Abstracts Archive - Page 1310 of 2425 - ACR Meeting Abstracts

Abstract Number: 1567 • 2017 ACR/ARHP Annual Meeting
A Mitogen-Associated Protein Kinase (MAPK) Associated Kinase 2 Inhibitor Decreases in Vitro Th17 and Monocyte Inflammatory Responses in Spondyloarthritis
Davide Simone, Hui Shi, Nuha Ansar, Alison Davies, Karen Doig and Paul Bowness, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom
Background/Purpose: The current biologic treatment for Ankylosing Spondylitis (AS) and Psoriatic Arthritis (PsA) are limited to TNF-a inhibitors (TNFi) and, more recently, IL-17A monoclonal antibodies.…
Abstract Number: 1568 • 2017 ACR/ARHP Annual Meeting
Existence of IL-6 and IL-17 Mediated Inflammation Amplifier Loop in Reactive Arthritis
Ramnath Misra¹, Sandeep Kumar², Rajeev Singh³, Abhisek Singh⁴, Daisuke Kamimura⁵, Smriti Chaurasia², Yasunobu Aria⁶, Tori Austria⁷, Ratnadeep Mukherjee⁸, Balachandran Ravindran⁹, Vikas Agarwal² and Masaaki Murakami¹⁰, ¹Clinical Immunology, Sanjay Gandhi Postgraduate of Medical Sciences, Lucknow, India, ²Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, ³Biochemistry, King George Medical University, Lucknow, India, ⁴Division of Molecular Neroimmunology, Post Doctoral Fellow, Sapporo, Japan, ⁵Molecular Neuroimmunology, Lecturer, Sapporo 060-0815,, Japan, ⁶Division of Molecular Neuroimmunology, Assistant Professor, Sapporo 060-0815, Japan, ⁷Division of Molecular Neuroimmunology, Special appointed - Assistant Professor, Sapporo 060-0815, Japan, ⁸Institute of Life Sciences, Ph D student, Bhubaneswar, India, ⁹Institute of Life Sciences, Distinguished Scientist, Bhubaneswar, India, ¹⁰Institute of Genetic Medicine, Director, Sapporo 060-0815, Japan
Background/Purpose: F759 mice with a single amino-acid substitution in signal transducer subunit of IL-6 receptor gp130 (Y759F) develops arthritisspontaneously due to IL-17A and IL-6 mediated…
Abstract Number: 1569 • 2017 ACR/ARHP Annual Meeting
Isotretinoin Induced Seronegative Spondyloarthropathy: Magnetic Resonance Imaging As Diagnostic and Prognostic Biomarker
Basant Elnady^1,2, Dalia Desouky^3,4, Tohamy Elkhouly^5,6, Noha Dawoud^7,8 and Hanady Kewan^9,10, ¹Assistant professor of rheumatology and rehabilitation, department of rheumatology and rehabilitation ، faculty of medicine, Benha university, Benha, Egypt, ²Rheumatology consultant ,Rheumatology division ,Al Hada Armed Forcec Hospital, Taif, Saudi Arabia, ³Assistant professor of public health and community medicine,department of public health and community medicine,Faculty of medicine, menoufia University, menoufia, Egypt, ⁴Assistant professor of public health and community medicine, department of family and community medicine، faculty of medicine, taif university, Taif, Saudi Arabia, ⁵Assistant professor of radiology, radiology department ، faculty of medicine, Benha university, Benha, Egypt, ⁶Radiology consultant , Department of radiology ,Alhada Armed Forces Hospital, Taif, Saudi Arabia, ⁷department of dermatology , andrology, and STDs, faculty of medicine, Menoufia university, menoufia, Egypt, ⁸department of dermatology, Alhada armed forces hospital, Tafi, Ksa, taif, Saudi Arabia, ⁹Department of radio-diagnosis, Faculty of medicine, Mansoura University., Mansoura, Egypt, ¹⁰Radiology consultant ,Department of radiology, Al Hada Armed Forces Hopital, taif, Saudi Arabia
Background/Purpose: Recent data has revealed occurrence of musculoskeletal manifestations in particular sacroiliitis and inflammatory back pain (IBP) secondary to isotretinoin therapy for acne valgaris, accordingly…
Abstract Number: 1570 • 2017 ACR/ARHP Annual Meeting
Monocytes from Male Patients with Ankylosing Spondylitis Display Decreased Osteoclastogenesis and Decreased RANKL/OPG Ratio
Valéria F. Caparbo¹, Carla G.S. Saad¹, Julio C. B. Moraes², Artur J de Brum-Fernandes³ and Rosa M R Pereira⁴, ¹Rheumatology Division, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil, ²Rheumatology Division, Faculdade de Medicina da Universidade de Sao Paulo, São Paulo, Brazil, ³Rheumatology Division, Université de Sherbrooke, Rheumatology Division, Canada, Sherbrooke, QC, Canada, ⁴Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil
Background/Purpose: Ankylosing Spondylitis (AS) is a chronic inflammatory disease characterized by new bone growth that leads to syndesmophyte formation and subsequent vertebral ankyloses, although AS…
Abstract Number: 1571 • 2017 ACR/ARHP Annual Meeting
Bimekizumab Dual Inhibition of IL-17A and IL-17F Provides Evidence of IL-17F Contribution to Chronic Inflammation in Disease-Relevant Cells
Ash Maroof¹, Remi Okoye¹, Tim Smallie¹, Dominique Baeten^2,3, Sophie Archer¹, Catherine Simpson¹, Meryn Griffiths¹ and Stevan Shaw¹, ¹UCB Pharma, Slough, United Kingdom, ²UCB Pharma, Brussels, Belgium, ³University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: IL-17A and IL-17F share structural homology and have similar biologic function.1 Although the contribution of IL-17A to immune-mediated inflammatory diseases has been widely reported,1,2…
Abstract Number: 1572 • 2017 ACR/ARHP Annual Meeting
MHC Associations of Ankylosing Spondylitis in East Asians Are Driven By HLA-B Amino-Acid Position 97, Confirming Findings in European Descent Subjects
Geng Wang¹, Adrian Cortes², So-Young Bang³, Paul Leo⁴, Matthew Brown⁴, Tae-Hwan Kim⁵ and Huji Xu¹, ¹Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China, ²Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, ³Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea, Republic of (South), ⁴Translational Genomics Group, Institute of Health and Biomedical Innovation, Queensland University of Technology, Translational Research Institute, Brisbane, Australia, ⁵Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea, Republic of (South)
Background/Purpose: Whilst HLA-B27 is the MHC allele associated with AS, there is strong evidence indicating that other HLA-B alleles and MHC genes are involved in…
Abstract Number: 1573 • 2017 ACR/ARHP Annual Meeting
In Vivo Phosphorylation of p38 in Monocytes Is Enhanced in Patients with Axial Spondyloarthritis (axSpA) at the Time of Diagnosis
Antti Kuuliala^1,2, Krista Kuuliala^1,3, Riitta Koivuniemi^2,4, Mari Hämäläinen⁵, Eeva Moilanen⁶, Hannu Kautiainen⁷, Heikki Repo^1,3 and Marjatta Leirisalo-Repo^2,4, ¹Bacteriology and Immunology, University of Helsinki, Helsinki, Finland, ²Rheumatology, Helsinki University Hospital, Helsinki, Finland, ³Helsinki University Hospital, Helsinki, Finland, ⁴Rheumatology, University of Helsinki, Helsinki, Finland, ⁵The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland, ⁶The Immunopharmacology Research Group, Faculty of Medicine and Life Sciences, University of Tampere and Tampere University Hospital, Tampere, Finland, Tampere, Finland, ⁷Unit of Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
Background/Purpose: Host response to microbes is considered to contribute to the pathogenesis to axSpA and other HLA-B27 associated diseases. The p38 MAP kinase pathway plays…
Abstract Number: 1574 • 2017 ACR/ARHP Annual Meeting
Gut Microbiota Perturbations in Reactive Arthritis
Julia Manasson¹, Nan Shen², Helga R. Garcia Ferrer^3,4, Carles Ubeda⁵, Isa Iraheta^3,4, Adriana Heguy⁶, Joan M. Von Feldt⁷, Luis R. Espinoza⁸, Abraham Garcia Kutzbach⁹, Leopoldo N. Segal¹⁰, Alexis Ogdie¹¹, Jose C. Clemente² and Jose U. Scher¹², ¹Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ²Department of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, ³Guatemalan Association against Rheumatic Diseases (AGAR), Guatemala City, Guatemala, ⁴Universidad Francisco Marroquin, Guatemala City, Guatemala, ⁵Institute for Research in Public Health, Valencia, Spain, ⁶Department of Pathology, New York University Genome Technology Center, New York University School of Medicine, New York, NY, ⁷Hospital of the University of Pennsylvania, Philadelphia, PA, ⁸Internal Medicine, LSU Health Sciences Center, New Orleans, LA, ⁹Internal Medicine, Rheumatology Unit (AGAR), Francisco Marroquin University, School of Medicine, Guatemala City, Guatemala, ¹⁰Department of Medicine, Division of Pulmonary and Critical Care, New York University School of Medicine, New York City, NY, ¹¹Division of Rheumatology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, ¹²New York University School of Medicine, New York, NY
Background/Purpose: Reactive arthritis (ReA) is an inflammatory condition occurring several weeks after gastrointestinal (GI) or genitourinary (GU) infections. HLA-B27 positivity is considered a risk factor,…
Abstract Number: 1575 • 2017 ACR/ARHP Annual Meeting
JMJD3 Epigenetically Regulate Ankylosing Spondylitis Inflammation through Th17 Differentiation
Hongxiao Liu¹, Ziqi Xu¹, Xinghua Feng¹, Xiaoyan Feng², Heqiu Zhang², Quan Jiang¹, Yanan Zhao³, Yuyang Wang¹ and Zhe Zhao¹, ¹Department of Rheumatology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China, ²Department of Vaccine Engineering, Beijing Institute of Basic Medical Sciences, Beijing, China, ³Department of Rheumatology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, BeiJing, China
JMJD3 epigenetically regulate ankylosing spondylitis inflammation through Th17 differentiation Background/Purpose: Inflammation is the initial stage of ankylosing spondylitis (AS), looking for possible inflammatory regulator will…
Abstract Number: 1576 • 2017 ACR/ARHP Annual Meeting
IL-23 Promotes Fecal Microbiota Dysbiosis Associated with Susceptibility to Spondyloarthritis and Ileitis in ZAP-70 Mutant SKG Mice
Linda Rehaume¹, Nicholas Matigian¹, Kate Ormerod², Alicia Kang¹, Richard Linedale¹, Olga Zbarskaya¹, Kristine Kikly³, Joshua Daly², Nancy Lachner², Philip Hugenholtz², Mark Morrison¹, Kim-Anh Lê Cao⁴ and Ranjeny Thomas¹, ¹The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia, ²Australian Centre for Ecogenomics, The University of Queensland, Brisbane, Australia, ³Biotechnology Discovery Research, Eli Lilly and Co, Indianapolis, IN, ⁴School of Mathematics and Statistics, Centre for Systems Genomics, The University of Melbourne, Melbourne, Australia
Background/Purpose: Identification of disease-associated or protective bacteria may elucidate new biomarkers or probiotic supplements for people suffering from SpA, or for people at-risk of disease…
Abstract Number: 1577 • 2017 ACR/ARHP Annual Meeting
Deciphering the Role of the Tissue Microenvironment in Shaping the Immune Landscape in Psoriatic Arthritis
Jin Hui Sherlynn Chan¹, Ying Ying Leung², Warren Fong², Yi Wei Yeo², Bhairav Paleja¹, Liyun Lai¹, Suzan Saidin¹, Camillus Chua¹, Sharifah Nur Hazirah¹, Su Li Poh¹, Andrea Hsiu Ling Low² and Salvatore Albani^1,3, ¹SingHealth Translational Immunology and Inflammation Centre (STIIC), Duke-NUS Medical School, Singapore, Singapore, ²Singapore General Hospital, Singapore, Singapore, ³KK Women's and Children's Hospital, Singapore, Singapore
Background/Purpose: Psoriatic arthritis (PsA) occurs in a third of patients with psoriasis (Ps) and up to 30% of patients with PsA do not have an…
Abstract Number: 1578 • 2017 ACR/ARHP Annual Meeting
The Initiation, but Not the Persistence, of Experimental Spondyloarthritis in HLA-B27/Huβ2m Transgenic Rats Is Crucially Dependent on the IL-23 Axis
Melissa van Tok^1,2, Songqing Na³, Joel Taurog⁴, Dominique Baeten^2,5 and Leonie van Duivenvoorde^1,2, ¹Amsterdam Rheumatology and immunology Center, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ²Clinical Immunology and Rheumatology/Experimental immunology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ³Eli Lilly and Company, Indianapolis, IN, ⁴Dept Int Med-Rheum Dis Div, University of Texas Southwestern Medical Center, Dallas, TX, ⁵Clinical Immunology and Rheumatology, Amsterdam Rheumatology and immunology Center, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: IL-17A is a central driver of spondyloarthritis (SpA) pathology. IL-17A production was originally proposed to be IL-23 dependent. Emerging preclinical and clinical evidence from…
Abstract Number: 1579 • 2017 ACR/ARHP Annual Meeting
Monocyte-Derived Dendritic Cells (MDDCs) from Spondyloarthritis (SpA) Patients Exhbit a Coordinated Downregulation of the Cholesterol (chol) Biosynthesis Pathway That Relates to Lipid Overload
Maxime Breban¹, Clémence Desjardin², Emmanuel Chaplais³, Alice Talpin³, Felicie Costantino⁴, Christophe Hue³, Aude Jobart-Malfait⁵, Benoit Maury⁶, Stanislas Grassin-Delyle³, Nelly Bonilla⁷, Ariane Leboime⁸, Roula Said Nahal⁹, Franck Letourneur⁷, Sébastien Jacques⁷, Anne Boland¹⁰, Jean-François Deleuze¹⁰, Gilles Chiocchia¹¹ and Henri-Jean Garchon^3,6,12, ¹Rheumatology, Ambroise Paré Hospital (AP-HP), Versailles Saint Quentin en Yvelines University, INSERM UMR1173, Boulogne-Billancourt, France, ²INSERM UMR1173, Montigny-le-Bretonneux, France, ³Inserm U1173, Montigny-le-Bretonneux, France, ⁴Hôpital Universitaire Ambroise Pare, Paris, France, ⁵INSERM-U1173, University of Versailles Saint-Quentin-en-Yvelines, France, Montigny-le-Bretonneux, France, ⁶University of Versailles Saint-Quentin, Simone Veil school of Health Sciences, Montigny-le-Bretonneux, France, ⁷Institut Cochin, Inserm U1016, Paris, France, ⁸Ambroise Paré Hospital Division of Rheumatology, Assistance Publique des Hopitaux de Paris, Boulogne-Billancourt, France, ⁹Ambroise Paré Hospital, Boulogne-Billancourt, France, ¹⁰Centre National de Recherche en Génomique Humaine, Evry, France, ¹¹Service d'Immunologie, Ambroise Paré Hospital, University of Versailles Saint-Quentin-en-Yvelines, Boulogne, France, Boulogne-Billancourt, France, ¹²Ambroise Paré Hospital Division of Genetics, AP-HP, Boulogne-Billancourt, France
Background/Purpose: Gene expression studies are useful to investigate the pathogenesis of complex diseases. The critical role of antigen-presenting cells such as dendritic cells (DCs) being…
Abstract Number: 1580 • 2017 ACR/ARHP Annual Meeting
HLA-B27/ Human β2-Microglobulin (β2m) Transgenic Drosophila Expresses Specific Cross-Vein Less (CVL) and Small-Eye Phenotypes Resulting from Disruption of the BMP/TGFβ Signaling Pathway
Benjamin Grandon¹, Nadège Jah², Aurore Rincheval-Arnold³, Isabelle Guénal³, Sébastien Gaumer³, Claudine Andre², Maxime Breban⁴ and Gilles Chiocchia⁵, ¹Inserm UMR 1173 and LGBC, 78180 Saint Quentin en Yvelines, France, ²Infection and inflammation, INSERM UMR1173, Montigny-le-Bretonneux, France, ³Laboratory of Genetic and Cellular Biology, Faculty of Health Sciences Simone Veil, Montigny-le-Bretonneux,, 78180 SAINT QUENTIN EN YVELINES, France, ⁴Rheumatology, Ambroise Paré Hospital (AP-HP), Versailles Saint Quentin en Yvelines University, INSERM UMR1173, Boulogne-Billancourt, France, ⁵Service d'Immunologie, Ambroise Paré Hospital, University of Versailles Saint-Quentin-en-Yvelines, Boulogne, France, Boulogne-Billancourt, France
Background/Purpose: The association between HLA-B27 and spondyloarthritis (SpA) remains unexplained more than 40 years after its discovery. To further explore the pathogenic role of HLA-B27,…
Abstract Number: 1581 • 2017 ACR/ARHP Annual Meeting
Differential Involvement of Synovial and Entheseal Inflammation in Mediating Pathological IL23 Axis Signaling in Spondyloarthritis
Ed Purdue¹, Josselyn Galdamez¹, Madeline Epsten², Rima Abhyankar³, Kathleen Hoyt⁴, Michelle Lewis⁴, Devan Dove⁴, Jon Hill⁵, Alexander Klimowicz⁴, Gerald Nabozny⁶, Joseph Wahle⁴ and Lisa A. Mandl⁷, ¹Research, Hospital for Special Surgery, New York, NY, ²Rheumatology, Hospital for Special Surgery, New York, NY, ³Hospital for Special Surgery, New York, NY, ⁴Department of Immunology and respiratory discovery research, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ⁵Department of Discovery research, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ⁶[email protected], Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ⁷Rheumatology, Hospital for Special Surgery/Weill Cornell Medicine, New York, NY
Background/Purpose: Although accumulating evidence continues to point toward a critical role for IL23 signaling in spondyloarthritis (SpA), the cellular and molecular events involved, as well…

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