Date: Sunday, October 21, 2018
Session Type: ACR Poster Session A
Session Time: 9:00AM-11:00AM
Background/Purpose: To delineateclinical characteristicsof patients with spondyloarthritis (SpA) in Japan in comparison to other areas of the world.
Methods: Utilizingthe COMOSPA data, an international cross-sectional observational study of SpA patients we analyzed information on demographics, disease characteristics, comorbidities,and risk factors. Patients were classified by region:Japan, other Asia (China, Singapore, South Korea, and Taiwan), and non-Asian countries (Europe, Americas, and Africa);patient characteristics, including diagnosis and treatment, were compared.
Results: Among 3984 patients included in the study, 161 were from centers in Japan, 933 from other Asian countries, and 2890 from other regions. Of SpA patients in Japan, 28.6%had peripheral SpA, whereas presenting symptoms were more predominantly axial in other Asian countries. Thistrendwas explained by the predominance of PsA patients among Japanese SpA patients. In contrast to the relatively low number in Japan, 54% of patients from other Asiancountries had pure axial SpAwithout peripheral features. HLA B27 testing, which is considered an integral part of the classificationof axial SpA, was only performed in 62%ofJapanese axial SpA patients. More than half of Japanese axial SpA patients were classified usingimaging criteria.
Conclusion: There is substantially more peripheral SpA in Japan compared to other parts of Asia, and other regions of the world. Aside from ethnicdifferences, increasing recognition of PsA,as well as a potential under-diagnosis of axial SpA due to the insufficient use of HLA B27 testingin Japan,may partly explain regionaldiscrepancies.
To cite this abstract in AMA style:Sawada H, Yoshida K, Ichikawa N, Inoue H, Kaneko Y, Kawasaki T, Matsui K, Morita M, Tada K, Takizawa N, Tamura N, Taniguchi A, Taniguchi Y, Tsujii S, Haji Y, Suda M, Yanaoka H, Rokutanda R, Okada M, López Medina C, Molto A, Dougados M, van der Heijde D, Kobayashi S, Tomita T, Kishimoto M. Clinical Characteristics of Spondyloarthritis Patients in Japan in Comparison to Other Regions of the World [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 10). https://acrabstracts.org/abstract/clinical-characteristics-of-spondyloarthritis-patients-in-japan-in-comparison-to-other-regions-of-the-world/. Accessed August 7, 2020.
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