Abstracts Archive - Page 1232 of 2607 - ACR Meeting Abstracts

Abstract Number: 685 • 2018 ACR/ARHP Annual Meeting
Changes in Key Laboratory Values with Tofacitinib 5mg BID Treatment in Patients with Psoriatic Arthritis and Rheumatoid Arthritis
William FC Rigby¹, Gerd R. Burmester², Oliver FitzGerald³, Valderilio F Azevedo⁴, Peter Nash⁵, Thijs Hendrikx⁶, Daniela Graham⁷, Cunshan Wang⁷ and Thomas Jones⁶, ¹Geisel School of Medicine at Dartmouth, Lebanon, NH, ²Charité – University Medicine Berlin, Berlin, Germany, ³Department of Rheumatology, St Vincent’s University Hospital, and Conway Institute for Biomolecular Research, University College, Dublin, Ireland, ⁴Universidade Federal do Paraná, Curitiba, Brazil, ⁵University of Queensland, Brisbane, Australia, ⁶Pfizer Inc, Collegeville, PA, ⁷Pfizer Inc, Groton, CT
Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor for the treatment of psoriatic arthritis (PsA) and rheumatoid arthritis (RA). In most countries where tofacitinib is…
Abstract Number: 686 • 2018 ACR/ARHP Annual Meeting
Five-Year Efficacy and Safety of Apremilast Treatment in Subjects with Psa: A Pooled Analysis of the 3 Phase III Studies
Arthur Kavanaugh¹, Dafna D Gladman², Christopher J. Edwards³, Georg Schett⁴, Benoit Guerette⁵, Nikolay Delev⁵, Lichen Teng⁵, Maria Paris⁵ and Philip J. Mease⁶, ¹University of California, San Diego, School of Medicine, La Jolla, CA, ²Krembil Research Institute, Toronto Western Hospital, Toronto, ON, Canada, ³University of Southampton, Southampton, United Kingdom, ⁴Friedrich-Alexander-Universität Erlangen, Nürnberg und Universitätsklinikum Erlangen, Erlangen, Germany, ⁵Celgene Corporation, Summit, NJ, ⁶Swedish Medical Center and University of Washington School of Medicine, Seattle, WA
Background/Purpose: Long-term apremilast (APR) efficacy and safety were evaluated for up to 5 yrs in adults with active PsA in the phase III PALACE 1-3…
Abstract Number: 687 • 2018 ACR/ARHP Annual Meeting
Clinical Characteristics of Spondyloarthritis Patients in Japan in Comparison to Other Regions of the World
Haruki Sawada¹, Kazuki Yoshida², Naomi Ichikawa³, Hisashi Inoue⁴, Yuko Kaneko⁵, Taku Kawasaki⁶, Kazuo Matsui⁷, Mitsuhiro Morita⁸, Kurisu Tada⁹, Naoho Takizawa¹⁰, Naoto Tamura⁹, Atsuo Taniguchi³, Yoshinori Taniguchi¹¹, Shigeyoshi Tsujii¹², Yoichiro Haji¹³, Masei Suda¹⁴, Haruyuki Yanaoka¹⁵, Ryo Rokutanda¹⁴, Masato Okada¹⁴, Clementina López Medina¹⁶, Anna Molto¹⁷, Maxime Dougados¹⁶, Désirée van der Heijde¹⁸, Shigeto Kobayashi¹⁹, Tetsuya Tomita²⁰ and Mitsumasa Kishimoto¹⁴, ¹Immuno-rheumatology Center, St. Luke's International Hospital, Tokyo, Japan, ²Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, ³Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ⁴Department of Orthopedic Surgery, Juntendo University School of Medicine, Tokyo, Japan, ⁵Department of Internal Medicine, Division of Rheumatology, Keio University School of Medicine, Tokyo, Japan, ⁶Department of Orthopedic Surgery, Shiga University of Medical Science, Shiga, Japan, ⁷Department of Rheumatology, Tonan Hospital, Hokkaido, Japan, ⁸Department of Orthopedic Surgery, Fujita Health University, Aichi, Japan, ⁹Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, ¹⁰Department of Rheumatology, Chubu Rosai Hospital, Aichi, Japan, ¹¹Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi, Japan, ¹²Department of Orthopedics, Osaka Minami Medical Center, Osaka, Japan, ¹³Department of Rheumatology, Daido Hospital, Aichi, Japan, ¹⁴Immuno-Rheumatology Center, St. Luke's International Hospital, Tokyo, Japan, ¹⁵St. Luke's International Hospital, Tokyo, Japan, ¹⁶Department of Rheumatology, Paris Descartes University, Cochin Hospital, Paris, France, ¹⁷Department of Rheumatology, Paris Descartes University, Cochin Hospital, Paris, Japan, ¹⁸Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ¹⁹Department of Internal Medicine, Juntendo University Koshigaya Hospital, Saitama, Japan, ²⁰Department of Orthopaedic Biomaterial Science, Osaka University Graduate School of Medicine, Osala, Japan
Background/Purpose: To delineateclinical characteristicsof patients with spondyloarthritis (SpA) in Japan in comparison to other areas of the world. Methods: Utilizingthe COMOSPA data, an international cross-sectional…
Abstract Number: 688 • 2018 ACR/ARHP Annual Meeting
Real Life Analysis of a Latin America Tertiary Spondyloarthritis Single-Center: High Frequency of Peripheral Involvement and Use of Synthetic Dmard
Andrea Shimabuco¹, Julio CB Moraes¹, Percival Sampaio-Barros², Cláudia Goldenstein-Schainberg¹, Celio R. Gonçalves¹, Ana CM Ribeiro¹ and Carla GS Saad¹, ¹Rheumatology Division, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ²Rheumatology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR., São Paulo, Brazil
Background/Purpose: The use of synthetic DMARDS (sDMARDs) in spondyloarthritis (SpA) has been increasingly questioned and restricted to peripheral disease, on the other hand, the use…
Abstract Number: 689 • 2018 ACR/ARHP Annual Meeting
Association of Kinesiophobia, Aerobic Exercise, Functional Impairment and Disease Activity of Patients with Rheumatoid Arthritis and Spondyloarthritis
Daniele Peres¹, Nicolas Tordi², Daniel Wendling³, Yoshimasa Sagawa⁴ and Clément Prati⁵, ¹EA 4267 PEPITE (FHU INCREASE) – Plateforme EPSI, Université de Bourgogne Franche-Comté, Besançon,, France, ²PEPITE EA 4267, Bourgogne Franche-Comté University, Besançon, France, ³Rheumatology, University Hospital - Bourgogne Franche Comté University, Besançon, France, ⁴Laboratoire de l'Exploration Fonctionnelle et Clinique du Mouvement (LEFCM), BESANCON, France, ⁵Rheumatology, University Hospital - Bourgogne Franche Comté University, Besancon, France
Association of kinesiophobia, aerobic exercise, functional impairment and disease activity of patients with rheumatoid arthritis and spondyloarthritis.Background/Purpose: Rheumatoid arthritis (RA) and spondyloarthritis (SA) are the…
Abstract Number: 690 • 2018 ACR/ARHP Annual Meeting
Subcutaneous Secukinumab Provides Sustained Inhibition of Radiographic Progression in Patients with Active Psoriatic Arthritis: 52-Week Results from a Phase 3 Study
Philip J. Mease¹, Désirée van der Heijde², Robert B.M. Landewé³, Shephard Mpofu⁴, Proton Rahman⁵, Hasan Tahir⁶, Atul Singhal⁷, Elke Böttcher⁸, Sandra V. Navarra⁹, Xuan Zhu¹⁰, Aimee Readie¹⁰, Luminita Pricop¹¹ and Ken Abrams¹⁰, ¹Swedish Medical Centre and University of Washington, Seattle, WA, ²Leiden University Medical Centre, Leiden, Netherlands, ³University of Amsterdam, Amsterdam, Netherlands, ⁴Novartis Pharma AG, Basel, Switzerland, ⁵Memorial University of Newfoundland and Labrador, St. John's, NF, Canada, ⁶Whipps Cross University Hospital, Barts Health NHS Trust, London, United Kingdom, ⁷Southwest Rheumatology, Dallas, TX, ⁸Rheumazentrum Favoriten, Vienna, Austria, ⁹University of Santo Tomas Hospital, Manila, Philippines, ¹⁰Novartis Pharmaceuticals Corporation, East Hanover, NJ, ¹¹Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA, East Hanover, NJ
Background/Purpose: Secukinumab (SEC), a fully human anti-interleukin-17A monoclonal antibody, significantly improved signs and symptoms and inhibited radiographic progression versus placebo (PBO) at Week (Wk) 24…
Abstract Number: 691 • 2018 ACR/ARHP Annual Meeting
A Service Evaluation of Reporting Standards of Computer Tomography Defined Sacroiliitis Suggestive of Axial Spondyloarthritis in Inflammatory Bowel Disease Patients Imaged for Non-Musculoskeletal Indications
Chong Seng Edwin Lim¹, Samantha Bee Lian Low², Baljeet Dhillon², Shin Azegami², Andoni Paul Toms² and Karl Gaffney¹, ¹Rheumatology, Norfolk and Norwich University Hospital, Norwich, United Kingdom, ²Radiology, Norfolk and Norwich University Hospital, Norwich, United Kingdom
Background/Purpose: A combined service evaluation by the rheumatology and radiology department was undertaken to understand the frequency and reporting standards of Computer Tomography-defined Sacroiliitis (CTSI)…
Abstract Number: 692 • 2018 ACR/ARHP Annual Meeting
TNF Inhibitor Dose Tapering in Axial Spondyloarthritis: A Systematic Review and Meta-Analysis
Daeria O. Lawson^1,2, Maria Eraso³, Lawrence Mbuagbaw⁴, Theresa Aves⁵, Alvin Leenus⁴, Marianinha Joanes⁶, Ahmed Omar^1,7 and Robert D Inman^8,9, ¹Rheumatology, Toronto Western Hospital, Toronto, ON, Canada, Toronto, ON, Canada, ²Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada, Hamilton, ON, Canada, ³Toronto Western Hospital, Toronto, ON, Canada, Tornoto, ON, Canada, ⁴McMaster University, Hamilton, ON, Canada, Hamilton, ON, Canada, ⁵St. Michael's Hospital, Toronto, ON, Canada, Toronto, ON, Canada, ⁶Boston University School of Medicine, Boston, MA, United States, Boston, MA, ⁷Rheumatology, University of Toronto, Toronto, ON, Canada, Toronto, ON, Canada, ⁸Toronto Western Hospital, Toronto, ON, Canada, Toronto, ON, Canada, ⁹University of Toronto, Toronto, ON, Canada, Toronto, ON, Canada
Background/Purpose: Patients with axial spondyloarthritis (axSpA) who have achieved a stable disease state and are undergoing treatment with tumour necrosis factor inhibitor (TNFi) therapy may…
Abstract Number: 693 • 2018 ACR/ARHP Annual Meeting
Combining Adalimumab with Methotrexate Does Not Improve Long Term Sustainability in Patients with Psoriatic Arthritis. Real World Evidence Report from the Quebec Database Rhumadata®
Omar Benryane¹, Louis Coupal² and Denis Choquette², ¹Médecine, Faculté de Médecine de l’Université de Montréal, Montréal, QC, Canada, ²Rheumatology, Institut de Recherche en Rhumatologie de Montréal (IRRM), Montréal, QC, Canada
Background/Purpose: Psoriatic Arthritis (PsA) in a musculoskeletal inflammatory condition associated with psoriasis. It has a heterogeneous set of clinical manifestations which include peripheral arthritis, axial…
Abstract Number: 694 • 2018 ACR/ARHP Annual Meeting
Combining Etanercept with Methotrexate Does Not Improve Long Term Sustainability in Patients with Psoriatic Arthritis. Real World Evidence Report from the Quebec Database Rhumadata®
Omar Benryane¹, Louis Coupal² and Denis Choquette², ¹Médecine, Faculté de Médecine de l’Université de Montréal, Montréal, QC, Canada, ²Rheumatology, Institut de Recherche en Rhumatologie de Montréal (IRRM), Montréal, QC, Canada
Background/Purpose: Psoriatic Arthritis (PsA) in a musculoskeletal inflammatory condition associated with psoriasis. It has a heterogeneous set of clinical manifestations which include peripheral arthritis, axial…
Abstract Number: 695 • 2018 ACR/ARHP Annual Meeting
Tumor Necrosis Factor Inhibitor Persistence and Reasons for Discontinuation in US Veterans with Axial Spondyloarthritis
Delamo Bekele¹, Elizabeth Cheng², Christian Geier^3,4, Kavya Ganuthula⁵, Jessica Walsh^6,7, Maureen Dubreuil^8,9, Daniel O. Clegg¹⁰, Prashant Kaushik¹¹, Bernard Ng^12,13,14,15, Elizabeth Chang¹⁶, Andreas Reimold^17,18, Siba P. Raychaudhuri¹⁹, Ryan Duong²⁰, Kristine A Kuhn²¹, Yujin Park²² and Gail S. Kerr²³, ¹Rheumatology, Mayo Clinic, Rochester, MN, ²Rheumatology, University of Colorado, Denver, CO, ³Rheumatology, Columbia University- NYP Hospital, New York, NY, ⁴Columbia University, New York, NY, ⁵Internal Medicine, VA Eastern Colorado Health Care System, Aurora, CO, ⁶Rheumatology Section, Salt Lake City Veterans Affairs, Salt Lake City, UT, ⁷Division of Rheumatology, Salt Lake City Veteran Affairs and University of Utah Medical Centers, Salt Lake City, UT, ⁸Rheumatology, VA Boston Healthcare System & Boston University School of Medicine, Boston, MA, ⁹Rheumatology, VA Boston Healthcare System, Boston, MA, ¹⁰Division of Rheumatology, University of Utah Medical Center, Salt Lake City, UT, ¹¹Rheumatology/Medicine, Stratton VAMC, Albany, NY, ¹²Rheumatology, Seattle VAMC, Seattle, WA, ¹³Rheumatology, VA Puget Sound Healthcare System, Seattle, WA, ¹⁴Michael E. DeBakey VA Medical Center Health Services Research and Development Center of Excellence, Houston, TX, ¹⁵Division of Rheumatology, University of Washington, Seattle, WA, ¹⁶Rheumatology, Phoenix VAHCS, Phoenix, AZ, ¹⁷Rheumatology, Dallas VAMC, Dallas, TX, ¹⁸Rheumatology, Dallas VA Medical Center and University of Texas - Southwestern, Dallas, TX, ¹⁹Rheumatology, Sacramento VAMC, Mather, CA, ²⁰Rheumatology, Denver Veterans Affairs Medical Center and UC Denver SOM, Denver, CO, ²¹Division of Rheumatology, Rocky Mountain Regional Veterans Affairs Medical Center/University of Colorado School of Medicine, Aurora, CO, ²²Health Economics and Outcomes Research, Novartis Pharmaceuticals Corporation, East Hanover, NJ, ²³Rheumatology, Washington DC VAMC, Georgetown and Howard University, Washington, DC
Background/Purpose: Although tumor necrosis factor inhibitors (TNFi) have favorably altered the treatment landscape for patients with axial spondyloarthritis (AxSpA), permanent therapy is infrequent. Further, the…
Abstract Number: 696 • 2018 ACR/ARHP Annual Meeting
Efficacy and Safety of Novel Targeted Synthetic DMARD and Biological DMARD in Active Psoriatic Arthritis: A Systematic Review, Meta-Analysis, and Network Meta-Analysis
Chenyang Lu^1,2, Beth Wallace^3,4,5, Wenyi Fu^2,6 and Yi Liu¹, ¹Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, Sichuan, China, Chengdu, China, ²Division of Rheumatology and Clinical Autoimmunity Center of Excellence, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, Ann Arbor, MI, ³VA Center for Clinical Management Research, VA Ann Arbor Health Care System, Ann Arbor, MI, ⁴Department of Internal Medicine, Division of Rheumatology, Michigan Medicine, Ann Arbor, MI, ⁵Institute for Healthcare Policy and Innovation, Michigan Medicine, Ann Arbor, MI, ⁶Department of Rheumatology and Immunology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China, Shenyang, China
Background/Purpose: Many targeted synthetic DMARD (tsDMARD) and biological DMARD (bDMARD) were recently approved for treatment of active psoriatic arthritis (PsA), but their comparative efficacy and…
Abstract Number: 697 • 2018 ACR/ARHP Annual Meeting
Clinical Results of Patients with Peripheral Psoriatic Arthritis Not Receiving Biological Therapy in a Multidisciplinary Unit
Clara Pérez-Velásquez¹, Maria Luz Garcia Vivar², Silvia Perez Barrio³, Eva Galindez-Agirregoikoa¹, Esther Ruíz Lucea¹, Ignacio Torre-Salaberri⁴, Olaia Fernández-Berrizbeitia¹, Ana Rosa Inchaurbe Pellejero², Juan Blanco Madrigal¹, Edurne Guerrero Basterretxea², Itziar Calvo Zorrilla², Oihane Ibarguengoitia², David Montero², Natalia Rivera-García¹, Maria Jesus Allande Lopez Linares¹ and Iñigo Gorostiza-Hormaetxe⁵, ¹Rheumatology, University Hospital of Basurto, Bilbao, Spain, ²Rheumatology, Rheumatology Department; Basurto University Hospital, Bilbao, Spain, ³Dermatology, University Hospital of Basurto, Bilbao, Spain, ⁴Rheumatology, Hospital Universitario de Basurto. Bilbao. Spain, Bilbao, Spain, ⁵Unit of Research, University Hospital of Basurto, Bilbao, Spain
Background/Purpose: We consider multidisciplinary management necessary, especially in a subgroup of patients with Psoriatic Arthritis (PsA) for complexity, cutaneous and / or joint involvement. Despite…
Abstract Number: 698 • 2018 ACR/ARHP Annual Meeting
Discontinuation of Methotrexate or TNF Inhibitors in Patients with Rheumatoid Arthritis, Psoriatic Arthritis, and Ankylosing Spondylitis
Michael D. George¹, Joshua Baker² and Alexis Ogdie³, ¹Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, ²Philadelphia VA Medical Center and University of Pennsylvania, Philadelphia, PA, ³Medicine/Rheumatology and Epidemiology, University of Pennsylvania, Philadelphia, PA
Background/Purpose: Methotrexate and TNF inhibitors (TNFi) are commonly used in the treatment of RA, PsA, and other SpA. While MTX is a mainstay of RA…
Abstract Number: 699 • 2018 ACR/ARHP Annual Meeting
New Onset/Recurrence of Inflammatory Arthralgia/Spondyloarthritis in Patients Treated with Vedolizumab for Intestinal Bowel Disease
Silvia Tamanini¹, Micaela Fredi², Chiara Bazzani¹, Maria Grazia Lazzaroni³, Melissa Fernandes⁴, Cecilia Nalli³, Angela Tincani³ and Franco Franceschini², ¹Rheumatology and Clinical Immunology, Spedali Civili of Brescia, Brescia, Italy, ²Department of Clinical and Experimental Sciences, Spedali Civili and University of Brescia, Brescia, Italy, Rheumatology and Clinical Immunology, Brescia, Italy, ³Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia, Italy, ⁴Autoimmune Unit/Internal Medicine Department, Hospital Curry Cabral, Centro Hospitalar de Lisboa Central (C.H.L.C), Lisbona, Portugal
Background/Purpose: Vedolizumab (VDZ) is a monoclonal antibody approved for inflammatory bowel disease, with a gut-specific mechanism of action, binding to α4β7 integrine expressed on gut-homing…

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