Plasmatic Glycoprotein and Lipoprotein Nuclear Magnetic Resonance Profiles Associated with Psoriatic Arthritis

Antonio Julià¹, Jose A Pinto-Tasende², Jordi Gratacós³, Rubén Queiro⁴, Carlos Alberto Montilla-Morales⁵, Juan Carlos Torre-Alonso⁶, Jose Javier Perez Venegas⁷, Antonio Fernandez-Nebro⁸, Emília Fernández⁹, Santiago Muñoz-Fernández¹⁰, Carlos M Gonzalez¹¹, Daniel Roig¹², Pedro Zarco¹³, Alba Erra¹⁴, Jesus Rodriguez¹⁵, Santos Castañeda¹⁶, Esteban Rubio-Romero¹⁷, Georgina Salvador¹⁸, Cesar Diaz-Torné¹⁹, Ricardo Blanco²⁰, Alfredo Willisch²¹, José Antonio Mosquera²², Paloma Vela²³, Jesús Tornero²⁴, Simón Sánchez-Fernández²⁵, Hector Corominas²⁶, Julio Ramírez²⁷, María López-Lasanta¹, Raül Tortosa¹, Núria Palau¹, Juan D. Cañete²⁸ and Sara Marsal¹, ¹Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain, ²Complejo Hospitalario Universitario de A Coruña, A Coruña, Spain, ³Rheumatology Department, Hospital Parc Taulí, Sabadell (Barcelona), Spain, ⁴Rheum-Derm Unit, Hospital Universitario Central de Asturias, Oviedo, Spain, ⁵Hospital Clínico Universitario de Salamanca. Spain, Salamanca, Spain, ⁶Unit Rheumatology, Hospital Monte Naranco, Oviedo, Spain, ⁷Rheumatology, Hospital de Jerez de la Frontera, Jerez de la Frontera, Spain, ⁸UGC de Reumatología, Instituto de Investigación Biomédica de Málaga (IBIMA) Hospital Regional Universitario de Málaga Departamento de Medicina y Dermatología, Universidad de Málaga, MÁLAGA, Spain, ⁹Hospital Universitario Infanta Sofía, Madrid, Spain, ¹⁰Hospital Universitario Infanta Sofia. Madrid. Spain, Mardid, Spain, ¹¹Servicio de Reumatología, Hospital General Universitario Gregorio Marañón, Madrid, Spain, ¹²Rheumatology Service, Hospital Universitari de Bellvitge, Hospitalet de Llobregat- Barcelona, Spain, ¹³H Fundación Alcorcón, Alcorcón, Spain, ¹⁴Rheumatology Department, Hospital Sant Rafael, Barcelona, Spain, ¹⁵Rheumatology, Hospital Universitari de Bellvitge, Barcelona, Spain, ¹⁶Hospital Universitario La Princesa, IIS-Princesa, Madrid, Spain, ¹⁷Hospital Universitario Virgen del Rocío. Sevilla. Spain, Sevilla, Spain, ¹⁸Rheumatology Unit., Hospital Mutua de Terrassa. Barcelona, Barcelona, Spain, ¹⁹Rheumatology Department, Hospital Universitari de la Santa Creu i Sant Pau, Barcelona, Spain, ²⁰Rheumatology Department,, Hospital Marqués de Valdecilla, Santander, Spain, ²¹Complexo Hospitalario de Ourense, Ourense, Spain, ²²Complejo Hospitalario Provincial de Pontevedra, Pontevedra, Spain, ²³Hospital General Universitario de Alicante, Alicante, Spain, ²⁴Rheumatology Department, Hospital Universitario Guadalajara, Guadalajara, Spain, ²⁵Rheumatology Department, Hospital General La Mancha Centro, Ciudad Real, Spain, ²⁶Rheumatology, Hospital Universitari de la Santa Creu i Sant Pau, Barcelona, Spain, ²⁷Rheumatology, Hospital Clínic de Barcelona, Barcelona, Spain, ²⁸Rheumatology Deparment, Hospital Clinic and IDIBAPS, Barcelona, Spain, Barcelona, Spain

Meeting: 2018 ACR/ARHP Annual Meeting

Keywords: Glycoproteins and psoriatic arthritis

Session Information

Date: Tuesday, October 23, 2018

Title: Spondyloarthritis Including Psoriatic Arthritis – Basic Science Poster

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose:

Psoriatic arthritis (PsA) is an autoimmune disease characterized by the chronic inflammation of the skin and joints. Inflammatory processes translate into changes of the serum protein profiles, including changes in lipoprotein and glycoproteins. Here we investigate the association of plasmatic lipoprotein and glycoprotein profiles with PsA.

Methods:

Plasma samples were obtained from 50 PsA patients -classified according to CASPAR – and 50 healthy controls. Lipoprotein and glycoprotein profiles were determined using NMR. For the lipoprotein profiles, VLDL, LDL, IDL and HDL concentration, lipid composition and particle properties were quantified. The glycoprotein profile was decomposed in four reproducible peak regions: LMW, Glyc-B, Glyc-A, Glyc-Lipid and baseline. Association analysis to disease was performed using logistic regression. Classifiers were built using rpart and accuracy was evaluated using ROCs.

Results:

We found a significant reduction on cholesterol and triglyceride IDL and LDLs in PsA patients compared to healthy controls (P<0.05). This was accompanied by a reduction also in the particle number for IDL and LDLs(P<0.005). Substantial number of changes were also observed in the plasma glycoprotein patterns, including a decrease of Gly-A and Glyc-Lipid peaks (P<0.05).. Using the plasma molecular patterns to predict the presence of PsA, we found a significant classifier for the lipoprotein pattern (ROC(95%CI) = 0.87(0.81-0.94)), and an optimal classifier for the glycoprotein pattern (ROC(95%CI) = 0.91(0.85-0.97)).

Conclusion:

Our results support that plasma NMR profiling could be a source of new useful biomarkers for PsA diagnosis and management.

Disclosure: A. Julià, None; J. A. Pinto-Tasende, None; J. Gratacós, None; R. Queiro, None; C. A. Montilla-Morales, None; J. C. Torre-Alonso, None; J. J. Perez Venegas, None; A. Fernandez-Nebro, None; E. Fernández, None; S. Muñoz-Fernández, None; C. M. Gonzalez, None; D. Roig, None; P. Zarco, None; A. Erra, None; J. Rodriguez, None; S. Castañeda, None; E. Rubio-Romero, None; G. Salvador, None; C. Diaz-Torné, None; R. Blanco, None; A. Willisch, None; J. A. Mosquera, None; P. Vela, None; J. Tornero, None; S. Sánchez-Fernández, None; H. Corominas, None; J. Ramírez, None; M. López-Lasanta, None; R. Tortosa, None; N. Palau, None; J. D. Cañete, AbbVie, Boehringer, 9; S. Marsal, None.

To cite this abstract in AMA style:

Julià A, Pinto-Tasende JA, Gratacós J, Queiro R, Montilla-Morales CA, Torre-Alonso JC, Perez Venegas JJ, Fernandez-Nebro A, Fernández E, Muñoz-Fernández S, Gonzalez CM, Roig D, Zarco P, Erra A, Rodriguez J, Castañeda S, Rubio-Romero E, Salvador G, Diaz-Torné C, Blanco R, Willisch A, Mosquera JA, Vela P, Tornero J, Sánchez-Fernández S, Corominas H, Ramírez J, López-Lasanta M, Tortosa R, Palau N, Cañete JD, Marsal S. Plasmatic Glycoprotein and Lipoprotein Nuclear Magnetic Resonance Profiles Associated with Psoriatic Arthritis [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 9). https://acrabstracts.org/abstract/plasmatic-glycoprotein-and-lipoprotein-nuclear-magnetic-resonance-profiles-associated-with-psoriatic-arthritis/. Accessed .

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