankylosing Spondylitis
Chen Zhou¹, Xuan Zhang² and Xiao Xinyue¹, ¹Peking Union Medical College Hospital, Beijing, China, ²Rheumatology, Peking Union Medical College Hospital, Beijing, China
Background/Purpose: Ankylosing spondylitis (AS) is a common chronic, systemic, inflammatory disease. Gut microbiome has been reported to play an important role in the homeostasis of…
Abstract Number: 2080 • 2018 ACR/ARHP Annual Meeting
Plasmatic Glycoprotein and Lipoprotein Nuclear Magnetic Resonance Profiles Associated with Psoriatic Arthritis
Antonio Julià¹, Jose A Pinto-Tasende², Jordi Gratacós³, Rubén Queiro⁴, Carlos Alberto Montilla-Morales⁵, Juan Carlos Torre-Alonso⁶, Jose Javier Perez Venegas⁷, Antonio Fernandez-Nebro⁸, Emília Fernández⁹, Santiago Muñoz-Fernández¹⁰, Carlos M Gonzalez¹¹, Daniel Roig¹², Pedro Zarco¹³, Alba Erra¹⁴, Jesus Rodriguez¹⁵, Santos Castañeda¹⁶, Esteban Rubio-Romero¹⁷, Georgina Salvador¹⁸, Cesar Diaz-Torné¹⁹, Ricardo Blanco²⁰, Alfredo Willisch²¹, José Antonio Mosquera²², Paloma Vela²³, Jesús Tornero²⁴, Simón Sánchez-Fernández²⁵, Hector Corominas²⁶, Julio Ramírez²⁷, María López-Lasanta¹, Raül Tortosa¹, Núria Palau¹, Juan D. Cañete²⁸ and Sara Marsal¹, ¹Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain, ²Complejo Hospitalario Universitario de A Coruña, A Coruña, Spain, ³Rheumatology Department, Hospital Parc Taulí, Sabadell (Barcelona), Spain, ⁴Rheum-Derm Unit, Hospital Universitario Central de Asturias, Oviedo, Spain, ⁵Hospital Clínico Universitario de Salamanca. Spain, Salamanca, Spain, ⁶Unit Rheumatology, Hospital Monte Naranco, Oviedo, Spain, ⁷Rheumatology, Hospital de Jerez de la Frontera, Jerez de la Frontera, Spain, ⁸UGC de Reumatología, Instituto de Investigación Biomédica de Málaga (IBIMA) Hospital Regional Universitario de Málaga Departamento de Medicina y Dermatología, Universidad de Málaga, MÁLAGA, Spain, ⁹Hospital Universitario Infanta Sofía, Madrid, Spain, ¹⁰Hospital Universitario Infanta Sofia. Madrid. Spain, Mardid, Spain, ¹¹Servicio de Reumatología, Hospital General Universitario Gregorio Marañón, Madrid, Spain, ¹²Rheumatology Service, Hospital Universitari de Bellvitge, Hospitalet de Llobregat- Barcelona, Spain, ¹³H Fundación Alcorcón, Alcorcón, Spain, ¹⁴Rheumatology Department, Hospital Sant Rafael, Barcelona, Spain, ¹⁵Rheumatology, Hospital Universitari de Bellvitge, Barcelona, Spain, ¹⁶Hospital Universitario La Princesa, IIS-Princesa, Madrid, Spain, ¹⁷Hospital Universitario Virgen del Rocío. Sevilla. Spain, Sevilla, Spain, ¹⁸Rheumatology Unit., Hospital Mutua de Terrassa. Barcelona, Barcelona, Spain, ¹⁹Rheumatology Department, Hospital Universitari de la Santa Creu i Sant Pau, Barcelona, Spain, ²⁰Rheumatology Department,, Hospital Marqués de Valdecilla, Santander, Spain, ²¹Complexo Hospitalario de Ourense, Ourense, Spain, ²²Complejo Hospitalario Provincial de Pontevedra, Pontevedra, Spain, ²³Hospital General Universitario de Alicante, Alicante, Spain, ²⁴Rheumatology Department, Hospital Universitario Guadalajara, Guadalajara, Spain, ²⁵Rheumatology Department, Hospital General La Mancha Centro, Ciudad Real, Spain, ²⁶Rheumatology, Hospital Universitari de la Santa Creu i Sant Pau, Barcelona, Spain, ²⁷Rheumatology, Hospital Clínic de Barcelona, Barcelona, Spain, ²⁸Rheumatology Deparment, Hospital Clinic and IDIBAPS, Barcelona, Spain, Barcelona, Spain
Background/Purpose: Psoriatic arthritis (PsA) is an autoimmune disease characterized by the chronic inflammation of the skin and joints. Inflammatory processes translate into changes of the…

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